共查询到20条相似文献,搜索用时 66 毫秒
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在“文革”中的 1 972年 ,山东省化学石油工业局 ,具有远见卓识 ,凭着非凡的胆识和勇气 ,在动乱的年代 ,支持创办了山东省化学工业的第一本刊物———《山东化工》。 30年过去了 ,《山东化工》现已发展壮大成为具有一定影响的国内外公开发行的正式刊物 ,每期 60余页正文 ,设有“科研与开发”、“生产与应用”、“专论与综述”、分析与测试”、“企业论坛”、“改革巡礼”、“人物专访”、“科技简讯”、“经济与市场”、“管理初探”、“企业快报”、“市场动态”、“综合信息”等 1 0余个栏目 ,读者涉及化工及相关行业的各级决策管理人员、… 相似文献
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紫砂壶“小世界,大乾坤”,可谓汇集器皿造型艺术的宝库.其间蕴藏着丰富多彩的完美器型,从“汉扁壶”、“掇球壶”、“仿古壶”、“线云壶”到“菱花壶”、“鱼化龙壶”、“合菊壶”、“风卷葵壶”等艺术造型,汇集着历代艺人的创作智慧,历经数百年来的反复提炼、修改,日臻完善,沿传至今,虽古犹新。 相似文献
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近日,风神轮胎公司的“HN237”、“HN254”、“HN3Q2”、“HN326”、“HN368”、“HN369”、“HN509”、“A2366”等八项轮胎花纹外观设计获得了国家知识产权局颁发的外观设计专利证书。截止目前,风神轮胎获外观专利授权量已达103项。 相似文献
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Ewelina Bratek-Gerej Apolonia Ziembowicz Elzbieta Salinska 《International journal of molecular sciences》2022,23(13)
Birth asphyxia causes brain injury in neonates, but a fully successful treatment has yet to be developed. This study aimed to investigate the effect of group II mGlu receptors activation after experimental birth asphyxia (hypoxia-ischemia) on the expression of factors involved in apoptosis and neuroprotective neurotrophins. Hypoxia-ischemia (HI) on 7-day-old rats was used as an experimental model. The effects of intraperitoneal application of mGluR2 agonist (5 mg/kg) and the specific mGluR3 agonist NAAG (5 mg/kg) (1 h or 6 h after HI) on apoptotic processes and initiation of the neuroprotective mechanism were investigated. LY379268 and NAAG applied shortly after HI prevented brain damage and significantly decreased pro-apoptotic Bax and HtrA2/Omi expression, increasing expression of anti-apoptotic Bcl-2. NAAG or LY379268 applied at both times also decreased HIF-1α formation. HI caused a significant decrease in BDNF concentration, which was restored after LY379268 or NAAG administration. HI-induced increase in GDNF concentration was decreased after administration of LY379268 or NAAG. Our results show that activation of mGluR2/3 receptors shortly after HI prevents brain damage by the inhibition of excessive glutamate release and apoptotic damage decrease. mGluR2 and mGluR3 agonists produced comparable results, indicating that both receptors may be a potential target for early treatment in neonatal HI. LY379268相似文献
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Yi He Salvador Alejo Prabhakar Pitta Venkata Jessica D. Johnson Ilanna Loeffel Uday P. Pratap Yi Zou Zhao Lai Rajeshwar R. Tekmal Edward R. Kost Gangadhara R. Sareddy 《International journal of molecular sciences》2022,23(13)
Ovarian cancer (OCa) is the deadliest gynecologic cancer. Emerging studies suggest ovarian cancer stem cells (OCSCs) contribute to chemotherapy resistance and tumor relapse. Recent studies demonstrated estrogen receptor beta (ERβ) exerts tumor suppressor functions in OCa. However, the status of ERβ expression in OCSCs and the therapeutic utility of the ERβ agonist for targeting OCSCs remain unknown. OCSCs were enriched from ES2, OV90, SKOV3, OVSAHO, and A2780 cells using ALDEFLUOR kit. RT-qPCR results showed ERβ, particularly ERβ isoform 1, is highly expressed in OCSCs and that ERβ agonist LY500307 significantly reduced the viability of OCSCs. Treatment of OCSCs with LY500307 significantly reduced sphere formation, self-renewal, and invasion, while also promoting apoptosis and G2/M cell cycle arrest. Mechanistic studies using RNA-seq analysis demonstrated that LY500307 treatment resulted in modulation of pathways related to cell cycle and apoptosis. Western blot and RT-qPCR assays demonstrated the upregulation of apoptosis and cell cycle arrest genes such as FDXR, p21/CDKN1A, cleaved PARP, and caspase 3, and the downregulation of stemness markers SOX2, Oct4, and Nanog. Importantly, treatment of LY500307 significantly attenuated the tumor-initiating capacity of OCSCs in orthotopic OCa murine xenograft models. Our results demonstrate that ERβ agonist LY500307 is highly efficacious in reducing the stemness and promoting apoptosis of OCSCs and shows significant promise as a novel therapeutic agent in treating OCa. LY500307相似文献
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Tomohiro Fujii Jun Nishikawa Soichiro Fukuda Naoto Kubota Junzo Nojima Koichi Fujisawa Ryo Ogawa Atsushi Goto Koichi Hamabe Shinichi Hashimoto Aung Phyo Wai Hisashi Iizasa Hironori Yoshiyama Kohei Sakai Yutaka Suehiro Takahiro Yamasaki Taro Takami 《International journal of molecular sciences》2022,23(18)
DNA methylation of both viral and host DNA is one of the major mechanisms involved in the development of Epstein–Barr virus-associated gastric carcinoma (EBVaGC); thus, epigenetic treatment using demethylating agents would seem to be promising. We have verified the effect of , which was discovered by screening for demethylating agents. MC180295 inhibited cell growth of the EBVaGC cell lines YCCEL1 and SNU719 in a dose-dependent manner. In a cell cycle analysis, growth arrest and apoptosis were observed in both YCCEL1 and SNU719 cells treated with MC180295. MKN28 cells infected with EBV were sensitive to MC180295 and showed more significant inhibition of cell growth compared to controls without EBV infection. Serial analysis of gene expression analysis showed the expression of genes belonging to the role of BRCA1 in DNA damage response and cell cycle control chromosomal replication to be significantly reduced after MC180295 treatment. We confirmed with quantitative PCR that the expression levels of BRCA2, FANCM, RAD51, TOP2A, and CDC45 were significantly decreased by MC180295. LMP1 and BZLF1 are EBV genes with expression that is epigenetically regulated, and MC180295 could up-regulate their expression. In conclusion, MC180295 inhibited the growth of EBVaGC cells by suppressing DNA repair and the cell cycle. MC180295相似文献
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氯化聚乙烯(CPE)在普通V带底胶中的应用研究 总被引:2,自引:1,他引:1
氯化聚乙烯与橡胶其混,用于普通V带底胶进行研究。并就各配合体系的选择及加工工艺对橡胶胶料的性能影响进行技术探索。结果表明,氯化聚乙烯与橡胶并用制造出性能良好具有优良的耐弯曲、耐疲劳、伸长率小的V带。 相似文献
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通过小区试验及62组同田对比示范实收亩产证实,硅肥亩施30~50kg,可增产稻谷5.9%~17.1%,其处理间“F”值及“t”测验垃达显著标准,其增产原因于促进秧苗早生,快发,对水稻白叶枯病可以缓解,提高稻谷的经济性状,其结论与河南省研究结果基本一致。 相似文献
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半水煤气脱硫装置的设计及工艺管理 总被引:1,自引:0,他引:1
结合“888”催化剂在半水煤气脱硫工段实际使用情况,论述了催化剂的选择、以Na2CO3为碱源的催化原理、生产中工艺指标的管理及常见问题的处理。 相似文献
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Liang Li Jinhang Liu Qin Liang Yu Feng Chao Wang Shaohua Wu Yongyu Li 《International journal of molecular sciences》2021,22(21)
Bud endodormancy is an important, complex process subject to both genetic and epigenetic control, the mechanism of which is still unclear. The endogenous hormone abscisic acid (ABA) and its signaling pathway play important roles in the endodormancy process, in which the type 2C protein phosphatases (PP2Cs) is key to the ABA signal pathway. Due to its excellent effect on endodormancy release, hydrogen cyanamide (HC) treatment is considered an effective measure to study the mechanism of endodormancy release. In this study, RNA-Seq analysis was conducted on endodormant floral buds of pear (Pyrus pyrifolia) with HC treatment, and the HC-induced PP2C gene PpPP2C1 was identified. Next, software prediction, expression tests and transient assays revealed that lncRNA PpL--derived Pp-miRn182 targets PpPP2C1. The expression analysis showed that HC treatment upregulated the expression of PpPP2C1 and downregulated the expression of PpL- T31511 and Pp-miRn182. Moreover, HC treatment inhibited the accumulation of ABA signaling pathway-related genes and hydrogen peroxide (H2O2). Furthermore, overexpression of Pp-miRn182 reduced the inhibitory effect of PpPP2C1 on the H2O2 content. In summary, our study suggests that downregulation of PpL- T31511-derived Pp-miRn182 promotes HC-induced endodormancy release in pear plants through the PP2C-H2O2 pathway. T31511相似文献
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An in situ polarization-dependent total reflection fluorescence yield EXAFS system has been developed to analyze the asymmetric structures of catalytically active metal sites on single crystal surfaces. This technique separately reveals the bonding feature parallel and perpendicular to the support surface. The systems of Cu ion on -quartz(0001), Co oxide on -alumina(0001), and Pt4 on -alumina(0001) were investigated as model surfaces of supported catalytic systems. The location of Cu sites on -quartz(0001), the epitaxial growth mode of Co3O4 on -alumina(0001), and the Pt raft structure with metal-support interaction in Pt4 / -alumina(0001) were observed. 相似文献