2016年-2020年专利到期的农药品种之氟吡菌胺

<正>我国农药行业转型升级最根本出路在于加大农药研发投入,创造和培育出具有自主知识产权的骨干农药品种;与此同时还要在产品开发过程中制定相应的知识产权战略,构建周密的产品知识产权保护网,进而依靠专利产品和技术获取超额利润。保护农药知识产权,维护农药开发和技术创新的积极性,对维护农药行业的健康发展十分重要。     

农药行业知识产权保护的实践与思考

农药属于精细化学品,产品数量多,技术含量高,市场竞争性强,因此,农药行业的知识产权保护对于消除恶性竞争,突破发展瓶颈,促进作物保护可持续发展是十分必要的。本文介绍了农药行业知识产权保护的实践,并提出了建议。     

2016年~2020年专利到期的农药品种之氟虫酰胺

<正>我国农药行业转型升级最根本出路在于加大农药研发投入,创造和培育出具有自主知识产权的骨干农药品种;与此同时还要在产品开发过程中制定相应的知识产权战略,构建周密的产品知识产权保护网,进而依靠专利产品和技术获取超额利润。保护农药知识产权,维护农药开发和技术创新的积极性,对维护农药行业的健康发展十分重要。     

加强知识产权保护足进我国农药工业转型升级

农药与知识产权的关系是：世界需要农药,农药需要科学技术,科学技术需要知识产权保护。简介了我国农药工业的现状,指出存在的问题,认为只有科学技术能够救农药。分析我国农药工业知识产权保护中存在的问题,得知加强知识产权保护,才能促进农药工业转型升级。     

2016年-2020年专利到期的农药品种之嘧苯胺磺隆

我国农药行业转型升级最根本出路在于加大农药研发投入,创造和培育出具有自主知识产权的骨干农药品种;与此同时还要在产品开发过程中制定相应的知识产权战略,构建周密的产品知识产权保护网,进而依靠专利产品和技术获取超额利润。保护农药知识产权,维护农药开发和技术创新的积极性,对维护农药行业的健康发展十分重要。农药领域的专利和行政保护较多,如何避免专利侵权及产权纠纷,也是农药企业十分关注的事情。本期开始陆续介绍2016年-2020年专利到期的农药品种。敬请关注!     

2014年农药行业知识产权与保护高峰论坛会议邀请函

<正>2013年我国农药行业逆势增长,赢得了业内人士的广泛关注。尽管形势喜人,我们还是应该清醒地认识到,当前行业还面临着产业结构转型升级、环保压力增大、传统产品产能过剩、生产成本上升、企业创新能力弱等诸多挑战,未来行业必需不断调整产业结构、加大兼并重组力度、提高创新能力、加大环保投入、实现转型升级。我国农药行业转型升级最根本出路在于加大农药研发投入,创造和培育出具有自主知识产权的骨干农药品种;与此同时还要在产品开发过程中学会制定相应的知识产权战略,构建周密的产品知识产权保护网,进而依靠专利产品和技术获取超额利润。为了帮助农药企业及时了解国际农药知识产权(包括专利、商标、反不正当竞争等)最新趋势、农药新品种专利申请情况、最新专利失效但有市场前景的农药品种,提升知识产权保护水平,进而提升企业竞争力,中国化工信息中心定于2014年3月29-30日在上海举办"2014年农药行业知识产权与保护高峰论坛",届时将邀请农业部药检所、商务部、国家知识产权局、中国化工信息中心、知名律     

2012年3月农药行业知识产权保护沟通交流会将举办

为了帮助农药行业各有关单位了解知识产权保护形势及面临的问题,了解专利法修改的最新动态,深入学习、掌握知识产权相关法律法规,有效应对知识产权保护中不断出现的新问题,中国化工信息中心决定举办＂农药行业知识产权保护沟通交流会＂,特邀请商务部、国家知识产权局、中国化工信息中心等有关领导、专家,通过主题发言、案例剖析、提问答疑、焦点讨论等形式,围绕知识产权保护前沿热点问题作针对性、实用性的解读与阐述,以期达到以下目的：1.从国家层面解读国内外农药知识产权保护战略,熟悉国内外通行的知识产权保护方法和规程;     

发明活性染料的启示

前言随着中美知识产权会谈达成协议,我国将加快实现保护知识产权的各项措施,并实行保护化学结构的专利法。在我国的化学工业中,医药、农药、染料行业关于创新研究的讨论已成为当前科技工作者考虑研究方向的热点。工业发达国家长期来对产品实行专利保护,直接     

部分农药产品的国内知识产权状况调查

加入WTO以来,随着我国知识产权事业的快速发展和知识产权执法力度的不断加强,国内众多农药企业正面临越来越多的知识产权纠纷问题。在这种情况下,了解现有农药产品的知识产权保护知识,对于农药企业规避知识产权纠纷无疑是非常必要的。本文对目前国内关注度较高的15个农药产品的知识产权状况进行了较为全面的调查,以供参考。     

部分农药产品的国内知识产权状况调查

加入WTO以来,随着我国知识产权事业的快速发展和知识产权执法力度的不断加强,国内众多农药企业正面临越来越多的知识产权纠纷问题。在这种情况下,了解现有农药产品的知识产权保护知识,对于农药企业规避知识产权纠纷无疑是非常必要的。针对15个热点农药产品进行了较为全面的知识产权状况调查后,继续对目前国内关注度较高的若干农药产品的知识产权状况进行调查,现将所调查结果公布如下,以供有关部门参考。     

污泥生物炭中氮硫行为及环境效应研究进展

污泥生物炭中氮硫元素含量高,其氮硫行为和环境效应对全球气候变化的影响不容忽视。以往的研究中,研究者往往以富碳生物炭作为主要研究对象,关注碳对全球气候变化的行为和功效,而对氮硫元素的作用关注不够。本文从原始污泥基本性质到其热解过程,再到生物炭的老化,逐步对污泥生物炭整个生命周期内氮硫的行为及其环境效应研究进行综述,并对未来应注重开展的研究方向进行展望,为生物炭中氮硫元素固定、释放及与之关联的环境效应和温室气体排放控制研究提供理论基础。分析表明,污泥中氮元素含量普遍高于硫元素,且热解过程中氮比硫更容易转移至气相产物。氮硫元素随热解温度的增加,在三相产物中的分配都是炭中持续减少,油中先增后减,气中一直增加。高温（＞800℃）条件下,气相中的氮含量高于固相,而硫元素则仍然主要存在于固相中。污泥生物炭老化及其环境效应研究表明,污泥生物炭氮硫元素与土壤的相互作用及其温室效应问题在今后的研究中应引起重视。     

Possible Role of Crystal-Bearing Cells in Tomato Fertility and Formation of Seedless Fruits

Crystal-bearing cells or idioblasts, which deposit calcium oxalate, are located in various tissues and organs of many plant species. The functional significance of their formation is currently unclear. Idioblasts in the leaf parenchyma and the development of crystal-bearing cells in the anther tissues of transgenic tomato plants (Solanum lycopersicon L.), expressing the heterologous FeSOD gene and which showed a decrease in fertility, were studied by transmission and scanning electron microscopy. The amount of calcium oxalate crystals was found to increase significantly in the transgenic plants compared to the wild type (WT) ones in idioblasts and crystal-bearing cells of the upper part of the anther. At the same time, changes in the size and shape of the crystals and their location in anther organs were noted. It seems that the interruption in the break of the anther stomium in transgenic plants was associated with the formation and cell death regulation of a specialized group of crystal-bearing cells. This disturbance caused an increase in the pool of these cells and their localization in the upper part of the anther, where rupture is initiated. Perturbations were also noted in the lower part of the anther in transgenic plants, where the amount of calcium oxalate crystals in crystal-bearing cells was reduced that was accompanied by disturbances in the morphology of pollen grains. Thus, the induction of the formation of crystal-bearing cells and calcium oxalate crystals can have multidirectional effects, contributing to the regulation of oxalate metabolism in the generative and vegetative organs and preventing fertility when the ROS balance changes, in particular, during oxidative stresses accompanying most abiotic and biotic environmental factors.     

Early Life Events and Maturation of the Dentate Gyrus: Implications for Neurons and Glial Cells

The dentate gyrus (DG), an important part of the hippocampus, plays a significant role in learning, memory, and emotional behavior. Factors potentially influencing normal development of neurons and glial cells in the DG during its maturation can exert long-lasting effects on brain functions. Early life stress may modify maturation of the DG and induce lifelong alterations in its structure and functioning, underlying brain pathologies in adults. In this paper, maturation of neurons and glial cells (microglia and astrocytes) and the effects of early life events on maturation processes in the DG have been comprehensively reviewed. Early postnatal interventions affecting the DG eventually result in an altered number of granule neurons in the DG, ectopic location of neurons and changes in adult neurogenesis. Adverse events in early life provoke proinflammatory changes in hippocampal glia at cellular and molecular levels immediately after stress exposure. Later, the cellular changes may disappear, though alterations in gene expression pattern persist. Additional stressful events later in life contribute to manifestation of glial changes and behavioral deficits. Alterations in the maturation of neuronal and glial cells induced by early life stress are interdependent and influence the development of neural nets, thus predisposing the brain to the development of cognitive and psychiatric disorders.     

Sp7 Transgenic Mice with a Markedly Impaired Lacunocanalicular Network Induced Sost and Reduced Bone Mass by Unloading

The relationship of lacunocanalicular network structure and mechanoresponse has not been well studied. The lacunocanalicular structures differed in the compression and tension sides, in the regions, and in genders in wild-type femoral cortical bone. The overexpression of Sp7 in osteoblasts resulted in thin and porous cortical bone with increased osteoclasts and apoptotic osteocytes, and the number of canaliculi was half of that in the wild-type mice, leading to a markedly impaired lacunocanalicular network. To investigate the response to unloading, we performed tail suspension. Unloading reduced trabecular and cortical bone in the Sp7 transgenic mice due to reduced bone formation. Sost-positive osteocytes increased by unloading on the compression side, but not on the tension side of cortical bone in the wild-type femurs. However, these differential responses were lost in the Sp7 transgenic femurs. Serum Sost increased in the Sp7 transgenic mice, but not in the wild-type mice. Unloading reduced the Col1a1 and Bglap/Bglap2 expression in the Sp7 transgenic mice but not the wild-type mice. Thus, Sp7 transgenic mice with the impaired lacunocanalicular network induced Sost expression by unloading but lost the differential regulation in the compression and tension sides, and the mice failed to restore bone formation during unloading, implicating the relationship of lacunocanalicular network structure and the regulation of bone formation in mechanoresponse.     

In vitro and in vivo evaluation of degradability and biocompatibility of poly(p-dioxanone) hemostatic clips for laparoscopic surgery

For the clinical application of biodegradable hemostatic surgical clips in laparoscopic surgery, it is necessary to determine their degradability and biocompatibility. Herein, in vitro and in vivo studies were undertaken to evaluate the degradability and biocompatibility of bioabsorbable clips made of poly(p-dioxanone). Changes in weight loss, pull-off force, differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) of the poly(p-dioxanone) clips were determined after they were degraded in deionized water and phosphate buffer saline for the in vitro experiment and in laparoscopic models of bile duct ligation(BDL) and right gastroepiploic artery ligation(GEAL) using New Zealand white rabbits for the in vivo experiment. Changes in weight loss and pull-off force were greater in the in vivo experiment than the in vitro experiment. DSC showed the greatest variation in the degree of crystallinity of the clips degraded in deionized water. Stark differences in SEM were observed after 4 weeks of degradation both in vitro and in vivo. Furthermore, the cytocompatibility of the clips was considered satisfactory because the L929 cells could adhere to the clips and proliferate adequately in the presence of the clip extract. Biocompatibility was inferred based on the histological analysis of BDL and GEAL, no significant inflammatory responses were observed after 4 weeks of ligation.     

Streptozotocin-Induced Diabetes Causes Changes in Serotonin-Positive Neurons in the Small Intestine in Pig Model

Serotonin (5-hydroxytryptamine or 5-HT) is an important neurotransmitter of the central and peripheral nervous systems, predominantly secreted in the gastrointestinal tract, especially in the gut. 5-HT is a crucial enteric signaling molecule and is well known for playing a key role in sensory-motor and secretory functions in the gut. Gastroenteropathy is one of the most clinical problems in diabetic patients with frequent episodes of hyperglycemia. Changes in 5-HT expression may mediate gastrointestinal tract disturbances seen in diabetes, such as nausea and diarrhea. Based on the double immunohistochemical staining, this study determined the variability in the population of 5-HT-positive neurons in the porcine small intestinal enteric neurons in the course of streptozotocin-induced diabetes. The results show changes in the number of 5-HT-positive neurons in the examined intestinal sections. The greatest changes were observed in the jejunum, particularly within the myenteric plexus. In the ileum, both de novo 5-HT synthesis in the inner submucosal plexus neurons and an increase in the number of neurons in the outer submucosal plexus were noted. The changes observed in the duodenum were also increasing in nature. The results of the current study confirm the previous observations concerning the involvement of 5-HT in inflammatory processes, and an increase in the number of 5-HT -positive neurons may also be a result of increased concentration of the 5-HT in the gastrointestinal tract wall and affects the motor and secretory processes, which are particularly intense in the small intestines.     

Molecular mechanisms of aging and immune system regulation in Drosophila

Aging is a complex process that involves the accumulation of deleterious changes resulting in overall decline in several vital functions, leading to the progressive deterioration in physiological condition of the organism and eventually causing disease and death. The immune system is the most important host-defense mechanism in humans and is also highly conserved in insects. Extensive research in vertebrates has concluded that aging of the immune function results in increased susceptibility to infectious disease and chronic inflammation. Over the years, interest has grown in studying the molecular interaction between aging and the immune response to pathogenic infections. The fruit fly Drosophila melanogaster is an excellent model system for dissecting the genetic and genomic basis of important biological processes, such as aging and the innate immune system, and deciphering parallel mechanisms in vertebrate animals. Here, we review the recent advances in the identification of key players modulating the relationship between molecular aging networks and immune signal transduction pathways in the fly. Understanding the details of the molecular events involved in aging and immune system regulation will potentially lead to the development of strategies for decreasing the impact of age-related diseases, thus improving human health and life span.     

Immunohistochemical Characteristics of the Human Carotid Body in the Antenatal and Postnatal Periods of Development

The evolutionary and ontogenetic development of the carotid body is still understudied. Research aimed at studying the comparative morphology of the organ at different periods in the individual development of various animal species should play a crucial role in understanding the physiology of the carotid body. However, despite more than two centuries of study, the human carotid body remains poorly understood. There are many knowledge gaps in particular related to the antenatal development of this structure. The aim of our work is to study the morphological and immunohistochemical characteristics of the human carotid body in the antenatal and postnatal periods of development. We investigated the human carotid bodies from 1 embryo, 20 fetuses and 13 adults of different ages using samples obtained at autopsy. Immunohistochemistry revealed expression of βIII-tubulin and tyrosine hydroxylase in the type I cells and nerve fibers at all periods of ontogenesis; synaptophysin and PGP9.5 in the type I cells in some of the antenatal cases and all of the postnatal cases; 200 kDa neurofilaments in nerve fibers in some of the antenatal cases and all of the postnatal cases; and GFAP and S100 in the type II cells and Schwann cells in some of the antenatal cases and all of the postnatal cases. A high level of tyrosine hydroxylase in the type I cells was a distinctive feature of the antenatal carotid bodies. On the contrary, in the type I cells of adults, the expression of tyrosine hydroxylase was significantly lower. Our data suggest that the human carotid body may perform an endocrine function in the antenatal period, while in the postnatal period of development, it loses this function and becomes a chemosensory organ.     

Study of the effect of ultrasonic treatment on the surface composition and the flotation performance of high-sulfur coal

This paper highlighted the use of X-ray diffraction, scanning electron microscopy and X-ray fluorescence spectroscopy to investigate the changes on the surface composition of high-sulfur coal and pyrite before and after ultrasonic conditioning. The results showed that ultrasonic conditioning resulted in a decrease in the contents of iron and sulfur in coal, an increase in the content of element carbon, and an increase in the purity of the coal. Conversely, ultrasonic conditioning led to an increase in the content of iron and sulfur in pyrite, a decrease in the impure content of calcium, and a relative increase in the purity of the pyrite after ultrasonic conditioning. This study verified that on the one hand, ultrasonic conditioning can promote the pyrite separation from the high-sulfur coal, with the separated pyrite taking the form of FeS; on the other hand, it can produce a cleaning effect on the surface of coal and pyrite with the consequent increase both in hydrophobicity of coal and hydrophilicity of pyrite. The paper introduced ultrasonic pre-treatment of the slurry and stepped froth removal tests of high-sulfur coal and the study on the yield, ash and sulfur content of clean coal in different phases. The results gave further evidence of the increases both in the rate and the selectivity of flotation. This study shows that ultrasonic conditioning can enhance the performance of de-sulphurization of high-sulfur coal flotation.     

Increased C-X-C Motif Chemokine Ligand 12 Levels in Cerebrospinal Fluid as a Candidate Biomarker in Sporadic Amyotrophic Lateral Sclerosis

Sporadic amyotrophic lateral sclerosis (sALS) is a fatal progressive neurodegenerative disease affecting upper and lower motor neurons. Biomarkers are useful to facilitate the diagnosis and/or prognosis of patients and to reveal possible mechanistic clues about the disease. This study aimed to identify and validate selected putative biomarkers in the cerebrospinal fluid (CSF) of sALS patients at early disease stages compared with age-matched controls and with other neurodegenerative diseases including Alzheimer disease (AD), spinal muscular atrophy type III (SMA), frontotemporal dementia behavioral variant (FTD), and multiple sclerosis (MS). SWATH acquisition on liquid chromatography-tandem mass spectrometry (LC–MS/MS) for protein quantitation, and ELISA for validation, were used in CSF samples of sALS cases at early stages of the disease. Analysis of mRNA and protein expression was carried out in the anterior horn of the lumbar spinal cord in post-mortem tissue of sALS cases (terminal stage) and controls using RTq-PCR, and Western blotting, and immunohistochemistry, respectively. SWATH acquisition on liquid chromatography-tandem mass spectrometry (LC–MS/MS) revealed 51 differentially expressed proteins in the CSF in sALS. Receiver operating characteristic (ROC) curves showed CXCL12 to be the most valuable candidate biomarker. We validated the values of CXCL12 in CSF with ELISA in two different cohorts. Besides sALS, increased CXCL12 levels were found in MS but were not altered in AD, SMA, and FTD. Therefore, increased CXCL12 levels in the CSF can be useful in the diagnoses of MS and sALS in the context of the clinical settings. CXCL12 immunoreactivity was localized in motor neurons in control and sALS, and in a few glial cells in sALS at the terminal stage; CXCR4 was in a subset of oligodendroglial-like cells and axonal ballooning of motor neurons in sALS; and CXCR7 in motor neurons in control and sALS, and reactive astrocytes in the pyramidal tracts in terminal sALS. CXCL12/CXCR4/CXCR7 axis in the spinal cord probably plays a complex role in inflammation, oligodendroglial and astrocyte signaling, and neuronal and axonal preservation in sALS.