共查询到18条相似文献,搜索用时 62 毫秒
1.
2.
3.
采用MCNP软件对国产6711型125I粒子源剂量率常数、径向剂量函数、一维各向异性函数和二维各向异性函数等四个剂量学参数进行模拟计算研究。结果表明,剂量率常数与TG 43-U1报告推荐值误差为-0.83%;获得了(0.05~10) cm范围内的径向剂量函数,并对(0.25~10) cm范围数据进行五阶多项式拟合,提高了拟合函数的精度;得到(0.25~7) cm范围内的一维各项异性函数和二维各向异性函数,通过与文献比较,发现国产6711型粒子源源芯结构的差异会引起一维各向异性函数和二维各向异性函数的偏大现象。 相似文献
4.
5.
国产125I粒子源的银棒末端结构为直角型,与典型的6711型粒子源结构略有不同,结构不同会对剂量计算参数产生一定影响。本文针对国产粒子源结构,利用蒙特卡罗方法计算美国医学物理学家协会(AAPM)在TG43-U1报告中推荐的剂量计算参数,并分析研究银棒末端结构对剂量计算参数的影响。模拟得到国产125I粒子源剂量率常数为0.955 cGy·h-1·U-1(空气比释动能强度基于点探测器计算得到),与TG43-U1推荐值较接近,两者仅相差1.03%,更加精细地计算了在源中垂线0.05~10 cm(1 cm间隔)范围内的径向剂量函数,拟合得到较好的经验公式,得到在0°~90°(5°间隔)、距源中心0.25~7 cm(2 cm间隔)范围内的二维各向异性函数,通过对比分析得到银棒末端为直角型结构时的二维各向异性函数在r=0.25 cm处会引起驼峰区。 相似文献
6.
利用中国先进研究堆(CARR)辐照制备125I的循环回路为全封闭的不锈钢细长管路系统。在入堆安装使用前,需对系统进行严格的调试实验,并测试系统的密封性,使其满足设计要求。本研究根据CARR的场所条件要求,设计125I制备循环回路模拟系统并进行调试,包括真空调试和氙气充气收气实验。采用长管路分段调试验证系统真空度并测定真空泄漏率;系统安装调试合格后,充入不同压力的天然氙气进行循环回收模拟实验。结果表明,设计的125I循环回路系统为细长多弯曲管路,系统密封性好,经氦质谱检漏测定值小于10-6 Pa•m3/s;天然氙气在系统中的导气实验结果表明,回收时间约为120 s,符合堆照生产125I的要求。实验结果证实了系统入堆安装调试的可行性,可为建立反应堆辐照制备125I回路系统提供参考。 相似文献
7.
8.
9.
10.
11.
125I粒子组织间植入近距离治疗恶性肿瘤 总被引:1,自引:0,他引:1
采用125I粒子植入法对20例恶性肿瘤患者的24个病灶进行治疗,以评价125I粒子组织间植入恶性肿瘤的可行性及不良反应。术前制定肿瘤组织间三维立体定向放射治疗计划,在全麻剖腹直视下、全麻腹腔镜下或局麻CT、局麻彩色多普勒导向下经皮穿刺将125I粒子植入恶性肿瘤病灶内。20例患者125I粒子植入均顺利完成,术中及术后1周观察粒子在病灶内的分布基本与计划相符合,未观察到粒子迁移;术中及术后不良反应较为轻微且易于处理;多数患者临床症状得到不同程度的缓解,血清肿瘤标志物水平呈现不同程度的下降; 病情完全缓解(CR)20.00%(4/20例), 部分缓解(PR)35.00%(7/20例), 稳定(SD)30.00%(6/20例),进展(PD)15.00%(3/20例),总有效率(CR+PR)55.00%(11/20例)。以上结果表明,125I粒子组织间植入近距离内放射治疗恶性肿瘤施术方便、安全有效,具有较高的临床价值,值得进一步推广及深入研究。 相似文献
12.
The end of silver rod of the domestic 125I brachytherapy source is right angle type, which is slightly different from the typical model of 6711 125I brachytherapy source. And it can have influence on the dose calculation parameters. Based on the structure of domestic 125I brachytherapy source, dose calculation parameters which are recommended by AAPM TG43-U1 were calculated by Monte Carlo method. The influence of the end of silver rod on the dose calculation parameters was studied. The simulation result of dose rate constant is 0.955 cGy·h-1·U-1 when the air kerma strength was calculated by the point detector, and the difference with the result of the TG43-U1 is within 1.03%. The radial dose function g(r) in the range of 0.05-10 cm at the transverse axis was calculated precisely. Then empiric equation was acquired by curve fitting. 2D anisotropy function F(r,θ) was calculated in 0°-90° and 0.25-7 cm. The source of the right angle structure of the end of the silver rod would cause a hump area of 2D anisotropy function when r equals 0.25 cm. 相似文献
13.
《Journal of Nuclear Science and Technology》2013,50(8):1095-1099
For two arrangement modes of two 125I brachytheray sources, a homo-longitudinal axis and a homotransverse axis, the sum of dose distributions caused by each single source and actual dose distribution of the two coexisting sources are calculated separately in a clinically interested area by Monte Carlo simulation. Comparisons between them are used to evaluate the mutual dose perturbation influence. The result shows, for the homo-longitudinal axis arrangement, obvious perturbation can be observed along the longitudinal direction when the distances between sources' centers, L, are 0.5 cm and 1.0 cm, up to 11:7 ± 0:4% and 4:8 ± 0:2%, respectively, but, can be negligible for the distance exceeding 2.0 cm. For the homo- transverse axis arrangement, the range of dose perturbation depends on the source length and distances between sources' centers, and an influence extent is greater than the former, e.g., 27:2 ± 1:1%, 15:4 ± 0:6%, and 7:0 ± 0:3% maximum for L = 0:5 cm, 1.0 cm, and 2.0 cm, respectively. As for dose perturbation induced by the source leaning which happened in actual implant sometimes, the result indicates a dose fluctuation became more acute with obliquity increasing. The maximum dose increasing, 54:5 ± 2:1% and 199:7 ± 7:8%, and the maximum dose decreasing, 42:6 ± 1:7% and 64:9 ± 2:6%, could be observed for 10° and 30° obliquity with L = 1:0 cm for the two arrangement modes respectively. 相似文献
14.
15.
本文叙述了用井型 NaI(T1)探测器的符合脉冲高度分布绝对测量~(125)I 活度的方法。用目前比较精确的核参数推导了计算公式。初步研究了样品体积和样品瓶的几何条件对测量结果的影响。测量结果的合成不确定度小于1%. 相似文献
16.
17.
^125I标记氧化低密度脂蛋白抗体 总被引:1,自引:0,他引:1
采用Iodogen法对氧化低密度脂蛋白抗体(OxLDL—Ab)进行了^125I标记,并对标记条件进行了优化;采用PD-10柱对标记抗体进行分离纯化,并对^125I-OxLDL—Ab的体外稳定性和活性进行评价。结果表明,^125I-OxLDL-Ab标记率〉80%,放化纯度〉95%,比活度达73.3TBq/g;^125I-OxLDL-Ab分别在生理盐水、含2%BSA的生理盐水和人血清中4℃放置96h,放化纯度降低均小于5%;^125I-OxLDL—Ab在体外与OxLDL结合的Ka为10.6±1.3GL/mol。以上结果提示^125I-OxLDL-Ab体外稳定性好,与OxLDL结合活性高,^125I标记对其活性影响小,可以用于体外放免诊断试剂盒的研究。 相似文献
18.
采用表面均匀覆盖钯层的0.5mm×3.0mm碳棒为载体,以银氨溶液为前体,110mAg为放射性示踪剂,水合肼为还原剂,在载体棒表面依次进行化学沉积103Pd、Ag、125I,可制备新型103 Pd-125I复合粒子源芯,实现103Pd和125I在同一载体表面的有效沉积,化学沉积银过程是103 Pd-125I复合粒子制备的关键。经优化的沉积条件为:AgNO3浓度2g/L,Na2EDTA浓度40g/L,NH3·H2O浓度16.25%,H4N2·H2O浓度5‰,沉积液pH10,反应时间60min,反应温度35℃。结果表明:化学沉积银层表面均匀,平整,呈银白色。 相似文献