Memory activation and expectancy as prospective predictors of alcohol and marijuana use.

This study examined whether indicators of drug-related memory associations predicted drug use prospectively. The predictive effects of outcome expectancies, sensation seeking, and other variables also were investigated. The results revealed that the memory association measures significantly predicted subsequent drug use. Outcome expectancies and sensation seeking predicted alcohol use, but not marijuana use. The findings suggest 2 possibly different aspects of cognition involved in drug use motivation: (a) a memory activation or implicit cognition component, representing the effects of memory associations that are prompted relatively spontaneously by the prevailing motivational and situational circumstances and (b) an outcome expectancy component, which is more likely to reflect explicit cognitions involved in introspection and deliberate decision-making processes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Implicit cognition in adolescent drug use.

Implicit cognitive responses to drug use cues and drug outcomes, assessed with measures of memory association, were studied in a sample of high-risk White and Latino adolescents. The utility of these responses as predictors of drug use was examined and compared with potentially confounding predictors, including gender, socioeconomic status, ethnicity, and acculturation. The background variables also served as potential moderators of the effects of implicit cognition. The results revealed that measures of memory association were consistent, direct-effect predictors of marijuana and alcohol use. In addition, these implicit cognitive measures were stronger predictors than were the background variables, and their predictive effects were not moderated by other variables. The results provide further support for the implicit cognition perspective in drug use. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Memory association and ambiguous cues in models of alcohol and marijuana use.

In parallel models of memory and expectancy theory, memory associations between drug-related cues and drug use may have motivational implications. This study examined whether these types of memory associations can be considered both a product and a predictor of alcohol and marijuana use consistent with a motivational model of drug use memory association. Results from a diverse college sample indicated that participants' memory associations to ambiguous cues were significantly related to alcohol and marijuana use independent of a number of possible correlates of these variables (e.g., family history of alcohol use acculturation and friends' drug use). The analytical models showed that these relationships held whether memory association was analyzed as a predictor or as a product of drug use. The results were consistent with the view that memory association is related to drug use through a parallel memory process akin to R. C. Bolles's (1972) concept of expectancy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Comparison of indirect assessments of association as predictors of marijuana use among at-risk adolescents.

In this study, the authors compared indirect measures that attempt to quantify the level of marijuana associations among adolescents. They also evaluated whether these various methods overlap or tap different aspects of associative processes that may act in concert to influence marijuana use. Automatic drug-relevant associations were assessed in 121 at-risk youth in continuation high schools in California with the use of a word association index and computer-based, reaction time measures (i.e., Implicit Association Test [IAT] and Extrinsic Affective Simon Task [EAST]). Measures of working memory capacity, sensation seeking, and explicit cognitions also were included in analyses as potential confounders. The word association index and the marijuana IAT excited D measure were significant predictors of marijuana use. The word association index accounted for more variance in marijuana use than did the IAT or EAST measures. Further, confirmatory factor analytic models of the indirect measures of marijuana use revealed a significant moderate correlation between the EAST Excitement and Word Association factors but no significant correlations between the Word Association and IAT factors. These findings suggest that there is some convergence among the different indirect measures, but these assessments also appear to tap different aspects of associative processes. The types of indirect measures evaluated in this work provide information about spontaneous cognitions related to substance use, capturing influences on behavior that are not evaluated with traditional explicit assessments of behavior. Findings from this work add to a growing body of research that implicates the importance of implicit associative processes in risk and health behaviors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Measuring alcohol expectancies with the implicit association test.

Researchers have relied primarily on self-report questionnaires to measure alcohol expectancies. These questionnaires assess explicit expectancies about alcohol but do not provide any measure of the implicit processes that might also play an important role in determining drinking. The implicit association test (IAT: A. G. Greenwald, D. E. McGhee, & L. K. Schwartz, 1998), a reaction time task, measures differential associations of 2 target concepts with an attribute. In this study, the IAT provided a measure of the strength of associations of alcohol concepts to positive or negative outcomes in memory. This implicit measure of alcohol expectancies successfully predicted alcohol use in 103 undergraduates. The findings also supported the hypothesis that an implicit measure of expectancy can add to the predictive power of existing questionnaire-based measures. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Associations of marijuana use and sex-related marijuana expectancies with HIV/STD risk behavior in high-risk adolescents.

Multiple studies suggest an association of marijuana use with increased rates of sexual risk behavior and sexually transmitted diseases (STDs). Most studies have focused on global associations of marijuana use with sexual risk outcomes and few have examined relevant cognitive variables. Adolescents in the juvenile justice system are at elevated risk for HIV/STDs and preliminary evidence suggests that marijuana is a potentially important cofactor for sexual risk behavior in this population. This study evaluated global, situational and event-level associations of marijuana use and sex-related marijuana expectancies with sexual risk outcomes in a large, racially diverse sample of adjudicated youth (n = 656, 66% male, mean age = 16.7 years). Cross-sectional and prospective analyses identified associations of marijuana use and dependence symptoms with sexual risk outcomes, including lower frequency of condom use and higher STD incidence. Stronger sex-related marijuana expectancies predicted greater intentions for and frequency of marijuana use in sexual situations. In event-level analyses that controlled for alcohol, marijuana use predicted a significantly decreased likelihood of condom use; this association was moderated by sex-related marijuana expectancies. Mediation analyses suggested that behavioral intentions partly accounted for the prospective association of expectancies with marijuana use before sex. These results provide further evidence that marijuana use is a potentially important cofactor for HIV/STD transmission in high-risk adolescents and suggest that cognitive factors could be important for characterizing this association. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Memory association and personality as predictors of alcohol use: mediation and moderator effects

We investigated the nature of the effects of memory associations on alcohol use and abuse. First, we determined if effects of memory associations on drinking problems are mediated entirely through the frequency of alcohol consumption or, alternatively, if such effects are more direct. Second, personality traits were assessed to evaluate whether they were confounded with memory association in their effects or whether they might moderate the effects of memory associations on alcohol use and abuse. The results showed that memory association measures directly and independently predicted alcohol consumption; these measures indirectly predicted problems from drinking, including drunk driving. None of the assessed personality variables moderated the predictive effects of memory association. The results are consistent with the view that memory associations influence behavior through cognitive processes that are not affected by personality traits or by cognitions emanating from such traits.     

Implicit and explicit measures of alcohol and smoking cognitions.

The present study tested convergent, discriminant, and incremental validity of implicit and explicit measures of alcohol and smoking cognitions. College-aged participants (n = 264) completed questionnaire measures of alcohol and smoking expectancies and behavior. Participants also completed the Implicit Association Test (IAT; Greenwald, McGhee, & Schwartz, 1998) for alcohol and smoking on two occasions, approximately 1 month apart. Psychometric qualities of these IATs were evaluated. Modest associations were found between implicit and explicit measures for the same substance. Both implicit and explicit measures had unique associations with use. Discriminant validity was stronger for alcohol measures than for smoking measures. These results support the utility of the IAT as a technique for assessing implicit associations about alcohol and smoking. They also provide some evidence that smoking motivations may make unique contributions to alcohol use. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Explicit and implicit measures of expectancy and related alcohol cognitions: A meta-analytic comparison.

Implicit measures assess the influence of past experience on present behavior in the absence of respondents’ awareness of that influence. Application of implicit measurement to expectancy and related alcohol cognition research has helped elucidate the links between alcohol-related experiences, the functioning of alcohol-related memory, and alcohol-related behavior. Despite these advances, a coherent picture of the role of implicit measurement has been difficult to achieve because of the diversity of implicit measures used. Two central questions have emerged: Do implicit measures assess a distinct aspect of the alcohol associative memory domain not accessible via explicit measurement; when compared with explicit measurement, do they offer unique prediction of alcohol consumption? To address these questions, the authors conducted a meta-analysis of studies using both implicit and explicit measures of alcohol expectancy and other types of alcohol-related cognition. Results indicate that implicit and explicit measures are weakly related, and although they predict some shared variance in drinking, each also contributes a unique component. Results are discussed in the context of the theoretical distinction made between the 2 types of measures. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Working memory capacity moderates the predictive effects of drug-related associations on substance use.

Some theories suggest that spontaneously activated, drug-related associations in memory may have a "freer reign" in predicting drug use among individuals with lower working memory capacity. This study evaluated this hypothesis among 145 at-risk youth attending continuation high schools (CHS). This is the 1st study to evaluate this type of dual-process interaction in the prediction of drug use among a sample of at-risk adolescents. The CHS students completed assessments of drug-related memory associations, working memory capacity, and drug use. Control variables included age, gender, ethnicity, and acculturation. Robust multiple regression using least trimmed squares estimation indicated that there was a significant linear by linear interaction between working memory capacity (assessed with the self-ordered pointing task) and drug-related associations (assessed with verb generation and cue-behavior association tasks) in the prediction of alcohol and cigarette use. Consistent with dual-process cognitive theories, drug-related associations in memory predicted drug use more strongly in students with lower levels of working memory capacity. These findings add to the literature implicating the influence of dual cognitive processes in adolescent risk behaviors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Pectin methyl esterase from orange fruit: characterization and localization by in-situ hybridization and immunohistochemistry

AIMS: Information concerning the association between marijuana use and opioid dependence and its treatment is needed to determine effective clinical guidelines for addressing marijuana use among opioid abusers. SETTING AND PARTICIPANTS: Marijuana use was assessed in 107 people enrolled in treatment for opioid dependence. DESIGN AND MEASUREMENT: Univariate comparisons of marijuana users and non-users and multivariate regression analyses were performed to examine associations between marijuana use and socio-demographic, psychosocial, medical and substance-use variables. The relationship between marijuana use and treatment outcome was also explored in a subset of this sample who received treatment that included buprenorphine detoxification and behavior therapy (N = 79). FINDINGS: Sixty-six per cent of participants were current marijuana users and almost all (94%) continued to use during treatment. Users were less likely to be married than non-users, and more likely to report financial difficulties, be involved in drug dealing and engage in sharing of needles (p < 0.05). A unique effect of marijuana use on drug dealing and sharing needles was retained after statistically controlling for the influence of heroin and alcohol use and other socio-demographic variables. No significant adverse relations were observed between marijuana use and treatment outcome. CONCLUSION: Pending a more comprehensive understanding of the function and consequences of marijuana use on psychosocial functioning, it appears that progress in treatment for opioid dependence can be made without mandating that patients abstain from marijuana use.     

Young-adult malt liquor drinkers: Prediction of alcohol problems and marijuana use.

Malt liquor (ML) is a cheap, high alcohol content beverage that is marketed to appeal to young adults. Findings from the few published studies of ML use suggest that it may be associated with excessive drinking, alcohol problems, and the use of illicit drugs. The authors conducted separate hierarchical multiple regressions to examine the role of ML use and psychosocial variables (e.g., personality, ML motives) in alcohol-related problems and marijuana use. Demographic characteristics served as controls. The sample consisted of 639 (456 men, 183 women) young adults (M = 22.9 years, SD = 4.2) who regularly (≥40 oz/week) consumed ML. ML use significantly and positively predicted alcohol problems, ML-specific problems, and marijuana use, above and beyond their associations with typical alcohol use. Marijuana was the illicit drug of choice, and 46% reported concurrent use of marijuana and ML. Those who concurrently used ML and marijuana began drinking at a younger age and reported more substance use (particularly marijuana) and more alcohol-related problems than did nonconcurrent users. These results suggest that ML use may represent a risk for alcohol problems and marijuana use. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Accessibility Effects on Implicit Social Cognition: The Role of Knowledge Activation and Retrieval Experiences.

Performance on measures of implicit social cognition has been shown to vary as a function of the momentary accessibility of relevant information. The present research investigated the mechanisms underlying accessibility effects of self-generated information on implicit measures. Results from 3 experiments demonstrate that measures based on response compatibility processes (e.g., Implicit Association Test, affective priming with an evaluative decision task) are influenced by subjective feelings pertaining to the ease of retrieving relevant information from memory, whereas measures based on stimulus compatibility processes (e.g., semantic priming with a lexical-decision task) are influenced by direct knowledge activation in associative memory. These results indicate that the mediating mechanisms underlying context effects on implicit measures can differ as a function of the task even when these tasks show similar effects on a superficial level. Implications for research on implicit social cognition and the ease-of-retrieval effect are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effectiveness of a marijuana expectancy manipulation: Piloting the balanced-placebo design for marijuana.

Although alcohol and nicotine administration studies have demonstrated that manipulating subjects’ expectancies regarding drug content affects drug response, research with marijuana has not adequately studied drug expectancy effects. The present pilot study was the first to evaluate the credibility and effect of expectancy manipulation on subjective measures and smoking patterns using a marijuana administration balanced-placebo design (BPD). In a 2 × 2 instructional set (told delta-9-tetrahydrocannabinol [THC] vs. told no THC) by drug (smoked marijuana with 2.8% THC vs. placebo) between-subjects design, the authors examined the effect of marijuana expectancy manipulation and the pharmacologic effect on affective and physiologic measures, cigarette ratings, and smoking behavior with 20 marijuana smokers (mean age = 20 years; 25% female). Large main effects of expectancy were found on ratings of cigarette potency, strength, taste, smell, and satisfaction, and observed smoking behavior. Pharmacologic effects were particularly evident for self-reported physical reactions to marijuana and cigarette potency and satisfaction ratings. This study demonstrated the feasibility of the BPD research with marijuana and yielded promising results for future studies examining the independent and combined effects of marijuana pharmacology and expectancies. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychopathology as a predictor of adolescent drug use trajectories.

The authors examined early psychopathology as a predictor of trajectories of drug use from ages 13-18 years. Six years of annual data were analyzed for 506 boys using a mixed effects polynomial growth curve model. They tested whether distinct measures of psychopathology and behavioral problems (i.e., attention-deficit/hyperactivity disorder, oppositional defiant disorder, conduct disorder, depression, and violence) assessed in early adolescence could prospectively predict level and change in alcohol and marijuana use. Higher levels of all of the types of psychopathology predicted higher levels of alcohol use, and higher levels of attention-deficit/hyperactivity disorder, conduct disorder, and violence predicted higher levels of marijuana use. Only conduct disorder predicted linear growth in alcohol use, and none of the measures predicted growth in marijuana use. The results suggest that drug use prevention programs should target youths with early symptoms of psychopathology. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Protein kinase C beta modulates thrombin-induced Ca2+ signaling and endothelial permeability increase

Epidemiological research indicates that the prevalence rate of drug use among adolescents has risen steadily during this decade, and although alcohol use has stabilized it is still highly prevalent. Psychosocial etiological models have typically examined main effects of risk and protective factors. This study examined moderating effects of intrapersonal skills on social (peer and parental) risks associated with alcohol and marijuana use among eighth-grade rural adolescents, an understudied population. Results indicated that the relationships of peer and parental attitudes, and peer usage to alcohol and marijuana use, are moderated by adolescents' decision-making and self-reinforcement skills. Social risk factors were strongly associated with increased alcohol and marijuana use among adolescents with poor intrapersonal skills. However, good decision-making and self-reinforcement skills diminished the influence of social risk factors on substance use. Results are discussed in terms of implications for psychosocial models of alcohol and drug use, and for designing effective school-based universal prevention interventions.     

Implicit measures of association in psychopathology research.

Studies obtaining implicit measures of associations in Diagnostic and Statistical Manual of Mental Disorders (4th ed., Text Revision; American Psychiatric Association, 2000) Axis I psychopathology are organized into three categories: (a) studies comparing groups having a disorder with controls, (b) experimental validity studies, and (c) incremental and predictive validity studies. In the first category, implicit measures of disorder-relevant associations were consistent with explicit beliefs for some disorders (e.g., specific phobia), but for other disorders evidence was either mixed (e.g., panic disorder) or inconsistent with explicit beliefs (e.g., pain disorder). For substance use disorders and overeating, expected positive and unexpected negative associations with craved substances were found consistently. Contrary to expectation, implicit measures of self-esteem were consistently positive for patients with depressive disorder, social phobia, and body dysmorphic disorder. In the second category, short-term manipulations of disorder-relevant states generally affected implicit measures as expected. Therapeutic interventions affected implicit measures for one type of specific phobia, social phobia, and panic disorder, but not for alcohol use disorders or obesity. In the third category, implicit measures had predictive value for certain psychopathological behaviors, sometimes moderated by the availability of cognitive resources (e.g., for alcohol and food, only when cognitive resources were limited). The strengths of implicit measures include (a) converging evidence for dysfunctional beliefs regarding certain disorders and consistent new insights for other disorders and (b) prediction of some psychopathological behaviors that explicit measures cannot explain. Weaknesses include (a) that findings were inconsistent for some disorders, raising doubts about the validity of the measures, and (b) that understanding of the concept “implicit” is incomplete. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cognitive function as an emerging treatment target for marijuana addiction.

Cannabis is the most widely used illicit substance in the world, and demand for effective treatment is increasing. However, abstinence rates following behavioral therapies have been modest, and there are no effective pharmacotherapies for the treatment of cannabis addiction. We propose a novel research agenda and a potential treatment strategy, based on observations that both acute and chronic exposure to cannabis are associated with dose-related cognitive impairments, most consistently in attention, working memory, verbal learning, and memory functions. These impairments are not completely reversible upon cessation of marijuana use, and moreover may interfere with the treatment of marijuana addiction. Therefore, targeting cognitive impairment associated with chronic marijuana use may be a promising novel strategy for the treatment of marijuana addiction. Preclinical studies suggest that medications enhancing the cholinergic transmission may attenuate cannabis-induced cognitive impairments, but these cognitive enhancing medications have not been examined in controlled human studies. Preliminary evidence from individuals addicted to other drugs suggests that computerized cognitive rehabilitation may also have utility to improve cognitive function in marijuana users. Future clinical studies optimally designed to measure cognitive function as well as drug use behavior would be needed to test the efficacy of these treatments for marijuana addiction. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-generated drug outcomes in high-risk adolescents.

The perceived outcomes of drug use were studied in a sample of high-risk adolescents. Participants' self-generated responses provided the actual words they used to describe drug outcomes as well as associative frequency norms valuable for future research. The authors also compared outcomes in terms of class of outcome (positive vs. negative) and class of drug (alcohol, marijuana, cigarettes, cocaine, speed, and LSD). Although the studied drugs have divergent pharmacological effects. participants self-generated some of the same outcomes (e.g., relaxation) across some of the drugs. In addition, outcomes self-generated as positive outcomes were very rarely also self-generated as negative outcomes. Finally, regressions revealed that self-generated responses were not predicted by ethnicity, gender, or previous drug use. Many drug use outcomes thus appeared to be available in memory regardless of previous drug use or other characteristics. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Memory accessibility and association of alcohol use and its positive outcomes.

Theoretical predictions involving memory associations between alcohol use and its positive outcomes were examined. In 2 preliminary studies, the availability from memory of outcomes from drinking was investigated. In subsequent studies, a measurement paradigm was used that decreased the accessibility of the association between drinking behavior and positive outcomes so that individual differences in drinking frequency might predict the accessibility of memory responses. In a final study, this paradigm was refined further by manipulating various types of alcohol-related cues. The results converge on a class of theory of memory association in which repeated drinking experiences influence the accessibility of thoughts about alcohol use and its most normatively frequent outcomes. The increased association of this behavior and its outcomes in memory has important implications for the cognitive mediation of alcohol use and abuse. (PsycINFO Database Record (c) 2010 APA, all rights reserved)