Supercritical carbon dioxide–assisted synthesis of stimuli-responsive magnetic poly(N-isopropylacrylamide)–ferrite biocompatible nanocomposites for targeted and controlled drug delivery

Supercritical carbon dioxide–assisted synthesis of poly(N-isopropylacrylamide)–ferrite nanocomposites was carried out by polymerization reaction of N-isopropyl acrylamide monomer in the presence of ferrite nanoparticles. They were characterized by Fourier transform infrared, X-ray diffraction, transmission electron microscopy, atomic force microscopy, and vibrating sample magnetometry analysis. Drug loading and release profiles were studied. Nanomaterials showed pH-dependent drug release profile. Polymer nanocomposites in comparison to ferrite nanoparticles showed impressive drug release activity, with a release percent of 20.98–76.54%, and greater biocompatibility in breast cancer cells, with a cell viability of 81–93%. This pH-dependent drug release activity and magnetic property of polymer nanocomposites can be used for controlled and targeted drug delivery.     

Synthesis of supramolecular biodendrimeric β-CD-(spacer-β-CD)21 via click reaction and evaluation of its application as anticancer drug delivery agent

The per-β-CD dendrimer (10), having 21 β-CD residues connected to the core β-CD in the primary and secondary sides with encapsulation efficacy and β-CDs moiety to preserve the biocompatibility properties was synthesized using click reaction. The dendritic network and β-CD cavity of the obtained dendrimer were utilized to form a supramolecular compound via the formation of a host-guest inclusion complex with methotrexate (MTX) drug molecule. The MTT assay of compound 10 showed very low toxicity on T47D cancer cells. In vitro drug release investigation at pHs 7.4, 5, and 3 indicated that the release manner was remarkably pH dependent.