Striatal dopaminergic D1 and D2 receptors after intracerebroventricular application of alloxan and streptozocin in rat

The purpose of this study was to evaluate the changes in condylar position following bilateral sagittal split ramus osteotomy with 5- and 10-mm setback in 1 symmetric human cadaver mandibles. A Plexiglas device was constructed to determine the mandibular morphology and the movements of the condyle and the proximal segments before and after surgery. There was no statistically significant relationship between mandibular morphology or the magnitude of setback and changes in condylar position postsurgery. All condyles and rami tipped in a highly variable fashion in the coronal plane. In the axial plane, the lateral pole of the condyles rotated predominantly anteriorly; the left side rotated significantly more than did the right. In the sample studied, the position of the condylar and proximal segments was altered in a highly variable and unpredictable manner, regardless of the magnitude of setback or the morphology of the mandible.     

Treatment of condylar hyperplasia of the mandible using unilateral ramus osteotomies

PURPOSE: The long-term outcome of bilateral and unilateral ramus osteotomies used for the treatment of unilateral condylar hyperplasia of the mandible are evaluated and compared. MATERIALS AND METHODS: Thirteen cases of unilateral condylar hyperplasia of the mandible were surgically treated during a 10-year period from 1985 to 1995. Seven of the patients were treated by bilateral ramus osteotomies alone; six were treated by unilateral ramus osteotomies of the affected side. Unilateral ramus osteotomy was combined with a maxillary Le Fort I procedure in two of the six cases. Preoperative analysis of patients, indications for case selection, and postoperative results relating to facial symmetry, temporomandibular joint (TMJ) pain, occlusion, and stability were compared in the two groups. RESULTS: The postoperative findings and long-term results in both groups of patients were favorable. Symmetry, arch coordination, and occlusion remained stable. TMJ pain and dysfunction were invariably cured postoperatively. Unilateral ramus osteotomies alone, or in combination with maxillary surgery when deemed feasible and applicable by preoperative clinical analysis, was sufficient to restore symmetry and occlusion in dentally compensated cases. CONCLUSIONS: This study shows that patients with unilateral condylar hyperplasia of the mandible and deviation can be treated favorably by unilateral ramus osteotomy of the affected side; bilateral ramus osteotomy did not have any advantage in such cases. In addition, this procedure, combined with a Le Fort I osteotomy of the maxilla, was also effective in restoring occlusal canting and facial symmetry in dentally compensated cases. However, bilateral ramus osteotomy was required in prognathic cases and in cases in which a unilateral procedure would cause excessive rotation of the contralateral condyle.     

Tooth wear and temporomandibular joint morphology in a skull material from the 17th century

Skeletal remnants from the skulls of 69 subjects from the 17th century have been studied focusing on TMJ morphology and tooth wear. Several of the skulls were damaged and altogether 68 condyles and 28 temporal components of the TMJ, and 97 dentate jaws could be examined. Tooth wear was extensive and most of the first molars in both jaws had lost most of their occlusal morphology. This is remarkable with respect to the fact that the great majority of the subjects had died before the age of 35 years, according to the age determination performed. The TMJs showed frequent remodelling but only rarely deformative changes. The frequent observation of a broken up compact bone layer on the condyle was interpreted as a post-mortem artefact. The results indicate adaptive response of the TMJs to the probably heavy masticatory function but do not support the suggested relationship between tooth wear and TMJ osteoarthrosis.     

Computerized cephalometric evaluation of orthognathic surgical precision and stability in relation to maxillary superior repositioning combined with mandibular advancement or setback

PURPOSE: A computerized, cephalometric, orthognathic surgical program (TIOPS) was applied in orthognathic surgical simulation, treatment planning, and postoperatively to assess precision and stability of bimaxillary orthognathic surgery. PATIENTS AND METHODS: Forty consecutive patients with dentofacial deformities requiring bimaxillary orthognathic surgery with maxillary superior repositioning combined with mandibular advancement or setback were included. All patients were managed with rigid internal fixation (RIF) of the maxilla and mandible and without maxillomandibular fixation (MMF). Preoperative cephalograms were analyzed and treatment plans produced by computerized surgical simulation. Planned, 5-week postoperative and 1-year postoperative maxillary and mandibular cephalometric-positions were compared. RESULTS: In the mandibular advancement group, the anterior maxilla was placed too far superiorly, with an inaccuracy of 0.4 mm. The posterior maxilla and the anterior mandible were placed in the planned positions. The lower posterior part of the mandibular ramus was placed too far anteriorly, with an inaccuracy of 2.0 mm. However, the mandibular condyles were accurately placed. In the setback group, the anterior maxilla was placed too far superiorly and posteriorly, with a vertical and sagittal inaccuracy of 1.0 mm and 0.7 mm, respectively. The posterior part of the maxilla was placed in a posterior position with an inaccuracy of 1.9 mm. The anterior mandible was placed too far anteriorly with an inaccuracy of 0.9 mm. The lower posterior part of the mandibular ramus was placed in a posterior position with an inaccuracy of 0.9 mm. However, the mandibular condyles were accurately placed. The statistical analysis of the 1-year stability data showed that the maxilla had moved 0.3 mm posteriorly in the advancement group and the lower incisors had moved 0.8 mm superiorly. No other significant positional maxillary or mandibular changes were found. In the setback group, the maxilla had moved 0.5 mm posteriorly, the anterior mandible 0.5 mm anteriorly, and the lower incisors 0.7 mm superiorly. No significant positional changes were seen in the mandibular ramus. CONCLUSION: The TIOPS computerized, cephalometric, orthognathic program is useful in orthognathic surgical simulation, planning, and prediction, and in postoperative evaluation of surgical precision and stability. The simulated treatment plan can be transferred to model surgery and finally to the orthognathic surgical procedures. The results show that this technique yields acceptable postoperative precision and stability.     

Acute treatment with the N-methyl-D-aspartate receptor antagonist MK-801: effect of concurrent administration of haloperidol or scopolamine on preproenkephalin mRNA levels of the striatum and nucleus accumbens of the rat brain

17 patients underwent an orthognathic operation. The condyle positioning plate was used in each sagittal split ramus osteotomy of mandible in order to maintain the condyle position. The results of postoperative X-ray examination showed that no obvious displacement of condyle in posterioranterior, and vertical dimension was detected in all joints and obvious horizontal condyle displacement were only found in two joints. Based on this work the author believe that condyle positioning plate is useful to position condyle during operation.     

Relationship of articular soft tissue contour and shape to the underlying eminence and slope profile in young adult temporomandibular joints

This study examined whether the overall shape of the articular soft tissue overlying the posterior slope and articular eminence of the temporal bone could be predicted by the underlying osseous contour in a histologic model of 51 central sagittal sections of young adult temporomandibular joints. Articular soft tissue and bone contours were traced, and osseous landmarks identified on the basis of joint geometry. Soft tissue thickness measurements were made under low power light microscopy. Seven categories of articular soft tissue pattern were identified. The soft tissue uniformly followed the osseous contour in only one (14%). A progressive increase in soft tissue thickness from the middle of the posterior slope to the articular crest was the most common pattern (35%) but did not describe most of the sample that was more asymmetric. Pattern was poorly predicted by the shape and slope of the temporal bone outline or by dental factors that describe anterior guidance and did not relate to disk displacement. The articular soft tissue compensated for flatter eminence slopes and osseous irregularities and maintained an intact surface. This study has clinical implications for radiographic interpretation of disk space, condyle translation pathways, and the integrity of the functional articular surface.     

Condylar position with rigid fixation versus wire osteosynthesis of a sagittal split advancement

PURPOSE: In this randomized clinical study, two groups of patients who underwent a bilateral sagittal split osteotomy and either wire osteosynthesis or rigid fixation were compared. PATIENTS AND METHODS: Cephalometric radiographs obtained before surgery, immediately after surgery, and at 8 weeks, 6 months, and 1 and 2 years after surgery were available for 125 of these patients, 63 with wire fixation and 62 with rigid fixation. All were traced by an independent examiner, and vertical and horizontal changes in condylar position were recorded for each period. RESULTS: Condylar movement was slightly different with the two fixation techniques beyond 8 weeks postsurgery, but the ultimate position of the condyle was not different. The condyles in both groups moved posterior and superior. There initially was a correlation between the amount of advancement and the amount the condyle moved inferior in both groups, but this diminished with time. In addition, there was a weak but significant positive relationship between forward rotation of the proximal segment and superior condylar position immediately after surgery, which did not exist at later periods. CONCLUSIONS: Whether wire osteosynthesis or rigid fixation was used, the ultimate condylar position was posterior and superior after a bilateral sagittal split osteotomy to advance the mandible. No single factor could be identified to account for this change. It is suggested that change in mechanical load may have resulted in remodeling and adaptation of the condyles.     

Diagnosis of ostechondritis dissecans of the femoral condyles: the value of the lateral x-ray view

The lateral X-ray view of the knee is more likely to yield the diagnosis of osteochondritis dissecans of the femoral condyles if the examiner is aware that most cases are located in the subarticular bone of the medial femoral condyle between two lines: The first extended anteriorly from the density of the roof of the intercondylar notch, and the second, extended distally from the posterior cortex of the distal femoral diaphysis.     

Mutation analysis and expression of the mottled gene in the macular mouse model of Menkes disease

OBJECTIVES: The purpose of this study was to evaluate the ability of two different panoramic imaging systems to produce cross-sectional images with accurate vertical dimensions of the posterior mandible. STUDY DESIGN: Three partially edentulous human cadaver mandibles were used for this study. On each mandible, three potential implant sites were arbitrarily identified in an area between the mental foramen and the ascending ramus. Each site was imaged using two different panoramic machines. Using each image, the mandible's outline, cortical thickness, and position of the mandibular canal were traced on clear acetate film. The mandibles were then sectioned at each site to serve as a gold standard. The cadaver sections and tracings (corrected for magnification) were measured, recording the overall mandibular height, distance from the crest of the ridge to the superior aspect of the mandibular canal, and the thickness of the cortical bone at the most inferior aspect of the mandible. RESULTS: There were no significant differences between either of the system's image measures and the gold standard when considering the distance between the crest and the mandibular canal. Differences were noted between the systems measures and the gold standard in the assessment of the cortical bone thickness and the overall mandibular height. CONCLUSIONS: Both imaging systems can be useful for vertical measurements of a potential implant site in the posterior mandible.     

Study on stress distribution of the condyle

OBJECTIVE: To investigate the internal state of stress distribution in healthy human condyles and to offer some references for application of the temporomandibular joint (TMJ) biomechanics. METHODS: Six male volunteers were selected to perform CT examination of the TMJ with 1.5 mm-thick sections at 1.5 mm intervals. Three dimensional image reconstruction of the joint was performed in the SUN workstation and the CT data were converted into the decimal system. The three dimensional finite element model mesh generation resulted from 1188 elements and 264 nodes in each condyle. Stress calculation was performed with SAP-V program, and the results were converted into mechanical density scalar. During the study, the internal state of stress distribution on each side condyle in every subject was analysed on the basis of loading on the anterior articular surface of the condyle. RESULTS: Stress was concentrated in the anterior articular surface of the condyle and was highest at the loading point. The condylar cortical bone was the main load-bearing area. The level of stress distribution in the cancellous bone of the condyle was very low. Near condylar neck stress was well-distributed on the cortical. The internal state of stress was essentially symmetrical on the same cuts of both side condyles. CONCLUSIONS: The results showed that three dimensional finite element analysis may indicate the internal state of stress distribution in the condyle, suggesting that a combination of the three dimensional finite element methods and the three dimensional imaging technique may be a useful means for diagnosis and treatment of TMJ diseases.     

Mandibular forces during simulated tooth clenching

Differential, functional loading of the mandibular condyles has been suggested by several human morphologic studies and by animal strain experiments. To describe articular loading and the simultaneous forces on the dental arch, static bites on a three-dimensional finite element model of the human mandible were simulated. Five clenching tasks were modeled: in the intercuspal position; during left lateral group effort; during left lateral group effort with balancing contact; during incisal clenching; and during right molar clenching. The model's predictions confirmed that the human mandibular condyles are load-bearing, with greater force magnitudes being transmitted bilaterally during intercuspal and incisal clenching, as well as through the balancing-side articulation during unilateral biting. Differential condylar loading depended on the clenching task. Whereas higher forces were found on the lateral and lateroposterior regions of the condyles during intercuspal clenching, the model predicted higher loads on the medial condylar regions during incisal clenching. The inclusion of a balancing-side occlusal contact seemed to decrease the forces on the balancing-side condyle. Whereas the predicted occlusal reaction forces confirmed the lever action of the mandible, the simulated force gradients along the tooth row suggest a complex bending behavior of the jaw.     

Problems associated with the atrophic mandible

A range of treatment options has been presented regarding the use of dental implants to rehabilitate patients who otherwise have compromised function using conventional tissue-borne prostheses. This patient population offers significant challenges to both the surgeon and the prosthodontist. Generally speaking, IODs retained on two or more endosteal osseointegrated implants; transosteal, subperiosteal, ramus frame implant-supported and implant-retained prostheses, and a totally implant-supported design offer options to treat the severely atrophic mandible. When bone support or volume is so lacking that augmentation procedures are required, bone grafting can be considered as a treatment option. The state-of-the-art of implant treatment for the atrophic mandible offers to the dental professional and patient a variety of options. Thus far, it is too early to make specific recommendations as to which treatment offers the best option for each patient. It is fair to say that the ISP remains the gold standard against which other treatments can be compared.     

Hematopoietic precursor cell exhaustion is a cause of proliferative defect in primitive hematopoietic stem cells (PHSC) after chemotherapy

The aim of the present study is to determine the possibility of measuring the bone mineral density (BMD) around implants by dual energy X-ray absorptiometry (DEXA). Therefore, the trabecular BMD was measured close to 127-600 microns and at a distance from various uncoated and Ca-P-coated implants inserted into the femoral condyle of goals. The implants were left in situ for 12 weeks. In addition, the bone-implant interface was evaluated histologically. For comparative reasons the BMD of non-implanted lateral and medial femoral condyles was also measured. The reproducibility of the measurements, expressed as a coefficient of variation, was found to be 0.44%. Moreover, the regions closest to the implants exhibited a higher BMD than all other regions, and the regions located in the medial condyle showed a higher BMD than the lateral condylar regions. Although the histological sections of the implants in the medial condyle demonstrated more bone contact with the coated than with the uncoated implants, a higher density was measured around the uncoated implants. The results regarding the non-implanted condyles indicated a higher density in the medial than in the lateral condyle. In view of these results, we conclude that BMD around dental implants depends on the location of the implant and that DEXA appears to be an excellent tool for analysing bone-implant reactions.     

Treatment of Class II, Division 2 in the late growth period

The "Deckbiss" with skeletal Class II jaw relationship sometimes presents a considerable therapeutic problem, particularly in the late growth period (DP3U), as regards the coordination of dental and skeletal treatment objectives. An effective treatment approach was demonstrated: a modified Herbst appliance used simultaneously with fixed appliances in the maxilla. The sample comprised 12 male (14.0 +/- 0.9 years old) and 10 female (12.3 +/- 0.4 years old) patients. Correction of the distal occlusion was achieved in all patients by means of the Herbst appliance, which was removed after an average time period of 6.4 +/- 0.2 months. In the mandible the multibracket appliances were then immediately inserted, and Class II elastics were used for retention. Maximum anchorage was required in the maxilla as well as in the mandible. Complete diagnostic records were made at the beginning of the treatment as well as 6 and 12 months later, in order to document skeletal and dental changes. A dental and skeletal Class I relationship was achieved in all cases. A significant improvement was recorded in the vertical jaw base relationship; this was still stable after a period of 12 months. In the dental area in particular, a so-called high-pull headgear effect (intrusion and distalization 16, 26) and intrusion of teeth 34, 44 were registered. Only a minor protrusion of the mandibular incisors was observed. Reinforcement of the bands reduced the failure rate significantly. The Herbst appliance does not represent a standard treatment for Class II. Its indication range is limited.     

Observations on structure of bone in human mandibular condyles with osteophyte formation

The purpose of this study was to investigate the functional characteristics of human mandibular condyles from a morphological viewpoint. The structure of bone in the human mandibular condyles with osteophyte formation was observed macroscopically and microscopically and compared with that in the condyles which seemed to be normal. The following observations were made: 1. Generally, it was observed that remodeling seemed to occur frequently in compact bone in the joint surface area of the mandibular condyle. 2. As the distribution of lamellar bone, nonlamellar, and bundle bone in the joint surface area changes, the compact bone seems to shift down and protrude forward. In larger osteophytes, trabeculae of cancellous bone-like structure are observed. However, the basic structure of compact bone, including haversian system and the interlamellae structure remains within the trabecullae. Therefore, observation revealed histologically that this is a compact bone. The macroscopical appearance of cancellous bone-like structure seems to be a result of functional demand. 4. It was concluded that the mandibular condyles accommodate the functional loads, and adoptational changes occur constantly in a stable manner.     

Spontaneous and induced minisatellite instability in the human genome

Two patients with recurrent parotid gland carcinoma required subtotal petrosectomy and infratemporal fossa type C approach. To achieve en bloc resection, the ascending mandibular ramus and the entire temporomandibular joint, including the adjacent temporal bone, were removed. An original technique for immediate reconstruction of the infratemporal region, including the glenoid fossa and the ramus of the mandible, is described. Rigid fixation, as well as good functional and aesthetic results, was achieved with autologous calvarial bone and full-thickness rib grafts, allowing the patients to mobilize their jaw very rapidly.     

Occipital condyle fracture and ligament injury: imaging by CT

The true incidence of fracture of the occipital condyles is unknown. It may be associated with instability at the craniocervical joint. CT is the modality of choice for the demonstration of these fractures, but its use for imaging of the associated ligament injury has not been reported. In order to demonstrate normal anatomy, occipital condyle fracture and ligament injury, and to estimate the incidence of this lesion, 21 children and young adults with high-energy blunt craniocervical injury were examined prospectively. Thin-slice, axial, contiguous, CT was performed from the base of C2 to above the foramen magnum. Bone and soft tissue windows and coronal, sagittal, and curvilinear 2D reconstructions were performed. Five occipital condyle fractures were identified in four patients (19 %), with demonstration of alar ligament injury in two cases and local hematoma in one. In four, artifacts or rotation precluded assessment of ligaments. In all remaining cases normal bone and ligament anatomy was demonstrated. Fracture of the occipital condyles following craniocervical injury is not uncommon in children and young adults. Normal bone and ligament anatomy and pathology can be safely and clearly demonstrated in seriously injured patients and others using this CT technique. Increased awareness of this entity and a low threshold for performing CT should avoid the potentially serious consequences of a missed diagnosis.     

Position of the mental foramen in adult black Zimbabwean mandibles: a clinical anatomical study

OBJECTIVE: To provide some anatomical information on the shape, size, and position of the mental foramen among Black Zimbabweans that could be used as reference material by dental and other health practitioners during clinical practice in Zimbabwe. DESIGN: Cross sectional anatomical study. SETTING: Department of Anatomy, Faculty of Medicine, University of Zimbabwe, Mount Pleasant, Harare, Zimbabwe. SUBJECTS: 32 mandibles derived from adult Black Zimbabweans. MAIN OUTCOME MEASURES: The shape of the mental foramen, its relation to the lower teeth and its position in relation to the mandibular symphysis, the posterior border of the ramus of the mandible, the lower border of the mandible, and the alveolar margin. RESULTS: The shape of the mental foramen was round in 14 out of 32 mandibles (43.8%) and was oval in the remaining 18 (56.3%). The percentage of occurrence of the mental foramen was highest below the lower second premolar tooth on the right side (position 4) and posterior to it on the left side (position 5). In the vertical plane, the mental foramen lay slightly below the midpoint of the distance between the lower border of the mandible and the alveolar margin (44.1% and 45.5% for the right and left sides respectively). In the horizontal plane, it lay approximately one quarter (27.3% for the right and 27.4% for the left sides) of the distance from the mandibular symphysis to the posterior border of the ramus of the mandible. CONCLUSION: The percentage distribution of the mental foremen in relation to the lower teeth in the adult Black Zimbabwean mandible was at variance with that of other population groups. However, the quantitative position of the mental foremen was bilaterally symmetrical in the adult Black Zimbabwean mandible. The latter observation is of clinical significance to dental and other health practitioners in Zimbabwe with regards to the achievement of effective mental nerve block anaesthesia and the prevention of damage to the mental nerve during surgical procedures on the lower jaw.     

Cross-sectional area of the mandible

PURPOSE: The anatomy of the mandible was examined by measuring the cross-sectional area (CSA) of multiple regions of 10 fully dentulous hemimandibles to provide a better understanding of regional structural differences that may have implications regarding biomechanical strength, surgical reconstruction, and fracture site frequency. MATERIALS AND METHODS: Fifteen cuts from the condyle to the symphysis were made of each hemimandible (n = 150 cuts). A Zeiss Videoplan digitizer was used to determine the CSA. RESULTS: The total CSA through the condyle was greater than the CSA through the condylar neck. The CSA through the ramus exceeded that of the condylar neck. The total CSA of the midramus was significantly greater than that of the upper ramus. The total CSA at the body, parasymphysis, and symphysis was significantly greater than at the mid-angle. The total CSA of the cortex increased anteriorly; these differences become significant between the condylar neck and the body, parasymphysis, and symphysis. The total CSA, and the CSA of the cortex and spongiosa, remained relatively constant from the inferior angle anteriorly. CONCLUSIONS: Significant differences exist in the CSA at different points, with an increase in the total, cortical, and spongiosal CSA anteriorly from the condylar neck to the angle. The total CSA and the CSA of the cortex and spongiosa remain relatively constant anterior to the inferior angle. These data suggest that bony CSA alone is not the sole factor in determining fracture site frequency.     

Mandibular condyle hyperplasia. Therapeutic review

Excessive cartilage growth on the condyle process of the mandible can result from primary hyperreactivity of the growth cartilage or be a secondary adaptation to an imbalance in occlusive and/or cervicofacial conditions. Treatment depends on the distinction between these two forms. Primary active overgrowth is treated by condylectomy sparing the distal apparatus although conservative surgery to re-centering the temporomandibular joint and re-establish symmetry without condylectomy may be used in quiescent moderately active forms saving the joint. For secondary forms, the joint is re-centering and symmetry is re-established without condylectomy. If started early enough, orthopaedic treatment can avoid the development of secondary forms resulting an imbalance in occlusive and/or cervicofacial conditions.