Early Development of Neurophysiological Processes Involved in Normal Reading and Reading Disability: A Magnetic Source Imaging Study.

This longitudinal study examined the development of the brain mechanism involved in phonological decoding in beginning readers using magnetic source imaging. Kindergarten students were assigned to 2 groups: those who showed mastery of skills that are important predictors of proficient reading (low-risk group) and those who initially did not show mastery but later benefited from systematic reading instruction and developed average-range reading skills at the end of Grade 1 (high-risk responders). Spatiotemporal profiles of brain activity were obtained during performance of letter-sound and pseudoword naming tasks before and after Grade 1 instruction. With few exceptions, low-risk children showed early development of brain activation profiles that are typical of older skilled readers. Provided that temporoparietal and visual association areas were recruited into the brain mechanism that supported reading, the majority of high-risk responder children benefited from systematic reading instruction and developed adequate reading abilities. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Brain mechanisms for reading and language processing in spina bifida meningomyelocele: A combined magnetic source- and structural magnetic resonance imaging study.

Objective: The development of the ability to process spoken and written language depends upon a network of left hemisphere temporal, parietal, and frontal regions. The present study explored features of brain organization in children with spina bifida meningomyelocele (SBM) and shunted hydrocephalus, who commonly present with precocious development of word reading skills and preservation of vocabulary and grammar skills. Method: Eight children with SBM were compared with 15 IQ and reading-level matched, typically developing controls on MRI-based morphometric and Magnetic Source Imaging-derived neurophysiological profiles. Results: Children with SBM showed reduced magnetic activity in left inferior parietal regions during spoken word recognition and pseudoword reading tasks. We also noted reduced surface area/volume in inferior parietal and posterior temporal regions in SBM and increased gray matter volumes in left middle frontal regions and gyral complexity in left posterior temporal and inferior parietal regions. Conclusions: A complex pattern of changes in cortical morphology and activation may serve as evidence for structural and functional brain reorganization ensuring preservation of language and decoding abilities in children with SBM. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Aberrant spatiotemporal activation profiles associated with math difficulties in children: A magnetic source imaging study.

The study investigates the relative degree and timing of cortical activation in parietal, temporal, and frontal regions during simple arithmetic tasks in children who experience math difficulties. Real-time brain activity was measured with magnetoencephalography during simple addition and numerosity judgments in students with math difficulties and average or above average reading skills (MD group, N = 14), students with below average scores on both math and basic reading tests (MD/RD group, N = 16) and students with above average scores on standardized math tests (control group, N = 25). Children with MD showed increased degree of neurophysiological activity in inferior and superior parietal regions in the right hemisphere compared to both controls and MD/RD students. Left hemisphere inferior parietal regions did not show the expected task-related changes and showed activity at a significant temporal delay. MD students also showed increased early engagement of prefrontal cortices. Taken together, these findings may indicate increased reliance on a network of right hemisphere parietal (and possibly frontal areas as well) for simple math calculations in students who experience math difficulties but perform within normal range in reading. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Functional disruption of the brain mechanism for reading: Effects of comorbidity and task difficulty among children with developmental learning problems.

Objective: The study investigated the relative degree and timing of cortical activation associated with phonological decoding in poor readers. Method: Regional brain activity was assessed during performance of a pseudoword reading task and a less demanding, letter-sound naming task by three groups of students: children who experienced reading difficulties without attention problems (N = 50, RD) and nonreading impaired (NI) readers either with (N = 20) or without attention-deficit/hyperactivity disorder (ADHD; N = 50). Recordings were obtained with a whole-head neuromagnetometer, and activation profiles were computed through a minimum norm algorithm. Results: Children with RD showed decreased amplitude of neurophysiological activity in the superior temporal gyrus, bilaterally, and in the left supramarginal and angular gyri during late stages of decoding, compared to typical readers. These effects were restricted to the more demanding pseudoword reading task. No differences were found in degree of activity between NI and ADHD students. Regression analyses provided further support for the crucial role of left hemisphere temporoparietal cortices and the fusiform gyrus for basic reading skills. Conclusions: Results were in agreement with fMRI findings and replicate previous MEG findings with a larger sample, a higher density neuromagnetometer, an overt pseudoword reading task, and a distributed current source-modeling method. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Neuroimaging and Psychopharmacology.

This review presents the most recent research concerning neuroimaging in developmental disabilities. Changes in structure and activation have been found in children with ADHD and learning disabilities, following intervention. For the children with learning disabilities changes in activation have been found following intensive behavioral and academic intervention. Structural and activation differences in the auditory processing regions of the brain were found prior to academic intervention, with activation differences found for those children responding to the reading programs. Children with ADHD have been found to show differences in brain structures with few studies evaluating the differences in activation following medication. Emerging evidence indicates differences in the frontal regions of the brain for children who respond successfully to medication. Finally, a discussion of the variables that can impact the results in neuroimaging studies is presented. Further study is needed in this area, and additional variables of concern are also discussed. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Verbal fluency deficits in patients with schizophrenia: Semantic fluency is differentially impaired as compared with phonologic fluency.

Patients with schizophrenia show deficits in phonologic (ability to name words that begin with a specific letter, e.g., F) and semantic (ability to name members of a category, e.g., "animals" fluency.) Whereas the former deficit has been presumed to reflect a dysfunction of the frontal lobe, the latter has been linked to frontal and temporoparietal brain areas. These 2 verbal fluency measures were studied in a sample of 27 schizophrenia patients and 24 normal controls who were matched on age and a putative measure of premorbid intellectual ability. A 2-min production task of switching between letters and between categories measured demand for flexibility. On switching and nonswitching tasks controls produced more words during semantic versus phonologic fluency. Conversely, schizophrenia patients produced more words for letters than for categories, suggesting dysfunction of the frontal and temporoparietal areas of the brain. Furthermore, the greater impairment of semantic fluency may be related to a breakdown of semantic information processing beyond "executive" search and retrieval. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Predicting Improvement After First-Grade Reading Difficulties: The Effects of Oral Language, Emergent Literacy, and Behavior Skills.

This study investigated the role of early literacy and behavioral skills in predicting the improvement of children who have experienced reading difficulties in 1st grade. The progress of 146 low-income children whose reading scores in 1st grade were below the 30th percentile was examined to determine (a) how the poorest readers in 1st grade progressed in reading achievement through 4th grade and (b) which emergent literacy and behavioral skills measured in kindergarten predicted differential 4th grade outcomes. Results indicated that the divergence between children who improved and those who did not was established by the end of 2nd grade. Further, individual linguistic skills and behavioral attributes measured in kindergarten contributed substantively to this difference. Implications for intervention timing and educational policy are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Developmental and instructional analyses of children's metacognition and reading comprehension.

Children's understanding of their own cognitive skills, or metacognition, has been hypothesized to play a major role in learning and development. In this study, we examine the developing relation between children's metacognition and reading comprehension. Children in third- and fifth-grade classes were given an experimental curriculum, Informed Strategies for Learning (ISL), designed to increase their awareness and use of effective reading strategies. In both grades, children in experimental classes made significant gains in metacognition and the use of reading strategies compared with children in control classes. The multivariate profiles of reading skills derived from the developmental analyses helped to identify subgroups of children who responded differently to the metacognitive instruction. Although there were specific aptitude-by-treatment interactions, there was a general trend for metacognition and strategic reading to become more congruent from 8 to 10 years of age. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Anger style, psychopathology, and regional brain activity.

Depression and anxiety often involve high levels of trait anger and disturbances in anger expression. Reported anger experience and outward anger expression have recently been associated with left-biased asymmetry of frontal cortical activity, assumed to reflect approach motivation. However, different styles of anger expression could presumably involve different brain mechanisms and/or interact with psychopathology to produce various patterns of brain asymmetry. The present study explored these issues by comparing resting regional electroencephalographic activity in participants high in trait anger who differed in anger expression style (high anger-in, high anger-out, both) and participants low in trait anger, with depression and anxiety systematically assessed. Trait anger, not anger-in or anger-out, predicted left-biased asymmetry at medial frontal EEG sites. The anger-in group reported higher levels of anxious apprehension than did the anger-out group. Furthermore, anxious apprehension moderated the relationship between trait anger, anger-in, and asymmetry in favor of the left hemisphere. Results suggest that motivational direction is not always the driving force behind the relationship of anger and left frontal asymmetry. Findings also support a distinction between anxious apprehension and anxious arousal. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Endothelin: role in hypertension

Thirty-nine elderly depressed patients as well as 15 demented patients with Alzheimer's disease and 11 healthy volunteers were imaged at rest with a high resolution single-slice 12-detector head scanner (SME-Neuro 900) and the cerebral perfusion marker 99mTc-Exametazime (HM-PAO). Statistical parametric maps were computed to compare early- and late-onset depressed, Alzheimer patients and healthy volunteers and to examine associations between regional perfusion and clinical and MRI variables. Patients with late-onset depression showed reductions in temporal lobe perfusion compared with early-onset depression and controls. Alzheimer patients had the expected reduced perfusion in temporoparietal and prefontal cortex, as well as basal ganglia, compared with healthy controls. Compared with depressed patients, they showed a relative reduction in temporoparietal cortex, only. This difference was more pronounced between Alzheimer patients and early onset, compared to late-onset patients with depression. Periventricular white matter changes on MRI were associated with temporal lobe reductions of tracer uptake in depression. In the Alzheimer group, deep white matter MRI changes were associated with frontal perfusion deficits. Our results support a vulnerability hypothesis, which predicts that patients with late-onset depression will show more brain changes than patients with an early onset of their illness. Statistical parametric mapping in patients with organic psychiatric brain syndromes is feasible and promising as a clinical and research method.     

Development of grammatical-sensitivity, phonological, and short-term memory skills in normally achieving and learning disabled children.

The development of a variety of grammatical-sensitivity and phonological skills was studied in 138 normally achieving, 65 reading-disabled, 63 arithmetic-disabled, and 15 attention deficit disordered (hyperactive) children 7 to 14 years old. Word recognition and phonics skills were highly related, and reading comprehension and phonics skills were less so. Grammatical sensitivity and short-term memory were significantly correlated with a variety of reading skills. Children with a reading disability showed a significant lag in the development of grammatical sensitivity and short-term memory and an even greater deficit in phonological skills. The children with a specific arithmetic disability had adequate grammatical abilities, but below-average memory skills at all ages. Children with an attention deficit but normal achievement scores did not have any major difficulties except on a reading-comprehension task that appears to have significant memory and attention components. The acquisition of reading skills is closely related to the development of grammatical and phonological skills, and deficiencies in these areas are related to difficulties with the acquisition of written language skills. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of healthy aging on the regional cerebral metabolic rate of glucose assessed with statistical parametric mapping

The aging process is thought to result in changes in synaptic activity reflecting both functional and structural cell derangement. However, previous PET reports on age-related changes in resting brain glucose utilization (CMRglc) have been discrepant, presumably because of methodological as well as subject screening differences. In contrast to other studies, which used a region of interest approach, the objective of the present work was to determine, by means of the SPM software, the changes in regional CMRglc as a function of age in 24 optimally healthy, unmedicated volunteers of ages from 20 to 67 years. Global CMRglc showed a significant decline with age (approximately 6% per decade, P < 0.05), which concerned all the voxels studied save for most of the occipital cortex and part of the cerebellum. The most significant effects (P < 0.001) concerned the association neocortex in perisylvian temporoparietal and anterior temporal areas, the insula, the inferior and posterior-lateral frontal regions, the anterior cingulate cortex, the head of caudate nucleus, and the anterior thalamus, in a bilateral and essentially symmetrical fashion. The high posterior parietal cortex was not sampled in this study. This distribution of changes in CMRglc with age may differ from that seen in Alzheimer' disease, where the earliest metabolic reduction has been shown to affect the posterior cingulate cortex.     

Legislative mandates: Implications for changes in school psychology training programs.

Public Laws 93-380 and 94-142, as well as many state statutes that assure full educational opportunities for all handicapped children, have directly affected school psychological services. School psychologists' skills in diagnosis, intervention, and remediation are being increasingly called on to meet the educational needs of handicapped children. Because of federal and state legislation, school psychology training programs need to provide their students with additional course work and/or field experiences to prepare them for the changes in role demands. Practitioners need professional continuing education programs to assure that their skills are also adequate to provide psychological services to all handicapped school children. (8 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Individual Behavioral Profiles and Predictors of Treatment Effectiveness for Children With Autism.

Differential responsiveness to intervention programs suggests the inadequacy of a single treatment approach for all children with autism. One method for reducing outcome variability is to identify participant characteristics associated with different outcomes for a specific intervention. In this investigation, an analysis of archival data yielded 2 distinct behavioral profiles for responders and nonresponders to a widely used behavioral intervention, pivotal response training (PRT). In a prospective study, these profiles were used to select 6 children (3 predicted responders and 3 predicted nonresponders) who received PRT. Children with pretreatment responder profiles evidenced positive changes on a range of outcome variables. Children with pretreatment nonresponder profiles did not exhibit improvements. These results offer promise for the development of individualized treatment protocols for children with autism. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The Development of Reading in Children Who Speak English as a Second Language.

Patterns of reading development were examined in native English-speaking (L1) children and children who spoke English as a second language (ESL). Participants were 978 (790 L1 speakers and 188 ESL speakers) Grade 2 children involved in a longitudinal study that began in kindergarten. In kindergarten and Grade 2, participants completed standardized and experimental measures including reading, spelling, phonological processing, and memory. All children received phonological awareness instruction in kindergarten and phonics instruction in Grade 1. By the end of Grade 2, the ESL speakers' reading skills were comparable to those of L1 speakers, and ESL speakers even outperformed L1 speakers on several measures. The findings demonstrate that a model of early identification and intervention for children at risk is beneficial for ESL speakers and also suggest that the effects of bilingualism on the acquisition of early reading skills are not negative and may be positive. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dietary cholesterol impairs memory and memory increases brain cholesterol and sulfatide levels.

Cholesterol and sulfatides play many important roles in learning and memory. To date, our observations about the effects of cholesterol on learning have been assessed during response acquisition; that is, the learning of a new memory. Here, we report for the first time to our knowledge, on the effect of a cholesterol diet on a previously formed memory. Rabbits were given trace conditioning of the nictitating membrane response for 10 days, then fed a 2% cholesterol diet for 8 weeks, and then assessed for memory recall of the initially learned task. We show that dietary cholesterol had an adverse effect on memory recall. Second, we investigated whether dietary cholesterol caused an increase in brain cholesterol and sulfatide levels in four major brain structures (hippocampus, frontal lobe, brainstem, and cerebellum) using a technique for analyzing myelin and myelin-free fractions separately. Although our data confirm previous findings that dietary cholesterol does not directly affect cholesterol and establish that it does not affect sulfatide levels in the brain, these levels did increase rather significantly in the hippocampus and frontal lobe as a function of learning and memory. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Disabilities of arithmetic and mathematical reasoning: perspectives from neurology and neuropsychology

Current research on brain-behavior relationships in disabilities of arithmetic and mathematical reasoning is reviewed from both a neurological and a neuropsychological perspective. Although no entirely satisfactory statement of the relationship between arithmetic skills and brain functions has yet emerged, investigators in this area have provided evidence regarding the involvement of some brain systems in processes of calculation. Also, the developmental importance of right- versus left-hemisphere integrity for the mediation of arithmetic learning and performance has been suggested. We propose that an account of brain-behavior relationships in children intended to explain and predict developmental disabilities of arithmetic learning needs to address several important content and processing distinctions in order to (a) encompass empirically derived subtypes of children with learning disabilities who exhibit difficulties with arithmetic and (b) provide adequate direction for future subtyping and intervention research.     

Age and schooling effects on emergent literacy and early reading skills.

This study examined the effects of age and schooling on emergent literacy and early reading skills of 337 children from low-income backgrounds. Children were followed longitudinally from the end of Head Start to the end of 1st grade. A subset of the sample (n?=?183) was followed through the end of 2nd grade. The oldest children in preschool and kindergarten had significantly stronger emergent literacy skills than classmates who were younger by 10 months. These differences did not translate to differences in reading skill at the end of 1st or 2nd grade. Children who began school a year earlier than same-age peers outperformed these peers on measures of both emergent literacy skills and early reading skills. The impact of a year of schooling on emergent literacy skills was 1.7 times greater than the impact of other processes associated with age. The impact of a year of schooling on early reading was 4.3 times stronger than the effect of age. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Prosody of syntactically complex sentences in the oral reading of young children.

Prosodic, or expressive, reading is considered to be one of the essential features of the achievement of reading fluency. The purpose of this study was to determine (a) the degree to which the prosody of syntactically complex sentences varied as a function of reading speed and accuracy and (b) the role that reading prosody might play in mediating individual differences in comprehension. Spectrographic analysis of 80 third graders' and 29 adults' reading of a syntactically complex text was carried out. Oral reading skill was measured through standardized assessments. Pitch changes (changes in fundamental frequency) and pause duration were measured for sentence-final words of basic declarative sentences, basic declarative quotatives, wh questions, and yes-no questions; words preceding commas in complex adjectival phrases; and words preceding phrase-final commas. Children who had quick and accurate oral reading had shorter and more adultlike pause structures, larger pitch declinations at the end of basic declarative sentences, and larger pitch rises at the end of yes-no questions. Furthermore, children who showed larger basic declarative sentence declinations and larger pitch rises following yes-no questions tended to demonstrate greater reading comprehension skills. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Beyond the pages of a book: Interactive book reading and language development in preschool classrooms.

The effects of a book reading technique called interactive book reading on the language and literacy development of 4 yr olds from low-income families were evaluated. Teachers read books to children and reinforced the vocabulary in the books by presenting concrete objects that represented the words and by providing children with multiple opportunities to use the book-related words. The teachers also were trained to ask open-ended questions and to engage children in conversations about the book and activities. This provided children with opportunities to use language and learn vocabulary in a meaningful context. Children who were in the interactive book reading intervention group scored significantly better than children in the comparison group on Peabody Picture Vocabulary Test—III and other measures of receptive and expressive language. Book reading and related activities can promote the development of language and literacy skills in young children. (PsycINFO Database Record (c) 2010 APA, all rights reserved)