Relation between circulating leptin concentrations and appetite during a prolonged, moderate energy deficit in women

BACKGROUND: On the basis of observations in rodents, leptin is thought to play a key role in the regulation of energy expenditure and food intake, but less is known of its influence on ingestive behavior and energy balance in humans. OBJECTIVE: We examined the effect in women of a chronic energy deficit on plasma leptin concentrations and self-reported appetite and explored possible relations between leptin and appetite sensations. DESIGN: Twelve healthy women (body mass index, in kg/m2: 23-37) participated in a metabolic ward study in which 3 wk of neutral energy balance was followed by 12 wk of energy deficit (energy intake reduced by 2 MJ/d and energy expenditure increased by 0.8 MJ/d). Body weight and composition were monitored, fasting leptin concentrations were measured 4 times, and feelings of hunger, fullness, desire to eat, and prospective consumption were monitored hourly throughout the day on 7 selected days. RESULTS: Adiposity-adjusted leptin decreased by 54% after 1 wk of a moderate energy deficit and remained low after 6 and 12 wk. Leptin was associated with self-reported hunger, desire to eat, and prospective consumption (range of r: -0.6 to -0.7, P < 0.01). The greatest hunger increase coincided with the largest percentage drop in circulating leptin and the lowest final leptin concentration. The relation between leptin and hunger was not influenced by amount of weight or body fat loss. CONCLUSIONS: These findings support the idea that leptin is a physiologic regulator of hunger during energy deficits in humans; the role of leptin in the long-term regulation of food intake warrants further study.     

Relation between the toxicity of certain chemicals and their electronic structure

Summary On the basis of the biological activity of various elements in Mendeleev's periodic system and their electronic structure, the authors determined a correlation which points to a decrease in toxicity of elements which increase in statistical weight of stable electronic configurations. Nonmetal and semimetal toxicity increases with an increase in the principal quantum number while the biological activity of transition metals decreases. The results obtained can be used for hygienic estimation of the biological action of inorganic substances.Printed as a discussion.Translated from Poroshkovaya Metallurgiya, No. 9(45), pp. 101–109, September, 1966.     

Relation between dietary behavior and body mass index, serum lipids and socioeconomic factors in urban residents

The purpose of this study was to obtain basic information of factors which improve the dietary behavior of urban residents. For this reason, we studied the relation between dietary behavior and BMI, serum lipids and socioeconomic factors. We surveyed the dietary behavior of those who underwent medical examinations at a health center in the city of A. The subjects for this study were 2,627 persons aged 30 to 69 years. For purposes of analysis, the data derived in the survey was divided into two types of categories. One category is that of practicing and non-practicing group relative to specific dietary behaviors. The other is that of better dietary behaviors group and worse dietary behaviors group. (1) A comparison between the practicing and non-practicing group showed that the mean value of the total cholesterol values for the former was lower than for the latter. Similar results for the triglyceride values was obtained. The mean value of the HDL-cholesterol values for the practicing group was higher than for the non-practicing group. (2) We also compared the better dietary behaviors group with the worse group. For women, the mean value of the body mass indices in the better dietary behaviors group was lower than in worse group. We obtained similar differences for women with regard to the mean values of total cholesterol values and triglyceride values. (3) More of Breslow's health practices were followed by the better dietary behaviors group than by the worse group. (4) The number of good dietary practices was significantly related to the following socioeconomic factors: marital status, floor area of residence, steady employment, and working hours. Better dietary behaviors showed parallel correlation with better health status. Dietary behaviors of younger generations and temporary workers showed a tendency of needing to be improved.     

Relation between coronary artery disease, aortic stiffness, and left ventricular structure in a population sample

With the use of the degenerated nucleotides that contain the conserved sequence of G protein-coupled receptor, we have identified a 648-bp clone (HDGRC02) from human genomic DNA with significant sequence homology to human neurotransmitter receptors. HDGRC02 was then used as a probe for the screening of full length gene. From human Lambda DASH II genomic library, a 1.6 Kb clone encoded a full length gene was isolated and named putative neurotransmitter receptor (PNR). PNR has a single open reading frame which predicts a 38.3 KD protein of 338 amino acids with seven transmembrane domain topography. The amino acid sequence of PNR exhibits considerable homology to the rat 5-HR1D receptor with 35% amino acid identity and 56% amino acid similarity. PNR also shows significant sequence homology to the 5-HT1D receptor from Japanese puffer fish fugu, to the 5-HT4L receptor from mouse, to the alpha-2 adrenergic receptor and to the D2 dopamine receptor. Northern blot analysis indicates that PNR is expressed in skeletal muscle and selected areas of the brain. A chromosome mapping study located the PNR gene with human chromosome band of 6q23. The findings in the present study demonstrate that PNR is a putative neurotransmitter receptor.     

Computer model for a multicomponent slag-forming mixture melt: Relation between its atomic structure and physicochemical properties

Experimental data on the density are used to perform molecular dynamics simulation (for the first time) of the multicomponent melt of a commercial slag-forming SiO₂-CaO-Al₂O₃-MgO-CaF₂-Na₂O-K₂O-FeO mixture using an ionic bond model. The simulation results are discussed and compared to available experimental and calculated data. The developed model exhibits a weak temperature dependence of the melt structure. A high diffusion mobility of fluorine ions and alkali metal ions as compared to other elements is revealed.     

Relation between the structure and the pitting corrosion resistance of hypereutectoid U10 steel

Polarization pitting corrosion tests are used to investigate the effect of a structure on the corrosion resistance of hypereutectoid U10 steel. In the steel structure, coarse-lamellar and fine-lamellar pearlite forms as a result of isothermal decomposition at temperatures of 500 and 650°C and fine-lamellar pearlite forms during additional annealing at 650°C for 10 or 300 min. The nonequilibrium structure of fine-lamellar pearlite obtained in the process of isothermal decomposition at a temperature of 500°C is found to have the maximum pitting corrosion resistance among the structural states under study.     

Correlation between the structure and internal friction of metallic glass Cu45Ti55

The structural change of metallic glass Cu₄₅Ti₅₅ from room temperature to 800 K is investigated by combining internal friction using the torsion penulum method with X-ray diffraction (XRD), differential scanning calorimetry (DSC), and transmission electron microscopy (TEM). The internal friction curve exhibits a point of inflection at about 640 K and an internal friction peak between 640 and 780 K, which corresponds to the precipitation of CuTi₂ (tetragonal) and a metastable phase I (tetragonal) and the formation of CuTi (tetragonal), respectively. The result shows that internal friction is closely related to the phase transition during crystallization, and there is much correspondence between internal friction and DSC in describing the crystallization behavior of metallic glasses.     

Behavior of peptides in capillary electrophoresis: effect of peptide charge, mass and structure

In the last decade the large potential of capillary electrophoresis as a technique for separation and characterization of peptides has been demonstrated extensively. In this field, a large number of chemical structures has to be taken into consideration, for which very often no data or even standards are available. As a result, there has been a strong desire to relate electrophoretic behavior to molecular properties and structure of the compounds. The activities in that direction, in the area of capillary zone electrophoresis, are critically reviewed. Special attention is paid to peptide charge, mass, hydrophobicity and structure, and their influence on the selectivity of the separation. Also, some complexation phenomena are discussed.     

Multiple perspectives of rejected, neglected, and accepted children: Relation between sociometric status and behavioral characteristics.

Hypothesized, on the basis of findings from several studies, that rejected children are more disruptive, aggressive, and socially inappropriate than are their classmates. Three groups of 39 rejected, 29 neglected, and 39 accepted children were randomly selected from 282 boys and 210 girls who were identified separately on the basis of sociometric scores for 492 children in Grades 3–6. The 3 groups were compared using multiple analysis of variance (MANOVA) on measures from 4 domains: peer behavioral attributions, teacher ratings, analog assertiveness task, and self-evaluation. Rejected Ss were clearly distinguished from their same-sex neglected and accepted classmates and were described by teachers and peers as aggressive, disruptive and inattentive. Neglected Ss were only marginally discriminable from same-sex accepted children. Neither neglected nor rejected Ss were differentiated from accepted Ss with respect to observed assertiveness and self-ratings of shyness, unhappiness, and feeling unaccepted. The results replicate previous findings for rejected children. Currently, there is not sufficient justification to consider the group of socially neglected children as a clinical category. (21 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relation between neuroticism and dimensions of relationship commitment: Evidence from gay, lesbian, and heterosexual couples.

The link between one's own and one's partner's neuroticism and components of one's own relationship commitment (perceived rewards, costs, match to ideal standard, alternatives, investments, and barriers) was examined for both partners from 61 gay, 42 lesbian, and 155 heterosexual couples. With controls for the other Big Five traits, one's own neuroticism and one's partner's neuroticism independently predicted costs, match to ideal standard, and alternatives. The link between one's neuroticism and these dimensions of one's commitment was mediated by one's life satisfaction, whereas the link between one's partner's neuroticism and these same dimensions was mediated by the partner's conflict resolution styles. It is concluded that neuroticism affects personal dedication to a relationship through both intrapersonal and interpersonal pathways. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Alcohol-aversion therapy: Relation between strength of aversion and abstinence.

Assessed the degree of alcohol aversion in 60 alcoholics (aged 21–60 yrs) who received emetic alcohol-aversion therapy. Based on prior aversion-therapy research, it was predicted that aversion therapy would result in the following changes in response to alcoholic, but not to nonalcoholic, flavors: (1) decreased consumption in taste tests, (2) more negative flavor ratings, (3) overt behavioral indicants of aversion (e.g., grimacing), and (4) increased tachycardic response. A positive correlation between posttreatment tachycardic response to alcohol and number of days to the first drink was also predicted. Results support these predictions. (25 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relation between death anxiety, belief in afterlife, and locus of control.

Administered a 4-part questionnaire, including Rotter's Internal-External Control Scale, the Death Anxiety Scale, Belief in Afterlife Scale-Form A, and the Fear of Death Scale, to 300 college-age Ss. Results did not support the hypothesized relationship between belief in an external locus of control and death anxiety or between externality and belief in afterlife. (PsycINFO Database Record (c) 2010 APA, all rights reserved)