Organ-characteristic of renal circulation (author''s transl)

1 The effect of a controlled release theophylline derivative (Phyllocontin Continus tablets) and an adrenoceptor agonist (salbutamol) was compared when taken singly and concomitantly in twenty patients with chronic bronchitis and additional reversible airways obstruction using a double-blind crossover technique. 2 The pulmonary function data showed a significant improvement in airways obstruction with an associated reduction in hyperinflation on combination therapy, as compared with either drug taken alone. 3 No significant improvement in patient symptoms occurred on combination therapy as compared with either drug taken alone. 4 A high incidence of side-effects was noted with both Phyllocontin Continus and salbutamol. Combination therapy, however, did not increase the frequency or severity of side-effects seen on either drug alone. 5 Although a proportion of patients showed evidence of intercurrent infection during the nine-week trial period, this did not appear to influence the results for the group as a whole.     

Suppression of prostanoid formation and regulation of peripheral circulation after surgery using thrombin inhibitor (MD805)

We studied the effects of thrombin generation due to surgical stress on prostanoid formation and peripheral circulation in anesthetized dogs. Three experimental groups were used, consisting of a control group (group 1), a thoracotomized group (group 2), and a thoracotomized group treated with thrombin inhibitor (MD805: a synthetic arginine derivative) (group 3). The plasma concentrations of thrombin-antithrombin III complex (TAT) and prostanoids were measured along with the hemodynamic parameters. The plasma concentrations of TAT and thromboxane B2 significantly increased 1h after a thoracotomy in group 2. However, neither concentration increased after a thoracotomy in group 3. The flow ratio of the brachial and femoral arteries to cardiac output significantly decreased 1h after a thoracotomy in group 2. This study indicates that thromboxane A2 was thus synthesized by the stimulation of endogenous thrombin, while it also reduced the peripheral blood flow after surgery.     

Cardiac resuscitation - a seven-year report (author's transl)

Over the 7-year period 1966 to 1973, cardiac resuscitation was performed in 315 cases. The reasons were circulatory arrest (ventricular fibrillation or asytole) in 228 and other life-threatening disturbances in 87 cases. During daytime, especially from 8 a.m. to 12 noon and from 4 to 8 p.m., a higher percentage of cases was successfully resuscitated and during these periods emergency personnel seemed to be more readily available. The underlying disease is one of the determinants for the prognosis, whereas age is without relevance. Over the last few years, together with a decrease in the frequency of emergency calls, the percentage of cases of successful resuscitation increased. 14.3% of all patients in whom resuscitation was undertaken were discharged from hospital.     

Simulation analysis of interatrial transposition of venous return (Mustard's operation)

Transposition of the great arteries is functionally corrected by Mustard's operation, an operation in which the atrial septum is removed and the resulting common atrial chamber repartitioned by a baffle to transpose venous return to the heart. To better understand the new physiology, a physically-based mathematical model of the infant circulation following Mustard's operation was developed and studied with the aid of computer simulation. The model reproduces certain clinical observations, including the tendency for mean pressure in both atria to be equal early postoperatively and for the pressure waveform to exhibit a steep y-descent in the systemic venous atrium. Simulation studies suggest that the mechanism for the former is transbaffle pressure coupling resulting from dynamic motion of the baffle; the mechanism for the latter is limitation of the extent of such baffle excursions. Dynamic volume of the two atria is found in the model to change according to the relative performance of the two ventricles, and stiffening the baffle leads to pressure waveforms characteristic of a small, noncompliant atrium. Mechanisms for venous "obstruction" and decompression were also studied. The baffle and its movements, however, have little effect upon cardiac output in the model, leaving unexplained the clinical observation of low output early postoperatively.     

Contextual correlates of adolescents' self-efficacy after smoking cessation.

Recent research has shown that daily changes in self-efficacy predict lapses and relapse into smoking after quitting among adolescent daily smokers, but it is not known if and how momentary self-efficacy is associated with affect-motivational states and external contexts. In the present study, 134 adolescent daily smokers were monitored daily during 1 week prior to and 3 weeks after they began their quit attempt. Participants completed questions on smoking, self-efficacy, affect-motivational states (craving and negative affect), and external contexts (seeing others smoke, experiencing a stressful event, and alcohol and coffee consumption) three times a day. Affect-motivational states as well as all external contexts (except for coffee consumption) were associated with lower self-efficacy when participants were still abstinent, but also after they had lapsed. Associations between the situational contexts and self-efficacy did not largely depend on individual characteristics such as baseline self-efficacy and age. Among girls, however, the negative associations between self-efficacy and negative affect and drinking alcohol were found to be stronger. These results show that adolescents' self-efficacy during a quit attempt may be responsive to affect-motivational states and external contexts, both before and after lapsing. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Burn wounds after resuscitation of a newborn girl

In resuscitation of an asphyctic newborn baby, a chemical hot pack was used for maintaining sufficient body temperature. The child lay for 45 min on the covered hot pack, which had a peak temperature of 54 degrees C. This led to a third degree burn (5% of BSA). The child needed split skin grafting. Control at four months of age showed a well-taken skingraft and the child was developing normally. We conclude that chemical hot packs should not be used for newborn babies unless the peak temperature in the packs is less than 44 degrees C.     

The so-called spontaneous nodular panniculitis (Weber-Christian lipodystrophy)

In 24 patients without liver disease lipids and LCAT activity were determined in the inferior vena cava, the hepatic vein, the pulmonary vein and in the left ventricle. The total cholesterol, free cholesterol and cholesterol ester concentrations are identical and differences in the LCAT activity cannot be demonstrated.