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肟醚(酯)农药活性化合物的研究与开发进展 总被引:6,自引:0,他引:6
概述了具有虫、菌、草等广谱生物活性的肟醚(酯)化合物,重点介绍了具有肟醚(酯)结构农药的研究与开发进展以及其结构特点和活性特点,并对肟醚(酯)化合物的几何异构与其生物活性的关系及几何异构体的相互转化进行了简述。 相似文献
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在农药中,醚类结构常常被选为有效的活性基团。如以苯草醚、嘧草醚等为代表的二芳基醚类除草剂,以多来宝、溴氟醚菊酯等为代表的1,2’-二芳基烷基醚类杀虫剂等。但1,1’-二芳基烷基醚化合物作为农药的应用尚未见报道。笔者在从事具有杀虫活性的芳基烷基肟醚化合物的研究过程中,得到较高分子量的副产物,经结构及生物活性研究, 相似文献
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某些烷基芳基酮肟苯氧基苄醚化合物具有拟除虫菊酯杀虫特性。我们曾合成以下结构肟醚类化合物,研究其合成方法、结构特性及生物活性。 相似文献
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新型具有含硫肟醚基的苯甲酰脲类化合物的合成及其杀虫活性研究 总被引:2,自引:0,他引:2
通过含硫不饱和肟醚与2,6-二氟苯甲酰异酯反应,合成了9个新的具有含硫肟醚基的苯甲酰脲类化合物,其结构均经^1HNMR、IR、LC/MS及元素分析确证,检测结果表明部分化合物表现出很高的杀虫活性。 相似文献
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新型二氯丙烯类杀虫剂的合成及杀虫活性 总被引:1,自引:0,他引:1
在研究以往二氯丙烯类杀虫剂的基础上,保留化合物的活性部分,改变其它可变基团,研究开发出九种新结构的化合物,结构经^1HNMR确认。杀虫活性测试结果表明,新化合物与先导化合物S-1812相比,具有相同或更高的杀虫效果,而且部分化合物的杀虫谱更宽,活性更高。 相似文献
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Sergio A. Caldarelli Dr. Jean‐Frédéric Duckert Dr. Sharon Wein Michèle Calas Prof. Christian Périgaud Prof. Henri Vial Dr. Suzanne Peyrottes Dr. 《ChemMedChem》2010,5(7):1102-1109
An innovative therapeutic approach based on the use of dicationic derivatives was previously designed to inhibit the biosynthesis of phosphatidylcholine in Plasmodium spp. Among these, bis‐thiazolium salts were shown to block proliferation of the malaria parasite at concentrations in the low nanomolar range. However, due to unsuitable molecular properties such as the presence of the two polar heads and flexibility in the linker, these compounds have low oral bioavailability. To characterize the structural requirements of the linker that lead to more rigid analogues with fewer rotatable bonds but which retain antimalarial activity, a new series of compounds incorporating an aryl moiety and eventually oxygen atoms were prepared, and their biological activity was evaluated. Structure–activity relationships suggest that the optimal linker construct is an aromatic group with two n‐butyl chains branched at the para position; two new leads (compounds 39 and 40 ) were selected for further development. 相似文献
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Synthesis and Evaluation of a Series of Bis(pentylpyridinium) Compounds as Antifungal Agents
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Dr. Daniel Obando Dr. Yasuko Koda Namfon Pantarat Dr. Sophie Lev Dr. Xiaoming Zuo Johanes Bijosono Oei Dr. Fred Widmer Prof. Julianne T. Djordjevic Prof. Tania C. Sorrell Prof. Katrina A. Jolliffe 《ChemMedChem》2018,13(14):1421-1436
A series of bis(4‐pentylpyridinium) compounds with a variety of spacers between the pyridinium headgroups was synthesised, and the antifungal activity of these compounds was investigated. Lengthening the alkyl spacer between the pentylpyridinium headgroups from 12 to 16 methylene units resulted in increased antifungal activity against C. neoformans and C. albicans, but also resulted in increased hemolytic activity and cytotoxicity against mammalian cells. However, inclusion of an ortho‐substituted benzene ring in the centre of the alkyl spacer resulted in decreased cytotoxicity and hemolytic activity, while maintaining antifungal potency. Replacement of the alkyl and aromatic‐containing spacers by more hydrophilic ethylene glycol groups resulted in a loss of antifungal activity. Some of the compounds inhibited fungal PLB1 activity, but the low correlation of this inhibition with antifungal potency indicates PLB1 inhibition is unlikely to be the predominant mode of antifungal action of this class of compounds, with preliminary studies suggesting they may act via disruption of fungal mitochondrial function. 相似文献
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Twenty compounds identified in vulpia (Vulpia myuros) residues as allelochemicals were individually and collectively tested for biological activity. Each exhibited characteristic allelochemical behavior toward the test plant, i.e., inhibition at high concentrations and stimulation or no effect at low concentrations, but individual activities varied. Allelopathins present in large quantities, such as syringic, vanillic, and succinic acids, possessed low activity, while those present in small quantities, such as catechol and hydrocinnamic acid, possessed strong inhibitory activity. The concept of a phytotoxic strength index was developed for quantifying the biological properties of each individual allelopathin in a concise, comprehensive, and meaningful format. The individual contribution of each allelopathin, assessed by comparing the phytotoxic strength index to the overall toxicity of vulpia residues, was variable according to structure and was influenced by its relative proportion in the residue. The majority of compounds possessed low or medium biological activity and contributed most of the vulpia phytotoxicity, while compounds with high biological activity were in the minority and only present at low concentration. Artificial mixtures of these pure allelochemicals also produced phytotoxicity. There were additive/synergistic effects evident in the properties of these mixtures. One such mixture, formulated from allelochemicals found in the same proportions as occur in vulpia extract, produced stronger activity than another formulated from the same set of compounds but in equal proportions. These results suggest that the exploration of the relative composition of a cluster of allelopathins may be more important than simply focusing on the identification of one or two compounds with strong biological activity and that synergism is fundamental to the understanding of allelopathy. 相似文献
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介绍了一些已知有非农药用途活性的生物发酵液和其活性物质的农药活性的最新研究,其中一些物质对病虫害的作用可与商业化制剂媲美。指出对已有各种用途天然源物质进行生物农药开发研究是开发农药的一个重要的途径。 相似文献
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The worldwide development of antimicrobial resistance forces scientists to search for new compounds to which microbes would be sensitive. Many new structures contain the 1,3,4-oxadiazole ring, which have shown various antimicrobial activity, e.g., antibacterial, antitubercular, antifungal, antiprotozoal and antiviral. In many publications, the activity of new compounds exceeds the activity of already known antibiotics and other antimicrobial agents, so their potential as new drugs is very promising. The review of active antimicrobial 1,3,4-oxadiazole derivatives is based on the literature from 2015 to 2021. 相似文献
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噻唑环和腙键结构均具有一定的生物活性,采用活性结构拼接法,将噻唑环与腙键相结合,设计并合成了16个2-芳醛腙噻唑类化合物,并采用MTT法对目标化合物进行体外抗肿瘤活性筛选。测试结果表明,该类新化合物对乳腺癌细胞株(MDA-MB-231、MDA-MB-468、MCF-7)具有一定的抗增殖活性。其中,N-(2-吡啶)甲醛-2-(4-苯基)噻唑腙的抗增殖活性最好,其IC50值分别为(0.21±0.11)、(0.18±0.10)、(0.17±0.08)μmol/L;而该化合物对其他肿瘤细胞亦具有一定的抗增殖活性,且相对乳腺癌细胞株的生物活性均在10倍及以上,说明其对乳腺癌细胞具有较好的生物活性和选择性,且毒副作用小,值得作为抗乳腺癌先导化合物进行进一步研究。 相似文献
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A. Sivasamy M. Krishnaveni P. G. Rao 《Journal of the American Oil Chemists' Society》2001,78(9):897-902
Several lipoamino acids were synthesized, in which n-octadecanoic acid (stearic acid) was coupled with the α-amino group of an amino acid. The products were characterized and
their identities confirmed by advanced analytical techniques like Fourier transform infrared 1H nuclear magnentic resonance spectroscopy, and differential scanning, calorimetry. Their surface properties, such as critical
micelle concentration (CMC) and foaming properties, biodegradability, and antimicrobial activity were also evaluated. The
N-stearoyl amino acids (NSA) had low CMC values, and some of them showed good foaming properties. They were screened for antimicrobial
activity against the gram-positive bacteria Staphylococcus aureus, Micrococcus luteus, and Bacillus cerceus, the gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, and the yeast Candida albicans. All the compounds inhibited at least one of these organisms. N-Stearoyl proline was the most effective, the order of antimicrobial activity being aromatic NSA> acidic NSA>basic NSA. However,
the effective inhibition by all the compounds indicates the desirability of more thorough investigation and suggests that
some of these compounds may have potential utility as biostatic additives in commercial products. All NSA are highly biodegradable
and can readily be removed under conditions of normal secondary sewage treatment. 相似文献