共查询到20条相似文献,搜索用时 15 毫秒
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Bowen Yao Haiyan Wang Qinqin Zhou Mingmao Wu Miao Zhang Chun Li Gaoquan Shi 《Advanced materials (Deerfield Beach, Fla.)》2017,29(28)
A poly(3,4‐ethylenedioxythiophene):poly(4‐styrenesulfonate) (PEDOT:PSS) hydrogel is prepared by thermal treatment of a commercial PEDOT:PSS (PH1000) suspension in 0.1 mol L?1 sulfuric acid followed by partially removing its PSS component with concentrated sulfuric acid. This hydrogel has a low solid content of 4% (by weight) and an extremely high conductivity of 880 S m?1. It can be fabricated into different shapes such as films, fibers, and columns with arbitrary sizes for practical applications. A highly conductive and mechanically strong porous fiber is prepared by drying PEDOT:PSS hydrogel fiber to fabricate a current‐collector‐free solid‐state flexible supercapacitor. This fiber supercapacitor delivers a volumetric capacitance as high as 202 F cm?3 at 0.54 A cm?3 with an extraordinary high‐rate performance. It also shows excellent electrochemical stability and high flexibility, promising for the application as wearable energy‐storage devices. 相似文献
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Simon Matoori Yinyin Bao Aaron Schmidt Eric J. Fischer Rafael Ochoa‐Sanchez Mlanie Tremblay Mariana M. Oliveira Christopher F. Rose Jean‐Christophe Leroux 《Small (Weinheim an der Bergstrasse, Germany)》2019,15(50)
Ammonia‐scavenging transmembrane pH‐gradient poly(styrene)‐b‐poly(ethylene oxide) polymersomes are investigated for the oral treatment and diagnosis of hyperammonemia, a condition associated with serious neurologic complications in patients with liver disease as well as in infants with urea cycle disorders. While these polymersomes are highly stable in simulated intestinal fluids at extreme bile salt and osmolality conditions, they unexpectedly do not reduce plasmatic ammonia levels in cirrhotic rats after oral dosing. Incubation in dietary fiber hydrogels mimicking the colonic environment suggests that the vesicles are probably destabilized during the dehydration of the intestinal chyme. The findings question the relevance of commonly used simulated intestinal fluids for studying vesicular stability. With the encapsulation of a pH‐sensitive dye in the polymersome core, the local pH increase upon ammonia influx could be exploited to assess the ammonia concentration in the plasma of healthy and cirrhotic rats as well as in other fluids. Due to its high sensitivity and selectivity, this polymersome‐based assay could prove useful in the monitoring of hyperammonemic patients and in other applications such as drug screening tests. 相似文献
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Photosensitive Nanoparticles Combining Vascular‐Independent Intratumor Distribution and On‐Demand Oxygen‐Depot Delivery for Enhanced Cancer Photodynamic Therapy 下载免费PDF全文
Caiyan Zhao Yujia Tong Xianlei Li Leihou Shao Long Chen Jianqing Lu Xiongwei Deng Xuan Wang Yan Wu 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(12)
In drug delivery, the poor tumor perfusion results in disappointing therapeutic efficacy. Nanomedicines for photodynamic therapy (PDT) greatly need deep tumor penetration due to short lifespan and weak diffusion of the cytotoxic reactive oxygen species (ROS). The damage of only shallow cells can easily cause invasiveness and metastasis. Moreover, even if the nanomedicines enter into deeper lesion, the effectiveness of PDT is limited due to the hypoxic microenvironment. Here, a deep penetrating and oxygen self‐sufficient PDT nanoparticle is developed for balanced ROS distribution within tumor and efficient cancer therapy. The designed nanoparticles (CNPs/IP) are doubly emulsified (W/O/W) from poly(ethylene glycol)‐poly(ε‐caprolactone) copolymers doped with photosensitizer IR780 in the O layer and oxygen depot perfluorooctyl bromide (PFOB) inside the core, and functionalized with the tumor penetrating peptide Cys‐Arg‐Gly‐Asp‐Lys (CRGDK). The CRGDK modification significantly improves penetration depth of CNPs/IP and makes the CNPs/IP arrive at both the periphery and hypoxic interior of tumors where the PFOB releases oxygen, effectively alleviating hypoxia and guaranteeing efficient PDT performance. The improved intratumoral distribution of photosensitizer and adequate oxygen supply augment the sensitivity of tumor cells to PDT and significantly improve PDT efficiency. Such a nanosystem provides a potential platform for improved therapeutic index in anticancer therapy. 相似文献
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Xue Zhang Shuo Wang Chuanjiao Xue Chengzhou Xin Yuanhua Lin Yang Shen Liangliang Li Ce‐Wen Nan 《Advanced materials (Deerfield Beach, Fla.)》2019,31(11)
Polymer‐based electrolytes have attracted ever‐increasing attention for all‐solid‐state lithium (Li) metal batteries due to their ionic conductivity, flexibility, and easy assembling into batteries, and are expected to overcome safety issues by replacing flammable liquid electrolytes. However, it is still a critical challenge to effectively block Li dendrite growth and improve the long‐term cycling stability of all‐solid‐state batteries with polymer electrolytes. Here, the interface between novel poly(vinylidene difluoride) (PVDF)‐based solid electrolytes and the Li anode is explored via systematical experiments in combination with first‐principles calculations, and it is found that an in situ formed nanoscale interface layer with a stable and uniform mosaic structure can suppress Li dendrite growth. Unlike the typical short‐circuiting that often occurs in most studied poly(ethylene oxide) systems, this interface layer in the PVDF‐based system causes an open‐circuiting feature at high current density and thus avoids the risk of over‐current. The effective self‐suppression of the Li dendrite observed in the PVDF–LiN(SO2F)2 (LiFSI) system enables over 2000 h cycling of repeated Li plating–stripping at 0.1 mA cm?2 and excellent cycling performance in an all‐solid‐state LiCoO2||Li cell with almost no capacity fade after 200 cycles at 0.15 mA cm?2 at 25 °C. These findings will promote the development of safe all‐solid‐state Li metal batteries. 相似文献
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Tian Yang Hui Wang Xue‐Mei Ou Chun‐Sing Lee Xiao‐Hong Zhang 《Advanced materials (Deerfield Beach, Fla.)》2012,24(46):6250-6250
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DNA‐Metalization: Synthesis and Properties of Novel Silver‐Containing DNA Molecules (Adv. Mater. 24/2016) 下载免费PDF全文
Gennady Eidelshtein Natalie Fardian‐Melamed Vitaly Gutkin Dmitry Basmanov Dmitry Klinov Dvir Rotem Yael Levi‐Kalisman Danny Porath Alexander Kotlyar 《Advanced materials (Deerfield Beach, Fla.)》2016,28(24):4944-4944
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Siow‐Feng Chong Rona Chandrawati Brigitte Städler Jeongju Park Jinhan Cho Yajun Wang Zhongfan Jia Volga Bulmus Thomas P. Davis Alexander N. Zelikin Frank Caruso 《Small (Weinheim an der Bergstrasse, Germany)》2009,5(22):2601-2610
Polymer hydrogels are used in diverse biomedical applications including drug delivery and tissue engineering. Among different chemical linkages, the natural and reversible thiol–disulfide interconversion is extensively explored to stabilize hydrogels. The creation of macro‐, micro‐, and nanoscale disulfide‐stabilized hydrogels commonly relies on the use of oxidizing agents that may have a detrimental effect on encapsulated cargo. Herein an oxidization‐free approach to create disulfide‐stabilized polymer hydrogels via a thiol–disulfide exchange reaction is reported. In particular, thiolated poly(methacrylic acid) is used and the conditions of polymer crosslinking in solution and on colloidal porous and solid microparticles are established. In the latter case, removal of the core particles yields stable, hollow, disulfide‐crosslinked hydrogel capsules. Further, a procedure is developed to achieve efficient disulfide crosslinking of multilayered polymer films to obtain stable, liposome‐loaded polymer‐hydrogel capsules that contain functional enzymatic cargo within the liposomal subcompartments. This approach is envisaged to facilitate the development of biomedical applications of hydrogels, specifically those including fragile cargo. 相似文献
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A V2O5/Conductive‐Polymer Core/Shell Nanobelt Array on Three‐Dimensional Graphite Foam: A High‐Rate,Ultrastable, and Freestanding Cathode for Lithium‐Ion Batteries 下载免费PDF全文
Jilei Liu Zhanxi Fan Chin Fan Ng Jianyi Lin Hua Zhang Ze Xiang Shen Hong Jin Fan 《Advanced materials (Deerfield Beach, Fla.)》2014,26(33):5794-5800
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Ferroelectric Coupling Effect on the Energy‐Band Structure of Hybrid Heterojunctions with Self‐Organized P(VDF‐TrFE) Nanomatrices 下载免费PDF全文
Kyung‐Sik Shin Tae Yun Kim Gyu Cheol Yoon Manoj Kumar Gupta Sung Kyun Kim Wanchul Seung Hyeok Kim Sungjin Kim SeongMin Kim Sang‐Woo Kim 《Advanced materials (Deerfield Beach, Fla.)》2014,26(32):5619-5625
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Lithium‐Ion Batteries: A V2O5/Conductive‐Polymer Core/Shell Nanobelt Array on Three‐Dimensional Graphite Foam: A High‐Rate,Ultrastable, and Freestanding Cathode for Lithium‐Ion Batteries (Adv. Mater. 33/2014) 下载免费PDF全文
Dongliang Chao Xinhui Xia Jilei Liu Zhanxi Fan Chin Fan Ng Jianyi Lin Hua Zhang Ze Xiang Shen Hong Jin Fan 《Advanced materials (Deerfield Beach, Fla.)》2014,26(33):5733-5733
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Poly(N‐phenylglycine)‐Based Nanoparticles as Highly Effective and Targeted Near‐Infrared Photothermal Therapy/Photodynamic Therapeutic Agents for Malignant Melanoma 下载免费PDF全文
Bang‐Ping Jiang Li Zhang Xiao‐Lu Guo Xing‐Can Shen Yan Wang Yang Zhu Hong Liang 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(8)
Malignant melanoma is a highly aggressive tumor resistant to chemotherapy. Therefore, the development of new highly effective therapeutic agents for the treatment of malignant melanoma is highly desirable. In this study, a new class of polymeric photothermal agents based on poly(N‐phenylglycine) (PNPG) suitable for use in near‐infrared (NIR) phototherapy of malignant melanoma is designed and developed. PNPG is obtained via polymerization of N‐phenylglycine (NPG). Carboxylate functionality of NPG allows building multifunctional systems using covalent bonding. This approach avoids complicated issues typically associated with preparation of polymeric photothermal agents. Moreover, PNPG skeleton exhibits pH‐responsive NIR absorption and an ability to generate reactive oxygen species, which makes its derivatives attractive photothermal therapy (PTT)/photodynamic therapy (PDT) dual‐modal agents with pH‐responsive features. PNPG is modified using hyaluronic acid (HA) and polyethylene glycol diamine (PEG‐diamine) acting as the coupling agent. The resultant HA‐modified PNPG (PNPG‐PEG‐HA) shows negligible cytotoxicity and effectively targets CD44‐overexpressing cancer cells. Furthermore, the results of in vitro and in vivo experiments reveal that PNPG‐PEG‐HA selectively kills B16 cells and suppresses malignant melanoma tumor growth upon exposure to NIR light (808 nm), indicating that PNPG‐PEG‐HA can serve as a very promising nanoplatform for targeted dual‐modality PTT/PDT of melanoma. 相似文献