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Max Pillong Jan A. Hiss Petra Schneider Yen‐Chu Lin Gernot Posselt Bernhard Pfeiffer Markus Blatter Alex T. Müller Simon Bachler Claudia S. Neuhaus Petra S. Dittrich Karl‐Heinz Altmann Silja Wessler Gisbert Schneider 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(40)
Specific interactions of peptides with lipid membranes are essential for cellular communication and constitute a central aspect of the innate host defense against pathogens. A computational method for generating innovative membrane‐pore‐forming peptides inspired by natural templates is presented. Peptide representation in terms of sequence‐ and topology‐dependent hydrophobic moments is introduced. This design concept proves to be appropriate for the de novo generation of first‐in‐class membrane‐active peptides with the anticipated mode of action. The designed peptides outperform the natural template in terms of their antibacterial activity. They form a kinked helical structure and self‐assemble in the membrane by an entropy‐driven mechanism to form dynamically growing pores that are dependent on the lipid composition. The results of this study demonstrate the unique potential of natural template‐based peptide design for chemical biology and medicinal chemistry. 相似文献
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Nanotheranostics: Dual‐Stimuli Responsive Nanotheranostics for Multimodal Imaging Guided Trimodal Synergistic Therapy (Small 6/2017)
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Shan Fang Jing Lin Chunxiao Li Peng Huang Wenxiu Hou Chunlei Zhang Jingjing Liu Sisi Huang Yongxiang Luo Wenpei Fan Daxiang Cui Yunsheng Xu Zhiming Li 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(6)
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Drug Delivery: Long‐Term Real‐Time In Vivo Drug Release Monitoring with AIE Thermogelling Polymer (Small 7/2017)
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Sing Shy Liow Qingqing Dou Dan Kai Zibiao Li Sigit Sugiarto Chris Yee Yung Yu Ryan Tsz Kin Kwok Xiaohong Chen Yun‐Long Wu Seow Theng Ong Atish Kizhakeyil Navin K. Verma Ben Zhong Tang Xian Jun Loh 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(7)
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Drug Delivery: Immune Cell‐Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery (Small 10/2017)
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Zhiwei Xie Yixue Su Gloria B. Kim Erhan Selvi Chuying Ma Virginia Aragon‐Sanabria Jer‐Tsong Hsieh Cheng Dong Jian Yang 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(10)
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