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异斯特维醇是由天然产物甜菊糖苷经酸解得到,其衍生物在生物活性方面的应用研究较多。本文对异斯特维醇衍生物在生物活性、催化剂、分子识别和超分子组装等领域的应用进行了综述。 相似文献
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根据环上取代基的不同咪唑并[2,1-b]噻唑衍生物具有多种多样的生物活性。通过对咪唑并[2,1-b]噻唑衍生物合成方法的不同进行分类,综述了近年来咪唑并[2,1-b]噻唑衍生物的合成及其生物活性,结果表明在咪唑并噻唑环上引入药理活性基团会增强其生物活性。咪唑并[2,1-b]噻唑环一般由Hanzstch方法合成,近年来也出现了一些新的合成方法,如Sonogashira、Suzuki反应和金属催化芳基化,对这些新方法合成咪唑并噻唑环及其衍生物也进行了综述。 相似文献
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Zihan Xiong Wei Wen Yifei Zhu Youbing Mu Zhiyuan Zhao Zhenggang Lan Xiaobo Wan Yunqi Liu 《大分子材料与工程》2023,308(7):2200688
Although the effects of electron-deficient group substitution on isoindigo on the corresponding conjugated polymers are extensively studied, the modification of isoindigo core with electron-rich groups has not been investigated. It is envisioned that the introduction of the methoxy group on isoindigo will not only tune the highest occupied molecular orbital (HOMO) energy level of the corresponding polymers but also introduce O···S “conformation lock” to increase the coplanarity of the polymers, which should facilitate hole transport. Herein, the syntheses of two methoxylated isoindigos and the investigations on the charge transport behaviors of their copolymers with bisthiophene ( 2T ) and bisthiazole ( 2Tz ) are reported. It is found that the substitution positions have a drastic influence on the UV–vis absorption and electrochemical properties for both monomers and polymers. Theoretical calculations and single crystal structure analysis confirm the existence of O···S “conformation lock”, however, both methoxy substitutions also change the aggregation behaviors of the corresponding polymers to a mixed face-on/edge-on orientation which has an adverse effect for charge transport. Among the four polymers, the polymer of 5,5'-methoxylated isoindigo and 2T exhibit the best hole mobility of 1.9 × 10−1 cm2 V−1 s−1. 相似文献
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Bilal Shahid Dangqiang Zhu Qian Wang Xiyue Yuan Irfan Ismail Yao Wu Zurong Du Renqiang Yang 《Polymer International》2020,69(6):564-570
To optimize the energy levels of the structural framework of isoindigo polymers, a series of asymmetric isoindigo based low bandgap polymers with chlorine, fluorine and thiazole substituents was constructed and their optical, electrochemical and photovoltaic properties were comparatively evaluated for the impact of different substitutions. In comparison with the polymer based on 2,2'‐bithiophene and isoindigo unit (PTi) with non‐substituted bithiophene as the donor moiety, the highest occupied molecular orbital energy level for the newly synthesized polymers is significantly decreased, and in turn an improvement of the open‐circuit voltage (VOC) is noted in the corresponding photovoltaic devices. More importantly, combined with a low bandgap of 1.32 eV, the energy losses (Eloss) could be reduced to 0.61 eV for polymer based on chlorinated 2,2'‐bithiophene and isoindigo unit (PCl). In addition, the halogen moieties are observed to be superior in device fabrication and give better values than the thiazole substituent. Both fluorinated and chlorinated polymer donors exhibited improved performance compared with the original polymer PTi. Consequently, this work not only presents the influence of different electron withdrawing substituents on the physicochemical and photovoltaic performance, but also backs the concept of how to reduce the energy loss via the heteroatom effect. © 2020 Society of Chemical Industry 相似文献
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线粒体单链DNA结合蛋白1(single-strand DNA-binding protein 1,SSBP1)是一种存在于线粒体的蛋白,主要参与线粒体相关生物学活动,目前相关研究发现,其与恶性肿瘤发生发展、转移及侵袭相关。本文就SSBP1与线粒体及恶性肿瘤之间的生物相关性作一综述。 相似文献
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Valentina Laghezza Masci Roberta Bernini Noemi Villanova Mariangela Clemente Vittoria Cicaloni Laura Tinti Laura Salvini Anna Rita Taddei Antonio Tiezzi Elisa Ovidi 《International journal of molecular sciences》2022,23(20)
The antitumor activity of polyphenols derived from extra virgin olive oil and, in particular the biological activity of HTyr, has been studied extensively. However, the use of HTyr as a therapeutic agent for clinical applications is limited by its low bioavailability and rapid excretion in humans. To overcome these limitations, several synthetic strategies have been optimized to prepare lipophenols and new compounds derived from HTyr to increase lipophilicity and bioavailability. One very promising ester is hydroxytyrosyl oleate (HTyr-OL) because the chemical structure of HTyr, which is responsible for several biological activities, is linked to the monounsaturated chain of oleic acid (OA), giving the compound high lipophilicity and thus bioavailability in the cellular environment. In this study, the in vitro cytotoxic, anti-proliferative, and apoptotic induction activities of HTyr-OL were evaluated against SH-SY5Y human neuroblastoma cells, and the effects were compared with those of HTyr and OA. The results showed that the biological activity of HTyr was maintained in HTyr-OL treatments at lower dosages. In addition, the shotgun proteomic approach was used to study HTyr-OL-treated and untreated neuroblastoma cells, revealing that the antioxidant, anti-proliferative and anti-inflammatory activities of HTyr-OL were observed in the unique proteins of the two groups of samples. 相似文献
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Heterocyclic compounds constitute a unique class of organic compounds endowed with a wide range of synthetic and pharmaceutical applications. Pyrimidinones and their fused analogues have received focused attention in this regard, partly due to their mimicry of nucleobases which consequently forges their interesting medicinal properties. Over the years, the medicinal chemistry research community has experienced an upsurge in articles describing the exploration of these scaffolds to develop effective therapeutic agents. Several biological activities, including antimicrobial, antiviral, anticancer, antidiabetic, anti-inflammatory, anticonvulsive, and antihistaminic, have been well documented. This minireview presents a compendium of recent developments (2017–2020) focused on the synthesis and biological activities of fused pyrimidinones. The goal is to update medicinal chemists on the therapeutic relevance of fused pyrimidinones and the molecular architecture of clinic-worthy drug candidates. A brief account of the structure-activity relationships (SAR) revealed from different biological assays is also discussed. 相似文献
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Lena Burri Nils Hoem Sebastiano Banni Kjetil Berge 《International journal of molecular sciences》2012,13(11):15401-15419
The biological activities of omega-3 fatty acids (n-3 FAs) have been under extensive study for several decades. However, not much attention has been paid to differences of dietary forms, such as triglycerides (TGs) versus ethyl esters or phospholipids (PLs). New innovative marine raw materials, like krill and fish by-products, present n-3 FAs mainly in the PL form. With their increasing availability, new evidence has emerged on n-3 PL biological activities and differences to n-3 TGs. In this review, we describe the recently discovered nutritional properties of n-3 PLs on different parameters of metabolic syndrome and highlight their different metabolic bioavailability in comparison to other dietary forms of n-3 FAs. 相似文献