共查询到15条相似文献,搜索用时 15 毫秒
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Ru‐Huei Fu Shih‐Ping Liu Ching‐Liang Chu Ya‐Hsien Lin Yu‐Chen Ho Shao‐Chih Chiu Wei‐Yong Lin Woei‐Cherng Shyu Shinn‐Zong Lin 《Journal of the science of food and agriculture》2013,93(1):76-84
BACKGROUND: Myricetin is a naturally occurring flavonoid that is found in many fruits, vegetables, teas and medicinal herbs. It has been demonstrated to have anti‐inflammatory properties, but, to date, no studies have described the immunomodulatory effects of myricetin on the functions of dendritic cells (DCs). The aim of this study was to evaluate the potential for myricetin to modulate lipopolysaccharide (LPS)‐stimulated activation of mouse bone marrow‐derived DCs. RESULTS: Our experimental data showed that treatment with myricetin up to 10 µg mL−1 does not cause cytotoxicity in cells. Myricetin significantly decreased the secretion of tumour necrosis factor‐α, interleukin‐6 and interleukin‐12p70 by LPS‐stimulated DCs. The expression of LPS‐induced major histocompatibility class II, CD40 and CD86 on DCs was also inhibited by myricetin, and the endocytic and migratory capacity of LPS‐stimulated DCs was blocked by myricentin. In addition, LPS‐stimulated DC‐elicited allogeneic T‐cell proliferation was reduced by myricetin. Moreover, our results confirmed that myricetin attenuates the responses of LPS‐stimulated activation of DCs via suppression of IκB kinase/nuclear factor‐κB and mitogen‐activated protein kinase‐dependent pathways. CONCLUSION: Myricetin has novel immunopharmacological activity, and modulation of DCs by myricetin may be an attractive strategy for the treatment of inflammatory and autoimmune disorders, and for transplantation. Copyright © 2012 Society of Chemical Industry 相似文献
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Mehmet Tuzcu Abdullah Aslan Zeynep Tuzcu Mehmet Yabas Ibrahim Halil Bahcecioglu Ibrahim Hanifi Ozercan Omer Kucuk Kazim Sahin 《Molecular nutrition & food research》2012,56(9):1477-1481
Cancer is one of the leading causes of death worldwide. Since dietary factors have been connected to a reduced risk of a diversity of human cancers, in this study we investigated the effects of tomato powder (TP) on the development of azoxymethane (AOM)‐induced colorectal cancer in Wistar rats, and possible mechanism(s) by which TP shows its chemopreventive activity. Here we show that TP added to feed at 5% rate decreases the rate of aberrant crypt foci (ACF) and reduces the development of adenocarcinoma and growth of AOM‐induced colorectal cancer in rats. In addition, we demonstrate that TP supplementation shows its chemopreventive activities through inhibition of cyclooxygenase‐2 (COX‐2) expression via NF‐κB pathway and promotion of apoptosis, as well as regulating Nrf2/HO‐1 signaling pathway in colorectal tissue of AOM‐treated rats. Our findings identify an intimate connection between dietary supplementation of TP and the decreased risk of colorectal cancer in rats, and suggest that consumption of TP would be a natural candidate for the prevention of colorectal cancer in men. 相似文献
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Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High‐Fat Diet in Mice through PPAR‐α and Nrf2 Upregulation with Concomitant SREBP‐1c and NF‐kB Downregulation 下载免费PDF全文
María C. Hernández‐Rodas Rodrigo Valenzuela Francisca Echeverría Miguel Ángel Rincón‐Cervera Alejandra Espinosa Paola Illesca Patricio Muñoz Alicia Corbari Nalda Romero Daniel Gonzalez‐Mañan Luis A. Videla 《Molecular nutrition & food research》2017,61(12)
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Ursolic acid increases energy expenditure through enhancing free fatty acid uptake and β‐oxidation via an UCP3/AMPK‐dependent pathway in skeletal muscle 下载免费PDF全文
Xia Chu Xuan He Zhiping Shi Chunjuan Li Fuchuan Guo Songtao Li Ying Li Changhao Sun 《Molecular nutrition & food research》2015,59(8):1491-1503