共查询到19条相似文献,搜索用时 140 毫秒
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压电生物传感器 总被引:1,自引:0,他引:1
虽然压电效应在上一世纪业已发现,但是压电石英晶体在化学传感器中的应用却是1995年Sauerbrey导出了频率-质量关系式之后才实现的.1964年King报道了第一个压电石英晶体检测器.至今,压电石英传感器已广泛用于气体、液体试样分析.我国姚守拙等人在压电石英晶体的分析应用领域率先进行了大量的研究工作.根据Sauerbrey方程,结合生物体中某些高选择反应,通过对石英晶体表面进行修饰,使其能选择性地与被检测物质作用,便可制成压电生物敏感元件(或压电生物传感器).1972年Shons首次用抗原涂膜压电晶体来检测溶液中的抗体,由于当时技术的限制及人们对该类传感器认识不足,未能得到较好地发展,直到本世纪80年代中期才为人们所重视.目前国外对此新领域的研究非常活跃,但国内尚未见压电生物传感器方面的研究报道.现对 相似文献
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压电传感器在环境监测中的应用 总被引:1,自引:0,他引:1
简要介绍了压电石英晶体微天平(QCM)及表现声波(SAW)压电传感器的基本原理,从QCM化学传感器毒气检测、QCM化学传感器液相检测、SAW化学传感器分析、压电生物传感器物质分析、压电生物传感器液相分析、压电传感器陈列、非质量效应压电传感器等方面介绍了近年来压电传感器在环境监测领域的研究进展,并展望了压电传感顺在环境监测中的应用前景。 相似文献
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DNA生物传感器的进展 总被引:2,自引:1,他引:1
DNA生物传感器是分子生物学与微电子学、电化学、光学等相结合的产物 ,它将在生命科学与信息科学之间架起一道桥梁 ,成为DNA信息分析检测最重要的技术之一。简要介绍了电化学DNA生物传感器、压电石英晶体DNA生物传感器、光学DNA生物传感器的结构原理 相似文献
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当前生命科学研究呈现为多学科交叉融会和多种新技术应用所形成的全方位体系,压电化学与生物传感是一个新兴的领域。生命过程伴随着生物分子的相互作用而产生质量的增减。压电石英晶体微天平(Quanz Crystal Microbalances,QCM)正是以其灵敏的压电质量传感功能及其简单的仪器装置、快捷的分析速度、低廉的检测成本等优点而博得生物学研究人员的青睐。近30年来,压电石英晶体微天平技术随着理论及仪器研制水平的提高,其在生物学领域的研究应用日新月异,已由过去单一的气相检测,发展成为能进行气液相检测、自动化程度高、能实现原位及在线检测的新型生物传感器。 相似文献
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《Sensors and actuators. A, Physical》1999,72(2):140-147
This paper shows the properties and the possibilities of carbon graphite-covered quartz crystal as an organic gas-sensing device. The carbon graphite formed on a side of quartz plate was supported by Pt electrodes. The prepared quartz crystals were heat treated for the enhancement of stability in the temperature range from 100 to 450°C. Impedance analysis of the carbon graphite-covered quartz crystal showed a larger admittance value than that of a lipid coated quartz crystal, which was based on our previous method for detecting gas components. Using the adsorption and desorption responses, the reproducibility and sensitivity are presented for describing the merits of carbon graphite-covered quartz crystal in the detection of organic gas components. The comparison of sensitivity between commercially available alcohol sensor and carbon graphite-covered quartz crystal is provided for a ppm of ethanol injection. These results prove that the carbon graphite-covered quartz crystals are usable as an organic gas sensor and as an analytical device. 相似文献
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以L-谷氨酸盐酸盐为敏感膜,将其涂于具有金电极的AT切型的石英振子上,制成敏感元件·该膜对NH3具有很高的频率响应,高的灵敏度和良好的选择特性。 相似文献
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石英晶体参数的快速和准确测量是石英晶体元件加工控制和成品检测的重要指标;介绍了基于π网络零相位法的石英晶体参数测量方法,并在此基础上,研制了以DSP和FPGA为核心的嵌入式数字鉴相处理系统,测量过程中系统直接控制信号发生器,并在数字信号处理器中实现快速牛顿下山测量算法,使得平均只需要进行5次搜索,就可以锁定石英晶体的谐振频率,从而实现晶体谐振频率的快速测量;实验表明系统测量精度达到2PPM,平均测量时间小于0.5秒。 相似文献
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A quartz crystal resonator's resonance frequency is sensitive to temperature. This sensitivity has been exploited in the past in thermometers made of single, macroscopic quartz resonators that can accurately detect temperature changes of μK. Using semiconductor microfabrication techniques, it is now possible to fabricate a large number of microresonators from a single quartz wafer. It is shown that combining the small thermal mass and high thermal isolation capability of such microresonators, the steep frequency versus temperature characteristics of resonators made of certain cuts of quartz and the low-noise characteristics of quartz crystal oscillators can result in high-performance infrared (IR) sensors and sensor arrays. In a microresonator sensor, the temperature change produced by the absorption of IR energy results in a frequency change that can be measured with a resolution that corresponds to a change in the resonator's temperature of less than a μK. Calculation shows that an array of microresonators in the 200 MHz-1 GHz range can be the basis of an uncooled IR imaging system with a noise equivalent temperature difference, NETD, of <0.01 K. The design and fabrication problems to be overcome before such microresonator arrays can be realized are discussed 相似文献
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为改善石英晶体振荡器的频率特性,减小温度影响,通过对石英晶体振荡器的频率-温度特性的研究,提出了以微处理器(STC89C52RC)为核心的基于AT切晶体谐振器的温度补偿技术,并介绍了系统结构、补偿原理及硬件电路,给出了补偿结果。本设计具有结构简单、功耗低等优点。 相似文献
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A novel quartz crystal microbalance (QCM) sensor with a high selectivity and sensitivity has been developed for the determination of Cu(II) ions, based on the modification of Cu(II) ion-imprinted polymer (Cu(II)-IIP) film onto a quartz crystal. The performance of the developed MIP-QCM sensor was evaluated and the results indicated that a sensitive MIP-QCM sensor could be fabricated. The obtained MIP-QCM sensor presents high-selectivity monitoring of Cu(II) ions, better reproducibility, shorter response time (6 min), wider linear range (0.001–50 μM) and lower detection limit (8 × 10−4 μM). The practical analysis of the MIP-QCM sensor confirms the feasibility of Cu(II) determination in wastewater. 相似文献
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石英晶体微天平传感的酶联免疫分析法测定免疫球蛋白IgM 总被引:2,自引:0,他引:2
结合酶联免疫分析技术与石英晶体微天平检测技术,发展了一种基于石英晶体微天平传感的免疫传感器用于测定血液中免疫球蛋白IgM的量.羊抗人IgM抗血清通过氨基硅烷化共键固定在石英晶体表面上,采用竞争吸附免疫分析法,以辣根过氧化物酶(HRP)标记的IgM作标记物,N-四甲联苯胺(TMB)和H2O2作酶的底物.结合在石英晶体微天平上的酶标记物催化TMB氧化形成沉淀,使石英晶体微天平的振荡频率发生改变,据此测定标记物HRP-IgM和IgM的量.实验优化了分析条件下,对IgM的检测范围为0.03μg/mL to 7μg/mL,它具有仪器简单、操作方便、灵敏度高等优点. 相似文献