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The egress strategy in high‐rise buildings has traditionally been based on the sole use of stairs for evacuation. However, it is becoming more common to include evacuation elevators in the egress strategy in high‐rise buildings. Traditionally, evacuation elevators have not been allowed as an evacuation route, and people have been instructed to not use elevators in case of fire. This means that people might still not consider evacuation elevators even if they are designed to be safe in case of fire. Even if people choose evacuation elevators, they might not be willing to wait very long for an elevator to arrive. Virtual reality (VR) experiments were conducted to study exit choice and the waiting time for evacuation elevators in high‐rise buildings. The experiment was performed in a VR lab with a VR model of an existing high‐rise building. Results suggest that a simple way‐finding system using green flashing lights can influence people to more likely choose the elevator as their first evacuation choice. The results also show that the general trend is that people wait for either a limited time (<5 min) or a long time (>20 min). Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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全面介绍了沉井方案的选择、沉井的制作、施工及沉井下沉过程中的纠偏处理,为闹市区高层建筑物地下室的施工提供了成功经验。 相似文献
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To predict the time that a building will take to be evacuated in an emergency and to design lift systems capable of dealing with the demand, building designers need an understanding of the likely exiting behaviour of occupants. Because of the inherent difficulties of carrying out research in human behaviour, a number of approaches have been used in this investigation, including analysis of data from past fire events and a number of surveys. The results from this work suggest that the split of occupants using the stairs or lifts to evacuate is governed predominantly by floor level of the occupant and that it is unreasonable to expect that occupants will wait indefinitely for a lift to arrive in an emergency situation. The drop‐off in the percentage of occupants that will continue to wait for a lift with increasing waiting time is dependent on floor height. These results will allow building designers to make more realistic assumptions when designing evacuation strategies incorporating lifts. It is also hoped that a better understanding of the reservations that building users may have about using lifts for evacuation in emergency situations will allow better occupant training programmes to be developed. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
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为进一步了解窑尾塔架在罕遇地震下的工作性能,现以我公司设计的宁夏建材集团产业扶贫产能置换建设5000 t/d项目窑尾塔架进行在罕遇地震下的静力弹塑性分析,简述操作流程,对其工作性能进行分析和总结,为今后类似的结构设计提供参考. 相似文献
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以减缩活性单体2-(2-丁氧乙氧基)乙醇丙烯酸酯(MBDEGAA)、丙烯酸(AA)、2-丙烯酰胺基-2-甲基丙磺酸(AMPS)与聚乙二醇单甲醚丙烯酸酯(MPEGAA)为聚合单体,在水溶液中通过聚合反应,合成了一种高分子聚合物(HP-SRA)。采用红外光谱、核磁共振氢谱和凝胶渗透色谱对HP-SRA分子结构和相对分子质量及其分布进行了表征。并测定了掺入质量分数为0.30%(固含量)的HP-SRA混凝土的减缩性能及应用性能。结果表明,当n(MPEGAA)∶n(MBDEGAA)∶n(AA)∶n(AMPS)=1∶2.15∶2.15∶1.10时,水泥砂浆减缩率最高,水泥净浆流动度及其保持能力最佳。在不影响混凝土应用性能基础上,减缩基团的引入有利于提高混凝土的减缩性能。 相似文献
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Carine Vergne‐Vaxelaire Franck Bordier Aurlie Fossey Marielle Besnard‐Gonnet Adrien Debard Aline Mariage Virginie Pellouin Alain Perret Jean‐Louis Petit Mark Stam Marcel Salanoubat Jean Weissenbach Vronique DeBerardinis Anne Zaparucha 《Advanced Synthesis u0026amp; Catalysis》2013,355(9):1763-1779
A high‐throughput screening of candidate nitrilases against 25 structurally diverse substrates allowed us to create a wide collection of 125 experimentally validated nitrilases. The enzymes were selected by genomic approach from 700 diverse prokaryotic species and one metagenome as representative of the nitrilase family diversity. The enzymatic screening of this collection expands the biocatalytic toolbox for chemical synthesis by providing a large number of tested nitrilases with their assigned substrates. Three examples illustrate the synthetic potential of our enzyme collection. The syntheses of carboxylic acid building blocks, a β‐substituted phenylpropanoic acid, a cyclic γ‐keto carboxylic acid and a mononitrile monocarboxylic acid, were achieved from the corresponding nitrile substrates, using three new nitrilases (two from Sphingomonas wittichii and one from Syntrophobacter fumaroxidans). Improvements of nitrilase activities through the optimization of reaction parameters and the preparative biocatalytic synthesis are presented for these three examples. 相似文献
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水泥熟料生产线窑尾钢结构框架是水泥厂建设项目中标志性建筑物,施工周期长、作业高度高、交叉作业多、施工危险性大,容易发生安全事故。本文以某6000t/d新型干法生产线窑尾钢结构框架为例,探讨了窑尾钢结构框架安装防护的安全措施。通过实际施工过程中的检验,安全生产绩效显著。 相似文献
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以天然橡胶(NR)/溴化丁基橡胶(BIIR)并用胶为主体材料制备建筑隔震支座用高阻尼胶料,考察NR/BIIR并用比、炭黑品种和用量以及增粘剂种类对胶料性能的影响。结果表明:减小NR/BIIR并用比,即增大BIIR用量可以有效增大胶料的等效阻尼比,但会降低胶料的强度和形变能力;选用高比表面积的炭黑N220及增大其用量,能够有效增大胶料的等效阻尼比,但炭黑用量增大到一定程度后胶料的强度和形变能力会迅速下降;树脂类增粘剂种类对胶料性能的影响不大,但苯酚乙炔树脂会减小胶料的等效阻尼比。 相似文献
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在装配车间,不适宜使用大型摇臂钻,但小型摇臂的行程不能满足要求,因此设计了这个旋转工作台。它具有旋转灵活、简单可靠、安全系数高和制造成本低的优点。虽然是针对FA009A的塔座底盘而设计,但是可以适用于类似的一般件,也就是说,在很大程度上,它具有通用性。 相似文献
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Behnam Meschi Amoli Ehsan Marzbanrad Anming Hu Y. Norman Zhou Boxin Zhao 《大分子材料与工程》2014,299(6):739-747
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采用高水气比耐硫变换工艺对含CO体积分数高达67.8%(干基)的粗煤气进行深度变换。通过对催化剂装填量的控制和变换炉上、下段气量的分配来控制炉温,使变换气中CO体积分数<0.4%(干基),满足了日产700 t合成氨装置的工艺要求。 相似文献
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Francesco Caponio Tommaso Gomes Carmine Summo Antonella Pasqualone 《European Journal of Lipid Science and Technology》2003,105(5):201-206
An experimental investigation was carried out to evaluate the quality of virgin olive oils obtained when either a hammer‐crusher or a disk‐crusher were used for the olive paste preparation; the effect of the temperature rise caused by rapid olive crushing was also assessed. Oxidative degradation in the oils obtained from hammer‐crushed olives was significantly higher than in those obtained from disk‐crushed olives as shown by the levels of oxidised triacylglycerols and the results of the oven test. A significant inverse correlation (p <0.001) was found between the Rancimat induction time values and the amounts of oxidised triacylglycerols as determined by the high‐performance size exclusion chromatography analysis of polar compounds. These findings suggested that polar compound analyses, just as routine analyses, may be used as a suitable analytical tool to effectively evaluate the quality of virgin olive oils. 相似文献
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Dr. Jeremy Murray Dr. Anthony M. Giannetti Micah Steffek Paul Gibbons Dr. Brian R. Hearn Dr. Frederick Cohen Christine Tam Christine Pozniak Brandon Bravo Dr. Joe Lewcock Priyadarshini Jaishankar Cuong Q. Ly Xianrui Zhao Dr. Yinyan Tang Dr. Preeti Chugha Prof. Michelle R. Arkin Dr. John Flygare Prof. Adam R. Renslo 《ChemMedChem》2014,9(1):2-2
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Dr. Jeremy Murray Dr. Anthony M. Giannetti Micah Steffek Paul Gibbons Dr. Brian R. Hearn Dr. Frederick Cohen Christine Tam Christine Pozniak Brandon Bravo Dr. Joe Lewcock Priyadarshini Jaishankar Cuong Q. Ly Xianrui Zhao Dr. Yinyan Tang Dr. Preeti Chugha Prof. Michelle R. Arkin Dr. John Flygare Prof. Adam R. Renslo 《ChemMedChem》2014,9(1):73-77
Although they represent attractive therapeutic targets, caspases have so far proven recalcitrant to the development of drugs targeting the active site. Allosteric modulation of caspase activity is an alternate strategy that potentially avoids the need for anionic and electrophilic functionality present in most active‐site inhibitors. Caspase‐6 has been implicated in neurodegenerative disease, including Huntington’s and Alzheimer’s diseases. Herein we describe a fragment‐based lead discovery effort focused on caspase‐6 in its active and zymogen forms. Fragments were identified for procaspase‐6 using surface plasmon resonance methods and subsequently shown by X‐ray crystallography to bind a putative allosteric site at the dimer interface. A fragment‐merging strategy was employed to produce nanomolar‐affinity ligands that contact residues in the L2 loop at the dimer interface, significantly stabilizing procaspase‐6. Because rearrangement of the L2 loop is required for caspase‐6 activation, our results suggest a strategy for the allosteric control of caspase activation with drug‐like small molecules. 相似文献