共查询到19条相似文献,搜索用时 218 毫秒
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<正> 碱金属硼氢化物MBH_4是制备其他硼氢化合物的基本原料,将其作为推进剂燃料或添加剂的探索一直受到广泛的重视,而作为有机合成中的选择性还原剂,则更有其独特之处。它除能将醛、酮、羧酸、酮等有效地还原成醇外,其立体选择性极强。反应可在温和的条件下进行,不需要特殊的无水无氧条件。可用醇或水作为反应介质。还可用于造纸、纺织业中漂白,橡胶、塑料工业中作发泡剂,无电电镀,金属离子的化学分离,以及燃料电池系统等。一、碱金属硼氢化物的工业制备到目前为止,真正形成工业生产能力的方法只有两种。 (一)硼酸酯法此法是先制出硼酸三甲酯,然后在较低温度下,氢化钠和硼酸三甲酯反应生成Na 相似文献
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介绍了有机合成反应中NaBH4与添加剂共同作用的反应,其中包括烯烃和炔烃的还原,羧酸的还原,氨基酸及其衍生物的还原,羧酸酯的还原,酰胺的还原,腈基的还原,酰氯的还原,硝基化合物的还原,醛酮的还原等。与LiAIH4的还原相比较,其反应条件更温和,反应过程更安全、易操控、易放大。 相似文献
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工业上多采用将苯基溴代物金属化后再经过硼化和酯化反应合成苯基硼酸频哪醇酯,但该方法具有反应条件苛刻、官能团兼容性差、收率较低等缺点。研究了以苯基氯代物为原料,在Pd催化体系下,以B2(pin)2为硼试剂,在室温下合成其硼酸酯的新方法。研究表明,在0.5 mol%Xphos-Pd-G2和0.25 mol%Xphos催化体系下,以B_2(pin)_2为硼试剂、K_3PO_4·7H_2O为碱、Et OH为溶剂,在室温下反应1 h,含不同取代基的苯基硼酸频哪醇酯收率均在92%以上。该方法具有原料廉价易得、官能团兼容性好、条件温和、操作简便、反应高效、适合大量制备等优点。 相似文献
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采用两种还原体系二异丁基氢化铝(DIBAl-H)/氢化铝锂(LiAlH4)和三异丁基铝[Al(i-Bu)3]/LiAlH4,将液体端羧基氟橡胶(LTCFs)还原得到液体端羟基氟橡胶(LTHFs)。傅里叶转换红外光谱、核磁共振氢谱和核磁共振氟谱分析均表明,两种还原体系均能将LTCFs中的碳-碳双键和羧基分别还原成碳-碳单键和和羟基。进一步对比两种还原体系的还原能力发现,DIBAl-H/LiAlH4更适合还原LTCFs,且在反应温度为60 ℃、反应时间为8 h、羰基/LiAlH4/DIBAl-H物质的量比为1/1/2的最优条件下LTCFs的还原率可达到88%。与传统强还原剂LiAlH4相比,DIBAl-H/LiAlH4可降低反应温度,且减小还原剂用量。 相似文献
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New thermosetting coatings using blocked carboxyl groups 总被引:1,自引:0,他引:1
Characteristics of blocked carboxylic acid compounds obtained by blocking carboxyl groups with alkyl vinyl ethers were studied, and new thermosetting coatings using blocked carboxyl groups and epoxide were also studied. Polybasic carboxylic acids were esterified with alkyl vinyl ethers to obtain blocked carboxylic acids having the hemiacetal ester moieties. Most of blocked carboxylic acids obtained were liquids and showed an excellent solubility in organic solvents and a good compatibility with epoxy resins. Although the blocked carboxylic acids were stable under ambient conditions, they could regenerate the corresponding carboxylic acids accompanied by the elimination of alkyl vinyl ethers by the thermal dissociation. They could be used as noble thermal latent hardeners. Curing of the blocked carboxyl groups and epoxide in the presence of relatively weak Lewis acid proceeded through a sequence of three-step reactions consisting of deblocking of alkyl vinyl ethers, esterification of epoxide, and the addition of alkyl vinyl ether to 2-hydroxyalkyl ester. The main product of the curing system was 2-acetalalkyl ester, but not 2-hydroxylalkyl ester. The new one-package thermosetting coatings using blocked carboxyl groups have been evaluated for use in the practical automotive and coil coatings line production. VOCs reduction, low-toxicity, and cost saving are satisfactory for the application of the systems. And the cured films of the coatings offered advantages in the high durability, the acid resistance and the soil resistance. 相似文献
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Katsunobu Takahashl Yuji Saito Yuji Inada 《Journal of the American Oil Chemists' Society》1988,65(6):911-916
Enzymes are distinguished from other catalysts by their high substrate specificity. This is a great asset when one wants to
apply them for syntheses of various compounds. Their usage, however, generally is limited to hydrophilic reaction media, because
they usually are not soluble and active in hydrophobic media. Recently, we have been able to make various enzymes soluble
and active in highly hydrophobic organic solvents. The key to this success is the chemical modification of enzymes with an
amphipathic synthetic polymer, polyethylene glycol. The activated polymers can be attached to enzymes in aqueous buffer solutions,
and once enzymes are modified they become soluble and active in various organic solvents such as benzene, toluene and cholorinated
hydrocarbons and exhibit high enzymic activities in these organic solvents. Modified hydrolytic enzymes catalyzed the reverse
reaction of hydrolysis in organic solvents. The modified lipase catalyzed various ester synthesis reactions. Because the reactions
were conducted in the pure solvent system, it also was possible to study the kinetics and the substrate specificity for ester
synthesis reaction. It also catalyzed the polymerization of a hydroxy group containing carboxylic acid due to the bifunctional
nature. The modified lipase catalyzed ester exchange between an ester and an alcohol, between an ester and a carboxylic acid
and between two esters in organic solvents. When the two substrates for ester exchange were liquid, the reaction could take
place without organic solvents. The modified lipase catalyzed an ester exchange reaction between trilaurin and triolein when
dissolved in these substrates. Dilauroyl-monooleoylglycerol and monolauroyl-dioleoyl-glycerol were formed from these two substrates
in the presence of the modified lipase. The modified enzyme was extremely thermostable in its substrates. In the ester synthesis
and ester exchange reactions, a trace amount of water was necessary for expression of the enzymic activity. It is suggested
that the amphipathic polymer molecules retained water in close proximity to the enzyme.
Presented at the symposium “The Biology, Biochemistry and Technology of Lipase” at the 78th annual meeting of the American
Oil Chemists’ Society held May 17–21, 1987, in New Orleans, Louisiana. 相似文献
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Polynorbornene (PNB) having methyl ester in side chain was partially hydrolyzed under alkaline condition in mixed organic solvents containing tetramethylammonium hydroxide as a base. Through hydrolysis of methyl ester group in PNB under basic condition, PNB having carboxylic acid can be obtained and degree of hydrolysis (DH) were evaluated by 1H NMR measurement from 0.1 to 0.8, depending upon reaction conditions such as reaction time, solvent, and amount of base. The resulting hydrolyzed PNB were characterized by differential scanning calorimetry, Fourier transform infrared spectroscopy, and size exclusion chromatography. No remarkable decreasing of molecular weight was observed and chain scission does not occur during the hydrolysis of PNB in the reaction condition examined here. The glass transition temperature of hydrolyzed PNB increased with increase in DH which can be attributed to the existence of intermacromolecular association of carboxylic acid in hydrolyzed PNB. Esterification of PNB having carboxylic acid was also carried out by using alkyl halide and DBU. 相似文献
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氟代苯甲醛是制造医药、农药、香料、染料等多种精细化工产品的中间体。综述了氟代苯甲醛化学合成方法的研究进展,包括氟代甲苯氧化法、氟代甲苯的氯化水解法、氟代苯甲醇氧化法、酯或羧酸还原法、氟苯的醛基化法、氟化法等。通过对各方法优缺点的探讨,对其工业应用前景进行了展望。 相似文献
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Tomoya Inoue Yuta Nemoto Takako Nagase Yasuhisa Hasegawa Yoshimichi Kiyozumi Koichi Sato Masateru Nishioka Satoshi Hamakawa Toshikazu Nishide Fujio Mizukami 《Korean Journal of Chemical Engineering》2008,25(3):437-442
We successfully developed zeolite membranes with hydrophilic character, by choosing appropriate zeolites in terms of hydrophilicity
and high acid tolerance. We evaluated thus developed membranes by their pervaporation (PV) performance, dehydration from acidic
organic solvent. The zeolite membranes we developed, based on merlinoite (MER), chabazite (CHA) or phillipsite (PHI), are
shown to exhibit stable dehydration performance, respectively. We successfully applied the membranes to the selective removal
of water in an ester condensation reaction starting from a stoichiometric mixture of a carboxylic acid and an alcohol. The
availability of pervaporation-assisted ester condensation reaction was validated by various kinds of combinations of carboxylic
acid and alcohols, which implies the general availability of pervaporation-assisted process intensification by zeolite membranes.
This paper was presented at the 11th Korea-Japan Symposium on Catatysis held at Seoul, Korea, May 21–24, 2007. 相似文献