共查询到20条相似文献,搜索用时 15 毫秒
1.
Faranak Mavandadnejad Mohammad Hossein Yazdi Seyed Mehdi Hassanzadeh Mehdi Mahdavi Mohammad Ali Faramarzi Hamidreza PazokiToroudi Ahmad Reza Shahverdi 《IET nanobiotechnology / IET》2018,12(1):57
Conventional hepatitis B vaccine contains alum but is less effective to induce Th1 response. Selenium nanoparticles and Bacillus Calmette–Guerin were reported as immune modulators. In this study, SeNPs were extracted from Mycobacterium bovis and characterised. SeNPs were mixed with HBs‐Ag and administered to the mice to investigate he immune response pattern. With an addition of Se ions at a sub‐inhibitory concentration to the Sauton medium broth after 24 h, SeNPs were extracted from M. bovis and characterised by Fourier transform infrared spectroscopy, dynamic light scattering, atomic forcemicroscopy, energy dispersive X‐ray spectrum, transmission electron microscopy, and thermogravimetric analysis. Furthermore, female inbred BALB/c mice were injected subcutaneously on the first, 14th, 28th day with 100 and 200 µg doses of that SeNPs supplemented with HBs‐Ag vaccine. Later, the total antibody, isotypes of Immunoglobulin G1, Interlukin 4, and interferon‐γ were measured by enzye‐linked immunosorbent assay. The size of the SeNPs was <150 nm. Level of total antibody and immunoglobulin G2a increased significantly in the group that received 200 µg/ml nano selenium extracted from M. bovis. SeNPs in dose of 200 µg coated with organic materials of M. bovis could induce an influential immune response in relation to the conventional HBs‐Ag vaccine.Inspec keywords: selenium, nanoparticles, nanofabrication, microorganisms, Fourier transform spectra, infrared spectra, light scattering, atomic force microscopy, X‐ray chemical analysis, transmission electron microscopy, thermal analysis, nanomedicineOther keywords: biosynthesis, selenium nanoparticles, Mycobacterium bovis, enhnced immune response, HBs antigens, Bacillus Calmette‐Guerin, immune modulators, biogenic SeNPs, immune response pattern, Sauton medium broth, Fourier transform infrared spectroscopy, dynamic light scattering, atomic force microscopy, energy dispersive X‐ray spectrum, transmission electron microscopy, thermogravimetric analysis, female inbred BALB/c mice, antibody, IgG1 isotype, IgG2a isotype, IL4 isotype, interferon‐γ, enzyme‐linked immunosorbent assay, bacterium, time 24 h, time 14 day, time 28 day, Se 相似文献
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Thomas Gheno Xuan L Liu Greta Lindwall Zi-Kui Liu Brian Gleeson 《Science and Technology of Advanced Materials》2015,16(5)
A thermodynamic database for the Al–Co–Cr–Ni system is built via the Calphad method by extrapolating re-assessed ternary subsystems. A minimum number of quaternary parameters are included, which are optimized using experimental phase equilibrium data obtained by electron probe micro-analysis and x-ray diffraction analysis of NiCoCrAlY alloys spanning a wide compositional range, after annealing at 900 °C, 1100 °C and 1200 °C, and water quenching. These temperatures are relevant to oxidation and corrosion resistant MCrAlY coatings, where M corresponds to some combination of nickel and cobalt. Comparisons of calculated and measured phase compositions show excellent agreement for the β–γ equilibrium, and good agreement for three-phase β–γ–σ and β–γ–α equilibria. An extensive comparison with existing Ni-base databases (TCNI6, TTNI8, NIST) is presented in terms of phase compositions. 相似文献
4.
Takahisa Omata Hiraku Nagatani Issei Suzuki Masao Kita 《Science and Technology of Advanced Materials》2015,16(2)
Ternary zincblende-derived I–III–VI2 chalcogenide and II–IV–V2 pnictide semiconductors have been widely studied and some have been put to practical use. In contrast to the extensive research on these semiconductors, previous studies into ternary I–III–O2 oxide semiconductors with a wurtzite-derived β-NaFeO2 structure are limited. Wurtzite-derived β-LiGaO2 and β-AgGaO2 form alloys with ZnO and the band gap of ZnO can be controlled to include the visible and ultraviolet regions. β-CuGaO2, which has a direct band gap of 1.47 eV, has been proposed for use as a light absorber in thin film solar cells. These ternary oxides may thus allow new applications for oxide semiconductors. However, information about wurtzite-derived ternary I–III–O2 semiconductors is still limited. In this paper we review previous studies on β-LiGaO2, β-AgGaO2 and β-CuGaO2 to determine guiding principles for the development of wurtzite-derived I–III–O2 semiconductors. 相似文献
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An environmentally friendly and rapid procedure was developed to synthesise silver nanoparticles (Ag‐NPs) by Chamaemelum nobile extract and to evaluate its in vivo anti‐inflammatory and antioxidant activities. The ultraviolet–visible absorption spectrum of the synthesised Ag‐NPs showed an absorbance peak at 422. The average size of spherical nanoparticles was 24 nm as revealed by transmission electron microscopy. Fourier transform infra‐red spectroscopy analysis supported the presence of biological active compounds involved in the reduction of Ag ion and X‐ray diffraction confirmed the crystalline structure of the metallic Ag. The anti‐inflammatory and antioxidant activity of the Ag‐NPs was investigated against carrageenan‐induced paw oedema in mice. The levels of malondialdehyde (MDA) and antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase and inflammatory cytokines tumour necrosis factor (TNF‐α), interferon gamma and interleukin (IL)‐6, IL‐1β were assessed in this respect. The results demonstrated that anti‐inflammatory activity of the Ag‐NPs might be due to the ability of the nanoparticles to reduce IL‐1β, IL‐6 and TNF‐α. Moreover, reduction of antioxidant enzymes along with an increase in MDA level shows that the anti‐inflammatory activity of the synthesised Ag‐NPs by C. nobile is attributed to its ameliorating effect on the oxidative damage.Inspec keywords: silver, nanoparticles, nanofabrication, ultraviolet spectra, visible spectra, particle size, transmission electron microscopy, Fourier transform infrared spectra, X‐ray diffraction, crystal structure, enzymes, molecular biophysics, tumours, biomedical materials, nanomedicineOther keywords: Chamaemelum nobile extract, oxidative stress, mice paw, silver nanoparticles, antiinflammatory activity, antioxidant activity, ultraviolet‐visible absorption spectrum, spherical nanoparticle size, transmission electron microscopy, Fourier transform infrared spectroscopy, biological active compounds, X‐ray diffraction, crystalline structure, carrageenan‐induced paw oedema, malondialdehyde, antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase, inflammatory cytokines, tumour necrosis factor, interferon gamma, interleukin, IL‐1β, IL‐6, TNF‐α, MDA level, Ag 相似文献
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K Zin Htut Angela M. Alicea-Serrano Saranshu Singla Ingi Agnarsson Jessica E. Garb Matja Kuntner Matja Gregori
Robert A. Haney Mohammad Marhabaie Todd A. Blackledge Ali Dhinojwala 《Journal of the Royal Society Interface》2021,18(179)
The spider major ampullate (MA) silk exhibits high tensile strength and extensibility and is typically a blend of MaSp1 and MaSp2 proteins with the latter comprising glycine–proline–glycine–glycine-X repeating motifs that promote extensibility and supercontraction. The MA silk from Darwin''s bark spider (Caerostris darwini) is estimated to be two to three times tougher than the MA silk from other spider species. Previous research suggests that a unique MaSp4 protein incorporates proline into a novel glycine–proline–glycine–proline motif and may explain C. darwini MA silk''s extraordinary toughness. However, no direct correlation has been made between the silk''s molecular structure and its mechanical properties for C. darwini. Here, we correlate the relative protein secondary structure composition of MA silk from C. darwini and four other spider species with mechanical properties before and after supercontraction to understand the effect of the additional MaSp4 protein. Our results demonstrate that C. darwini MA silk possesses a unique protein composition with a lower ratio of helices (31%) and β-sheets (20%) than other species. Before supercontraction, toughness, modulus and tensile strength correlate with percentages of β-sheets, unordered or random coiled regions and β-turns. However, after supercontraction, only modulus and strain at break correlate with percentages of β-sheets and β-turns. Our study highlights that additional information including crystal size and crystal and chain orientation is necessary to build a complete structure–property correlation model. 相似文献
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Noriaki Hirota Fuxing Yin Tsukasa Azuma Tadanobu Inoue 《Science and Technology of Advanced Materials》2010,11(2)
In this study, the 0.2% yield stress of duplex stainless steel was evaluated using a compound Hall–Petch equation. The compound Hall–Petch equation was derived from four types of duplex stainless steel, which contained 0.2–64.4 wt% δ-ferrite phase, had different chemical compositions and were annealed at different temperatures. Intragranular yield stress was measured with an ultra-microhardness tester and evaluated with the yield stress model proposed by Dao et al. Grain size, volume fraction and texture were monitored by electron backscattering diffraction measurement. The kγ constant in the compound equation for duplex stainless steel agrees well with that for γ-phase SUS316L steel in the temperature range of 1323–1473 K. The derived compound Hall–Petch equation predicts that the yield stress will be in good agreement with the experimental results for the Cr, Mn, Si, Ni and N solid-solution states. We find that the intragranular yield stress of the δ-phase of duplex stainless steel is rather sensitive to the chemical composition and annealing conditions, which is attributed to the size misfit parameter. 相似文献
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Marcela A. Moretton Diego A. Chiappetta Alejandro Sosnik 《Journal of the Royal Society Interface》2012,9(68):487-502
Rifampicin-loaded poly(ε-caprolactone)–b-poly(ethylene glycol)–poly(ε-caprolactone) flower-like polymeric micelles display low aqueous physical stability over time and undergo substantial secondary aggregation. To improve their physical stability, the lyoprotection–lyophilization process was thoroughly characterized. The preliminary cryoprotectant performance of mono- and disaccharides (e.g. maltose, glucose), hydroxypropyl-β-cyclodextrin (HPβCD) and poly(ethylene glycol) (PEG) of different molecular weights was assessed in freeze–thawing assays at −20°C, −80°C and −196°C. The size and size distribution of the micelles at the different stages were measured by dynamic light scattering (DLS). A cryoprotectant factor (fc) was determined by taking the ratio between the size immediately after the addition of the cryoprotectant and the size after the preliminary freeze–thawing assay. The benefit of a synergistic cryoprotection by means of saccharide/PEG mixtures was also assessed. Glucose (1 : 20), maltose (1 : 20), HPβCD (1 : 5) and glucose or maltose mixtures with PEG3350 (1 : 20) (copolymer:cryoprotectant weight ratio) were the most effective systems to protect 1 per cent micellar systems. Conversely, only HPβCD (1 : 5) cryoprotected more concentrated drug-loaded micelles (4% and 6%). Then, those micelle/cryoprotectant systems that displayed fc values smaller than 2 were freeze-dried. The morphology of freeze-dried powders was characterized by scanning electron microscopy and atomic force microscopy and the residual water content analysed by the Karl Fisher method. The HPβCD-added lyophilisates were brittle porous cakes (residual water was between 0.8% and 3%), easily redispersable in water to form transparent systems with a minimal increase in the micellar size, as determined by DLS. 相似文献
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M. Kurylowicz H. Paulin J. Mogyoros M. Giuliani J. R. Dutcher 《Journal of the Royal Society Interface》2014,11(94)
The influence of surface topography on protein conformation and association is used routinely in biological cells to orchestrate and coordinate biomolecular events. In the laboratory, controlling the surface curvature at the nanoscale offers new possibilities for manipulating protein–protein interactions and protein function at surfaces. We have studied the effect of surface curvature on the association of two proteins, α-lactalbumin (α-LA) and β-lactoglobulin (β-LG), which perform their function at the oil–water interface in milk emulsions. To control the surface curvature at the nanoscale, we have used a combination of polystyrene (PS) nanoparticles (NPs) and ultrathin PS films to fabricate chemically pure, hydrophobic surfaces that are highly curved and are stable in aqueous buffer. We have used single-molecule force spectroscopy to measure the contour lengths Lc for α-LA and β-LG adsorbed on highly curved PS surfaces (NP diameters of 27 and 50 nm, capped with a 10 nm thick PS film), and we have compared these values in situ with those measured for the same proteins adsorbed onto flat PS surfaces in the same samples. The Lc distributions for β-LG adsorbed onto a flat PS surface contain monomer and dimer peaks at 60 and 120 nm, respectively, while α-LA contains a large monomer peak near 50 nm and a dimer peak at 100 nm, with a tail extending out to 200 nm, corresponding to higher order oligomers, e.g. trimers and tetramers. When β-LG or α-LA is adsorbed onto the most highly curved surfaces, both monomer peaks are shifted to much smaller values of Lc. Furthermore, for β-LG, the dimer peak is strongly suppressed on the highly curved surface, whereas for α-LA the trimer and tetramer tail is suppressed with no significant change in the dimer peak. For both proteins, the number of higher order oligomers is significantly reduced as the curvature of the underlying surface is increased. These results suggest that the surface curvature provides a new method of manipulating protein–protein interactions and controlling the association of adsorbed proteins, with applications to the development of novel biosensors. 相似文献
10.
Microcrystals of α-tetragonal (α-t) boron with unit cell parameters a=9.05077(6) and c=5.13409(6) Å and measured density 2.16–2.22 g cm−3 were obtained by pyrolysis of decaborane B10H14 at pressures of 8–9 GPa and temperatures of 1100–1600 ○C. The crystal structure is in good agreement with the model proposed by Hoard et al (1958 J. Am. Chem. Soc.
80 4507). However, compared to the original model, we found small deformations of icosahedra and changes in the interatomic distances within the unit cell of the synthesized α-t boron. 相似文献
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Juliane Teichmann Mirko Nitschke Dagmar Pette Monika Valtink Stefan Gramm Frauke V H?rtel Thomas Noll Richard H W Funk Katrin Engelmann Carsten Werner 《Science and Technology of Advanced Materials》2015,16(4)
Two established material systems for thermally stimulated detachment of adherent cells were combined in a cross-linked polymer blend to merge favorable properties. Through this approach poly(N-isopropylacrylamide) (PNiPAAm) with its superior switching characteristic was paired with a poly(vinyl methyl ether)-based composition that allows adjusting physico-chemical and biomolecular properties in a wide range. Beyond pure PNiPAAm, the proposed thermo-responsive coating provides thickness, stiffness and swelling behavior, as well as an apposite density of reactive sites for biomolecular functionalization, as effective tuning parameters to meet specific requirements of a particular cell type regarding initial adhesion and ease of detachment. To illustrate the strength of this approach, the novel cell culture carrier was applied to generate transplantable sheets of human corneal endothelial cells (HCEC). Sheets were grown, detached, and transferred onto planar targets. Cell morphology, viability and functionality were analyzed by immunocytochemistry and determination of transepithelial electrical resistance (TEER) before and after sheet detachment and transfer. HCEC layers showed regular morphology with appropriate TEER. Cells were positive for function-associated marker proteins ZO-1, Na+/K+-ATPase, and paxillin, and extracellular matrix proteins fibronectin, laminin and collagen type IV before and after transfer. Sheet detachment and transfer did not impair cell viability. Subsequently, a potential application in ophthalmology was demonstrated by transplantation onto de-endothelialized porcine corneas in vitro. The novel thermo-responsive cell culture carrier facilitates the generation and transfer of functional HCEC sheets. This paves the way to generate tissue engineered human corneal endothelium as an alternative transplant source for endothelial keratoplasty. 相似文献
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Sathyanarayanan Ravi Sathish Kumar Kokati Venkata Bhaskara Rao 《IET nanobiotechnology / IET》2016,10(5):308
The present study focuses on the biosynthesis of gold nanoparticles (AuNPs) using Streptomyces coelicoflavus (S. coelicoflavus) SRBVIT13 isolated from marine salt pan soils collected from Ongole, Andhra Pradesh, India. The biosynthesised AuNPs are characterised by UV–visible spectroscopy, X‐ray diffraction, Fourier transform infrared spectroscopy, high‐resolution transmission electron microscopy and energy‐dispersive X‐ray analysis. Transmission electron microscopy study suggests that the biosynthesised AuNPs are spherical in shape within a size range of 12–20 nm (mean diameter as 14 nm). The anti‐type II diabetes activity of AuNPs is carried out by testing it in vitro α ‐glucosidase and α ‐amylase enzyme inhibition activity and in vivo postprandial anti‐hyperglycemic activity in sucrose and glucose‐loaded streptozotocin induced diabetic albino Wister rats. AuNPs has shown a significant inhibitory activity of 84.70 and 87.82% with IC50 values of 67.65 and 65.59 μg/mL to α ‐glucosidase and α ‐amylase enzymes, while the diabetic rats have shown significant reduction in the post postprandial blood glucose level by 57.80 and 88.09%, respectively compared with control group after AuNPs treatment at the concentration of 300 and 600 mg/kg body weight. Hence, this biosynthesised AuNPs might be useful in combating type II diabetes mellitus for the betterment of human life.Inspec keywords: gold, nanoparticles, ultraviolet spectra, visible spectra, X‐ray diffraction, Fourier transform infrared spectra, transmission electron microscopy, X‐ray chemical analysis, diseases, enzymes, nanomedicine, biochemistry, spectrochemical analysisOther keywords: gold nanoparticles, Streptomyces coelicoflavus SRBVIT13, biosynthesis, UV–visible spectroscopy, X‐ray diffraction, Fourier transform infrared spectroscopy, high‐resolution transmission electron microscopy, energy‐dispersive X‐ray analysis, antitype II diabetes activity, in vitro enzyme inhibition activity, in vivo postprandial antihyperglycemic activity, streptozotocin induced diabetic albino Wister rats, type II diabetes mellitus, Au 相似文献
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Yong-Qing Cao Xin Lin Zhi-Tai Wang Li-Lin Wang Meng-Hua Song Hai-Ou Yang Wei-Dong Huang 《Science and Technology of Advanced Materials》2015,16(6)
Laser remelting has been performed on Ni-30 wt.% Sn hypoeutectic alloy. An anomalous eutectic formed at the bottom of the molten pool when the sample was remelted thoroughly. 3D morphologies of the α-Ni and Ni3Sn phases in the anomalous eutectic region were obtained and investigated using serial sectioning reconstruction technology. It is found that the Ni3Sn phase has a continuous interconnected network structure and the α-Ni phase is distributed as separate particles in the anomalous eutectic, which is consistent with the electron backscatter diffraction pattern examinations. The α-Ni particles in the anomalous eutectic are supersaturated with Sn element as compared with the equilibrium phase diagram. Meanwhile, small wavy lamella eutectics coexist with anomalous eutectics. The Trivedi–Magnin–Kurz model was used to estimate undercooling with lamellar spacing. The results suggest that the critical undercooling found in undercooling solidification is not a sufficient condition for anomalous eutectic formation. Besides, α-Ni particles in the anomalous eutectic do not exhibit a completely random misorientation and some neighboring α-Ni particles have the same orientation. It is shown that both the coupled and decoupled growth of the eutectic two phases can generate the α-Ni + Ni3Sn anomalous eutectic structure. 相似文献
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Rémi Longtin Juan Ramon Sanchez-Valencia Ivan Shorubalko Roman Furrer Erwin Hack Hansrudolf Elsener Oliver Gr?ning Paul Greenwood Nalin Rupesinghe Kenneth Teo Christian Leinenbach Pierangelo Gr?ning 《Science and Technology of Advanced Materials》2015,16(1)
The joining of macroscopic films of vertically aligned multiwalled carbon nanotubes (CNTs) to titanium substrates is demonstrated by active vacuum brazing at 820 °C with a Ag–Cu–Ti alloy and at 880 °C with a Cu–Sn–Ti–Zr alloy. The brazing methodology was elaborated in order to enable the production of highly electrically and thermally conductive CNT/metal substrate contacts. The interfacial electrical resistances of the joints were measured to be as low as 0.35 Ω. The improved interfacial transport properties in the brazed films lead to superior electron field-emission properties when compared to the as-grown films. An emission current of 150 μA was drawn from the brazed nanotubes at an applied electric field of 0.6 V μm−1. The improvement in electron field-emission is mainly attributed to the reduction of the contact resistance between the nanotubes and the substrate. The joints have high re-melting temperatures up to the solidus temperatures of the alloys; far greater than what is achievable with standard solders, thus expanding the application potential of CNT films to high-current and high-power applications where substantial frictional or resistive heating is expected. 相似文献
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Riku Fagerlund Marcelo Behar Karen T. Fortmann Y. Eason Lin Jesse D. Vargas Alexander Hoffmann 《Journal of the Royal Society Interface》2015,12(110)
The magnitude, duration and oscillation of cellular signalling pathway responses are often limited by negative feedback loops, defined as an ‘activator-induced inhibitor’ regulatory motif. Within the NFκB signalling pathway, a key negative feedback regulator is IκBα. We show here that, contrary to current understanding, NFκB-inducible expression is not sufficient for providing effective negative feedback. We then employ computational simulations of NFκB signalling to identify IκBα molecular properties that are critical for proper negative feedback control and test the resulting predictions in biochemical and single-cell live-imaging studies. We identified nuclear import and nuclear export of IκBα and the IκBα–NFκB complex, as well as the free IκBα half-life, as key determinants of post-induction repression of NFκB and the potential for subsequent reactivation. Our work emphasizes that negative feedback is an emergent systems property determined by multiple molecular and biophysical properties in addition to the required ‘activator-induced inhibitor’ relationship. 相似文献
17.
Nanjundaswamy Marishetty Hemmaragala Heidi Abrahamse Blassan P. George 《IET nanobiotechnology / IET》2017,11(4):377
In the previous report, the authors showed the gold nanoparticle (GNP) functionalised multiple N ‐methylated fragments of the residue (32–37) of beta (β)‐amyloid protein (1–42), CGGIGLMVG and CGGGGGIGLMVG toward disruption of β ‐amyloid (1–42), the predominant component of senile plaques. Herein the in vitro antimicrobial activities of both normal and multiple N ‐methylated sequences of CGGIGLMVG and CGGGGGIGLMVG were screened and it was found that all the eight sequences including four (non‐functionalised with GNP) to possess activity against both Gram‐positive [Staphylococcus aureus (ATCC 43300) and Enterococcus faecalis (ATCC 5129)] and Gram‐negative [Escherichia coli (ATCC 35218), Pseudomonas aeruginosa (ATCC 27853) and Klebsiella pneumoniae (ATCC 700603)] bacteria. Among them, N ‐methylated sequences CGGIGLMVG and CGGGGGIGLMVG shown remarkable activity against Gram‐positive bacteria.Inspec keywords: microorganisms, gold, nanoparticles, nanomedicineOther keywords: GNP functionalisation, N‐methylation, β‐amyloid residue, Gram‐positive bacterium, gold nanoparticle functionalised multiple N‐methylated fragments, beta β‐amyloid protein, CGGGGGIGLMVG, Staphylococcus aureus, ATCC 43300, Enterococcus faecalis, ATCC 5129, Escherichia coli, ATCC 35218, Pseudomonas aeruginosa, ATCC 27853, Klebsiella pneumoniae, ATCC 700603, Au 相似文献
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Yegireddy Muralidhar Mekapogu Alpha Raj Tollamadugu NagaVenkata KrishanVara Prasad Thota Venkata Chaitanya Kumar Kaliki Adilaxmamma Chinthamaneni Srilatha G. Sreeenivasa Rao Pothireddy Sreevani Nagireddy Aparna 《IET nanobiotechnology / IET》2017,11(6):682
Mastitis is an important economic disease causing production losses in dairy industry. Antibiotics are becoming ineffective in controlling mastitis due to the emergence of resistant strains requiring the development of novel therapeutic agents. In this study, the authors present the phytochemical synthesis of silver nanoparticles (AgNPs) with acetyl‐11‐α‐keto‐β‐boswellic acid and evaluation of their activity in Staphylococcus aureus induced murine mastitis. Boswellic acid mediated AgNP (BANS) were oval, polydispersed (99.8 nm) with an minimum inhibitory concentration of 0.033 µg ml−1 against S. aureus, inhibitory concentration (IC50) of 30.04 µg ml−1 on mouse splenocytes and safe at an in vivo acute oral dose of 3.5 mg kg−1 in mice. Mastitis was induced in lactating mice by inoculating S. aureus (log10 5.60 cfu) and treated 6 h post‐inoculation with BANS (0.12 mg kg−1, intramammary and intraperitoneal), and cefepime (1 mg kg−1, intraperitoneal). S. aureus inoculated mice showed increased bacterial load, neutrophil infiltration in mammary glands and elevated C‐reactive protein (CRP) in serum. Oxidative stress was also observed with elevated malondialdehyde level, superoxide dismutase (SOD) and catalase (CAT) activities. BANS treatment significantly (P < 0.05) reduced bacterial load, CRP, SOD, CAT activities and neutrophil infiltration in affected mammary glands. BANS could be a potential therapeutic agent for managing bovine mastitis.Inspec keywords: nanomedicine, nanoparticles, silver, antibacterial activity, drugs, diseases, enzymesOther keywords: antibacterial effects, antiinflammatory effects, antioxidant effects, acetyl‐11‐α‐keto‐β‐boswellic acid, mediated silver nanoparticles, experimental murine mastitis, economic disease, dairy industry, resistant strains, phytochemical synthesis, Staphylococcus aureus, minimum inhibitory concentration, inoculating S. aureus, neutrophil infiltration, mammary glands, elevated C‐reactive protein, superoxide dismutase, catalase, bovine mastitis, Ag 相似文献
20.
James B. Mehl 《Journal of research of the National Institute of Standards and Technology》2007,112(3):163-173
The boundary-shape formalism of Morse and Ingard is applied to the acoustic modes of a deformed spherical resonator (quasisphere) with rigid boundaries. For boundary shapes described by r = a [1 − ε ℱ(θ, ϕ)], where ε is a small scale parameter and ℱ is a function of order unity, the frequency perturbation is calculated to order ε2. The formal results apply to acoustic modes whose angular dependence is designated by the indices ℓ and m. Specific examples are worked out for the radial (ℓ = 0) and triplet (ℓ = 1) modes, for prolate and oblate spheroids, and for triaxial ellipsoids. The exact eigenvalues for the spheroids, and eigenvalue determined with finite-element calculations, are shown to agree with perturbation theory through terms of order ε2. This work is an extension of the author’s previous papers on the acoustic eigenfrequencies of deformed spherical resonators, which were limited to the second-order perturbation for radial modes [J. Acoust. Soc. Am. 71, 1109-1113 (1982)] and the first order-perturbation for arbitrary modes [J. Acoust. Soc. Am. 79, 278–285 (1986)]. 相似文献