Postmenopausal bleeding (author's transl)

In the study reported here, 554 cases of postmenopausal bleeding were analyzed, i.e. 4.1% of the gynecological cases admitted during the 11 years from 1961 to 1971. In over one-third of these cases (35.3%) bleeding was caused by genital carcinoma. Among nonmalignant causes, endometrial atrophy was the most common (28.5%) followed by uterine polyposis (21.2%). As expected, corpus carcinoma (51%) was the most commonly found malignant genital disease, followed by cervical cancer (38%) which, surprisingly, is almost as common. The time-lapse between onset of bleeding and hospitalization with diagnosis is alarmingly long. In our patients it averages 19.2 weeks, is 36.3 weeks in corpus carcinoma cases and 16.3 weeks in women with cervical cancer.     

Urodynamic assessment of women with urethral syndrome (author's transl)

Thirty women presenting with urethral syndrome were investigated. A full urologic, radiologic, gynecologic and urodynamic assessment was carried out. In most patients the cause of their troubles was found. In 19 of them an obstruction was demonstrated. Two types of obstruction were seen: The first occurred mainly in postmenopausal women. Here, a narrow distal segment of the urethra was demonstrated. The second type of obstruction was seen mainly in younger patients. The cause was an incomplete relaxation or a spasm of the external striated sphincter. Other causes of symptoms were instability and atony of the detrusor. In some women no cause for their symptoms and recurrent urinary infection was found.     

Dumping-prophylaxis (author's transl)

The dumping syndrome is due to a vigorous reflex distension of the jejunum, caused by the stomach violently evacuating its contents. The aim of treatment is to overcome the drastic evacuation by restoring the rhythmic peristalsis of the stomach (eukinetics). This can be achieved by a special diet. Every meal should begin with well chewed solids (pulp) and avoid all fluids. With a well organised medical staff a complete success can be achieved. Surgical measures in Dumping can be avoided.     

Severe intoxication with leponex (author's transl)

The clinical picture and the therapeutic management of a severe case of self-poisoning with Leponex (clozapin) are presented. In particular, the grave complications, their possible aetiology and the value of the administration of cortisone are discussed. Forced diuresis or haemodialysis are ineffective measures on account of the low serum concentrations of Leponex.     

Experiences with cephradine (Sefril) in septical-surgery (author's transl)

100 patients with septic-surgical diseases were treated with the cephalosporine-derivate Cephradine (Sefril). 79 patients were treated by surgical intervention in advance of the antibiotic therapy, 21 by Sefril in combination with conservative therapy only. The continuance of medication amounted to two weeks in 94%. A complete healing of the pyogenic infection was obtained in 86 patients. Complications occured in 6%.     

Arabinosyladenine in ophthalmology (author's transl)

Arabinosyladenine (Ara-A) is an antiviral compound employed for ophthalmological lesions in the form of a 3 p. cent ointment. This purine nucleoside has been shown to possess antiviral activity against several ADN viruses, including herpes simplex virus, but it is ineffective against ARN viruses. Its action in superficial herpetic keratitis is comparable with that of idoxuridine, tolerance to the two compounds being almost identical. Ara-A is of value for treating superficial keratitis lesions not responding to idoxuridine. The weak intra-ocular penetration of Ara-A explains its lack of efficacy in stromal keratitis and herpetic kerato-uveitis, forms in which certain analogues of Ara-A could be beneficial.