Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species

The interaction of a living organism with external foreign agents is a central issue for its survival and adaptation to the environment. Nanosafety should be considered within this perspective, and it should be examined that how different organisms interact with engineered nanomaterials (NM) by either mounting a defensive response or by physiologically adapting to them. Herein, the interaction of NM with one of the major biological systems deputed to recognition of and response to foreign challenges, i.e., the immune system, is specifically addressed. The main focus is innate immunity, the only type of immunity in plants, invertebrates, and lower vertebrates, and that coexists with adaptive immunity in higher vertebrates. Because of their presence in the majority of eukaryotic living organisms, innate immune responses can be viewed in a comparative context. In the majority of cases, the interaction of NM with living organisms results in innate immune reactions that eliminate the possible danger with mechanisms that do not lead to damage. While in some cases such interaction may lead to pathological consequences, in some other cases beneficial effects can be identified.     

Effects of viscoelastic properties of engine cover sealing system on noise and vibration attenuation

Automobile engine cam cover seals are made of elastomeric materials and used to seal the interfaces between cover and underlying structures. The design of engine cam cover seals has been traditionally focused on the sealability aspects. Recently, there has been additional demand that these seals be designed as vibration isolators to attenuate the radiated noise from the engine. To accomplish this goal, the frequency-dependent viscoelastic properties of the sealing components will have to be considered during the design process. This article examines the frequency-dependent viscoelastic properties of some commonly used elastomeric seals at various mounting configurations. An analytical spatial transmissibility method is used for evaluating the design of elastomeric sealing system for reducing vibration and radiated noise.     

发动机悬置研究综述

介绍了发动机悬置的研究现状，传统的被动式橡胶悬置和液压悬置不能满足轿车多工况减振、降噪要求，主动悬置由于其优良的减振、降噪性能必将成为新一代悬置的发展方向。     

A large area solid state detector made of ultra high purity p-type Si

A Surface Barrier Detector for environmental monitoring was fabricated with an ultrahigh purity p-type Si crystal. The crystal had a nominal resistivity of 50 kΩ cm, and Al was evaporated on the outer surface to form a positive electrode of 50 mm ø. The excellent light-tightness and adhesivity of the Al layer enables direct mounting of samples on the detector and decontamination of the surface with wetted soft tissues.The energy resolution for α and β particles is 36 and 33 keV fwhm respectively and simultaneous measurement of both α and β particles can be carried out. The detector fabrication procedure, its characteristics and application are reported in this paper.     

Cover Picture: Fabrication of Elastomeric Wires by Selective Electroless Metallization of Poly(dimethylsiloxane) (Adv. Mater. 1/2008)

Tricia Carmichael and co‐workers employ a simple, low‐cost method for the fabrication of patterned metal films on elastomeric poly(dimethylsiloxane) (PDMS) substrates, as described on p. 59. The metal/PDMS composites are electrically conductive and mechanically flexible, making them suitable for use in the fabrication of lightweight, flexible devices such as wearable electronics, biocompatible sensors, and artificial nerves, skins, and muscles. Copper wires on PDMS remain conductive when subjected to linear strains of up to 52 %. The utility of these wires is demonstrated by using them as laminated top contacts in an organic light‐emitting device.     

Electron microscopy characterization of an as-fabricated research reactor fuel plate comprised of U–7Mo particles dispersed in an Al–2Si alloy matrix

To understand the microstructural development of nuclear fuel plates during irradiation, it is imperative to know the microstructure of a fuel plate after all the fabrication steps have been completed and before it is inserted into the reactor. To this end, a U–7 wt.% Mo alloy research reactor dispersion fuel plate with Al–2 wt.% Si matrix was destructively examined using scanning and transmission electron microscopy to characterize the developed microstructure after fabrication. Of particular interest for this study was how the Si that was added to the fuel matrix partitioned between the various fuel plate phases during fabrication. Si was added to the matrix so that the microstructure that developed during fuel fabrication would exhibit good irradiation behavior. SEM analysis was used to identify the representative microstructure, the compositions of the various phases, and the partitioning behavior of the fuel and matrix constituents. TEM analysis was employed to definitively identify the phases in the U–7Mo alloy and the phases that formed due to diffusional interactions between the fuel particles and matrix during fuel plate fabrication. The TEM results are the first reported for an as-fabricated U–7 wt.% Mo dispersion fuel plate with an Al alloy matrix. SEM results showed that a significant portion of the original γ-(U–Mo) fuel particles had transformed to a lamellar microstructure, comprised of α-U and either γ or γ' phases, and the fuel/matrix interaction layers were enriched in Si. TEM analysis identified an ordered fcc (U–Mo)(Al–Si)₃ type of phase, which formed at the decomposed U–7Mo/matrix interface and extended into the lamellar microstructure. Some regions of the U–7Mo particles retained the single-phase γ-(U–Mo). Small precipitate phases were observed in the fuel meat matrix that contained Fe, Al, and Si. The Si that is added to the matrix of a U–Mo dispersion fuel plate to improve irradiation performance appears to result in the creation of a Si-rich (U–Mo)(Al–Si)₃ type of fuel/matrix interaction layer during fabrication that appears to exhibit favorable behavior during irradiation compared to the behavior of the layers that form in U–Mo dispersion fuel plates without Si in the matrix.     

High speed fabrication of aluminum nanostructures with 10 nm spatial resolution by electrochemical replication

A high fidelity electrochemical replication technique for the rapid fabrication of Al nanostructures with 10?nm lateral resolution has been successfully demonstrated. Aluminum is electrodeposited onto a lithographically patterned Si master using a non-aqueous organic hydride bath of aluminum chloride and lithium aluminum hydride at room temperature. Chemical pretreatment of the Si surface allows a clean detachment of the replicated Al foil from the master, permitting its repetitive use for mass replication. This high throughput technique opens up new possibilities in the fabrication of Al-related nanostructures, including the growth of long range ordered anodic alumina nanochannel arrays.     

Diffraction gratings of photosensitive ZrO2 gel films fabricated with the two-ultraviolet-beam interference method

Photosensitive ZrO(2) gel films were patterned with a two-beam interference method by use of a 325-nm-wavelength He-Cd laser for the first time to our knowledge. The ZrO(2) gel films were prepared from Zr(O-n-C(4)H(9))(4) chemically modified with benzoylacetone. We fabricated uniform gratings with a 0.5-mum period on Si or SiO(2) substrates by etching the gel films in ethyl alcohol after UV irradiation. A maximum diffraction efficiency of 28% was attained with the grating fabricated on Si substrate under a Littrow mounting condition by use of a 633-nm-wavelength He-Ne laser. Blazed gratings could also be fabricated.     

Facile and Clean Release of Vertical Si Nanowires by Wet Chemical Etching Based on Alkali Hydroxides

A simple method to release Si nanowires (SiNWs) from a substrate, with their original length almost intact, is demonstrated. By exploiting the unique chemistry involved for the fabrication of vertical arrays of SiNWs in metal‐assisted chemical etching (MaCE) based either on HF/AgNO₃ or HF/H₂O₂ chemistries, wet etching with alkali hydroxides such as NaOH or KOH preferentially attacks the bottom part of the vertical SiNWs. A protective layer of Si oxide is found to exist on the outer wall of the SiNWs and to play the key role of etch mask during the release‐etching by alkali hydroxides. The clean release of SiNWs also enables the repeated use of the Si substrate for the fabrication of vertical SiNW arrays by MaCE. The released SiNWs are further used for the fabrication of field‐effect transistors on a flexible plastic substrate. The method developed here, when combined with a suitable assembling technique, can be very useful in implementing flexible electronics, or in the fabrication of SiNW composites with other functional materials.     

Fabrication of mid-infrared frequency-selective surfaces by soft lithography

We describe the fabrication of large areas (4 cm(2)) of metallic structures or aperture elements that have ~100-350-nm linewidths and act as frequency-selective surfaces. These structures are fabricated with a type of soft lithography-near-field contact-mode photolithography-that uses a thin elastomeric mask having topography on its surface and is in conformal contact with a layer of photoresist. The mask acts as an optical element to create minima in the intensity of light delivered to the photoresist. Depending on the type of photoresist used, lines of, or trenches in, photoresist are formed on the substrate by exposure, development, and lift-off. These surfaces act as bandpass or bandgap filters in the infrared.     

Implantable microdevice for peripheral nerve regeneration: materials and fabrications

Rapid innovations in tissue engineering have increased the likelihood that fabricated microdevices for neuro-regeneration can finally be applied to humans. The advent of microdevices has created strong interest in many fields, including diagnostics, drug/gene delivery, and tissue engineering. The integration of microfluidics and tissue engineering is believed to hold promise in applications for neuro-regeneration. Early clinical results suggest that the fabrication of microdevices with appropriate properties indeed yields multi-functional applications with enhanced efficacy and less adverse effects. A prerequisite for advancing this area of research is the development of apt devices for nerve restoration, which can provide molecular, electrical, and micro-environmental cues for efficient neuronal cell regeneration. Based on the increasing clinical application of fabrication methods and continued efforts to advance this technology, it is likely that microdevice fabrication will become an effective method for achieving the above-mentioned criteria. Therefore, the aim of this review is to provide basic information on the fabrication of microdevices by focusing exclusively on several kinds of biomaterials, such as biocompatible, biodegradable, non-conducting, conducing, elastomeric and thermoplastic materials with natural, synthetic polymers, inorganic biomaterials, and physiochemical parameter for neuro-regeneration. We also discuss distinctive nerve growth factors and neural cell types within the context of developing micro-based neuro-degenerative applications. The information provided in this review is important with regards to the safe and widespread use of microdevice fabrication, particularly in the neuro-regenerative field.     

3D printing in X-ray and Gamma-Ray Imaging: A novel method for fabricating high-density imaging apertures

Advances in 3D rapid-prototyping printers, 3D modeling software, and casting techniques allow for cost-effective fabrication of custom components in gamma-ray and X-ray imaging systems. Applications extend to new fabrication methods for custom collimators, pinholes, calibration and resolution phantoms, mounting and shielding components, and imaging apertures. Details of the fabrication process for these components, specifically the 3D printing process, cold casting with a tungsten epoxy, and lost-wax casting in platinum are presented.     

A yolk-shell design for stabilized and scalable li-ion battery alloy anodes

Silicon is regarded as one of the most promising anode materials for next generation lithium-ion batteries. For use in practical applications, a Si electrode must have high capacity, long cycle life, high efficiency, and the fabrication must be industrially scalable. Here, we design and fabricate a yolk-shell structure to meet all these needs. The fabrication is carried out without special equipment and mostly at room temperature. Commercially available Si nanoparticles are completely sealed inside conformal, thin, self-supporting carbon shells, with rationally designed void space in between the particles and the shell. The well-defined void space allows the Si particles to expand freely without breaking the outer carbon shell, therefore stabilizing the solid-electrolyte interphase on the shell surface. High capacity (～2800 mAh/g at C/10), long cycle life (1000 cycles with 74% capacity retention), and high Coulombic efficiency (99.84%) have been realized in this yolk-shell structured Si electrode.     

Imaging profiles of light intensity in the near field: applications to phase-shift photolithography

We describe a method of imaging the intensity profiles of light in near-field lithographic experiments directly by using a sensitive photoresist. This technique was applied to a detailed study of the irradiance distribution in the optical near field with contact-mode photolithography carried out by use of elastomeric phase masks. The experimental patterns in the photoresist determined by scanning electron microscopy and atomic force microscopy were compared with the corresponding theoretical profiles of intensity calculated by use of a simple scalar analysis; the two correlate well. This comparison makes it possible to improve the theoretical models of irradiance distribution in the near field. Analysis of the images highlights issues in the experimental design, provides a means for the optimization of this technique, and extends its application to the successful fabrication of test structures with linewidths of ~50 nm.     

Fast patterning of poly(methyl methacrylate) by a novel soft molding approach and its application to the fabrication of silver structures

A novel single-step approach for the fabrication of poly(methyl methacrylate) structures by soft molding of a 5 wt% solution in acetone is reported. The use of a low weight solution and of a solvent with high volatility ensures a very fast patterning, down to 10 s. In addition, the process is extremely simple and cost-effective, since just one elastomeric mold is needed, and areas as large as 1 cm² were patterned uniformly and defect-free. The process was applied to the fabrication of silver structures by silver deposition via electroless plating or evaporation followed by poly(methyl methacrylate) removal. Structures of various shapes and sizes, with dimensions in the micrometer and submicrometer range were successfully fabricated, showing the versatility of the process. This silver patterning process is particularly well suited for applications in microelectronics and optoelectronics, such as the fabrication of transparent electrodes for solar cells and displays, manufacturing of metal etching masks and wiring of printed circuits.     

Study on dynamic and mechanical characteristics of carbon fiber- and polyamide fiber-reinforced seismic isolators

Seismic isolators are used to decrease the energy and forces of earthquakes. The weight of conventional steel-reinforced elastomeric isolators (SREIs) is high, mostly due to the use of multiple steel shim plates. On the contrary, the damping ratio of SREIs is relatively low. Accordingly, this research utilizes a new approach in which the steel shim plates are replaced by carbon and polyamide fibers. This study attempts to obtain the dynamic and mechanical properties of such carbon fiber- and polyamide fiber-reinforced elastomeric isolators, in comparison with SREIs. In this work, a number of specimens were initially designed and manufactured. Afterwards, compression and cyclic shear tests were performed on them. In the shear tests, due to the limitations of the testing machine, a constant vertical load was not applied. All three types of isolator specimen were cylindrical, with identical diameter and height. The steel-, carbon fiber-, and polyamide fiber-reinforced elastomeric isolator specimens had 16, 23, and 23 reinforcement layers, respectively. To decrease the effect of manufacturing errors on the dynamic and mechanical characteristics of the specimens, 6 samples of each isolator type were manufactured, i.e., a total of 18 samples. The outcome of the experiments revealed that the use of flexible reinforcement resulted in a damping increase of up to 20 and 30 % for the carbon fiber- and polyamide fiber-reinforced elastomeric isolators, respectively. Furthermore, the carbon fiber design provides more reasonable performance for the isolators compared with the use of polyamide fiber.     

An observation on quartz resonator aging

Aging and acceleration sensitivity of certain fabrication lots of quartz resonators show a trend that may arise from a common predominating mechanism, such as stresses arising from the mounting structure. The presence or absence of such a trend is discussed. As part of the work on bulk-acoustic-wave (BAW) resonators, a database of all known parameters of the resonators in question was assembled. Resonator processing and electrical parameters were examined for correlations with the acceleration sensitivity. A similar effort was being undertaken in regard to resonator aging, and possible correlations between the aging and acceleration sensitivities of the various resonators were examined. The results for two such fabrication lots are shown. The magnitude of the observed aging was typically in the 10(-10) per day range. The identity of the common contributor is unknown at the present time. It is likely that mounting related stresses are the common contributor.     

Graphene Coating of Silicon Nanoparticles with CO2‐Enhanced Chemical Vapor Deposition

Understanding the growth of graphene over Si species is becoming ever more important as the huge potential for the combination of these two materials becomes more apparent, not only for device fabrication but also in energy applications, particularly in Li‐ion batteries. Thus, the drive for the direct fabrication of graphene over Si is crucial because indirect approaches, by their very nature, require processing steps that, in general, contaminate, damage, and are costly. In this work, the direct chemical vapor deposition growth of few‐layer graphene over Si nanoparticles is systematically explored through experiment and theory with the use of a reducer, H₂ or the use of a mild oxidant, CO₂ combined with CH₄. Unlike the case of CH₄, with the use of CO₂ as a mild oxidant in the reaction, the graphene layers form neatly over the surface and encapsulate the Si particles. SiC formation is also prevented. These structures show exceptionally good electrochemical performance as high capacity anodes for lithium‐ion batteries. Density functional theory studies show the presence of CO₂ not only prevents SiC formation but helps enhance the catalytic activity of the particles by maintaining an SiO_x surface. In addition, CO₂ can enhance graphitization.     

Promising electroplating solution for facile fabrication of Cu quantum point contacts

In this article,we report on the fabrication and transport measurements of Cu quantum point contacts prepared by a novel,electrochemically assisted mechanically controllable break junction (EC-MCBJ) method.By employing photolithography and wet-etching processes,suspended electrode pairs were patterned and fabricated successfully on Si microchips.Rather than adopting an acid Cu electroplating solution,a novel alkaline electroplating solution was developed and utilized to establish Cu nanocontacts between electrode pairs.Typically,the widths of the as-fabricated Cu nanocontacts were found to be smaller than 18 nm.A large number of Cu quantum point contacts were then produced and characterized by a home-built MCBJ setup.In addition to the conventional histogram,where peaks tend to decrease in amplitude with increasing conductance,an anomalous type of conductance histogram,exhibiting different peak amplitudes,was observed.Through statistical analysis of the maximum allowable bending of the Si microchips,and theoretical calculations,we demonstrated that our alkaline Cu electroplating solution affords Cu nanocontacts that are compatible with subsequent MCBJ operations,which is essential for the fabrication of Cu quantum point contacts.As sophisticated e-beam lithography is not required,the EC-MCBJ method is fast,simple,and cost-effective.Moreover,it is likely to be suitable for the fabrication and characterization of quantum point contacts of various metals from their respective electroplating solutions.     

Membrane growth of nanoporous silicates via the self-assembly monolayer

The self-assembly monolayer (SAM) method was used for membrane fabrication, in which Si wafers were treated separately with N-trimethoxysilylpropyl-n,n,n-tri-n-butylammonium bromide (TMSP-TBA) and N-trimethoxysilylpropyl-n,n,n-trimethylammonium chloride (TMSP-TMA) to form monolayers on the Si surfaces. To grow silicate membranes on the organosilyl-treated Si wafers, a series of silicate sols were prepared with composites of tetraethylorthosilicate (TEOS) and methyltriethoxysilane (MTES) as silicate sources, and tetrapropylammonium bromide (TPABr) was used as an organic template. Their microstructures were investigated in detail by comparing them using SEM and XRD. The use of MTES hindered the formation of microporous channels in the calcined silicate samples. The calcined silicate samples became totally amorphous over 20% loading of MTES. In addition, their structural information was supported by spectroscopic (FT-IR and solid-state 29Si NMR) analyses.