共查询到20条相似文献,搜索用时 10 毫秒
1.
2.
Amir Reza JALILIAN Saeed SHANESAZZADEH Pejaman ROWSHANFARZAD Fatemeh BOLOURINOVIN Abbas MAJDABADI 《核技术(英文版)》2008,19(3):159-164
[61Cu]-labeled pyruvaldehyde-bis (N-4-methylthiosemicarbazone) (61Cu-PTSM), a promising agent made for imaging blood perfusion, was produced via the natZn(p,x)61Cu nuclear reaction in a 30 MeV cyclotron, and separated by a two-step column chromatography method developed in our laboratory using a cation and an anion exchange resin. After 150μA irradiation for 76 min, about 6.006 Ci of 61Cu2 was obtained with a radiochemical separation yield of 95% and a radionuclidic purity of 99%. 61Cu-PTSM was prepared using an optimized method with in-house synthesized PTSM ligand for radiolabeling following quality control procedures using RTLC and HPLC. The tracer is mostly incorporated in heart, kidneys and brain compared to free copper cation as a control. These are in agreement with former reports. In conclusion, [61Cu]-PTSM was prepared at the radiopharmaceutical scales with high quality and is a potential PET tracer in the perfusion study of the heart, kidney, brain and tumors. 相似文献
3.
4.
JIANG Shu-Bin LUO Shun-Zhong LIU Guo-Ping DENG Hou-Fu BING Wen-Zeng WANG Wen-Jin WEI Hong-Yuan HUShu 《核技术(英文版)》2003,14(2)
TTHMP (triethylenetetraaminehexamethylenephosphonic acid) was labeled with 153Sm. The labeling condition, stability, mole ratio of 153Sm to TTHMP, rabbit bone imaging and bio-distribution of 153Sm-TTHMP in mice were investigated. The results showed that weak basie media and high concentration ligands were favorable to form 153Sm-TTHMP; labeling compounds were stable at pH 7 in 7 days. The results also indicated that the chemical mole ratio of 153Sm-TTHMP is n(153Sm) : n(TTHMP) = 1 : 1 and skeleton uptake of 153Sm-TTHMP is high((13.96±3.51)%/g at 1h post injection and (13.54±2.98)%/g at 48h post injection), while the non-target tissue uptake is relatively low, so 153Sm-TTHMP is a promising bone tumor therapeutic agent. 相似文献
5.
JIANG Shu-Bin LUO Shun-Zhong HU Shu DENG Hou-Fu BIN Wen-Zeng WANG Wen-Jin WEI Hong-Yuan LEI Yon 《核技术(英文版)》2004,15(2):102-105
1 Introduction Metastases to skeleton from prostate, breast, andlung cancer are frequent in clinical practice. The pal-liation of patients with extreme pain of bone metasta-ses was of primary importance in clinical managementof patients with advanced cancer. Based on concentra-tion at sites of increased bone turnover, ra-dio-therapeutics was an effective alternative to con-ventional therapies. 153Sm-EDTMP (ethylene diaminetetramethylene phosphonate) has been developed topalliate su… 相似文献
6.
JALILIAN Amir Reza YOUSEFNIA Hassan FAGHIHI Reza AKHLAGHI Mehdi ZANDI Hassan 《核技术(英文版)》2009,20(3):157-162
This work was conducted for radiolabeling of an anticancer antibiotic, i.e. doxorubicin with 61Cu for pro-duction of possible tracer used in PET oncology. 61Cu was prepared with natural zinc target and 22 MeV150 mA pro-tons via natZn(p, xn)61Cu reaction with a yield of 123.2 MBq·μA-1·h-1. Optimization reactions were performed for pH, temperature and concentration. Biodistribution of the tracer was studied in normal and fibrosarcoma bearing mice. At the optimized conditions, ITLC showed that radiochemical purity was over 97% with a specific activity of 2.22×103MBq ·mmol-1·L-1. This was kept unchanged even with presence of human serum as well as room temperature for 5 h. Biodistribution of the tracer in fibrosarcoma bearing mice demonstrated significant tumor uptake after 2 h. This tracer can be used in the detection of various tumors responding to doxorubicin chemotherapy using PET scan and/or determination of tumor therapy response to doxorubicin chemotherapy. 相似文献
7.
~(153)Gd骨密度计源芯体的烧结工艺为:将加有4%石蜡的~(153)Gd_2O_3粉末于专用模具中压制成形,再于1400℃氢气气氛中烧结成直径3mm、厚度1mm及放射性活度大于3.7×10~(10)Bq的骨密度计源陶瓷芯体。 相似文献
8.
9.
Amir Reza JALILIAN Yousef YARI-KAMRANI Pejman ROWSHANFARZAD Mahseed SABET Mohsen KAMALI-DEHGHAN Abbas MAJDABADI 《核技术(英文版)》2008,19(6)
Co-55 (t1/2=17.53 h) was produced by 150 μA irradiation of a natural nickel target using 15 MeV protons. It was separated from the irradiated target material by two ion exchange chromatography steps with a radiochemical yield of>95% and was used for the preparation of [55Co]vancomycin ([55Co]VAN). Optimization studies were per-formed using Co-57 due to its longer half-life. Cobalt-57 (t1/2=271.79 d) was produced by irradiation of a natural nickel target with 150 μA current of 22 MeV protons. The 57Co was separated from the irradiated target material using a no-carrier-added method with a radiochemical yield of>97%. Both products were controlled for radionuelide and chemical purity. The solutions of [55Co]VAN were prepared (radiochemical yield>80%) starting with 55Co acetate and vancomycin at room temperature after 30 min. A precise solid phrase extraction (SPE) method was developed using Si Sep-Pak in order to purify/reconstitute the final formulation for animal studies. [55Co]VAN showed a radiochemical purity of more than 99%. The resultant specific activity was about 1.15 TBq/mmol. It is proved that the tracer is stable in the final product and in presence of human serum at 37℃ up to 24 h. Biodistribution study of [55Co]VAN in normal rats was undertaken for up to 72 h. 相似文献
10.
本文介绍了生产~(153)Gd骨密度计源的原理、工艺和结果。采用天然Eu_2O_3作靶材料,汞阴极电解法分离得的~(153)Gd,经压制、烧结法制成源芯体。源的活度>3.7×10~10Bq,放射性核纯度>99.99%。 相似文献
11.
Amir Reza JALILIAN Yousef YARI-KAMRANI Pejman ROWSHANFARZAD Mahseed SABET Mohsen KAMALI-DEHGHAN Abbas MAJDABADI 《核技术(英文版)》2008,19(6)
Co-55 (t1/2=17.53 h) was produced by 150 μA irradiation of a natural nickel target using 15 MeV protons. It was separated from the irradiated target material by two ion exchange chromatography steps with a radiochemical yield of >95% and was used for the preparation of [55Co]vancomycin ([55Co]VAN). Optimization studies were per- formed using Co-57 due to its longer half-life. Cobalt-57 (t1/2=271.79 d) was produced by irradiation of a natural nickel target with 150 μA current of 22 MeV protons. The 57Co was ... 相似文献
12.
153Sm-DTPA-PNIPAAm的制备及其在荷瘤鼠体内的分布 总被引:1,自引:1,他引:0
合成了带双功能偶联剂二乙三胺五醋酸(DTPA)的热敏高分子DTPA-PNIPAAm,它保持了聚(N-异丙基丙烯酰胺)(PNIPAAm)的热敏性.探讨了153Sm-DTPA-PNIPAAm的制备条件和体外稳定性,经皮下瘤内注入后标记物在荷瘤鼠体内的分布.结果表明,室温下153Sm-DTPA-PNIPAAm的最佳标记条件为,pH=7~9,配体质量为20~25 mg,反应时间大于20 min;最高标记率为93.4%;标记物的体外稳定性较高,76 h内标记物的放化纯度保持在96.5%以上;皮下瘤内注入后,标记物主要滞留在注入点肿瘤组织内,3 d时其滞留率为(83.2±9.7)%. 相似文献
13.
研究了各种因素对153Sm-HEDTMP(羟乙基乙二胺三甲撑膦酸)在羟基磷灰石(HA)上吸附的影响。结果表明,室温下153Sm-HEDTMP在HA上吸附20 min即可达到平衡,温度对吸附量影响不明显;过量配体会使配合物吸附量降低;吸附量在酸性条件下较高,153Sm3 在HA上的吸附能力最强,饱和吸附容量可达720μmol.g-1;153Sm-HEDTMP饱和吸附容量为61μmol.g-1;Ca2 对吸附有强烈的促进作用。EDTMP和HEDTMP对配合物的解吸率较高;生理盐水的解吸作用不明显。 相似文献
14.
AKHLAGHI Mehdi AHI Leyla Pashaye JALILIAN Amir Reza GAROUSI Javad POUR-HERAVI Mohammad Reza Abdolrahim 《核技术(英文版)》2009,20(3):163-169
In order to prepare a specific melanocortin type 2 receptor (MC2R) ligand, b1-24-corticotrophin was pre-pared in one-step reaction with [18F] SFB and b-1-24-corticotrophin pharmaceutical solution (1 mg/mL, pH=6.5). [18F]SFB was prepared in a semi-automated module in two steps with an overall radiochemical yield of 47% to EOB (not-decay corrected) in 90 min. The 18F-labeled intermediates and 18F-labeled peptide was checked by RTLC and HPLC. The results show that the radiochemical purity is >95% and the yield to EOB (not-decay corrected) is 29% for final 18F-labeled peptide at optimized conditions. Preliminary in vivo studies in normal mice were performed to deter-mine biodistribution of the 18F-labeled peptide for 150 min. The results show that the major tracer uptake is consistent with the natural distribution of MC2R receptors in mammals. Testes/blood and testes/muscle ratios for 18F-labeled peptide at 150 min were 184 and 1.56, respectively, and adipocyte/blood and adipocyte/muscle ratios at 120 min were 221 and 142, respectively. The data support the specific receptor binding of the radiolabeled peptide as reported for MC2R receptor accumulation in adipocytes and testes and demonstrates the retention of biological activity of the pep-tide. This tracer can be used in detection of MC2R distribution in malignancies and sex organ diseases. 相似文献
15.
16.
17.
1 INTRODUCTIONSamarium-153 ethylenedialninetetramethylene phosphonic acid ("'Sin-EDTMP) iselective in the palation of painful bony metastases[1]. Pain relief is seen in 60%~90%of patients treated with "'Sin-EDTMP, and the onset Of pain relief generally beginswithin 1 week of administration. The critical organ in 153Sin-EDTMP therapy is thered bone marrow and myelotoalcity can be a significant side effect of the administrationof therapeutic activities of 153Sin-EDTMP[2]. There is… 相似文献
18.
153Sm-EDTMP与云克联合治疗转移性骨肿瘤疼痛的临床价值 总被引:3,自引:0,他引:3
为探讨^153Sm-EDTMP(^153钐-乙二胺四亚甲基膦酸)与云克(^99Tc-MDP,即^99锝-亚甲基二膦酸盐)联合治疗转移性骨肿瘤疼痛的临床价值。对210例癌骨转移患者分别为^153Sm-EDTMP单独治疗或与云克联合治疗,观察其疗效。结果显示,^153Sm-EDTMP单独治疗组,止痛有效率为83.7%,转移灶消失或缩小的总有效率为21.6%;^153Sm-EDTMP与云克静脉滴注联合治疗组,止痛有效率为94.7%,转移灶消失或缩小的总有效率为35.1%。后者明显高于单独治疗组。表明^153Sm-EDTMP联合云克静脉滴注对恶性肿瘤多发性骨转移所致疼痛有明显疗效,且安全无副作用。联合治疗组疗效优于单独治疗组。 相似文献
19.
合成了纳米羟基磷灰石,制备的153Sm-EDTMP-nanoHA和153Sm-citrate-nanoHA体外稳定性良好。153Sm-EDTMP-nanoHA新西兰兔显像对比度较好,骨骼系统显示清晰,肝脾显影清晰,肾脏显影,血清除快;153Sm-citrate-nanoHA新西兰兔显像,肝脾显影清晰,血清除快,肾脏几乎不显影,说明主要通过肝胆排泄。153Sm-EDTMP-nanoHA对肝癌SMMC-7721和乳腺癌MCF-7细胞的半抑制率浓度分别是1.98g/L和0.075g/L,153Sm-citrate-nanoHA则分别是1.89g/L和0.094g/L。153Sm-EDTMP-nanoHA和153Sm-citrate-na-noHA较同等浓度下的单一nanoHA的半抑制率浓度低得多,具有很高的深入研究价值。 相似文献
20.
《核技术(英文版)》2016,(2):35-43
~(99m)Tc-BnAO, as a nonnitroaromatic hypoxia marker, is the subject of intensive research in recent years. In this study, a butene amine oxime–nitrotriazole(Bn AO–NT)was synthesized and radiolabeled with ~(99m)Tc in high yield.Cellular uptakes of~(99m)Tc-Bn AO–NT and ~(99m)Tc-Bn AO were tested using murine sarcoma S180 and hepatoma H22 cell lines. The highest hypoxic cellular uptake of~(99m)TcBn AO–NT was 27.11 ± 0.73 and 14.85 ± 0.83 % for the S180 and H22 cell lines, respectively, whereas the normoxic cellular uptake of the complex was about 4–8 % for both cell lines. For~(99m)Tc-Bn AO, the highest hypoxic cellular uptake was 30.79 ± 0.44 and 9.66 ± 1.20 % for the S180 and H22 cell lines, respectively, while the normoxic cellular uptake was about 5 % for both cell lines. Both~(99m)Tc-Bn AO–NT and~(99m)Tc-Bn AO complexes showed hypoxic/normoxic differentials in the two cell lines, but the results were more significant for the S180 cell line. The in vitro results suggested that S180 may be better than H22 cell line in hypoxic biological evaluation of Bn AO complexes. The biodistribution study was tested using a S180 tumor model. The complex~(99m)Tc-Bn AO–NT showed a selective enrichment in tumor tissues: At 4 h, the tumor-to-muscle ratio was 3.79 ± 0.98 and the tumor-to-blood ratio was 2.31 ± 0.34.Compared with the results of ~(99m)Tc-Bn AO, the latter was at the same level. In vitro and in vivo studies demonstrated that ~(99m)Tc-Bn AO–NT could be a hypoxia-sensitive radiotracer for monitoring hypoxic regions in a sarcoma S180 tumor. 相似文献