Identifying brain regions contributing to Alzheimer's disease using self regulating particle swarm optimization

In this article, we developed an approach for detecting brain regions that contribute to Alzheimer's disease (AD) using support vector machine (SVM) classifiers and the recently developed self regulating particle swarm optimization (SRPSO) algorithm. SRPSO employs strategies inspired by the principles of learning in humans to achieve faster and better optimization results. The classifiers for distinguishing subjects into AD patients and cognitively normal (CN) individuals were built using grey matter (GM) and white matter (WM) volumetric features extracted from structural magnetic resonance (MR) images. It could be observed from results that the classifier built using both GM and WM features provided accuracy of 89.26% which is better than the performance of classifiers built using either GM or WM features only. Moreover, consideration of clinical features in addition to volumetric features improves the accuracy further to 94.63% which is better than the performance reported by recent works in literature. In order to identify the brain regions that are important for AD vs CN classification problem, we used SRPSO to extract GM and WM features that yield better classification performance. Using 50 features identified by SRPSO, an accuracy of 89.39% was obtained which is close to the accuracy based on all features. The features identified by SRPSO were mapped back to the brain to identify brain regions that exhibit degeneration in AD. In addition to identifying areas known to be involved in AD like cerebellum, hippocampus, this helped in finding newer areas that might contribute towards AD.     

An improved machine learning technique based on downsized KPCA for Alzheimer's disease classification

Alzheimer's disease (AD), a neurodegenerative disorder, is a very serious illness that cannot be cured, but the early diagnosis allows precautionary measures to be taken. The current used methods to detect Alzheimer's disease are based on tests of cognitive impairment, which does not provide an exact diagnosis before the patient passes a moderate stage of AD. In this article, a novel classifier of brain magnetic resonance images (MRI) based on the new downsized kernel principal component analysis (DKPCA) and multiclass support vector machine (SVM) is proposed. The suggested scheme classifies AD MRIs. First, a multiobjective optimization technique is used to determine the optimal parameter of the kernel function in order to ensure good classification results and to minimize the number of retained principle components simultaneously. The optimal parameter is used to build the optimized DKPCA model. Second, DKPCA is applied to normalized features. Downsized features are then fed to the classifier to output the prediction. To validate the effectiveness of the proposed method, DKPCA was tested using synthetic data to demonstrate its efficiency on dimensionality reduction, then the DKPCA based technique was tested on the OASIS MRI database and the results were satisfactory compared to conventional approaches.     

Alzheimer disease classification using KPCA,LDA, and multi‐kernel learning SVM

Early diagnosis of Alzheimer disease (AD) and mild cognitive impairment (MCI) is always useful. Preventive measures might have an impact on reducing AD risk factors. Structural magnetic resonance (MR) imaging, one of the vital sensitive biomarkers for cerebral atrophy in the brain, is used to extract volumetric feature by FreeSurfer and the CIVET toolbox. All of the structural magnetic resonance imaging (s‐MRI) data that we used were downloaded from the Alzheimer's disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu) of imaging data. This novel approach is applied for the diagnosis of AD and MCI from healthy controls (HCs) combining extracted features with the MMSE (mini‐mental state examination) scores, applying a two sample t‐test to select a subset of features. The subset of features is fed to kernel principal component analysis (KPCA) module to project data onto the reduced principal component coefficients at higher dimensional kernel space to increase the linear separability. Then, the kernel PCA coefficients are projected into the more efficient linear discriminant space using linear discriminant analysis. A multi‐kernel learning support vector machine (SVM) is used on newly projected data for stratification of AD and MCI from HCs. Using this approach, we obtain 93.85% classification accuracy when detecting AD from HCs for segmented volumetric features (using FreeSurfer) with high sensitivity and specificity. When distinguishing MCI from HCs and AD using volumetric features after subcortical segmentation, the detection rate reaches 86.54% and 75.12%, respectively.     

Multimodal magnetic resonance imaging for Alzheimer's disease diagnosis using hybrid features extraction and ensemble support vector machines

Magnetic resonance imaging (MRI) is increasingly used in the diagnosis of Alzheimer's disease (AD) in order to identify abnormalities in the brain. Indeed, cortical atrophy, a powerful biomarker for AD, can be detected using structural MRI (sMRI), but it cannot detect impairment in the integrity of the white matter (WM) preceding cortical atrophy. The early detection of these changes is made possible by the novel MRI modality known as diffusion tensor imaging (DTI). In this study, we integrate DTI and sMRI as complementary imaging modalities for the early detection of AD in order to create an effective computer-assisted diagnosis tool. The fused Bag-of-Features (BoF) with Speeded-Up Robust Features (SURF) and modified AlexNet convolutional neural network (CNN) are utilized to extract local and deep features. This is applied to DTI scalar metrics (fractional anisotropy and diffusivity metric) and segmented gray matter images from T1-weighted MRI images. Then, the classification of local unimodal and deep multimodal features is first performed using support vector machine (SVM) classifiers. Then, the majority voting technique is adopted to predict the final decision from the ensemble SVMs. The study is directed toward the classification of AD versus mild cognitive impairment (MCI) versus cognitively normal (CN) subjects. Our proposed method achieved an accuracy of 98.42% and demonstrated the robustness of multimodality imaging fusion.     

A multi‐modal,multi‐atlas‐based approach for Alzheimer detection via machine learning

The use of biomarkers for early detection of Alzheimer's disease (AD) improves the accuracy of imaging‐based prediction of AD and its prodromal stage that is mild cognitive impairment (MCI). Brain parcellation‐based computer‐aided methods for detecting AD and MCI segregate the brain in different anatomical regions and use their features to predict AD and MCI. Brain parcellation generally is carried out based on existing anatomical atlas templates, which vary in the boundaries and number of anatomical regions. This works considers dividing the brain based on different atlases and combining the features extracted from these anatomical parcellations for a more holistic and robust representation. We collected data from the ADNI database and divided brains based on two well‐known atlases: LONI Probabilistic Brain Atlas (LPBA40) and Automated Anatomical Labeling (AAL). We used baselines images of structural magnetic resonance imaging (MRI) and ¹⁸F‐fluorodeoxyglucose positron emission tomography (FDG‐PET) to calculate average gray‐matter density and average relative cerebral metabolic rate for glucose in each region. Later, we classified AD, MCI and cognitively normal (CN) subjects using the individual features extracted from each atlas template and the combined features of both atlases. We reduced the dimensionality of individual and combined features using principal component analysis, and used support vector machines for classification. We also ranked features mostly involved in classification to determine the importance of brain regions for accurately classifying the subjects. Results demonstrated that features calculated from multiple atlases lead to improved performance compared to those extracted from one atlas only.     

Kernel-like impurity detection according to colour band spectral image using GA/SVM

Kernel-like impurities (KLIs) have the similar colour, shape, texture and specific gravity with sound kernels. The amount of the KLIs is an important parameter for evaluating the quality of wheat. However, it is difficult to classify KLIs from sound kernels with normal methods because of these similar features. In this study, a machine vision system with a linear colour charged coupled device used to acquire images of kernels and a software package developed to extract various features from the images were used to classify 1169 sound kernels and 896 KLIs. Three methods—genetic algorithm (GA)/support vector machine (SVM), principal components analysis/SVM and linear discriminant analysis—were applied for the classification. The performance of GA/SVM for detecting KLIs was very outstanding, and the accuracy of testing sets could reach 99.34%. GA/SVM has the potential to improve the KLI classification accuracy in machine vision system. It is feasible to extract a small quantity of useful features without any extra image or data processing for online KLI classification.     

Detection and classification of large bowel obstruction from X-ray images using machine learning algorithms

Large bowel obstruction (LBO) occurs when there is a blockage or twisting in the large bowel that prevents wastes and gas from passing through. If left untreated, the blockage cuts off blood supply to the colon, causing sections of it to die which results in high rates of morbidity and fatality. The examination of clinical symptoms of LBO involves careful inspection of the cecum and colon. Radiologists use X-rays to inspect the clinical signs. Some research has been done to automate the detection of related abdominal and intestinal diseases. However, all these studies concentrate only on detecting Crohn's, ulcerative colitis, Acute Appendicitis, colorectal cancer, celiac diseases, liver diseases, and chronic kidney diseases. Automatic detection and classification of LBO has not been given due attention so far to the best of the authors knowledge. To address this challenge, we have designed a model for the detection and classification of LBO. The models development comprises of stages such as preprocessing, detection, segmentation, feature extraction, and classification. We used YOLOv3 for detection and used a gray scale level co-occurrence matrix (GLCM), and a convolutional neural network for feature extraction, while support vector machine (SVM) and softmax were used for classification. The proposed model achieved a diagnostic accuracy of 89% when feature extraction methods such as CNN and median filter with softmax classifier were used. CNN and Gaussian filter with soft max classifier achieved 91%, while CNN and anisotropic filter with soft max classifier achieved 92%. GLCM with threshold segmentation and Gaussian filter with SVM classifier achieved 87%, while CNN with watershed segmentation and Gaussian filter with SVM classifier achieved 97% and CNN-GLCM with watershed segmentation and anisotropic diffusion filter with SVM classifier achieved 98% for detection and classification of LBO. Finally, this paper presented a performance analysis of various machine learning approaches for detection and classification of LBO. Hence, our model is designed to assist human experts (Radiologists) in diagnosing LBO.     

Performance analysis of EM,SVD, and SVM classifiers in classification of carcinogenic regions of medical images

In this article, the performance analysis of Expectation Maximization (EM), Singular Value Decomposition (SVD), and Support Vector Machines (SVM) classifiers for classification of carcinogenic regions from various medical images is carried out. Cancer detection is one of the critical issues where excessive care needs to be taken for better diagnosis. Any classifier needs to detect the cancer with respect to the efficiency in time of detection and performance. Due to these, three classifiers are selected: Expectation Maximization (EM), Singular Value Decomposition (SVD), and Support Vector Machines (SVM). EM classifier performs as the optimizer and SVD classifier performs as the dual class classifier. SVM classifier is used as both optimizer and classifier for multiclass classification procedure and for wide stage cancer detection procedures. The performance analysis of all the three classifiers are analyzed for a group of 100 cancer patients based on the benchmark parameter such as Performance Measures and Quality Metrics. From the experimental results it is evident, that the SVM classifier significantly outperforms other classifiers in the classification of carcinogenic regions of medical images.     

Magnetic resonance brain image classification based on weighted‐type fractional Fourier transform and nonparallel support vector machine

To classify brain images into pathological or healthy is a key pre‐clinical state for patients. Manual classification is tiresome, expensive, time‐consuming, and irreproducible. In this study, we aimed to present an automatic computer‐aided system for brain‐image classification. We used 90 T2‐weighted images obtained by magnetic resonance images. First, we used weighted‐type fractional Fourier transform (WFRFT) to extract spectrums from each magnetic resonance image. Second, we used principal component analysis (PCA) to reduce spectrum features to only 26. Third, those reduced spectral features of different samples were combined and were fed into support vector machine (SVM) and its two variants: generalized eigenvalue proximal SVM and twin SVM. A 5 × 5‐fold cross‐validation results showed that this proposed “WFRFT + PCA + generalized eigenvalue proximal SVM” yielded sensitivity of 99.53%, specificity of 92.00%, precision of 99.53%, and accuracy of 99.11%, which are comparable with the proposed “WFRFT + PCA + twin SVM” and better than the proposed “WFRFT + PCA + SVM.” Besides, all three proposed methods were superior to eight state‐of‐the‐art algorithms. Thus, WFRFT is effective, and the proposed methods can be used in practical. © 2015 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 25, 317–327, 2015     

Earlier detection of cancer regions from MR image features and SVM classifiers

In this article, we examine the use of several segmentation algorithms for medical image classification. This work detects the cancer region from magnetic resonance (MR) images in earlier stage. This is accomplished in three stages. In first stage, four kinds of region‐based segmentation techniques are used such as K‐means clustering algorithm, expectation–maximization algorithm, partial swarm optimization algorithm, and fuzzy c‐means algorithm. In second stage, 18 texture features are extracting using gray level co‐occurrence matrix (GLCM). In stage three, classification is based on multi‐class support vector machine (SVM) classifier. Finally, the performance analysis of SVM classifier is analyzed using the four types of segmentation algorithm for a group of 200 patients (32—Glioma, 32—Meningioma, 44—Metastasis, 8—Astrocytoma, 72—Normal). The experimental results indicate that EM is an efficient segmentation method with 100% accuracy. In SVM, quadratic and RBF (σ = 0.5) kernel methods provide the highest classification accuracy compared to all other SVM kernel methods. © 2016 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 26, 196–208, 2016     

Providing an efficient intelligent transportation system through detection,tracking and recognition of the region of interest in traffic signs by using non-linear SVM classifier in line with histogram oriented gradient and Kalman filter approach

With a focus on new researches in the area of intelligent transportation systems (ITS), an efficient approach has been investigated here. Based on the present view point, analysis of traffic signs are first considered via intelligence based approach, which is carried out through three main stages including detection, tracking and recognition, respectively, in this research. The key role of detection is to identify traffic signs by classification of road sign shapes in accordance with their signatures. This classification consists of four different shapes of circle, semicircle, triangle and square, as well. The linear classification of traffic sign is also carried out via support vector machine (SVM) by using one against all (OAA), since the present SVMs classifiers realized via linear kernel. The next step is to track traffic sign. It should be noted that this technique is now developed to reduce the searching mode in case of the whole area to be optimized its computational processing, consequently. This research work is investigated by realizing Kalman filter approach, where, finally, in recognition step, a feature of the region of interest (ROI) has been extracted for SVM classification. Histogram of oriented gradient (HOG) is realized in organizing the approach, as long as Gaussian kernel is also developed for non-linear SVM classifier.     

A support vector machine integrated system for the classification of operation anomalies in nuclear components and systems

A support vector machine (SVM) approach to the classification of transients in nuclear power plants is presented. SVM is a machine-learning algorithm that has been successfully used in pattern recognition for cluster analysis. In the present work, single- and multiclass SVM are combined into a hierarchical structure for distinguishing among transients in nuclear systems on the basis of measured data. An example of application of the approach is presented with respect to the classification of anomalies and malfunctions occurring in the feedwater system of a boiling water reactor. The data used in the example are provided by the HAMBO simulator of the Halden Reactor Project.     

Analysis and classification of malignancy in pancreatic magnetic resonance images using neural network techniques

Computer-aided diagnosis (CAD) is a computerized way of detecting tumors in MR images. Magnetic resonance imaging (MRI) has been generally used in the diagnosis and detection of pancreatic tumors. In a medical imaging system, soft tissue contrast and noninvasiveness are clear preferences of MRI. Inaccurate detection of tumor and long time consumption are the disadvantages of MRI. Computerized classifiers can greatly renew the diagnosis activity, in terms of both accuracy and time necessity by normal and abnormal images, automatically. This article presents an intelligent, automatic, accurate, and robust method to classify human pancreas MRI images as normal or abnormal in terms of pancreatic tumor. It represents the response of artificial neural network (ANN) and support vector machine (SVM) techniques for pancreatic tumor classification. For this, we extract features from MR images of pancreas using the GLCM method and select the best features using JAFER algorithm. These features are analyzed by five classification techniques: ANN BP, ANN RBF, SVM Linear, SVM Poly, and SVM RBF. We compare the results with benchmark data set of MR brain images. The analytical outcome presents that the two best features used to classify the MR images using ANN BP technique have 98% classification accuracy.     

Machine Learning Approach for COVID-19 Detection on Twitter

Social networking services (SNSs) provide massive data that can be a very influential source of information during pandemic outbreaks. This study shows that social media analysis can be used as a crisis detector (e.g., understanding the sentiment of social media users regarding various pandemic outbreaks). The novel Coronavirus Disease-19 (COVID-19), commonly known as coronavirus, has affected everyone worldwide in 2020. Streaming Twitter data have revealed the status of the COVID-19 outbreak in the most affected regions. This study focuses on identifying COVID-19 patients using tweets without requiring medical records to find the COVID-19 pandemic in Twitter messages (tweets). For this purpose, we propose herein an intelligent model using traditional machine learning-based approaches, such as support vector machine (SVM), logistic regression (LR), naïve Bayes (NB), random forest (RF), and decision tree (DT) with the help of the term frequency inverse document frequency (TF-IDF) to detect the COVID-19 pandemic in Twitter messages. The proposed intelligent traditional machine learning-based model classifies Twitter messages into four categories, namely, confirmed deaths, recovered, and suspected. For the experimental analysis, the tweet data on the COVID-19 pandemic are analyzed to evaluate the results of traditional machine learning approaches. A benchmark dataset for COVID-19 on Twitter messages is developed and can be used for future research studies. The experiments show that the results of the proposed approach are promising in detecting the COVID-19 pandemic in Twitter messages with overall accuracy, precision, recall, and F1 score between 70% and 80% and the confusion matrix for machine learning approaches (i.e., SVM, NB, LR, RF, and DT) with the TF-IDF feature extraction technique.     

Classification of Electroencephalogram Signals Using LSTM and SVM Based on Fast Walsh-Hadamard Transform

Classification of electroencephalogram (EEG) signals for humans can be achieved via artificial intelligence (AI) techniques. Especially, the EEG signals associated with seizure epilepsy can be detected to distinguish between epileptic and non-epileptic regions. From this perspective, an automated AI technique with a digital processing method can be used to improve these signals. This paper proposes two classifiers: long short-term memory (LSTM) and support vector machine (SVM) for the classification of seizure and non-seizure EEG signals. These classifiers are applied to a public dataset, namely the University of Bonn, which consists of 2 classes –seizure and non-seizure. In addition, a fast Walsh-Hadamard Transform (FWHT) technique is implemented to analyze the EEG signals within the recurrence space of the brain. Thus, Hadamard coefficients of the EEG signals are obtained via the FWHT. Moreover, the FWHT is contributed to generate an efficient derivation of seizure EEG recordings from non-seizure EEG recordings. Also, a k-fold cross-validation technique is applied to validate the performance of the proposed classifiers. The LSTM classifier provides the best performance, with a testing accuracy of 99.00%. The training and testing loss rates for the LSTM are 0.0029 and 0.0602, respectively, while the weighted average precision, recall, and F1-score for the LSTM are 99.00%. The results of the SVM classifier in terms of accuracy, sensitivity, and specificity reached 91%, 93.52%, and 91.3%, respectively. The computational time consumed for the training of the LSTM and SVM is 2000 and 2500 s, respectively. The results show that the LSTM classifier provides better performance than SVM in the classification of EEG signals. Eventually, the proposed classifiers provide high classification accuracy compared to previously published classifiers.     

Imbalanced Data Classification Using SVM Based on Improved Simulated Annealing Featuring Synthetic Data Generation and Reduction

Imbalanced data classification is one of the major problems in machine learning. This imbalanced dataset typically has significant differences in the number of data samples between its classes. In most cases, the performance of the machine learning algorithm such as Support Vector Machine (SVM) is affected when dealing with an imbalanced dataset. The classification accuracy is mostly skewed toward the majority class and poor results are exhibited in the prediction of minority-class samples. In this paper, a hybrid approach combining data pre-processing technique and SVM algorithm based on improved Simulated Annealing (SA) was proposed. Firstly, the data pre-processing technique which primarily aims at solving the resampling strategy of handling imbalanced datasets was proposed. In this technique, the data were first synthetically generated to equalize the number of samples between classes and followed by a reduction step to remove redundancy and duplicated data. Next is the training of a balanced dataset using SVM. Since this algorithm requires an iterative process to search for the best penalty parameter during training, an improved SA algorithm was proposed for this task. In this proposed improvement, a new acceptance criterion for the solution to be accepted in the SA algorithm was introduced to enhance the accuracy of the optimization process. Experimental works based on ten publicly available imbalanced datasets have demonstrated higher accuracy in the classification tasks using the proposed approach in comparison with the conventional implementation of SVM. Registering at an average of 89.65% of accuracy for the binary class classification has demonstrated the good performance of the proposed works.     

Feature selection and fault‐severity classification–based machine health assessment methodology for point machine sliding‐chair degradation

In this paper, we propose an offline and online machine health assessment (MHA) methodology composed of feature extraction and selection, segmentation‐based fault severity evaluation, and classification steps. In the offline phase, the best representative feature of degradation is selected by a new filter‐based feature selection approach. The selected feature is further segmented by utilizing the bottom‐up time series segmentation to discriminate machine health states, ie, degradation levels. Then, the health state fault severity is extracted by a proposed segment evaluation approach based on within segment rate‐of‐change (RoC) and coefficient of variation (CV) statistics. To train supervised classifiers, a priori knowledge about the availability of the labeled data set is needed. To overcome this limitation, the health state fault‐severity information is used to label (eg, healthy, minor, medium, and severe) unlabeled raw condition monitoring (CM) data. In the online phase, the fault‐severity classification is carried out by kernel‐based support vector machine (SVM) classifier. Next to SVM, the k‐nearest neighbor (KNN) is also used in comparative analysis on the fault severity classification problem. Supervised classifiers are trained in the offline phase and tested in the online phase. Unlike to traditional supervised approaches, this proposed method does not require any a priori knowledge about the availability of the labeled data set. The proposed methodology is validated on infield point machine sliding‐chair degradation data to illustrate its effectiveness and applicability. The results show that the time series segmentation‐based failure severity detection and SVM‐based classification are promising.     

3d discrete wavelet transform for computer aided diagnosis of Alzheimer's disease using t1‐weighted brain MRI

Early and antemortem diagnosis of Alzheimer's disease (AD) may help in the development of appropriate treatment and in slowing down the disease progression. In this work, a three‐phase computer aided approach is suggested for classification of AD patients and controls using T1‐weighted MRI. In the first phase, smoothed modulated gray matter (GM) probability maps are obtained from T1‐weighted MRIs. In the second phase, 3D discrete wavelet transform is applied on GM of five brain regions, which are well‐documented regions affected in AD, to construct features. In the third phase, a minimal set of relevant and nonredundant features are obtained using Fisher's discriminant ratio and minimum redundancy maximum relevance feature selection methods. To check the efficacy of the proposed approach, experiments were carried out on three datasets derived from the publicly available OASIS database, using three commonly used classifiers. The performance of the proposed approach was evaluated using three performance measures namely sensitivity, specificity and classification accuracy. Further, the proposed approach was compared with the existing state‐of‐the‐art techniques in terms of three performance measures, ROC curves, scoring and computation time. Irrespective of the datasets and the classifiers, the proposed method outperformed the existing methods. In addition, the statistical test also demonstrated that the proposed method is significantly better in comparison to the other existing methods. The appreciable performance of the proposed method supports that it will assist clinicians/researchers in the classification of AD patients and controls.     

Ensemble Machine Learning Based Identification of Pediatric Epilepsy

Epilepsy is a type of brain disorder that causes recurrent seizures. It is the second most common neurological disease after Alzheimer’s. The effects of epilepsy in children are serious, since it causes a slower growth rate and a failure to develop certain skills. In the medical field, specialists record brain activity using an Electroencephalogram (EEG) to observe the epileptic seizures. The detection of these seizures is performed by specialists, but the results might not be accurate due to human errors; therefore, automated detection of epileptic pediatric seizures might be the optimal solution. This paper investigates the detection of epileptic seizures by applying supervised machine learning techniques. The techniques applied on the data of patients with ages seven years and below from children’s hospital boston massachusetts institute of technology (CHB-MIT) scalp EEG database of epileptic pediatric signals. A group of Naïve Bayes (NB), Support vector machine (SVM), Logistic regression (LR), k-nearest neighbor (KNN), Linear discernment (LD), Decision tree (DT), and ensemble learning methods were applied to the classification process. The results demonstrated the outperformance of the present study by achieving 100% for all parameters using the Ensemble learning model in contrast to state-of-the-art studies in the literature. Similarly, the SVM model achieved performance with 98.3% for sensitivity, 97.7% for specificity, and 98% for accuracy. The results of the LD and LR models reveal the lower performance i.e., the sensitivity at 66.9%–68.9%, specificity at 73.5%–77.1%, and accuracy at 70.2%–73%.     

Malware Detection Using Nonparametric Bayesian Clustering and Classification Techniques

Computer security requires statistical methods to quickly and accurately flag malicious programs. This article proposes a nonparametric Bayesian approach for classifying programs as benign or malicious and simultaneously clustering malicious programs. The analysis is based on the dynamic trace (DT) of instructions under the first-order Markov assumption. Each row of the trace’s transition matrix is modeled using the Dirichlet process mixture (DPM) model. The DPM model clusters programs within each class (malicious or benign), and produces the posterior probability of being a malware which is used for classification. The novelty of the model is using this clustering algorithm to improve the classification accuracy. The simulation study shows that the DPM model outperforms the elastic net logistic (ENL) regression and the support vector machine (SVM) in classification performance under most of the scenarios, and also outperforms the spectral clustering method for grouping similar malware. In an analysis of real malicious and benign programs, the DPM model gives significantly better classification performance than the ENL model, and competitive results to the SVM. More importantly, the DPM model identifies clusters of programs during the classification procedure which is useful for reverse engineering.