High-performance liquid chromatographic determination of midazolam in rat brain

The authors tested whether perfectionism dimensions interact with specific stress to predict depression over time. A sample of 103 current and former patients completed measures of perfectionism and depression at Time 1 and measures of stress and depression 4 months later. After controlling Time 1 depression, self-oriented perfectionism interacted only with achievement stress to predict Time 2 depression. Socially prescribed perfectionism did not interact with achievement or social stress to predict Time 2 depression, but it did predict Time 2 depression as a main effect. The results provide support for the contention that perfectionism dimensions are involved in vulnerability to depression over time.     

Dimensions of perfectionism, daily stress, and depression: A test of the specific vulnerability hypothesis.

Tested whether perfectionism dimensions interact with specific stressors to predict depression. A depressed patient sample (N?=?51) and a general psychiatric sample (N?=?94) completed measures of perfectionism, hassles, and depression. Ss in Sample 2 also completed other personality measures to assess the amount of unique variance in depression. Partial support was obtained: In both samples, self-oriented perfectionism interacted only with achievement stressors to predict depression. Socially prescribed perfectionism interacted with interpersonal stress in Sample 1 and with achievement stress in Sample 2 to predict depression. Several personality variables, including socially prescribed perfectionism, accounted for unique variance in depression. The results suggest that perfectionism dimensions are associated with depression and may constitute specific vulnerability factors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relative stability of dimensions of perfectionism in depression.

Investigated the degree of absolute change, affective state dependence, and relative trait stability of several dimensions of perfectionism assessed by two popular, multidimensional measures. The study sample was 105 adult outpatients from a university hospital mood disorders program who met diagnostic criteria for major depressive episode at Time 1 and did not meet criteria for major depressive episode one year later (Time 2). Mean total scores on the Beck Depression Inventory decreased by almost 50% (from 28 to 15). Absolute change on perfectionism indices was smaller but significant for some maladaptive dimensions. Correlational, regression, and path analyses all indicated the presence of affective state dependence for several maladaptive dimensions of perfectionism (e.g., concern over mistakes, socially prescribed perfectionism). However, in all cases strong evidence was also found for the enduring trait stability of these dimensions. The results support a state-trait conceptualization of maladaptive perfectionism dimensions, which denotes stable individual difference variables that are elevated in the depressive state. Adaptive aspects of perfectionism showed little or no evidence of affective state dependence, consistent with findings from other research. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Personality, negative social interactions, and depressive symptoms.

Examined the associations among the frequency of negative social interactions, personality traits, and depressive symptoms in university students. 176 Ss completed measures of negative social interactions, sociotropy, autonomy, perfectionism, and depressive symptoms. It was found in the total sample that higher depression symptoms scores were correlated significantly with the frequency of negative social interactions, sociotropy, autonomy, and socially prescribed perfectionism. Additional results indicate that the frequency of negative social interactions accounted for unique variance in depressive symptoms over and above the variance predicted by personality traits, but it did not interact with these personality traits to predict unique variance in depressive symptoms. It was also found that the reported frequency of negative social interactions was correlated positively with socially prescribed perfectionism, sociotropy, and autonomy, especially among women. The current findings are discussed in terms of their implications for specific vulnerability and stress generation models of personality, life events, and depressive symptoms. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Acculturative stress, perfectionism, years in the United States, and depression among Chinese international students.

The present study examined whether maladaptive perfectionism (i.e., discrepancy between expectations and performance) and length of time in the United States moderated the association between acculturative stress and depression. Data were collected through online surveys from 189 Chinese international students from China and Taiwan attending a midwestern university. Results from a hierarchical regression showed that there were significant main effects of acculturative stress and maladaptive perfectionism on depression, no significant two-way interactions, and a significant three-way interaction, indicating that acculturative stress, maladaptive perfectionism, and length of time in the United States interacted to predict depression. Low maladaptive perfectionism buffered the effect of acculturative stress on depression only for those who had been in the United States for a relatively longer period of time. Implications for counseling and future research directions are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dimensions of perfectionism in unipolar depression.

We tested the hypothesis that self-oriented perfectionism, other-oriented perfectionism, and socially prescribed perfectionism are related differentially to unipolar depression. The Multidimensional Perfectionism Scale was administered along with measures of depression and anxiety to 22 depressed patients, 22 matched normal control Ss, and 13 anxiety patients. It was found that the depressed patients had higher levels of self-oriented perfectionism than did either the psychiatric or normal control Ss. In addition, depressed patients and anxious patients reported higher levels of socially prescribed perfectionism than did the normal control Ss. The results suggest that various dimensions of perfectionism may play an important role in clinical depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perfectionism in chronic and state symptoms of depression.

Tested whether perfectionism dimensions uniquely predict chronic unipolar and chronic bipolar symptoms. A sample of 121 patients and former patients (mean age 46.1 yrs) completed the Multidimensional Perfectionism Scale, the General Behavior Inventory, and the Beck Depression Inventory. The results confirm that the perfectionism dimensions are related to chronicity of depression symptoms. Whereas self-oriented perfectionism was uniquely associated only with chronic unipolar symptoms, both socially prescribed and other-oriented perfectionism were uniquely associated with chronic bipolar symptoms. Importantly, these relationships remained significant after controlling for the effects of concurrent state depression. Finally, only socially prescribed perfectionism was uniquely associated with state depression. The results provide support for the position that perfectionism dimensions are important in both chronic. and state depression symptoms, but the perfectionism dimensions may differ in terms of their degree of association with various facets of depressive phenomena. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perfectionism and bulimic symptoms in African American college women: Dimensions of perfectionism and their interactions with perceived weight status.

This study had 2 primary aims: (a) to examine the unique relations between maladaptive and adaptive dimensions of perfectionism and bulimic symptoms and (b) to test an interactive model of perfectionism and perceived weight status for bulimic symptoms in a sample of African American female undergraduates. The sample consisted of 97 women at Time 1 and 70 women at Time 2 about 5 months later, with bulimic symptoms assessed at both time points. Results showed that maladaptive perfectionism, but not adaptive perfectionism, was uniquely related to bulimic symptoms in cross-sectional analyses. Tests of interaction effects indicated that maladaptive perfectionism interacted with perceived weight status to identify elevated bulimic symptoms such that women with high levels of maladaptive perfectionism who felt overweight exhibited the highest levels of bulimic symptoms, both concurrently and prospectively after controlling for Time 1 levels of bulimic symptoms. This study highlights the relevance of maladaptive perfectionism to bulimic symptoms in African American college women. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dyadic perfectionism as a predictor of relationship continuity and distress among college students.

This study examined the nature and impact of dyadic perfectionism over a 3-month interval within a sample of 116 college students who were currently involved in an intimate heterosexual relationship. Dyadic perfectionism scores were stable and correlated as expected with scores on concurrent measures of adult attachment orientations and relationship satisfaction. Logistic regression analyses revealed that, controlling for initial commitment status and adult attachment orientations, Time 1 dyadic perfectionism scores significantly and uniquely predicted relationship continuity 3 months later. Lastly, controlling for social desirability, relationship commitment status, and Time 1 adult attachment orientation scores, Time 1 dyadic perfectionism scores also uniquely predicted Time 2 relationship distress. Findings provide additional evidence that dyadic perfectionism is a risk factor for relationship dysfunction. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perfectionism, stress, and social (dis)connection: A short-term study of hopelessness, depression, and academic adjustment among honors students.

This study tested models of perfectionism predicting psychological distress and academic adjustment and moderators and mediators of those associations in 2 successive cohorts of high-achieving university honors students (N = 499). Participants completed measures early and late in the semester. Adaptive (high standards) and maladaptive (self-critical perceptions of inadequacy in meeting performance expectations) dimensions of perfectionism were found to be significantly associated, in generally expected directions, with concurrent and prospective perceived stress, social connectedness, depression, hopelessness, and perceived academic adjustment. However, some perfectionism effects were reduced when earlier psychological distress and adjustment were controlled in analyses predicting later distress and adjustment. Several effects were moderated and at least partially mediated by perceived stress and social connection. The results suggest several counseling implications for high-achieving, perfectionistic students. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perfectionism as a predictor of subsequent adjustment: Evidence for a specific diathesis–stress mechanism among college students.

The relations among perfectionism, stress, subsequent psychological symptoms, and hopelessness were examined among 215 college students. Hierarchical regression analyses were conducted to determine whether dimensions of perfectionism (P. Hewitt & G. Flett, 1991) predicted psychological symptoms and hopelessness (1 month later), and the extent to which stress scores added incremental validity to these predictions. Results indicated that socially prescribed perfectionism was a significant predictor of both adjustment measures. In addition, stress accounted for a significant amount of additional variance in predicting adjustment beyond perfectionism. Consistent with a diathesis–stress model, a significant Perfectionism × Stress interaction was found in predicting scores on adjustment measures beyond perfectionism and stress. However, this interaction was only found for socially prescribed perfectionism. Results provide support for a specific diathesis–stress mechanism and important implications for developing specific interventions in working with perfectionistic college students. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Long-term stability of depression, anxiety, and stress syndromes.

At Time 1, 3,540 participants completed the Depression Anxiety Stress Scales (DASS). At Time 2, 3 to 8 years later, the DASS was readministered to 882 of these participants. There was strong evidence for selective stability of the syndromes of depression, anxiety, and stress. Each Time 2 scale was best predicted by the same scale at Time 1, with no significant increase in prediction from the other 2 Time 1 scales. Stability of the 3 syndromes did not vary systematically over the intervals studied. The results support the longitudinal stability of depression, anxiety, and stress and, in particular, draw attention to the distinction between anxiety symptoms and tension–stress symptoms. The results were interpreted as supporting the existence of syndrome-specific vulnerabilities, over and above a primary general vulnerability to emotional distress. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The multidimensional structure of perfectionism in clinically distressed and college student samples.

Confirmatory factor analysis was used to evaluate 2 multidimensional measures of perfectionism (R. 0 Frost, P. Marten, C. Lahart, & R. Rosenblate, 1990; P. L. Hewitt & G. L. Flett, 1991). On a first-order level, support was found for Hewitt and Flett's (1991) original 3-factor conceptualization of perfectionism, although only for an empirically derived 15-item subset. Support was also obtained for 5 of the 6 dimensions proposed by R. O. Frost et al. (1990), but the model only displayed good fit when a refined scale containing 22 of the original 35 items was used. A second-order analysis found evidence for 2 higher-order factors of adaptive and maladaptive perfectionism. Perfectionism dimensions correlated in expected directions with personality domains, symptom distress, and academic achievement. The brief measures of perfectionism also retained the construct-related validity displayed by the full-item versions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

State dependence and trait stability of perfectionism: A short-term longitudinal study.

The authors examined state dependency on depression, trait stability, and state-trait characteristics of perfectionism in a short-term longitudinal study of university students. Relative stability of perfectionism was assessed with test-retest correlations across 3 time points, and results showed higher rank order and relative stability for perfectionism scores compared with depression scores. Regression and path analyses to disentangle directions of effects revealed that initial maladaptive perfectionism scores remained robust predictors of later perfectionism scores, even after the authors controlled for prior and concurrent depression and other dimensions of perfectionism. Perfectionism proved to be quite stable and was a significant predictor of later depression. Perfectionism was also not meaningfully altered by state changes in depression. The overall findings indicate that perfectionism appears to have substantial relative stability, and perfectionistic discrepancy in particular is a clear vulnerability factor for depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-esteem as a mediator between perfectionism and depression: A structural equations analysis.

This study of college students (N?=?464) examined the association between adaptive and maladaptive dimensions of perfectionism and 2 mental health outcomes (self-esteem and depression). Confirmatory factor analysis was used to develop and assess the measurement model used in this study. Structural equations modeling was used to test a mediational model derived from prior theory and research. Analyses supported the existence of 2 perfectionism factors. Path models revealed that adaptive perfectionism was not directly or indirectly (through self-esteem) associated with depression. Maladaptive perfectionism was negatively associated with self-esteem and positively associated with depression. Self-esteem also buffered the effects of maladaptive perfectionism on depression. Distinguishing adaptive from maladaptive perfectionism is discussed in the context of recommendations for practice and future research. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perfectionism, attachment, and adjustment.

This research examined differences between types of perfectionists and whether perfectionism related to attachment, academic integration, and depression. University students completed the same attachment and perfectionism measures in two studies. In the 2nd study, measures of academic integration and depression were also used. Replicated cluster analyses revealed 3 groups of perfectionists: adaptive, maladaptive, and nonperfectionists. Attachment predicted type of perfectionist, with adaptive perfectionists reporting more secure attachments than did maladaptive perfectionists. Adaptive perfectionists also had better academic integration than maladaptive perfectionists. Maladaptive perfectionists, on average, reported depression in the clinically significant range. Results revealed academic and emotional benefits of adaptive perfectionism, contrasted with the adverse emotional effects and no academic advantages of maladaptive perfectionism. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Risk Factors for Course of Posttraumatic Stress Disorder Among Vietnam Veterans: A 14-Year Follow-Up of American Legionnaires.

Risk factors affecting the course of posttraumatic stress disorder (PTSD) are poorly understood. As part of a larger study on characterizing exposure to herbicides in Vietnam, the authors investigated this issue in a random sample of 1,377 American Legionnaires who had served in Southeast Asia during the Vietnam War and were followed over a 14-year period. High combat exposure, perceived negative community attitudes at homecoming, minority race, depression symptoms at Time 1, and more anger at Time 1 predicted a more chronic course. Community involvement at Time 1 was protective and associated with decreased risk at Time 2. Discomfort in disclosing Vietnam experiences was associated with an increased risk for developing PTSD but did not predict its course. Combat exposure predicted PTSD course more strongly than any other risk factor. Findings suggest recovery from PTSD is significantly influenced by perceived social support. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relation between depressive symptoms and stressful life events in a sample of disadvantaged mothers.

The bidirectional relation between life events and self-reported depression was examined across a 1-year period. With Time 1 depression controlled, Time 2 stress accounted for an additional 10% of Time 2 depressive symptoms. Health-related stress, family violence, and financial stress at Time 2 predicted Time 2 depression after control for Time 1 depression. With Time 1 stress controlled, Time 2 depression accounted for 8% of the variance in Time 2 stress. Time 2 depression predicted Time 2 health-related stress, financial stress, household changes, spouse–partner stress, family violence stress, and substance abuse stress, controlling for each of these stressors at Time 1. The results describe a complex relation between stress and depression and suggest that the relation between stress and depression is moderated by the type of stress. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Patterns of hemispheric perceptual asymmetries: Left hemispatial biases predict changes in anxiety and positive affect in undergraduate women.

Consistent with the tripartite model of anxiety and depression, hemispheric asymmetries may be differentially associated with depressive and anxious symptoms. Indeed, research has demonstrated that asymmetries do exist when examining hernispatial biases in both anxious and depressed individuals; however, the magnitude and direction of these asymmetries has been variable. The Chimeric Faces Task was used here to measure these asymmetries, along with measures for current and future levels of anxiety and depression. Results indicated that (a) increased left hemispatial biases at Time 1 predict increased anxiety (i,e., physiological hyperarousal) at Time 2 among 63 female undergraduate students (aged 18-47 yrs) and (b) decreased left hernispatial biases at Time 1 predict decreased positive affectivity at Time 2 among the same participants. The possibility that hemispatial biases represent a vulnerability to future anxiety and depression is discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Coping with Gulf War combat stress: Mediating and moderating effects.

The authors examined relationships between method of coping with combat-related stress and psychological symptoms among Gulf War Army personnel (N?=?1,058). Participants were surveyed on return from the Gulf region (Time 1) with the Coping Responses Inventory (R. Moos, 1990) and a measure of combat exposure. Outcomes were symptom measures of posttraumatic stress disorder (PTSD) and depression. At Time 2 (18–24 months) participants completed the same symptom measures and an index of postwar stress. Higher proportions of approach-based coping in the war zone were related to lower levels of psychological symptoms. Combat exposure moderated the effects of coping on Time 1 PTSD. Coping predicted changes in symptoms of depression but not PTSD. Combat exposure affected changes in depression through postwar stress but had a direct negative effect on PTSD. (PsycINFO Database Record (c) 2010 APA, all rights reserved)