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1.
Docosenoic acid from rapeseed oil or herring oil in the diet of the young rat promoted an accumulation of cardiac lipid. The
triglyceride fraction accounted for most of the deposited fat and contained a high concentration of the docosenoic acid. Liquid
rapeseed oil, partially hydrogenated rapeseed oil or partially hydrogenated herring oil increased the amount of cardiac fatty
acids at 1 week and led to the development of degenerative lesions at 16 weeks. Whale or seal oils low in C22 fatty acids produced little effect on the amount of lipids in the heart of rats or gerbils. The latter species receiving
20% rapeseed oil in the diet showed a peak in cardiac lipid deposition at 4 days with similar levels of total fatty acids
to that of rats, but with a lower concentration of erucic acid. Oil fromLimnanthes douglasii and hydrogenated herring oil also increased the amount of cardiac fatty acids in gerbils. A high intake of docosenoic acid
was common to the animals displaying the cardiac alterations.
Presented at the AOCS Meeting, Atlantic City, October 1971. 相似文献
2.
Lennart Svensson 《Lipids》1983,18(3):171-178
The influence of dietary partially hydrogenated marine oils on distribution of phospholipid fatty acids in rat liver microsomes
was studied with particular reference to the metabolism of linoleic acid. Five groups of weanling rats were fed diets containing
20% (w/w) peanut oil (PO), partially hydrogenated peanut oil (HPO), partially hydrogenated Norwegian capelin oil (HCO), partially
hydrogenated herring oil (HHO), and rapeseed oil (RSO) for 10 weeks. The partially hydrogenated oils were supplemented with
linoleic acid corresponding to 4.6 cal % in the diets. Accumulation of linoleic acid and reduced amount of total linoleic
acid metabolites were observed in liver microsomal phospholipids from rats fed partially hydrogenated oils as compared to
PO feeding. The most striking effects on the distribution of ω6-polyunsaturated fatty acids was obtained after feeding HHO,
a marine oil with a moderate content oftrans fatty acids in comparison with HPO but rich in isomers of eicosenoic and docosenoic acids. Liver microsomal Δ6-as well as Δ6-desaturase activities as measured in vitro were reduced in rats kept on HHO as compared to PO dietary treatment. The results
obtained suggest that the dietary influence of partially hydrogenated marine oils on the metabolism of linoleic acid might
be better related to the intake of isomeric eicosenoic and docosenoic acids than to the total intake oftrans fatty acids. 相似文献
3.
J. Opstvedt H. Svaar P. Hansen J. Pettersen F. T. Langmark S. M. Barlow I. F. Duthie 《Lipids》1979,14(4):356-371
A series of 4 experiments with piglets and one experiment with rats has been conducted to establish the cardiac lipid status
of weanling (3 weeks old) male animals fed fats with different contents of docosenoic fatty acids. Experimental fats were
rapeseed oil (RSO) (48.0% 22∶1), refined fish oil (RFO) (14.6% 22∶1), partially hydrogenated fish oil (PHFO) (14.3% 22∶1)
and lard (0% 22∶1) combined with sunflower seed oil (SFO) in different proportions in diets with 21% total fat. Lipidosis
could not be detected in piglets as increased heart weights, by chemical assay for myocardial contents of triglycerides, or
by accumulation of docosenoic fatty acids or nonesterified fatty acids (NEFA). In rats, diets with RSO at a level of 16% increased
myocardial triglyceride and docosenoic fatty acid contents about 7 times while the effect on cardiac NEFA was inconsistent.
Histological examinations of the hearts revealed stainable intracellular fat droplets in some piglets fed 16% RSO for 8 to
13 days, but not after 2,4 and 6 and 16, 19 and 22 days of feeding. After 10 days of feeding, mild to moderate histological
lipidosis was found in piglets fed diets containing 2% or more of 22∶1 fatty acids, with no significant difference between
RSO, RFO and PHFO in this respect. The same diets in rats gave about 5 times more histological lipidosis than in piglets.
This is attributed to a difference in species response, the rat reacting in a more pronounced manner than the piglet. The
cardiac lipidosis no-effect level in piglets corresponded to a daily intake of docosenoic fatty acids of 0.4 g per kg body
weight. Mild lipidosis was also found in a few animals on docosenoic acid-free diets. 相似文献
4.
Cardiac fatty acids were studied in young rats fed marine oils for 1 week. When the diet contained 0, 0.5, 1, 2, 4, 8 or 16%
by weight of partially hydrogenated oil from Norwegian capelin, the concentration of fatty acids in the cardiac tissue was
elevated only at the highest level. The amount of the lipid and the content of docosenoic acid in the heart were less than
those observed with 15% partially hydrogenated oil from Canadian herring. Nonhydrogenated Peruvian anchovy oil lacking docosenoic
acid produced no change in the amount of fat deposited. The extent of fatty acid accumulation in the heart was related to
the dietary C22 acids. 相似文献
5.
The aim of the present study was to investigate the influence of partially hydrogenated vegetable and marine oils on membrane
composition and function of liver microsomes and platelets with particular reference to the metabolism of linoleic acid and
the production of arachidonic acid metabolites. Four groups of male weanling rats were fed linoleic acid supplemented diets
containing 20% (w/w) of partially hydrogenated low erucic acid rapeseed oil (HLRSO), partially hydrogenated herring oil (HHO),
olive oil (OO) and trierucin + triolein (TE) for 10 weeks. An additional two groups were fed partially hydrogenated low erucic
acid rapeseed oil and partially hydrogenated herring oil without linoleic acid supplementation (HLRSO- and HHO-, respectively).
Substantial amounts oftrans fatty acids were incorporated into liver microsomes (12.6% in group HLRSO) and platelets (7.0% in group HLRSO-). This incorporation
was not dependent on the dietary linoleic acid level. Hepatic microsomal Δ5-desaturase activity was significantly increased after HLRSO feeding compared to OO feeding. Δ6-Desaturase activity did not vary in the linoleic acid supplemented groups. Both Δ5- and Δ6-desaturase activities were significantly increased in groups without linoleic acid supplementation.
Docosenoic acid was incorporated into platelet phospholipids in contrast to liver microsomes. In the platelet, docosenoic
acid seemed to have a special preference for phosphatidylserine. Very small amounts were incorporated into platelet phosphatidylinositol.
Feeding diets HLRSO, HHO and OO did not influence rat platelet cyclooxygenase or 12-lipoxygenase activity. Platelets from
rats fed TE, however, produced significantly less 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) than platelets from
rats fed OO. Feeding of HLRSO- and HHO- resulted in a significantly diminished production of the arachidonic acid metabolites
12-HETE, 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and 6-keto-prostaglandin F1α in stimulated platelets and aorta. Thus, high dietary levels oftrans isomers of monoenoic acids do not interfere with platelet cyclooxygenase or lipoxygenase activity provided sufficient amounts
of linoleic acid are available. 相似文献
6.
Metabolism of erucic acid in perfused rat liver: Increased chain shortening after feeding partially hydrogenated marine oil and rapeseed oil 总被引:1,自引:1,他引:1
E. N. Christiansen M. S. Thomassen R. Z. Christiansen H. Osmundsen K. R. Norum 《Lipids》1979,14(10):829-835
The metabolism of [14-14C] erucic acid was studied in perfused livers from rats fed on diets containing partially hydrogenated marine oil or rapeseed
oil for three days or three weeks. Control rats were given groundnut oil. Chain-shortening of erucic acid, mainly to 18∶1,
was found in all dietary groups. In the marine oil and rapeseed oil groups, the percentage of chain-shortened fatty acids
in very low density lipoproteins-triacylglycerols (VLDL-TG) exported from the liver increased after prolonged feeding. A similar
increase was found in liver TG only with partially hydrogenated marine oil. This oil, rich intrans fatty acids, thus seemed to be more effective in promoting chain-shortening. The fatty acid composition of the secreted and
stored TG differed both with respect to total fatty acids and radioactively labeled fatty acids, indicating that at least
2 different pools of TG exist in the liver. The lack of lipidosis in livers from rats fed dietary oils rich in 22∶1 fatty
acids is discussed in relation to these findings. In conclusion, a discussion is presented expressing the view that the reversal
of the acute lipidosis in the hearts of rats fed rapeseed oil or partially hydrogenated marine oils is, to a large extent,
derived from the increased chain-shortening capacity of erucic acid in liver. 相似文献
7.
K. Ilsemann Irene Reichwald K. D. Mukherjee 《European Journal of Lipid Science and Technology》1976,78(5):181-187
Effect of Hydrogenation on Stability and Nutritional Properties of Low-Erucic Rapeseed Oils Low-erucic rapeseed oils, Lesira and Erglu, were converted to more stable edible oils by selective hydrogenation of the linolenic acid moieties while retaining most of the linoleic acid groups. Feeding Lesira oil, hydrogenated Lesira oil, soybean oil and hydrogenated soybean oil to rats did not result in any appreciable differences in growth rates, whereas feeding conventional rapeseed oil caused extensive depression of growth. Among all the groups of animals the group fed conventional rapeseed oil showed the highest weights of heart and liver. The fatty acid patterns of depot and organ lipids did not show any major difference between the groups fed hydrogenated fats and those fed the corresponding unhydrogenated oils. The fatty acid composition of the organ lipids did not reveal deficiency in essential fatty acids. In the groups fed Lesira oil and hydrogenated Lesira oil half of the animals investigated exhibited myocardial lesions of light degree, probably due to the relatively high residual level of long-chain monoenoic fatty acids, whereas in the groups fed soybean oil and hydrogenated soybean oil only one-eighth of the rats examined exhibited such effects. The occurrence and severity of these myocardial lesions are known to be much higher in rats fed conventional rapeseed oils. 相似文献
8.
The influence of dietary partially hydrogenated marine oils containing docosenoic acid on rat heart mitochondrial membrane
phospholipid fatty acid composition was studied with particular reference to cardiolipin and oxidative phosphorylation. Five
groups of male weanling rats were fed diets containing 20% (w/w) peanut oil (PO), partially hydrogenated peanut oil (HPO),
partially hydrogenated Norwegian capelin oil (HCO), partially hydrogenated herring oil (HHO), and rapeseed oil (RSO) for 10
weeks. All the cardiac phospholipids investigated were influenced by the experimental diets. An increased amount of arachidonic
acid observed in phosphatidylethanolamine (PE) after feeding partially hydrogenated oils suggests a changed regulation of
the arachidonic acid metabolism in comparison with PO treatment. 22∶1 originating from the dietary oils was incorporated only
to a small extent into phosphatidylcholine (PC) and PE. A selective incorporation of 18∶1 isomers into the 1- and 2-positions
of PC and PE with respect to geometry and position of the double bond was observed. Large amounts of 18∶1trans were incorporated into the 1-position of PC and PE, irrespective of the amount of 18∶2 supplemented to the diets, replacing
a considerable proportion of stearic acid in this position. After feeding HHO and RSO, the content of 22∶1 in mitochondrial
cardiolipin of rat heart was found to be 3% (mainly cetoleic acid) and 10% (mainly erucic acid), respectively, indicating
a high affinity forcis isomers of 22∶1, but also a considerable resistance against incorporation oftrans isomers was observed. The ability of rat cardiac mitochondria to oxidize palmitoylcarnitine and to synthesize ATP was depressed
after feeding HHO and RSO. Dietarycis isomers of 22∶1 seem to have a specific ability to interfere with cardiac ATP synthesis and also to alter the fatty acid
composition of cardiolipin of rat heart. 相似文献
9.
R. G. Ackman 《Lipids》1974,9(12):1032-1035
Myocardial alterations were observed in 5 groups of rats fed diets containing 20% fat for 16 weeks. The incidence was comparable
to that from other studies and uniform at 6/20 in hearts from rats fed: partially hydrogenated herring oil to give dietary
levels of either 16.7% or 4.6% 22∶1; partially hydrogenated redfish/flatfish oil to give 4.5% 22∶1 in the dietary fat; and
peanut oil (of unknown origin) containing 0.1% 22∶1. The incidence was 9/20 in the hearts of rats fed an unrefined and unprocessed
redfish oil at a dietary level of 16.0% 22∶1 in fatty acids. 相似文献
10.
Male Sprague-Dawley rats, 3 weeks of age, were fed semisynthetic diets containing test oils at 20% by weight for 3 days, 1
week, and 16 weeks. The test oils contained up to 22.3% erucic acid. Growth retardation was evident in rats fed rapeseed oil
high in erucic acid, and soybean oil and Tower rapeseed oil diets containing about 5% erucic acid. Cardiac triglyceride accumulation
was found in rats fed diets containing about 5% erucic acid but not in rats fed Tower rapeseed oil which contains 0.2% of
this acid. The cardiac free fatty acid levels were low, 50–100 μg/g of wet heart tissue, and were not affected by feeding
diets containing about 5% erucic acid. Feeding a diet containing a high erucic acid rapeseed oil did result in higher free
fatty acid levels but only at 3 days and 1 week; the level at 16 weeks was similar to the other oils. The fatty acid analysis
of cardiac triglycerides and free fatty acids showed high percentages of erucic acid at 3 days and 1 week; at 16 weeks these
levels had declined significantly. The results indicate that the accumulated erucic and eicosenoic acids, at 3 days and 1
week, accounted for the increase in cardiac free fatty acids when rats were fed the high erucic acid rapeseed oil. There appears
to be no evidence that the early cardiac triglyceride or free fatty acid accumulation is related to the formation of the long
term myocardial lesions.
Contribution No. 739 Animal Research Institute. 相似文献
11.
The incidence of cardiac lesions in male rats fed rapeseed oil (Brassica campestris, cultivar ‘Span’) was lower with partially hydrogenated oil (iodine value 78) than with the liquid oil which had been treated
in various ways. Another rapeseed oil (Brassica napus, cultivar ‘Tower’) was similarly improved when hydrogenated to iodine value 76.6, but not at iodine value 97.1, as demonstrated
in both Sprague-Dawley and Wistar rats. The improved nutritional quality of hydrogenated oil appeared not to be related to
the decreased concentration of linolenic acid, because that fatty acid in linseed oil with or without erucic acid did not
increase the incidence of lesions. A relatively high concentration of docosahexaenoic acid in the cardiac fatty acids was
observed in adversely affected groups, but a lower concentration was found with the appropriately hydrogenated rapeseed oil.
Presented in part at the AOCS Meeting, Chicago, September 1976. 相似文献
12.
Groups of rats were fed diets containing 25% fish oil (FO), 25% soybean oil, 25% partially hydrogenated fish oil (PHFO), 25%
partially hydrogenated soybean oil (PHSO), 25% partially hydrogenated coconut oil or 0.3% clofibrate for 3 wk. After the animals
were fasted for 24 hr, hepatocytes were isolated and ketogenesis from added palmitate, linoleatecis andtrans, arachidonate and docosahexaenoate was measured. Ketogenesis after oil feeding was significantly stimulated (two-to threefold)
only in cells from the PHFO-and PHSO-fed rats. The stimulation was most apparent with the long chain unsaturated fatty acids
as substrates. These fatty acids were relatively poor ketone body precursors in control hepatocytes. Essential fatty acid
deficiency did not seem to be the reason for this stimulation. Clofibrate also stimulated ketogenesis significantly (1.5-
to 3-fold). The degree of stimulation increased with chain length and degree of unsaturation of the substrate. The activity
of the enzyme 2,4-dienoyl-CoA reductase was also studied in the same groups. Its activity was stimulated about fourfold in
the clofibrate-treated rats and to a lesser extent by the PHFO, PHSO and FO diets. The activity showed no correlation with
the content of unsaturated fatty acids in the diet or their oxidation in isolated hepatocytes. The 2,4-dienoyl-CoA reductase,
therefore, does not seem to be a regulatory enzyme in the metabolism of dietary polyunsaturated fatty acids. It is concluded
that an induction of the peroxisomal β-oxidation system most likely is involved in the reported increases in ketogenesis from
very long chain polyunsaturated fatty acids. 相似文献
13.
Heart mitochondrial oxidation of palmityl CoA and pyruvic acid was studied in rats and in the monkeyMacaca fascicularis to determine the effects of feeding partially hydrogenated herring oil. Herring oil glycerides contain cetoleic acid (cis-11-docosenoic) which could have a similar effect to erucic acid (cis-13-docosenoic) in causing a rat cardiomyopathy. The initial rat heart mitochondrial response to dietary cetoleic acid (67%cis, 33%trans) was an in vitro decrease in palmityl CoA oxidation. Prolonged feeding of cetoleic acid mixture was associated with a significant
metabolic adaptation, increasing pyruvate and palmityl CoA oxidation above control levels. In vitro addition of cetoleyl CoA
(purecis isomer) stimulated pyruvate dehydrogenase activity, a possible response to decreased β-oxidation. There was no significant
adaptive change in pyruvate or palmityl CoA use in monkeys after prolonged feeding of partially hydrogenated herring oil.
Cetoleyl CoA was a good substrate for monkey heart carnitine acyl transferase even in the presence of palmityl CoA. These
observations suggest that C22 fatty acids may be matabolized more rapidly in monkey heart than in rat heart. Metabolic differences argue against using
the rat as an experimental model for studying possible cardiotoxic effects of docosenoic acids in primates. 相似文献
14.
The back and belly fat of pigs fed a diet containing 20% by wt rapeseed oil (22% erucic acid) for 16 weeks was rendered into
oil. This rendered pig fat, which contained 5.6% erucic acid, was fed to male rats in three separate experiments at 20% by
wt of the diet for 16 weeks. In experiment I rendered pig fat was compared only toBrassica campestris var. Span rapeseed oil containing 4.8% erucic acid. In experiments II and III, rendered pig fat was compared to commerical
lard containing 0.2% docosenoic acid, commercial lard to which 5.4% free erucic acid was added, and Span rapessed oil. There
was no significant (P<0.01) differences observed in the level of erucic acid in the hearts of rats fed diets of rendered pig
fat, Span rapeseed oil, or commercial lard plus erucic acid. However, the incidence (P<0.001) and severity (P<0.01) of cardiac
lesions were significantly higher in Span rapeseed oil fed rats compared to rats fed control diets. The number of rats affected
or the severity of lesions in the rendered pig fat fed group was not significantly different from controls. The results of
this study indicate that the myocardial lesions associated with feeding 20% rapeseed oil diets are not related to the content
of erucic acid per se. The possible reasons why rapeseed oil causes cardiac lesions in rats are discussed. It is suggested
that a triglyceride imbalance in the oil might play an important role in causing these lesions in rats.
Contribution No. 585, Animal Research Institute, Agriculture Canada, Ottawa, Canada, K1A 0C6. 相似文献
15.
G. A. Nolew 《Journal of the American Oil Chemists' Society》1981,58(1):31-37
A 91-day feeding study evaluated soybean oil, rapeseed oil, fully hydrogenated soybean oil, fully hydrogenated rapeseed oil,
fully hydrogenated superglycerinated soybean oil and fully hydrogenated superglycerinated rapeseed oil at 7.5% of the diet
in rats; a 16-wk feeding study evaluated soybean oil and the three rapeseed oils or fats at 15% of the diet. Each fat was
fed to 40 rats as a mixture with soybean oil making up 20% of a semi-synthetic diet. No significant differences in body weight
gains or diet-related pathology were seen in the 91-day study although the rats fed liquid rapeseed oil had slightly heavier
hearts, kidneys and testes than the others. The rats fed the four fully hydrogenated fats ate more feed and had lower feed
efficiencies than those fed oils but no differences were seen among the four hydrogenated fats. In the 16-wk feeding study,
no pronounced pathology related to the diet was seen although the rats fed liquid rapeseed oil had a slightly higher incidence
of histiocytic infiltration of cardiac muscle than the rats in the other groups. The female rats fed the three rapeseed oil
fats gained significantly less weight and the females fed liquid rapeseed oil had enlarged hearts compared to the other groups.
The absorbabilities of the six fats were measured in the 91-day study when fed as a mixture with soybean oil and as the sole
source of dietary fat in a separate 15-day balance study. The four fully hydrogenated fats were poorly absorbed and the absorption
of behenic acid from the two hydrogenated rapeseed oils was found to be 12% and 17% in the balance study and 8-40% in the
feeding study. The adverse biological effects of unhydrogenated rapeseed oil containing erucic acid as reported in the literature
do not occur with fully hydrogenated rapeseed oil. In addition, the low absorbability of the fully hydrogenated rapeseed oil
is an added factor in its biological inertness. 相似文献
16.
The fatty acid patterns of triacylglycerols (TG) from very low density lipoprotein (VLDL) in blood plasma and liver-perfusate
from rats fed partially hydrogenated marine oil or rapeseed oil were determined. In the plasma from rats fed rapeseed oil
for three days and three weeks, there was a small but significant decrease in the percentage of 22∶1 fatty acid from 17.2
to 11.2% with length of feeding. In liver-perfusate, the comparable decrease with dietary rapeseed oil was from 18.5 to 5.2%,
and with dietary marine oil from 13.4 to 8.0%. In contrast to the liver-perfusate, the remaining liver had only a very low
22∶1 composition (ca 2%) independent of feeding period or diet. The results indicated that the liver exported the very long
chain fatty acids and that an adaptation took place after three days feeding with rapeseed oil or marine oil. This adaptation
in the liver could possibly explain why TG accumulation in hearts, which appears after three days' feeding with rapeseed oil
or marine oil, disappears after an extended feeding period. 相似文献
17.
The incorporation of dietary isomeric fatty acids into the membranes of liver mitochondria was investigated. Three groups
of rats were fed diets containing 3% sunflower seed oil plus 15%, 20%, or 25% partially hydrogenated arachis oil. A fourth
group was fed 25% partially hydrogenated arachis oil, but no sunflower seed oil. All diets were given for 3, 6, or 10 weeks.
After 10 weeks, the content oftrans fatty acids in the lipids of the mitochondrial membranes was 15–19% of the total fatty acids. The composition of thetrans- and thecis-octadecenoic acids in the lipids of the mitochondrial membranes was similar for all groups supplemented with sunflower seed
oil (SO), irrespective of time and dietary level of partially hydrogenated arachis oil (HAO). Thecis 18∶1 (n−8), which was a major isomer of the partially hydrogenated arachis oil, was almost excluded from the mitochondrial
fatty acids. Likewise, the content oftrans 18∶1 (n−8) was considerably lower in the mitochondrial lipids than in the diet. On the contrary, the content oftrans 18∶1 (n−6) was higher in the mitochondrial lipids than in the diet. In the group fed without sunflower seed oil, isomers
of linoleic acid and arachidonic acid were observed in the lipids of mitochondrial membranes.
Presented in part at the ISF Congress, Marseille, September 1976. 相似文献
18.
Partially hydrogenated marine oils containing 18∶1-, 20∶1- and 22∶1-isomers and partially hydrogenated peanut oil containing
18∶1-isomers were fed as 24–28 wt % of the diet with or without supplement of linoleic acid. Reference groups were fed peanut,
soybean, or rapeseed oils with low or high erucic acid content. Dietary monoene isomers reduced the conversion of linoleic
acid into arachidonic acid and the deposition of the latter in liver and heart phosphatidylcholine. This effect was more pronounced
for the partially hydrogenated marine oils than for the partially hydrogenated peanut oil. The content oftrans fatty acids in liver phospholipids was similar in groups fed partially hydrogenated fats. The distribution of various phospholipids
in heart and liver was unaffected by the dietary fat. The decrease in deposition of arachidonic acid in rats fed partially
hydrogenated marine oils was shown in vitro to be a consequence of lower Δ6-desaturase activity rather than an increase in
the peroxisomal β-oxidation of arachidonic acid. The lower amounts of arachidonic acid deposited may be a result of competition
in the Δ6-desaturation not only from the C22-and C20-monoenoic fatty acids originally present in the partially hydrogenated
marine oil, but also from C18- and C16-monoenes produced by peroxisomal β-oxidation of the long-chain fatty acids.
Part of this work was presented at the ISF-AOCS Congress, New York City, 1980. 相似文献
19.
Male, weanling rats were fed, for up to six weeks, corn oil (CO), rapeseed oil (RSO), partially hydrogenated fat (HF), or
a mixture of partially hydrogenated fat and corn oil (HF+CO). The respiratory activity of their isolated heart mitochondria,
their hormone-sensitive lipase activity, and the fatty acid compositions of the phospholipids of the mitochondria were determined.
The results indicated that heart mitochondria isolated from rats which had been fed corn oil (CO) had a higher rate of oxygen
uptake, showed higher respiratory control ratios, higher ADP/0 ratios and a higher rate of ATP synthesis than the heart mitochondria
isolated from those fed rapeseed oil or hydrogenated fats. The oxygen uptake rates of the rat heart mitochondria isolated
from each dietary group of rats was in order: oleyl carnitine ≫ erucyl carnitine > elaidyl carnitine. The decreased capacity
to oxidize substrate by heart mitochondria which had been isolated from the hearts of rats fed rapeseed or hydrogenated soybean
oil as compared with those fed corn oil as a sole source of dietary fat seemed related to the mitochondria lipid composition.
The type of dietary fat fed had a pronounced influence on the mitochondrial fatty acid compositions of phosphatidylcholine,
phosphatidylethanolamine, and cardiolipin. The lipase activity of the RSO-fed group did not show any increment with either
epinephrine or supplemental ATP treatment. The substrate preference for lipase activity in myocardium was corn oil-triglycerides
> trierucin > trielaidin > tripalmitin. However, cardiac lipid accumulation did not seem related to lipase activity in the
myocardium.
Taken from a thesis submitted by Chi Ming Lee Hsu in partial fulfillment of the Ph.D. degree in Food Science, University of
Illinois at Urbana-Champaign. 相似文献
20.
Male Sprague-Dawley rats, 4 weeks old, were subjected to an ambient temperature of 4 C for periods up to 24 days and fed a
synthetic diet containing one of the following oils: peanut oil (PO), rapeseed oil (RO), low erucic acid rapeseed oil (LO),
and partially hydrogenated marine oil (HO), each at 20% w/w. A parallel experiment using the same oils was performed at room
temperature (23 C). During cold stress, animals on the RO diet showed higher mortality than all other groups; all 20 animals
in this group died within 5 days. At room temperature, however, all animals survived. The lipid accumulation in the heart
reached its peak in all groups after 3 days and then gradually declined. The accumulation was most pronounced in the RO animals
and coincided with the high mortality at 4 C. The fatty acid composition of the cardiac triglycerides reflected that of the
diet, while the composition of the cardiac lecithin was only marginally modified. 相似文献