共查询到16条相似文献,搜索用时 62 毫秒
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该文以2,6-二氯吡啶为原料,用甲醇/氢氧化钠体系进行甲氧基取代,用硝酸钾/浓硫酸进行硝化反应,再用氨水氨解,制得2-氨基-3-硝基-6-甲氧基吡啶(III),最后用氯化亚锡在75℃下反应4h还原III,再用二硫化碳环化合成2-巯基-5-甲氧基咪唑并[4,5-b]吡啶,总收率为43.6%。产物结构用IR、1HNMR和MS作了表征。 相似文献
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咪唑并[1,2-b]哒嗪的合成研究 总被引:5,自引:0,他引:5
咪唑并[1,2-b]哒嗪是第四代头孢菌素——头孢唑兰的重要中间体。以3,6-二氯哒嗪为原料,经氨解得到3-氨基-6-氯哒嗪,与溴乙醛成环形成6-氯咪唑并[1,2-b]哒嗪,再在催化剂作用下氢解成咪唑并[1,2-b]哒嗪。考察了反应温度、时间、物料配比、压力、催化剂用量等反应条件对收率的影响。总收率达到41%。用熔点,核磁共振谱和元素分析对产品结构进行表征。 相似文献
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咪唑并[1,2-b]哒嗪 总被引:2,自引:0,他引:2
付春 《精细与专用化学品》2005,13(5):14-15
介绍了咪唑并[1,2-b]哒嗪的合成方法、用途、生产及需求.以3,6-二录哒嗪为原料,经氨化、环合、脱氯得咪唑并[1,2-b]哒嗪。咪唑并[1,2-b]哒嗪是合成头孢类抗生素的侧链中间体,因合成难度较大,成为国内开发头孢唑兰的瓶颈. 相似文献
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以2-氯烟酸为起始原料,经过还原、氧化、肟化及环合反应合成了标题化合物,4步反应总收率67.21%.产品经1HNMR和质谱表征.该方法具有操作简单、成本低、环境友好等优点,适合工业化生产. 相似文献
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以色酮类化合物和1,3一二取代5-氨基吡唑化合物为原料,在分子碘催化下制备一系列新颖的多取代吡唑【3,4-b】吡啶衍生物(3a-3j),收率高达85%-92%,所有化合物的结构经^1HNMR和MS等表征。 相似文献
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Ravindra Chintaman Phadke Dinesh Wamanrao Rangnekar 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》1986,36(5):230-235
Synthesis of 2-triazolylthiazolo[4,5-b]quinoxaline derivatives was achieved by diazotisation of 2-aminothiazolo[4,5-b]quinoxaline and its 6-nitro derivative using orthophosphoric acid and sodium nitrite with a trace of nitric acid, coupling with suitable aromatic amines and subsequent cyclisation of the resulting ortho amino azo compounds. Diazotisation of 2,6-diaminothiazolo[4,5-b]quinoxaline with concentrated hydrochloric acid and sodium nitrite and subsequent coupling and cyclisation resulted in the 6-triazolylthiazolo[4,5-b]quinoxaline derivatives. These compounds were applied on polyester as fluorescent disperse dyes. 相似文献
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《Journal of Sulfur Chemistry》2013,34(6):605-615
Derivatives containing the cyclohepta4′,5′thieno[2′,3′:4,5]pyrimido[1,2-b][1,2,4,5]-tetrazin-6-one system were prepared from the reaction of 3-amino-2-thioxo-1,2,3,5,6,7,8,9-octahydro-4H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-one (5) or its 2-methylthio derivative 6 with hydrazonoyl chlorides 9. The mechanism of the studied reactions has been discussed and the biological activity of the isolated products has been evaluated. 相似文献