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Marta Zaleskaya ukasz Dobrzycki Jan Romaski 《International journal of molecular sciences》2020,21(24)
A tripodal, squaramide-based ion-pair receptor 1 was synthesized in a modular fashion, and 1H NMR and UV-vis studies revealed its ability to interact more efficiently with anions with the assistance of cations. The reference tripodal anion receptor 2, lacking a crown ether unit, was found to lose the enhancement in anion binding induced by presence of cations. Besides the ability to bind anions in enhanced manner by the “single armed” ion-pair receptor 3, the lack of multiple and prearranged binding sites resulted in its much lower affinity towards anions than in the case of tripodal receptors. Unlike with receptors 2 or 3, the high affinity of 1 towards salts opens up the possibility of extracting extremely hydrophilic sulfate anions from aqueous to organic phase. The disparity in receptor 1 binding modes towards monovalent anions and divalent sulfates assures its selectivity towards sulfates over other lipophilic salts upon liquid–liquid extraction (LLE) and enables the Hofmeister bias to be overcome. By changing the extraction conditions from LLE to SLE (solid–liquid extraction), a switch of selectivity from sulfates to acetates was achieved. X-ray measurements support the ability of anion binding by cooperation of the arms of receptor 1 together with simultaneous binding of cations. 相似文献
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Pillar[n]quinones and pillar[n-m]arene[m]quinones are oxidation products of pillar[n]arenes. Their molecular structure resembles the parent compounds. However, their map of electron density is different. Each 1,4-benzoquinone ring, which replaces a 1,4-dialkoxy-substituted benzene ring decreases the electron density in the interior cavity and increases the electron density on the upper and lower rim of the pillar. The electron donor character is stepwise transformed to an electron acceptor status. This effect alters the complexation tendencies, which are the most interesting properties of these macrocyclic host systems. 相似文献
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设计合成了两个结构简单的绕丹宁衍生物,在CH_2Cl_2-DMSO混合溶剂中利用紫外-可见吸收光谱研究了其与多种阴离子的相互作用,发现它们的吸收光谱对氟离子呈现特异性变化,吸收滴定实验确认它们与氟离子间相互作用的化学计量比为1:1,~1H NMR进一步证实它们与氟离子的作用类型为氢键或脱质子作用。 相似文献
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Zoey Warmerdam Bianca E. Kamba My-Hue Le Thomas Schrader Lyle Isaacs Peter Bayer Fraser Hof 《Chembiochem : a European journal of chemical biology》2022,23(2):e202100502
Methylated free amino acids are an important class of targets for host-guest chemistry that have recognition properties distinct from those of methylated peptides and proteins. We present comparative binding studies for three different host classes that are each studied with multiple methylated arginines and lysines to determine fundamental structure-function relationships. The hosts studied are all anionic and include three calixarenes, two acyclic cucurbiturils, and two other cleft-like hosts, a clip and a tweezer. We determined the binding association constants for a panel of methylated amino acids using indicator displacement assays. The acyclic cucurbiturils display stronger binding to the methylated amino acids, and some unique patterns of selectivity. The two other cleft-like hosts follow two different trends, shallow host (clip) following similar trends to the calixarenes, and the other more closed host (tweezer) binding certain less-methylated amino acids stronger than their methylated counterparts. Molecular modelling sheds some light on the different preferences of the various hosts. The results identify hosts with new selectivities and with affinities in a range that could be useful for biomedical applications. The overall selectivity patterns are explained by a common framework that considers the geometry, depth of binding pockets, and functional group participation across all host classes. 相似文献
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合成了一种新的阴离子受体化合物PySN,通过1H NMR对其进行了表征。受体分子结合不同阴离子的紫外-可见光谱和荧光发射光谱变化表明:在非质子性溶剂中,PySN可选择性识别和传感氟离子、醋酸根及磷酸二氢根离子。 相似文献
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新型阴离子孪连表面活性剂的合成 总被引:1,自引:0,他引:1
系列长链环氧烷与不同短链二醇在75~80℃、NaH作用下合成了系列中间体孪连长链二醇,此中间体再与1,3-丙烷磺酸内酯在THF、NaH中反应得到了疏水链长度和连接基长度不同的7种磺酸盐孪连表面活性剂。核磁共振氢谱及红外光谱的结构分析证实了它们的结构。它们的表面张力为26.5~34 mN/m,临界胶束浓度为0.001~0.01 mmol/L,结果表明,它们的表面活性比相应碳链的常规表面活性剂强很多。疏水链长度和连接基长度的增长,有助于表面活性的提高。 相似文献
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将珍珠改性涤纶母粒与负离子母粒均匀混合后,通过熔融纺丝的方法制备出复合功能纤维,对其进行了灰分测试,并依据GB/T 5009—2003分析了纤维中氨基酸成分,结果显示:珍珠负离子改性涤纶中所含氨基酸种类多达18种,其中对纤维性能影响最为重要的酪氨酸质量分数为0.0012%。在室温条件下,使用空气负离子测试仪测试了复合功能纤维的负离子释放量及远红外线发射率,结果显示:该纤维负离子释放量最大值可达到6000个/cm3,远红外线发射率F(814μm)>0.88。使用扫描电子显微镜观察了珍珠改性涤纶的微观结构,可见超细珍珠粒子较均匀地分布在纤维表面,并与纤维有着紧密的结合。 相似文献
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Lindsey A. Miles Lina Ny Malgorzata Wilczynska Yue Shen Tor Ny Robert J. Parmer 《International journal of molecular sciences》2021,22(4)
The ability of cells to promote plasminogen activation on their surfaces is now well recognized, and several distinct cell surface proteins have been demonstrated to function as plasminogen receptors. Here, we review studies demonstrating that plasminogen bound to cells, in addition to plasminogen directly bound to fibrin, plays a major role in regulating fibrin surveillance. We focus on the ability of specific plasminogen receptors on eukaryotic cells to promote fibrinolysis in the in vivo setting by reviewing data obtained predominantly in murine models. Roles for distinct plasminogen receptors in fibrin surveillance in intravascular fibrinolysis, immune cell recruitment in the inflammatory response, wound healing, and lactational development are discussed. 相似文献
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Taste receptors are responsible for detecting their ligands not only in taste receptor cells (TRCs) but also in non-gustatory organs. For several decades, many research groups have accumulated evidence for such “ectopic” expression of taste receptors. More recently, some of the physiologic functions (apart from taste) of these ectopic taste receptors have been identified. Here, we summarize our current understanding of these ectopic taste receptors across multiple organs. With a particular focus on the specialized epithelial cells called tuft cells, which are now considered siblings of type II TRCs, we divide the ectopic expression of taste receptors into two categories: taste receptors in TRC-like cells outside taste buds and taste receptors with surprising ectopic expression in completely different cell types. 相似文献
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二氧化碳汽提法尿素装置高压甲铵冷凝器在壳程水侧,由于氯离子在上下管板缝隙内的富集,而导致316L不锈钢管束产生应力腐蚀SCC破裂,是长期影响大型尿素装置安稳长满优生产和设备服役寿命最重要的原因之一。本文提出一种全新的电化学腐蚀控制方法使得人们有可能在不改变设备工艺参数和设备结构,不花许多钱,不费许多时间的前提下,从根本上控制这种应力腐蚀破裂的发生与发展。 相似文献
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Host-guest binding of anions in organic solvents may find attractive applications in ion sensing and transport, if the host can extract the negatively charged guest species from its solvation sphere. The most powerful means to dismantle the anionic guest from solvent molecules that is required for selective binding is to provide positive charges in the host compound. They have to be counterbalanced by negatively charged subsites in order to conserve electroneutrality, but must avoid collapse into ion pairing with the cationic sites. According to this concept the cage compound 3 was constructed by attachment of anionic tetraphenylborate moieties to the parent macrotricyclic amine 1 . The betainic product 3 was shown to be soluble in water-immiscible dipolar organic solvents like propylene carbonate and formed inclusion complexes with chloride and bromide in the gas phase as well as in solution. 相似文献
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介绍了树脂法去除工业盐酸中铁及重金属离子的新工艺,讨论了阴离子交换树脂的工业盐到中除铁的工艺及参数。 相似文献