A Versatile Theranostic Nanoemulsion for Architecture‐Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy

To design a clinically translatable nanomedicine for photodynamic theranostics, the ingredients should be carefully considered. A high content of nanocarriers may cause extra toxicity in metabolism, and multiple theranostic agents would complicate the preparation process. These issues would be of less concern if the nanocarrier itself has most of the theranostic functions. In this work, a poly(ethylene glycol)‐boron dipyrromethene amphiphile (PEG‐F₅₄‐BODIPY) with 54 fluorine‐19 (¹⁹F) is synthesized and employed to emulsify perfluorohexane (PFH) into a theranostic nanoemulsion (PFH@PEG‐F₅₄‐BODIPY). The as‐prepared PFH@PEG‐F₅₄‐BODIPY can perform architecture‐dependent fluorescence/photoacoustic/¹⁹F magnetic resonance multimodal imaging, providing more information about the in vivo structure evolution of nanomedicine. Importantly, this nanoemulsion significantly enhances the therapeutic effect of BODIPY through both the high oxygen dissolving capability and less self‐quenching of BODIPY molecules. More interestingly, PFH@PEG‐F₅₄‐BODIPY shows high level of tumor accumulation and long tumor retention time, allowing a repeated light irradiation after a single‐dose intravenous injection. The “all‐in‐one” photodynamic theranostic nanoemulsion has simple composition, remarkable theranostic efficacy, and novel treatment pattern, and thus presents an intriguing avenue to developing clinically translatable theranostic agents.     

Input-to-state learning of recurrent neural networks with delay and disturbance

This article deals with the issue of input-to-state stabilization for recurrent neural networks with delay and external disturbance. The goal is to design a suitable weight-learning law to make the considered network input-to-state stable with a predefined -gain. Based on the solution of linear matrix inequalities, two schemes for the desired learning law are presented via using decay-rate-dependent and decay-rate-independent Lyapunov functionals, respectively. It is shown that, in the absence of external disturbance, the proposed learning law also guarantees the exponential stability of the network. To illustrate the applicability of the present weight-learning law, two numerical examples with simulations are given.     

Plasmonic coupling-enhanced in situ photothermal nanoreactor with shape selective catalysis for C-C coupling reaction

Carbon-carbon (C-C) coupling reactions represent one of the most powerful tools for the synthesis of complex natural products, bioactive molecules developed as drugs and agrochemicals. In this work, a multifunctional nanoreactor for C-C coupling reaction was successfully fabricated via encapsulating the core-shell Cu@Ni nanocubes into ZIF-8 (Cu@Ni@ZIF-8). In this nanoreactor, Ni shell of the core-shell Cu@Ni nanocubes was the catalytical active center, and Cu core was in situ heating source for the catalyst by absorbing the visible light. Moreover, benefiting from the plasmonic resonance effect between Cu@Ni nanocubes encapsulated in ZIF-8, the absorption range of nanoreactor was widened and the utilization rate of visible light was enhanced. Most importantly, the microporous structure of ZIF-8 provided shape-selective of reactant. This composite was used for the highly shape-selective and stable photocatalysed C-C coupling reaction of boric acid under visible light irradiation. After five cycles, the nanoreactor still remained high catalytical activity. This Cu@Ni@ZIF-8 nanoreactor opens a way for photocatalytic C-C coupling reactions with shape-selectivity.

     

三级连续碳化法生产纳米碳酸钙新工艺研究

采用有效容积依次递增的预塔、中塔、后塔三个碳化塔串联,塔内气液连续逆流操作、塔间气液连续并流或错流操作,严格控制氢氧化钙浆液的浓度、流量、温度和碳化气的浓度、流量,并通过pH计或电导仪进行跟踪检测碳化度,可实现纳米碳酸钙生产工艺连续化、产品质量稳定化、产量规模化.     

深基坑挡土支护钻孔灌注桩设计方法

在高层建筑深基坑挡土支护中，用锚杆拉结钻孔灌注桩作挡土墙是近年来应用的主要方法之一。以烟台龙睛大厦深基坑挡土支护为例，介绍了用锚杆拉结的钻孔灌注桩设计方法。     

基于体积配比原理的乳化液自动配比装置

根据乳化液的人工配置存在的配比浓度不稳定,常常达不到《煤矿安全规程》规定的3%~5%的要求,介绍了一种基于体积配比原理的乳化液自动配比装置,该装置配置的乳化液浓度不仅达到了《煤矿安全规程》规定的浓度,而且配比浓度稳定且配置的乳化液高度清洁,完全达到了煤矿技术要求。     

部分国家能源战略及对我国的启示

本文通过对美国、日本、英国、俄罗斯、伊朗、印尼的能源发展对比分析，分别归纳出了发达国家、资源大国、发展中国家在新时期的能源战略特点，并对我国未来一段时间能源战略提出了相关建议。     

工程塑料系列泵的设计及在矿山等行业的应用

介绍了可输送含颗粒介质的HTB型、大流量工程塑料泵的材质、水力模型、压制、轴封结构研制设计，及在矿山等行业中的应用。