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Electroporation creates aqueous pathways by short high-voltage pulses resulting in a transient perme- abilization of stratum corneum and an increase in the transdermal delivery rate.However the aqueous pathways will reseal after pulsing,which leads to the rapid drop of transdermal flux.In the present study,the surfactants were added to the donor solution to hinder the shrinkage and resealing of the electropore,and to prolong the lifetime of the aqueous pathways with the consideration that the surfactants could reduce the surface energy of the electropore. These effects of surfactants were demonstrated by the dynamic electrical resistance of the skin and the fluorescent imaging of the local transport regions.Piroxicam(PIX)was transported percutaneously in the presence of surfactants in vitro.Owing to the longer lifetime of aqueous pathways,together with the promotion of PIX availability at the barrier exterior and the improvement in the partition of PIX into the aqueous pathways,the presence of surfactants led to a remarkable increase in the transdermal delivery rate during electroporation and a significant growth of the accumulative transdermal amount of PIX. 相似文献
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本文开发了一种新型微孔膜气体分布器,并对使用该分布器时鼓泡塔反应器内气液传质性能进行了研究。实验结果表明,使用这种新型膜气体分布器可以得到细小均匀的气泡,较大幅度地增大了气液传质比表面积,从而大大强化了反应器的传质能力。 相似文献
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膜反应器及其在生物工程中的应用 总被引:3,自引:0,他引:3
本文对膜反应器的研究现状及其在生物工程中的应用进行了评述,并就各类膜反应器存在的主要问题和研究方向作了讨论。 相似文献
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多孔催化剂有效系数的计算,无论在催化剂工程设计的理论研究中还是在实际应用中,都是十分重要的。近二十年来,人们用各种不同的方法求解催化剂的有效系数。这方面的情况,我们已经在另一篇文章中进行过综述,本文不再详述。本文引入等效温度的概念,从物理上寻求催化剂有效系数的近似解析解。我们曾在以前几篇文章中谈到了利用等效温度法计算球催化剂的有效系数、本文则是将等效温度法应用于园柱形催化剂的有效系数的计算,并将n=0.5,n=1.5,n=2.0,n=2.5等四种情况下所获得的计算结果与计算机数值解进行了比较。结果表明,利用等效温度法求解催化剂的有效系数不仅大大简化了计算过程,而且计算的精度也比较高。 相似文献
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