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排序方式: 共有260条查询结果,搜索用时 15 毫秒
1.
Number of software applications demands various levels of security at the time of scheduling in Computational Grid. Grid may offer these securities but may result in the performance degradation due to overhead in offering the desired security. Scheduling performance in a Grid is affected by the heterogeneities of security and computational power of resources. Customized Genetic Algorithms have been effectively used for solving complex optimization problems (NP Hard) and various heuristics have been suggested for solving Multi-objective optimization problems. In this paper a security driven, elitist non-dominated sorting genetic algorithm, Optimal Security with Optimal Overhead Scheduling (OSO2S), based on NSGA-II, is proposed. The model considers dual objectives of minimizing the security overhead and maximizing the total security achieved. Simulation results exhibit that the proposed algorithm delivers improved makespan and lesser security overhead in comparison to other such algorithms viz. MinMin, MaxMin, SPMinMin, SPMaxMin and SDSG. 相似文献
2.
Ashley Lui Robert Sparks Rekha Patel Niketa A. Patel 《International journal of molecular sciences》2021,22(3)
Type 2 diabetes mellitus is a metabolic disorder defined by systemic insulin resistance. Insulin resistance in adipocytes, an important regulator of glucose metabolism, results in impaired glucose uptake. The trafficking protein, sortilin, regulates major glucose transporter 4 (Glut4) movement, thereby promoting glucose uptake in adipocytes. Here, we demonstrate the presence of an alternatively spliced sortilin variant (Sort17b), whose levels increase with insulin resistance in mouse 3T3L1 adipocytes. Using a splicing minigene, we show that inclusion of alternative exon 17b results in the expression of Sort17b splice variant. Bioinformatic analysis indicated a novel intrinsic disorder region (IDR) encoded by exon 17b of Sort17b. Root mean square deviation (RMSD) and root mean square fluctuation (RMSF) measurements using molecular dynamics demonstrated increased flexibility of the protein backbone within the IDR. Using protein–protein docking and co-immunoprecipitation assays, we show robust binding of Glut4 to Sort17b. Further, results demonstrate that over-expression of Sort17b correlates with reduced Glut4 translocation and decreased glucose uptake in adipocytes. The study demonstrates that insulin resistance in 3T3L1 adipocytes promotes expression of a novel sortilin splice variant with thus far unknown implications in glucose metabolism. This knowledge may be used to develop therapeutics targeting sortilin variants in the management of type 2 diabetes and metabolic syndrome. 相似文献
3.
The kinetics of colour (measured as Hunter ‘a’ value) degradation in tomato puree (Lycopersicon esculentum L.) has been studied over a temperature range of 50–120 °C (isothermal condition), and also during normal open pan cooking,
pressure cooking and cooking in a newly developed and patented fuel-efficient ‘EcoCooker’ (non-isothermal condition). The
degradation of colour as measured by Hunter ‘a’ value was found to follow first order kinetics. The temperature dependence of degradation was adequately modelled by Arrhenius
equation. A mathematical model has been developed using the isothermal parameters obtained to predict correctly the losses
of red colour from the time–temperature data of non-isothermal heating/processing method. The results obtained indicate a
colour degradation of similar magnitude in all the three modes of cooking used in the study. 相似文献
4.
Vinay Singh K. Uvanesh Rashmi Rekha Behera Samrat Baruah Tarun Agarwal Indranil Banerjee 《Polymer-Plastics Technology and Engineering》2016,55(9):879-888
This study discusses about the effect of polysaccharides (agar, gum tragacanth, and guar gum) on the properties of the core (organogel)–shell [poly(vinyl alcohol)] microparticles. The size, swelling, and mucoadhesive properties of the poly(vinyl alcohol) microparticles were altered in the presence of the polysaccharides. Thermal analysis confirmed the presence of organogels within the microparticles. Fourier transform infrared spectroscopy confirmed the presence of the polysaccharides within the microparticles. The microparticles were biocompatible in nature. Drug release indicated that an alteration in the shell composition can be used for altering drug release. Ciprofloxacin-loaded microparticles showed sufficient antimicrobial efficiency. 相似文献
5.
Rekha Agrawal Jyoti Shah Govind Gupta Ritu Srivastava Chhemendra Sharma Ravinder Kotnala 《应用聚合物科学杂志》2020,137(48):49566
A facile and eco-friendly synthesis of polypyrrole from monomer pyrrole using nominal amount of ferric chloride hexahydrate (FeCl3.6H2O) oxidant in aqueous solution by chemically oxidative polymerization method has been reported. The use of aqueous solvent and ferric chloride hexahydrate salt in polypyrrole synthesis have an eco-friendly route favorable for the production of polypyrrole in large quantities. The synthesized polypyrrole samples exhibit good electrical conductivity (2 S/cm) and yield of 80% for reaction time of 8 hr at 5°C. Quality and properties of polypyrrole samples have been thoroughly investigated with varying reaction time and temperature while other synthesis parameters like molar ratio of oxidant to monomer, oxidant concentration, and solvent were kept constant. X-ray diffraction analysis of polypyrrole with a shorter reaction time shows the presence of iron oxide (Fe2O3) peaks. The complete reaction may not occur at shorter reaction times due to which residual ferric ions converted into Fe2O3. X-ray photoelectron spectroscopy measurement of polypyrrole also confirms the formation of Fe2O3. Appropriate selection of reaction time and temperature produced pure phase polypyrrole with high yield and good conductivity. Synthesized polypyrrole by our eco-friendly and cost-effective technique exhibits prominent electromagnetic shielding effectiveness value of 30 dB in the X-band (8–12 GHz). 相似文献
6.
M. Rekha H.R. Manjunath N. Nagaraju 《Journal of Industrial and Engineering Chemistry》2013,19(1):337-346
Mn/Al2O3 and Mn/ZrO2 were prepared by precipitation method. Their catalytic activity was investigated in the synthesis of biologically important bis(indolyl)methanes via, a condensation reaction between an indole and different aldehydes. The materials exhibited excellent catalytic activity (TOF in the range 180–380 h?1) and produced the expected product in good yield and selectivity. Isolation of product from the reaction mixture was simple and neat. The catalysts were found to be recyclable and used up to five cycles without any loss in their catalytic activity. Mn/ZrO2 was also found to be a better catalyst than Mn/Al2O3 in terms of isolated yield of the product and recyclability. Mn/ZrO2 catalyst was found to be selective for aldehydes and not for ketones. In order to investigate the relationship between the catalytic activity and physico-chemical properties, Mn/Al2O3 and Mn/ZrO2 were characterized for their surface and bulk properties by PXRD, BET, TPD-NH3 and SEM techniques. A good correlation between the catalytic activity of the materials and the concentration of the acid sites with intermediate strength was observed. Mn/ZrO2 exhibited rod like structure. This material was found to be a general catalyst for the synthesis of a number of bis(indolyl)methane derivatives with good yield and selectivity. 相似文献
7.
Puffing or popping is a common method of processingAmaranthus cruentus (Syn.Amaranthus paniculatus L. or Rajgeera) grain. Investigations into the effect of this processing treatment have shown the percent unsaturation in
the oil to decrease from 75.5% to 62.3%. The maximum effect is on linoleic acid, the quantity of which decreased sharply from
46.8% to 27.0%. Squalene also increased by 15.5%, due to puffing of amaranth seeds. 相似文献
8.
Sandip B. Bankar Mahesh V. Bule Rekha S. Singhal Laxmi Ananthanarayan 《Food and Bioprocess Technology》2009,2(4):344-352
A number of nutritional factors influencing glucose oxidase (EC 1.1.3.4) production by Aspergillus niger NCIM 545 were studied. The synthesis of glucose oxidase by A. niger was investigated in two steps using submerged fermentation at 30 ± 2 °C and 180 rpm for 96 h. Primarily, nutritional components
were selected by one-factor-at-a-time method, and the significance of each component with respect to glucose oxidase production
was identified by Plackett–Burman design (seven variables including six nutritional viz. sucrose, sodium nitrate, peptone,
calcium carbonate, magnesium sulfate, and potassium dihydrogen phosphate, and one dummy or unassigned variable were studied
with eight experiments). In the second step, concentration of most significant factors and their interaction were studied
with response surface methodology (central composite design). Each variable in the design was studied at five different levels,
with all variables taken at a central coded value of zero. Considerable amount of glucose oxidase was produced from A. niger species with sucrose as the carbon source, sodium nitrate as the inorganic nitrogen source, and peptone as the organic nitrogen
source. Glucose oxidase activity increased remarkably by 28.93 fold (from 0.00993 to 0.29 U ml−1) with CaCO3-supplemented media. The outcome of Plackett–Burman design showed CaCO3, peptone, and MgSO4 as significant parameters. Further optimization using a three-factor central composite design with 20 experiments increased
yield of glucose oxidase from 0.29 to 2.05 U ml−1 (sevenfold) with a decrease in cultivation time from 96 to 72 h. 相似文献
9.
10.
Tumor Cell Phenotyping: Circulating Tumor Cell Phenotyping via High‐Throughput Acoustic Separation (Small 32/2018)
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