Windowing Design Method for Polynomial-Based Interpolation Filters

An efficient implementation for finding digitally the interpolated samples is the Farrow structure. It mimics digitally a hybrid system where a continuous-time (CT) signal is reconstructed using an analog reconstruction filter having a piecewise-polynomial impulse response. The interpolated samples are obtained by sampling reconstructed signal. This paper introduces a generalized design method for polynomial-based interpolation filters and Farrow structure. The proposed method also can be used to calculate the coefficients of Selva interpolator. In this approach, the ideal CT impulse response is truncated by using CT window functions. The obtained windowed impulse response is then approximated using the piecewise Taylor polynomial approximation. Length of the impulse response and degree of the approximating polynomial can be arbitrarily selected, and in this way the transition band width can be controlled. However, if CT fixed-window functions are used, the stopband attenuation is determined by window type and remains approximately constant with increase of length and order of the impulse response. The stopband attenuation can be controlled by using CT dynamic windows such as Kaiser window. The presented windowing design method is an effective tool for calculation of the Farrow structure coefficients, with filter performance that is comparable to the frequency domain design.     

Synthesis and characterization of monetite and hydroxyapatite whiskers obtained by a hydrothermal method

High temperature hydrothermal syntheses, using calcium nitrate tetrahydrate, sodium dihydrogen phosphate and urea as precursors, and characterization of hydroxyapatite (HAp) whiskers are reported herein. The morphology and chemical composition of the crystals from a monetite to a hydroxyapatite phase were controlled by varying the starting concentrations of the precursors and the solution pH through the amount of urea that is decomposed during heating. X-ray diffraction (XRD) analysis, infrared spectroscopy (IR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM) and high-resolution TEM (HRTEM) were used to investigate the products of the syntheses in order to find the optimum reaction conditions for obtaining the desired morphology and phase composition. Different morphologies ranging from single crystals of monetite through rods and plates of hydroxyapatite with different size distribution to whisker-like single hydroxyapatite crystal were achieved by simply varying the starting concentration of urea. Structural refinement of the hydroxyapatite whiskers confirmed a strong preferential orientation along the c-axis direction of the hexagonal crystal structure, which was significantly different from the usually observed random crystal orientation. TEM and SEM analysis of the apatite whiskers confirmed single crystal structure with the a c-axis orientation parallel to the long axis of the whiskers, with sizes up to 150 μm in length, 10 μm in width and with a thickness of about 300 nm, that grew from the same centre of nucleation, forming flaky-like particles.     

Anticancer Potential of (Pentamethylcyclopentadienyl)chloridoiridium(III) Complexes Bearing κP and κP,κS‐Coordinated Ph2PCH2CH2CH2S(O)xPh (x=0–2) Ligands

Iridium(III) complexes of the type [Ir(η⁵‐C₅Me₅)Cl₂{Ph₂PCH₂CH₂CH₂S(O)_xPh‐κP}] (x=0–2; 1 – 3 ) and [Ir(η⁵‐C₅Me₅)Cl{Ph₂PCH₂CH₂CH₂S(O)_xPh‐κP,κS}][PF₆] (x=0–1; 4 and 5 ) with 3‐(diphenylphosphino)propyl phenyl sulfide, sulfoxide, and sulfone ligands Ph₂PCH₂CH₂CH₂S(O)_xPh were designed, synthesized, and characterized fully, including X‐ray diffraction analyses for complexes 3 and 4 . In vitro studies against human thyroid carcinoma (8505C), submandibular carcinoma (A253), breast adenocarcinoma (MCF‐7), colon adenocarcinoma (SW480), and melanoma (518A2) cell lines provided evidence for the high biological potential of the neutral and cationic iridium(III) complexes. Neutral iridium(III) complex 5 proved to be the most active, with IC₅₀ values up to about 0.1 μM , representing activities of up to one order of magnitude higher than cisplatin. Using 8505C cells, apoptosis was shown to be the main mechanism through which complex 5 exerts its tumoricidal action. The described iridium(III) complexes represent potential leads in the search for novel metal‐based anticancer agents.     

The effect of lignin on the structure and characteristics of composite coatings electrodeposited on titanium

Composite coatings based on lignin, obtained by electrophoretic deposition (EPD) on titanium, were investigated. The aim of this work was to produce hydroxyapatite/lignin (HAP/Lig) coatings on titanium and to investigate the effect of the lignin concentration on microstructure, morphology, phase composition, thermal behavior and cytotoxicity of the HAP/Lig coatings. An organosolv lignin was used for the production of the composite coatings studied in this research. The properties of HAP/Lig coatings were characterized using X-ray diffraction (XRD) analysis, scanning electron microscopy (SEM), thermogravimetric analysis (TGA), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR) and X-ray photoelectron spectroscopy (XPS), as well as the MTT test of cytotoxicity. The results showed that higher lignin concentrations protected the HAP lattice during sintering, thereby improving the stability of the HAP/Lig coatings. The cell survival of peripheral blood mononuclear cells (PBMC) after proliferation indicates that the HAP/Lig coating with 1 wt% Lig electrodeposited on titanium was non-toxic with significant promise as a potential bone-repair material.     

Shear bond strength to dentine of dental adhesives containing hydroxyapatite nano-fillers

The aim of this study was to compare the effect of hydroxyapatite (HAP) nano-rods (HAP_rods) and HAP nano-sticks (HAP_sticks) added to commercial adhesives on the macro-shear bond strength (SBS) to dentine and morphology of the adhesive–dentine interface. HAP was added to Single Bond Universal (SBU, 3M ESPE) and Te-Econom Bond (TeE; Ivoclar Vivadent), in the form of water suspensions to avoid agglomeration of nano-particles and to achieve HAP concentrations of 0.5, 1.0 and 1.5 wt%. Following a ‘total-etch’ or a ‘self-etch’ protocol, the adhesives were applied to flat dentine surface of 162 intact human, third molars (N = 6/group). Composite (Z250, 3M ESPE) was built-up using a split stainless steel mould, 3 mm in diameter. SBS was tested using a universal testing machine at 1 mm/min until fracture. Data were statistically analysed using two-way and one-way analysis of variance with Tukey’s post-test (α = 0.05). HAP_rods had no significant effect on SBS of the tested adhesives while HAP_sticks improved bond strength to dentine only of adhesives applied following the ‘total-etch’ total-etch protocol. SBS values of SBU containing 1% HAP_sticks (15.10 ± 2.96 MPa) and TeE containing 0.5% HAP_sticks applied following the total-etch protocol (12.96 ± 4.48 MPa) were higher than those of their respective control groups (10.36 ± 2.68 and 7.97 ± 3.64 MPa). Samples with higher SBS showed more ‘mixed’ failures. HAP nano-fillers may improve bond strength of total-etch adhesives without an adverse effect on adhesive dispersion on dentine and its ability to infiltrate dentinal tubules.     

The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders

Autism Spectrum Disorder (ASD) is a set of neurodevelopmental disorders characterised by behavioural impairment and deficiencies in social interaction and communication. A recent study estimated that 1 in 89 children have developed some form of ASD in European countries. Moreover, there is no specific treatment and since ASD is not a single clinical entity, the identification of molecular biomarkers for diagnosis remains challenging. Besides behavioural deficiencies, individuals with ASD often develop comorbid medical conditions including intestinal problems, which may reflect aberrations in the bidirectional communication between the brain and the gut. The impact of faecal microbial composition in brain development and behavioural functions has been repeatedly linked to ASD, as well as changes in the metabolic profile of individuals affected by ASD. Since metabolism is one of the major drivers of microbiome–host interactions, this review aims to report emerging literature showing shifts in gut microbiota metabolic function in ASD. Additionally, we discuss how these changes may be involved in and/or perpetuate ASD pathology. These valuable insights can help us to better comprehend ASD pathogenesis and may provide relevant biomarkers for improving diagnosis and identifying new therapeutic targets.     

Distortion Minimization: A Framework for the Design of Plane Geometric Anamorphosis

Anamorphosis, as a drawing, represents shapes on a surface such that they appear in their natural form only under specific viewing conditions. Although anamorphoses are mainly studied in a historical context, they are currently experiencing a revival. Plane geometric anamorphoses are a specific sub-type of anamorphic drawings. Some practical problems may arise during the design and realization of plane geometric anamorphosis causing the 3D illusionistic effect to be impaired. The aim of this paper is to identify and analyze these problems. In the paper we use parametric analysis to quantify the distortion that may appear because the point of view is offset from the preferred point of view, and to simulate the deviations that can appear because of the errors in onsite realization. The analysis leads to a framework for the design of plane geometric anamorphosis that minimizes the impairment of the anamorphic illusion.     

CAD based shape optimization for gas turbine component design

In order to improve product characteristics, engineering design makes increasing use of Robust Design and Multidisciplinary Design Optimisation. Common to both methodologies is the need to vary the object’s shape and to assess the resulting change in performance, both executed within an automatic loop. This shape change can be realised by modifying the parameter values of a suitably parameterised Computer Aided Design (CAD) model. This paper presents the adopted methodology and the achieved results when performing optimisation of a gas turbine disk. Our approach to hierarchical modelling employing design tables is presented, with methods to ensure satisfactory geometry variation by commercial CAD systems. The conducted studies included stochastic and probabilistic design optimisation. To solve the multi-objective optimisation problem, a Pareto optimum criterion was used. The results demonstrate that CAD centric approach enables significant progress towards automating the entire process while achieving a higher quality product with the reduced susceptibility to manufacturing imperfections.     

An investigation of the usability of image-based CAPTCHAs using PROMETHEE-GAIA method

Multimedia Tools and Applications - Today, it is difficult to find an adequate Web site with a registration form that is not protected with some automated human proof test. One of the oldest...     

Fast and accurate NURBS fitting for reverse engineering

Fast and accurate fitting of non-uniform rational B-spline (NURBS) curves and surfaces through large sets of measured data is an important problem in applications such as reverse engineering and geometric modelling. This paper presents a method for realising significant improvements in the computational efficiency of this task. The basic idea is that the sparsity structures of the relevant matrices that are specific to the problem of NURBS fitting can be precisely defined and that full exploitation of these structures leads to significant savings in both computational and storage requirements. These savings allow for a large number of control points to be used in order to define the surface and consequently to improve the accuracy of shape representation. The achieved computational complexity is linear in both the number of measured points and the number of control points while the storage requirements of the algorithm are linear with the number of control points only. The complexity analysis, as well as the analysis of actual running times is presented. The results demonstrate that, using this approach, highly complex shapes may be modelled accurately with a single NURBS surface.