A Versatile Theranostic Nanoemulsion for Architecture‐Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy

To design a clinically translatable nanomedicine for photodynamic theranostics, the ingredients should be carefully considered. A high content of nanocarriers may cause extra toxicity in metabolism, and multiple theranostic agents would complicate the preparation process. These issues would be of less concern if the nanocarrier itself has most of the theranostic functions. In this work, a poly(ethylene glycol)‐boron dipyrromethene amphiphile (PEG‐F₅₄‐BODIPY) with 54 fluorine‐19 (¹⁹F) is synthesized and employed to emulsify perfluorohexane (PFH) into a theranostic nanoemulsion (PFH@PEG‐F₅₄‐BODIPY). The as‐prepared PFH@PEG‐F₅₄‐BODIPY can perform architecture‐dependent fluorescence/photoacoustic/¹⁹F magnetic resonance multimodal imaging, providing more information about the in vivo structure evolution of nanomedicine. Importantly, this nanoemulsion significantly enhances the therapeutic effect of BODIPY through both the high oxygen dissolving capability and less self‐quenching of BODIPY molecules. More interestingly, PFH@PEG‐F₅₄‐BODIPY shows high level of tumor accumulation and long tumor retention time, allowing a repeated light irradiation after a single‐dose intravenous injection. The “all‐in‐one” photodynamic theranostic nanoemulsion has simple composition, remarkable theranostic efficacy, and novel treatment pattern, and thus presents an intriguing avenue to developing clinically translatable theranostic agents.     

Tunable passively Q-switched thulium doped fluoride fibre (TDFF) laser using reduced graphene oxide-silver (rGO-Ag) as saturable absorber

A tunable, passively Q-switched thulium doped fluoride fibre (TDFF) laser using a reduced-graphene oxide-silver (rGO-Ag) thin film as a saturable absorber (SA) for S band operation is proposed and its efficacy demonstrated. Over a pump power range of 91.4?mW up to 158.6?mW, passively generated Q-switched pulses are observed with repetition rates from 20 to 34.5?kHz and pulse widths from 3.1 to 7.1?µs. The highest pulse energy observed is 101.2?nJ with a signal to noise ratio of ～42?dB. The proposed laser has a tuning range ～52?nm from 1458 to 1510?nm with a tunable bandpass filter (TBPF) introduced into the cavity.     

The analysis for morphological evolution and crystallography of degenerate pearlite in 100Mn13 steel

During approximate 773 K aging treatment of 100Mn13 steel, degenerate pearlite will occur and evolve into lamellar pearlite during growth process. The microstructures of degenerate pearlite and its evolutionary lamellar pearlite are observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The results show that after 748 K, 773 K and 798 K aging, degenerate pearlites occur at grain boundary. At growth front of degenerate pearlite forming at 773 K and 798 K, pearlite presents a morphology of short lamellae of carbide and ferrite, indicating a trend of developing into lamellar pearlite. The higher the temperature is, the more obvious the trend is, and even a conventional lamellar pearlite has developed. However, there is no morphological evolution for degenerate pearlite forming at 748 K aging. Besides, the constituents of degenerate pearlite is identified as M₂₃C₆ and ferrite, and Kurdjumov-Sachs orientation relationship exists between them, (01 )_α//( 1 )_M23C6, [111]_α//[110]_M23C6. This orientation relationship maintains in morphological evolution from degenerate pearlite to lamellar pearlite.     

An evaluation of Acacia mearnsii tannin as an aluminum corrosion inhibitor in acid,alkaline, and neutral media

The electrochemical behavior of aluminum in tannin from Acacia mearnsii bark was evaluated by potentiodynamic polarization curves and electrochemical impedance spectroscopy (EIS) in media under three different pH conditions: acid, alkaline, and neutral. A relationship among pH, polymerization grade (PG), zeta potential, surface, and electrochemical properties was observed in the inhibition performance of the tannin. At high pH, the oligomer structure of the tannin was affected, resulting in a low PG (4) and high zeta potential (−75 mV), and consequently, the inhibition efficiency decreased (68%) in comparison with that in acid (99%) and neutral media (96%). The values obtained indicate a physisorption mechanism for the aluminum corrosion inhibition in the studied conditions.     

深基坑挡土支护钻孔灌注桩设计方法

在高层建筑深基坑挡土支护中，用锚杆拉结钻孔灌注桩作挡土墙是近年来应用的主要方法之一。以烟台龙睛大厦深基坑挡土支护为例，介绍了用锚杆拉结的钻孔灌注桩设计方法。     

基于体积配比原理的乳化液自动配比装置

根据乳化液的人工配置存在的配比浓度不稳定,常常达不到《煤矿安全规程》规定的3%~5%的要求,介绍了一种基于体积配比原理的乳化液自动配比装置,该装置配置的乳化液浓度不仅达到了《煤矿安全规程》规定的浓度,而且配比浓度稳定且配置的乳化液高度清洁,完全达到了煤矿技术要求。     

部分国家能源战略及对我国的启示

本文通过对美国、日本、英国、俄罗斯、伊朗、印尼的能源发展对比分析，分别归纳出了发达国家、资源大国、发展中国家在新时期的能源战略特点，并对我国未来一段时间能源战略提出了相关建议。     

工程塑料系列泵的设计及在矿山等行业的应用

介绍了可输送含颗粒介质的HTB型、大流量工程塑料泵的材质、水力模型、压制、轴封结构研制设计，及在矿山等行业中的应用。     

煤炭企业仓库管理中存在的问题及对策

对煤炭企业仓库管理中存在计划管理准确性预见性不强,物资储备不够合理;估价入账太多,人员业务水平有待提高,库房办公条件有待改善,提出了提高计划的准确性,合理储备物资,调整库存结构,做好估价工作,提高人员素质和业务水平,改善办公条件,办公室与库房分开的改进方法及对策。     

山西"德元府"品牌下的产品战略--推出"德元府"地特产品品牌战略研究之三

用全新的理念，分析、策划了在山西“德元府”强大品牌下粗杂粮食品、醋业、乳业、豆制品、食用油、干鲜果、调味品、纯净水系列产品族中，从产品开发、生产到价格、包装、服务等方面的产品战略。