Solar ultraviolet irradiation of human cornea, lens, and retina: equations of ocular irradiation

Photochemical damage of ocular tissues by solar radiation depends on the spectral composition of the radiation in the environment, the geometry of the coupling of that radiation to the eye, the spectral transmittances of the ocular components and any auxiliary lenses used, the spectral sensitivity of the irradiated tissue, the accumulated exposure dose, and the action of repair processes. This paper provides formulas for quantitative estimation of corneal, lenticular, and retinal UV irradiances from the sunlit environment under clear sky conditions. Applications of these formulas for ocular irradiation will be presented in subsequent papers for the cornea, lens, and retina, and the results will be evaluated using weighting functions for the sensitivity of ocular tissue.     

Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response

We describe an automated method to locate and outline blood vessels in images of the ocular fundus. Such a tool should prove useful to eye care specialists for purposes of patient screening, treatment evaluation, and clinical study. Our method differs from previously known methods in that it uses local and global vessel features cooperatively to segment the vessel network. We evaluate our method using hand-labeled ground truth segmentations of 20 images. A plot of the operating characteristic shows that our method reduces false positives by as much as 15 times over basic thresholding of a matched filter response (MFR), at up to a 75% true positive rate. For a baseline, we also compared the ground truth against a second hand-labeling, yielding a 90% true positive and a 4% false positive detection rate, on average. These numbers suggest there is still room for a 15% true positive rate improvement, with the same false positive rate, over our method. We are making all our images and hand labelings publicly available for interested researchers to use in evaluating related methods.     

低噪声、低失真、16位、1Msps SAR ADC的驱动课程设计要点477

引言设计一种能够提供不打任何性能折扣的ADC驱动拓扑结构是颇具挑战性,特别是在围绕一款诸如1Msps LTC(R)2393-16等超低噪声SAR ADC进行设计的时候.     

Locating the optic nerve in a retinal image using the fuzzy convergence of the blood vessels

We describe an automated method to locate the optic nerve in images of the ocular fundus. Our method uses a novel algorithm we call fuzzy convergence to determine the origination of the blood vessel network. We evaluate our method using 31 images of healthy retinas and 50 images of diseased retinas, containing such diverse symptoms as tortuous vessels, choroidal neovascularization, and hemorrhages that completely obscure the actual nerve. On this difficult data set, our method achieved 89% correct detection. We also compare our method against three simpler methods, demonstrating the performance improvement. All our images and data are freely available for other researchers to use in evaluating related methods.     

Eigendecomposition of Images Correlated on $S^{1}$, $S^{2}$, and $SO(3)$ Using Spectral Theory

Eigendecomposition represents one computationally efficient approach for dealing with object detection and pose estimation, as well as other vision-based problems, and has been applied to sets of correlated images for this purpose. The major drawback in using eigendecomposition is the off line computational expense incurred by computing the desired subspace. This off line expense increases drastically as the number of correlated images becomes large (which is the case when doing fully general 3-D pose estimation). Previous work has shown that for data correlated on S ¹ , Fourier analysis can help reduce the computational burden of this off line expense. This paper presents a method for extending this technique to data correlated on S ² as well as SO(3) by sampling the sphere appropriately. An algorithm is then developed for reducing the off line computational burden associated with computing the eigenspace by exploiting the spectral information of this spherical data set using spherical harmonics and Wigner-D functions. Experimental results are presented to compare the proposed algorithm to the true eigendecomposition, as well as assess the computational savings.     

Integration of Radioactive Material with Microcalorimeter Detectors

Microcalorimeter detectors with embedded radioactive material offer many possibilities for new types of measurements and applications. We will discuss the designs and methods that we are developing for precise deposition of radioactive material and its encapsulation in the absorber of transition-edge sensor (TES) microcalorimeter detectors for two specific applications. The first application is total nuclear reaction energy (Q) spectroscopy for nuclear forensics measurements of trace actinide samples, where the goal is determination of ratios of isotopes with Q values in the range of 5–7 MeV. Simplified, rapid sample preparation and detector assembly is necessary for practical measurements, while maintaining good energy resolution. The second application is electron capture spectroscopy of isotopes with low Q values, such as \(^{163}\) Ho, for measurement of neutrino mass. Detectors for electron capture spectroscopy are designed for measuring energies up to approximately 6 keV. Their smaller heat capacity and physical size present unique challenges. Both applications require precise deposition of radioactive material and encapsulation in an absorber with optimized thermal properties and coupling to the TES. We have made detectors for both applications with a variety of designs and assembly methods, and will present their development.     

Brown Superfund Basic research Program: a multistakeholder partnership addresses real-world problems in contaminated communities

The NIEHS funds several basic and applied research programs, many of which also require research translation or outreach. This paper reports on a project by the Brown University Superfund Basic Research Program (SBRP), in which outreach and research translation teams collaborated with state regulatory agency personnel and community activists on a legislative initiative to mitigate the financial impacts of living in a contaminated community. The Environmentally Compromised Home Ownership (ECHO) program makes home equity loans of up to $25,000 available to qualified applicants. This collaboration provides a case study in community engagement and demonstrates how research translation and outreach activities that are clearly differentiated yet well-integrated can improve a suite of basic and applied research. Although engaging diverse constituencies can be difficult community-engaged translation and outreach have the potential to make research findings more useful to communities, address some of the social impacts of contamination, and empower stakeholders to pursue their individual and collectively held goals for remediation. The NIEHS has recently renewed its commitment to community-engaged research and advocacy, making this an optimal time to reflect on how basic research programs that engage stakeholders through research translation and outreach can add value to the overall research enterprise.     

症状性颅内动脉狭窄支架成形术后早期新发缺血性脑损害的临床研究

目的分析症状性颅内动脉狭窄支架成形术后早期发生的缺血性脑损害情况,探讨颅内动脉狭窄支架成形术的早期疗效和安全性。方法对２９例症状性颅内动脉狭窄行WingSpan支架成形术治疗的患者,在支架成形术前、术后（７２h内）行弥散磁共振成像（DWI ）检查,结合患者一般临床情况、手术情况、新发缺血性脑损害等资料,以NIHSS评分评价神经系统障碍严重程度,系统评价WingSpan支架成形术治疗颅内动脉狭窄早期的安全性和疗效。结果支架成形术患者术前及术后即刻平均狭窄分别为（７２．３±１０．７）％与（２９．５±１３．９）％。并发症发生率为１７．２％,神经系统并发症２例（６．９％）。DWI 检出的新发缺血性脑损害１３例（４４．８％）,其中无症状者１１例（８４．６％）。１３例中共检出新发缺血性脑损害病灶６３个,其中５５个（８７．３％）位于靶血管供血区域,８个（１２．７％）位于非靶血管供血区域。２个（３．２％）出现在支架覆盖血管相关穿支供血区域。永久神经功能障碍的并发症率为０,无病死率。结论DWI 检查在评价颅内动脉狭窄支架成形术中的安全性具有重要参考价值。应用WingSpan支架系统治疗症状性颅内动脉狭窄围手术期安全有效。术后早期有一定比率的缺血性脑损害发生,尽管大部分是无症状的,但应引起临床医师的重视。     

Use of nisin-coated plastic films to control Listeria monocytogenes on vacuum-packaged cold-smoked salmon

Cold-smoked (Salmo salar) salmon samples were surface-inoculated with a cocktail of three nisin-resistant strains of L. monocytogenes (PSU1, PSU2 and PSU21) to a level of approximately 5 x 10(2) or 5 x 10(5) CFU/cm2 of salmon surface. The inoculated smoked salmon samples were vacuum-packaged with control film (no nisin) or nisin-coated plastic films and stored at either 4 or 10 degrees C. When the inoculated smoked salmon samples were packaged with film coated with 2000 IU/cm2 of nisin, a reduction of 3.9 log CFU/cm2 (compared with control) was achieved at either temperature for samples inoculated with 5 x 10(2) CFU/cm(2 of L. monocytogenes after 56 (4 degrees C) and 49 (10 degrees C) days of storage while reductions of 2.4 and 0.7 log CFU/cm2 were achieved for samples inoculated with a high level of L. monocytogenes (5 x 10(5) CFU/cm2) after 58 (4 degrees C) and 43 (10 degrees C) days, respectively. For samples packaged in film coated with 500 IU/cm2 of nisin, reductions of 0.5 and 1.7 log CFU/cm2 were achieved for samples inoculated with a low level of L. monocytogenes (5 x 10(2) CFU/cm2) after 56 (4 degrees C) and 49 (10 degrees C) days of storage while reductions of 1.8 and 0.8 log CFU/cm2 were achieved for samples inoculated with high level of L. monocytogenes after 58(4 degrees C) and 43 (10 degrees C) days, respectively. In addition, nisin inhibited the proliferation of background microbiota on smoked salmon in a concentration-dependent manner at both storage temperatures although the bacteriostatic effect was more pronounced at refrigeration temperature. This work highlights the potential for incorporating nisin into plastic films for enhancing the microbial safety of smoked salmon as well as controlling its microbial spoilage.