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排序方式: 共有207条查询结果,搜索用时 15 毫秒
1.
Neil Maiden Kristine Pitts Kevin Pudney Konstantinos Zachos 《International journal of human-computer interaction》2019,35(7):605-619
There has been little research to investigate the impact of software to support the care for older people with dementia care. This article reports the evaluation of software adapted to support one key person-centered task for the care of older residents with dementia – recording and sharing daily care notes. The evaluation on the dementia wing of 1 residential home for over 6 months revealed that use of the software on mobile devices carried by the carers increased the number and volume of daily care notes recorded, but only for the types of content that were already being recorded by carers. Carers reported more advantages that resulted from daily care notes once in digital form than from the documenting task, as well as barriers to the use of mobile digital software to record daily care notes. 相似文献
2.
Psychologists are often asked to testify in court. However, concerns have been expressed in both the legal and psychological literatures about the quality of these services. This article presents survey results comparing the practice patterns of generally licensed psychologists with those of specialist forensic diplomates in providing risk evaluations. Results suggest that general clinicians frequently perform these evaluations, but forensic diplomates use more modern risk instruments, are more aware of the scientific literature, and provide the court with more information about the scientific basis of their testimony. The implication of these results for legal professionals, psychologist training, and practice are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
3.
Sitai Liang Bijaya K. Nayak Kristine S. Vogel Samy L. Habib 《International journal of molecular sciences》2021,22(8)
The role of tumor protein 63 (TP63) in regulating insulin receptor substrate 1 (IRS-1) and other downstream signal proteins in diabetes has not been characterized. RNAs extracted from kidneys of diabetic mice (db/db) were sequenced to identify genes that are involved in kidney complications. RNA sequence analysis showed more than 4- to 6-fold increases in TP63 expression in the diabetic mice’s kidneys, compared to wild-type mice at age 10 and 12 months old. In addition, the kidneys from diabetic mice showed significant increases in TP63 mRNA and protein expression compared to WT mice. Mouse proximal tubular cells exposed to high glucose (HG) for 48 h showed significant decreases in IRS-1 expression and increases in TP63, compared to cells grown in normal glucose (NG). When TP63 was downregulated by siRNA, significant increases in IRS-1 and activation of AMP-activated protein kinase (AMPK (p-AMPK-Th172)) occurred under NG and HG conditions. Moreover, activation of AMPK by pretreating the cells with AICAR resulted in significant downregulation of TP63 and increased IRS-1 expression. Ad-cDNA-mediated over-expression of tuberin resulted in significantly decreased TP63 levels and upregulation of IRS-1 expression. Furthermore, TP63 knockdown resulted in increased glucose uptake, whereas IRS-1 knockdown resulted in a decrease in the glucose uptake. Altogether, animal and cell culture data showed a potential role of TP63 as a new candidate gene involved in regulating IRS-1 that may be used as a new therapeutic target to prevent kidney complications in diabetes. 相似文献
4.
Edin Alagic Kristine Spildo Arne Skauge Jonas Solbakken 《Journal of Petroleum Science and Engineering》2011,78(2):220-227
Injection of brine with lower salinity than the connate brine has proven to give a moderate increase in oil recovery in sandstones. Recent research has shown that this process will significantly benefit from introducing surfactant optimised for low salinity environment.The mechanisms underlying increased recovery by low salinity brine injection are not yet fully understood. However, research to date suggests that they are related to complex crude oil/brine/rock interactions. With this in mind, the present paper investigates primarily how the extent of oil recovery from Berea sandstones subjected to long term exposure of crude oil is influenced by (1) low salinity water injection and (2) combined process low salinity water injection with surfactant flooding.Core displacement tests were conducted on four Berea cores (30 cm), two in a natural state and two that had been subject to extensive crude oil ageing at high temperature. Results obtained from different flooding steps are discussed in terms of oil recovery and effluent properties including turbidity, pH- and ion analysis (Na+, Mg2+, Ca2+). The results effectively illustrate that oil recoveries from the aged cores are higher during both low salinity water injection and low salinity water injection combined with surfactant flooding. An assessment of how tertiary oil recovery in aged and unaged cores varies with surfactant concentration is also presented.Effluent ion analysis from low salinity water floods showed that Mg2+ ions were strongly retained in the aged core while Ca2+ ions were being produced from both aged and unaged cores. The latter was attributed mainly to calcite dissolution. Results obtained from pressure profiles, effluent ion analysis and turbidity tests suggest higher production and elution of fine particles from the unaged core. 相似文献
5.
Rheological properties of a hydrophobically modified anionic polymer: Effect of varying salinity and amount of hydrophobic moieties
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Hydrophobically modified polyelectrolytes have been suggested as an alternative to the more commonly used polyelectrolytes in enhanced oil recovery (EOR) applications involving polymers. Compared to regular polyelectrolytes, the hydrophobically modified polyelectrolytes are known to be more stable at high salinities. In this study, we have investigated the influence of brine salinity and ionic composition for a series of six hydrophobically modified polyelectrolytes with the same polymer backbone, but with an increasing average number of hydrophobic groups per polymer molecule. Polymer characterization has been performed using a combination of steady‐state shear viscosity and dynamic oscillatory measurements. Hydrophobic interactions leading to a change in rheological properties was only observed above a threshold value for the concentration of hydrophobe. At the threshold value, salt‐induced hydrophobic interactions were observed. For higher concentrations of hydrophobe, high salinity solutions showed one order of magnitude increase in viscosity compared to the polymer without hydrophobic groups. This could partly be explained by an increase in elasticity. These findings have important implications for polymer selection for EOR. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 43520. 相似文献
6.
Laurence Feldmeyer Kristine Heidemeyer Nikhil Yawalkar 《International journal of molecular sciences》2016,17(8)
Acute generalized exanthematous pustulosis (AGEP) is a severe, usually drug-related reaction, characterized by an acute onset of mainly small non-follicular pustules on an erythematous base and spontaneous resolution usually within two weeks. Systemic involvement occurs in about 20% of cases. The course is mostly benign, and only in rare cases complications lead to life-threatening situations. Recent studies highlight the importance of genetic variations in interleukin-36 receptor antagonist gene (IL-36RN) in the pathogenesis of this disease. The physiopathology of AGEP remains unclear, but an involvement of innate and acquired immune cells together with resident cells (keratinocytes), which recruit and activate neutrophils via production of cytokines/chemokines such as IL-17, IL-36, granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor alpha (TNFα) and chemokine (C-X-C motif) ligand 8 (CXCL8)/IL-8, has been postulated. Treatment is based on the removal of the causative drug, supportive care, infection prevention and use of potent topical or systemic steroids. 相似文献
7.
Habitat fragmentation has interactive effects on the population genetic diversity and individual behaviour of a freshwater salmonid fish
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Casper H.A. Van Leeuwen Kristine Dalen Jon Museth Claudia Junge L. Asbjørn Vøllestad 《河流研究与利用》2018,34(1):60-68
Sufficient genetic diversity can aid populations to persist in dynamic and fragmented environments. Understanding which mechanisms regulate genetic diversity of riverine fish can therefore advance current conservation strategies. The aim of this study was to investigate how habitat fragmentation interacted with population genetic diversity and individual behaviour of freshwater fish in large river systems. We studied a population of the long‐distance migratory, iteroparous freshwater salmonid European grayling (Thymallus thymallus) in south‐eastern Norway. Genotyping (n = 527) and radio‐tracking (n = 54) of adult fish throughout a 169‐km river section revealed three major migration barriers limiting gene flow and depleting genetic diversity upstream. Individuals from upstream areas that had dispersed downstream of barriers showed different movement behaviour than local genotypes. No natal philopatry was found in a large unfragmented river section, in contrast to strong fidelity to spawning tributaries known for individuals overwintering in lakes. We conclude that (a) upstream sub‐populations in fragmented rivers show less genetic variation, making it less likely for them to adapt to environmental changes; (b) fish with distinct genotypes in the same habitat can differ in their behaviour; (c) spawning site selection (natal philopatry) can differ between fish of the same species living in different habitats. Together this implies that habitat loss and fragmentation may differently affect individual fish of the same species if they live in different types or sections of habitat. Studying behaviour and genetic diversity of fish can unravel their complex ecology and help minimize human impact. 相似文献
8.
The Use of the Concept of Ecological Networks in Nature Conservation Policies and Planning Practices
The concept of Ecological Networks is popular in nature conservation policies. This paper reflects on advantages and disadvantages of using this concept in planning and realizing ecological ambitions. It focuses on how the concept is variously interpreted and used by different people. A case study on the Ecological Network and its users in the province of Gelderland in the Netherlands shows that concepts can be useful for promoting ideas and uniting people. However, the use of a concept can also lead to misleading consensus and hidden responsibilities, which can frustrate the implementation of the Ecological Networks. 相似文献
9.
Kristine Dery Richard Hall Nick Wailes Sharna Wiblen 《The Journal of Strategic Information Systems》2013,22(3):225-237
Available evidence suggests that the adoption of IT-enabled Human Resource Information Systems (HRIS) has not produced the widely predicted transformation of Human Resources (HR) to a strategic business partner. We examine the relationship between HRIS and the HR function by applying actor-network theory (ANT) to an HRIS implementation project. The focus on how actor networks are formed and reformed during implementation may be particularly well suited to explaining why the original aims of the HRIS can be displaced or lost in translation. We suggest that the approach afforded by ANT enables us to better understand the ongoing and contingent process of HRIS implementations. 相似文献
10.
Experiencing Nature: Embodying Animals in Immersive Virtual Environments Increases Inclusion of Nature in Self and Involvement With Nature
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Sun Joo Ahn Joshua Bostick Elise Ogle Kristine L. Nowak Kara T. McGillicuddy Jeremy N. Bailenson 《Journal of Computer-Mediated Communication》2016,21(6):399-419
Immersive virtual environments (IVEs) produce simulations that mimic unmediated sensory experiences. 3 experiments (N = 228) tested how different modalities increase environmental involvement by allowing users to inhabit the body of animals in IVEs or watch the experience on video. Embodying sensory‐rich experiences of animals in IVEs led to greater feeling of embodiment, perception of being present in the virtual world, and interconnection between the self and nature compared to video. Heightened interconnection with nature elicited greater perceptions of imminence of the environmental risk and involvement with nature, which persisted for 1 week. Although the effect sizes were small to moderate, findings suggest that embodied experiences in IVEs may be an effective tool to promote involvement with environmental issues. 相似文献