Increase in leukocyte adhesiveness and aggregation with stress: a model of human congestive heart failure

Stress has a significant influence on the function of the human organism. A simple, rapid, inexpensive, and reliable marker for stress would therefore be of great value. We have recently noted that stress increases the state of leukocyte adhesiveness and aggregation in the peripheral blood. We evaluated 64 patients who had various degrees of congestive heart failure, a condition known to induce a state of physiologic stress, to verify whether a relation exists between the intensity of the stress response and the magnitude of leukocyte adhesiveness. Included in the 64 were 53 patients without congestive heart failure, 23 with compensated failure, 22 with significant congestive heart failure, and 19 with florid pulmonary edema. The percentage of aggregated leukocytes in these four group was 6% +/- 4%, 6% +/- 4%, 10.5% +/- 5%, and 15% +/- 14%. Values for the third and fourth group differed in a statistically significant way. Thus, with further investigation into additional stress-inducing conditions, the state of leukocyte adhesion and aggregation may prove to be a reliable marker for the detection of stress and an inexpensive tool for quantifying its severity.     

Deviant auditory stimuli activate human left and right auditory cortex differently

Infrequent "deviant' auditory stimuli embedded in a homogeneous sequence of "standard' sounds evoke a neuromagnetic mismatch field (MMF), which is assumed to reflect automatic change detection in the brain. We investigated whether MMFs would reveal hemispheric differences in cortical auditory processing. Seven healthy adults were studied with a whole-scalp neuromagnetometer. The sound sequence, delivered to one ear at time, contained three infrequent deviants (differing from standards in duration, frequency, or interstimulus interval) intermixed with standard tones. MMFs peaked 9-34 msec earlier in the right than in the left hemisphere, irrespective of the stimulated ear. Whereas deviants activated only one MMF source in the left hemisphere, two temporally overlapping but spatially separate sources, one in the temporal lobe and another in the inferior parietal cortex, were necessary to explain the right-hemisphere MMFs. We suggest that the bilateral MMF components originating in the supratemporal cortex are feature specific whereas the right-hemisphere parietal component reflects more global auditory change detection. The results imply hemispheric differences in sound processing and suggest stronger involvement of the right than the left hemisphere in change detection.     

Database as a genre of new media

After the novel, and subsequently cinema privileged narrative as the key form of cultural expression of the modern age, the computer age introduces its correlate — database. Why does new media favour database form over others? Can we explain ist popularity by analysing the specificity of the digital medium and of computer programming? What is the relationship between database and another form, which has traditionally dominated human culture — narrative? In addressing these questions, I discuss the connection between computer's ontology — the way software represents the world — and the new cultural forms privileged by computer culture such as database. I propose that computerisation of culture involves projection of two fundamental parts of computer software — data structures and algorithms — onto the cultural sphere. Thus CD-ROMs and Web databases are cultural manifestations of one half of this ontology — data structures; while new media narratives are manifestations of the second part — algorithms. I conclude by proposing that in computer culture database and narrative do not have the same status. Given that on the level of data organisation most new media objects are databases, it is not surprising that on the level of form database also dominates new media culture.     

An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload

Adipocyte iron overload is a maladaptation associated with obesity and insulin resistance. The objective of the current study was to determine whether and how adipose tissue macrophages (ATMs) regulate adipocyte iron concentrations and whether this is impacted by obesity. Using bone marrow-derived macrophages (BMDMs) polarized to M0, M1, M2, or metabolically activated (MMe) phenotypes, we showed that MMe BMDMs and ATMs from obese mice have reduced expression of several iron-related proteins. Furthermore, the bioenergetic response to iron in obese ATMs was hampered. ATMs from iron-injected lean mice increased their glycolytic and respiratory capacities, thus maintaining metabolic flexibility, while ATMs from obese mice did not. Using an isotope-based system, we found that iron exchange between BMDMs and adipocytes was regulated by macrophage phenotype. At the end of the co-culture, MMe macrophages transferred and received more iron from adipocytes than M0, M1, and M2 macrophages. This culminated in a decrease in total iron in MMe macrophages and an increase in total iron in adipocytes compared with M2 macrophages. Taken together, in the MMe condition, the redistribution of iron is biased toward macrophage iron deficiency and simultaneous adipocyte iron overload. These data suggest that obesity changes the communication of iron between adipocytes and macrophages and that rectifying this iron communication channel may be a novel therapeutic target to alleviate insulin resistance.     

Millimeter-wave Detectors Based on Antenna-coupled Low-barrier Schottky Diodes

The principles of construction of millimeter wave detectors based on low-barrier Schottky diodes and planar antennas are discussed. The modified planar slot antenna with low beam spillover at the resonant frequency of 94 GHz has been developed. Experiments have been carried out to investigate detecting characteristics of the diodes with differential contact resistances \( R_{j} = 1 \div 1000\;{\text{k}}\Omega \) at zero bias. Experimental data are well correspond to calculations in a simple model of detector. At \( R_{j} = 20 \div 100\;{\text{k}}\,\OmegaΩ \) the maximum of rf-to-dc voltage sensitivity - more than 10000 V/W - is obtained. At lower values of \( R_{j} = 2 \div 6\;{\text{k}}\,\Omega Ω \) a better noise equivalent power (NEP), around 10^?12 W Hz^?1/2, is predicted.     

Radiation-Induced Fault Simulation of SOI/SOS CMOS LSI’s Using Universal Rad-SPICE MOSFET Model

The methodology of modeling and simulation of environmentally induced faults in radiation hardened SOI/SOS CMOS IC’s is presented. It is realized at three levels: CMOS devices – typical analog or digital circuit fragments – complete IC’s. For this purpose, a universal compact SOI/SOS MOSFET model for SPICE simulation software with account for TID, dose rate and single event effects is developed. The model parameters extraction procedure is described in great depth taking into consideration radiation effects and peculiarities of novel radiation-hardened (RH) SOI/SOS MOS structures. Examples of radiation-induced fault simulation in analog and digital SOI/SOS CMOS LSI’s are presented for different types of radiation influence. The simulation results show the difference with experimental data not larger than 10–20% for all types of radiation.     

The effect of electron damage on silicon solar cells coated with diamond‐like carbon films

The unique properties of the diamond‐like carbon (a:DLC), such as high mechanical hardness and abrasive resistance, optical transparency in the visible and IR spectral regions and high thermal conductivity, provide this material with advantages over other types of protecting materials for solar cells. Furthermore, the a:DLC films are inert to corrosive gases and other corrosive agents. Resistance to radiation damage of the a:DLC films deposited on solar cells is very important for space application. In the study we investigate the effect of electron damage on silicon solar cells coated with a:DLC films. We measure the I – V characteristic and the spectral response and calculate the values of the seven parameters of the double exponential solar cell model (usually not investigated) as a function of electron fluence irradiation. In addition we obtain also the usual external parameters I_sc, V_oc, I_m, V_m, FF, and efficiency) of the solar cells. We investigate solar cells with and without anti‐reflecting coating coated with a:DLC films which were exposed to electron radiation. The main findings show that the solar cells with a:DLC films of thickness up to 500 nm degrade similarly to regular silicon cells exposed to electron irradiation. The degradation of the spectral response of the solar cell is mainly in the range of longer wavelengths and the irradiation affects the solar cell parameters (mainly the reverse saturation currents). Copyright © 2000 John Wiley & Sons, Ltd.     

Synthesis and Evaluation of a Series of Bis(pentylpyridinium) Compounds as Antifungal Agents

A series of bis(4‐pentylpyridinium) compounds with a variety of spacers between the pyridinium headgroups was synthesised, and the antifungal activity of these compounds was investigated. Lengthening the alkyl spacer between the pentylpyridinium headgroups from 12 to 16 methylene units resulted in increased antifungal activity against C. neoformans and C. albicans, but also resulted in increased hemolytic activity and cytotoxicity against mammalian cells. However, inclusion of an ortho‐substituted benzene ring in the centre of the alkyl spacer resulted in decreased cytotoxicity and hemolytic activity, while maintaining antifungal potency. Replacement of the alkyl and aromatic‐containing spacers by more hydrophilic ethylene glycol groups resulted in a loss of antifungal activity. Some of the compounds inhibited fungal PLB1 activity, but the low correlation of this inhibition with antifungal potency indicates PLB1 inhibition is unlikely to be the predominant mode of antifungal action of this class of compounds, with preliminary studies suggesting they may act via disruption of fungal mitochondrial function.     

Production and Sensitivity Evaluation of Nanocrystalline RDX‐based Explosive Compositions

The initiation sensitivity of cyclotrimethylenetrinitramine (RDX) was investigated as a function of crystal size. For this study, RDX powders with mean crystal sizes of ca. 200 and 500 nm were prepared by rapid expansion of supercritical solutions (RESS) with carbon dioxide as the solvent. Initiation sensitivity testing to impact, sustained shock, and electrostatic discharge stimuli was performed on uncoated as well as wax‐coated specimens. The test data revealed that in a direct comparison to coarser grades the nanocrystalline RDX‐based samples were substantially less sensitive to shock and impact stimuli. Furthermore, the 500 nm RDX‐based specimens exhibited the lowest sensitivity values, an indication that minima in shock and impact sensitivities with respect to crystal size exist.