Bioengineered magnetoferritin nanozymes for pathological identification of high-risk and ruptured atherosclerotic plaques in humans

Atherosclerotic plaque rupture results in thrombus formation and vessel occlusion, and is the leading cause of death worldwide. There is a pressing need to identify plaque vulnerability for the treatment of carotid and coronary artery diseases. Nanomaterials with enzyme-like properties have attracted significant interest by providing biological, diagnostic and prognostic information about the diseases. Here we showed that bioengineered magnetoferritin nanoparticles (M-HFn NPs) functionally mimic peroxidase enzyme and can intrinsically recognize plaque-infiltrated active macrophages, which drive atherosclerotic plaque progression and rupture and are significantly associated with the plaque vulnerability. The M-HFn nanozymes catalyze the oxidation of colorimetric substrates to give a color reaction that visualizes the recognized active macrophages for one-step pathological identification of plaque vulnerability. We examined 50 carotid endarterectomy specimens from patients with symptomatic carotid disease and demonstrated that the M-HFn nanozymes could distinguish active macrophage infiltration in ruptured and high-risk plaque tissues, and M-HFn staining displayed a significant correlation with plaque vulnerability (r = 0.89, P < 0.0001).

     

Study of equivalent efficiency calibration method for radioactive gas source measured on HPGe detectors

ABSTRACT

In view of the complexity of current detection efficiency calibration of radioactive gas sources, a method using solid planar sources to be equivalent to gas sources was studied. For the 50 mL gas source box, an optimal equivalent scheme was selected by Monte Carlo Simulations. Then, the full-energy-peak efficiency curve of gas sources at the measurement position of 25 cm, with source-to-detector distance of 25 cm, was fitted by measuring solid planar sources with known activity. To verify the accuracy of the efficiency curve, ⁴¹Ar, ¹³³Xe and ⁸⁷Kr gases were produced and determined by length-compensated method. Then, their full-energy-peak efficiencies at 25 cm position away from the detector were directly calibrated. The percentage efficiency deviations between interpolation from the efficiency curve and direct calibration are all less than 2.5%, which proves the accuracy of the equivalent method. This calibration method is a general one and can be also used for some other radioactive sample measurements, such as non-destructive analysis of gaseous fission product samples with a suitable source-to-detector distance.     

浮选气泡矿化机理研究

简要阐述了浮选过程中气泡矿化的形式及阶段,解析了气泡和矿粒表面的粘附机理以及其过程中受热力学、动力学和时间分布等因素的影响,深入地了解气泡在三相体系中的矿化机理,为今后对浮选工艺的改进提供了基本依据.     

试述会计电算化的管理与岗位职责

介绍了会计电算化的工作原理，管理体制和岗位职责，实现会计电算化是规范现代化会计工作的重要组成部分。     

液压系统常见故障及其排除方法浅析

介绍了液压传动系统的主要组成部分,分析了液压系统常见故障的产生原因,提出相应的消除方法.     

用于30MHz～1GHiz电磁辐射骚扰测量的全电波暗室场地校验方法

详细介绍了最新国际标准CISPR 16-1-4:2004第5.8条给出的两种评估方法-场地参考法(site reference method)和归一化场地衰减法NSA.为评估全电波暗室的性能提供重要技术依据.     

升压技术在治理有害气体中的应用

矿井为抽出式通风时,综采工作面采用局部升压通风控制有害气体效果明显.本文介绍了升压技术在马脊梁矿治理有害气体中的应用,经济效益显著.     

从仓储库房火灾中获得的经验和教训

历史的经验表明,当灾害性火灾发生后,人们对火灾进行调查所获得的经验和教训推动了仓储库房防火的进步。下面讨论由这种方式得出的经验和教训。1自动喷水灭火系统的设计应和火灾危险相匹配该教训来源于含有可燃物质的气溶胶罐仓库的自动喷水灭火系统的防火评估。1978年在新泽西     

以创新的思维和勇气,打造浦江住宅精品

介绍了黄浦江两岸综合开发的基本情况，分析了未来滨江住宅的市场形势与发展机遇探讨了滨江住宅的开发理念、价值取向，提出了建设中需注意的问题。     

女性标签主义——厨卫设计风潮面面观

继简约、经典主义风格之后，一种全新的、带有浓厚女性主义色彩的家居装饰风格开始涌现，并逐渐汇成潮流，成为流行的风向标。[编者按]