Systematic Review: Targeted Molecular Imaging of Angiogenesis and Its Mediators in Rheumatoid Arthritis

Extensive angiogenesis is a characteristic feature in the synovial tissue of rheumatoid arthritis (RA) from a very early stage of the disease onward and constitutes a crucial event for the development of the proliferative synovium. This process is markedly intensified in patients with prolonged disease duration, high disease activity, disease severity, and significant inflammatory cell infiltration. Angiogenesis is therefore an interesting target for the development of new therapeutic approaches as well as disease monitoring strategies in RA. To this end, nuclear imaging modalities represent valuable non-invasive tools that can selectively target molecular markers of angiogenesis and accurately and quantitatively track molecular changes in multiple joints simultaneously. This systematic review summarizes the imaging markers used for single photon emission computed tomography (SPECT) and/or positron emission tomography (PET) approaches, targeting pathways and mediators involved in synovial neo-angiogenesis in RA.     

Substrate Analysis on the Design of Wide-Band Antenna for Sub-6 GHz 5G Communication

Wireless Personal Communications - A compact triple band antenna with stacked T-shaped strips inside a rectangular ring monopole has been proposed. This novel structure with a slot in the defected...     

Magnetically Driven Silver‐Coated Nanocoils for Efficient Bacterial Contact Killing

The increasing threat of multidrug‐resistant bacterial strains against conventional antibiotic therapies represents a significant worldwide health risk and intensifies the need for novel antibacterial treatments. In this work, an effective strategy to target and kill bacteria using silver‐coated magnetic nanocoils is reported. The coil palladium (Pd) nanostructures are obtained by electrodeposition and selective dealloying, and subsequently coated with nickel (Ni) and silver (Ag) for magnetic manipulation and antibacterial properties, respectively. The efficiency of the nanocoils is tested in the treatment of Gram‐negative Escherichia coli (E. coli) and Gram‐positive methicillin‐resistant Staphylococcus aureus (S. aureus), both of which represent the leading multidrug‐resistant bacterial pathogens. The nanocoils show highly effective bacterial killing activity at low concentrations and in relatively short durations of treatment time. Three different investigation techniques, LIVE/DEAD assay, colony‐forming unit counting, and scanning electron microscope, reveal that the antibacterial activity is a result of bacterial membrane damage caused by direct contact with the nanocoil. The low cytotoxicity toward fibroblast cells along with the capability of precise magnetic locomotion makes the proposed nanocoil an ideal candidate to combat multidrug‐resistant bacteria in the field of biomedical and environmental applications.     

Total Power Optimization for Combinational Logic Using Genetic Algorithms

Power consumption is a top priority in high performance circuit design today. Many low power techniques have been proposed to tackle the ever serious, highly pressing power consumption problem, which is composed of both dynamic and static power in the nanometer era. The static power consumption nowadays receives even more attention than that of dynamic power consumption when technology scales below 100 nm. In order to mitigate the aggressive power consumption, various existing low power techniques are often used; however, they are often applied independently or combined with two or at most three different techniques together, and that is not sufficient to address the escalating power issue. In this paper, we present a power optimization framework for the minimization of total power consumption in combinational logic through multiple V _dd assignment, multiple V _th assignment, device sizing, and stack forcing, while maintaining performance requirements. These four power reduction techniques are properly encoded into the genetic algorithm and evaluated simultaneously. The overhead imposed by the insertion of level converters is also taken into account. The effectiveness of each power reduction mechanism is verified, as are the combinations of different approaches. Experimental results are presented for a number of 65 nm benchmark circuits that span typical circuit topologies, including inverter chains, SRAM decoders, multiplier, and a 32 bit carry adder. Our experiments show that the combination of four low power techniques is the effective way to achieve low power budget. The framework is general and can be easily extended to include other design-time low power techniques, such as multiple gate length or multiple gate oxide thickness.     

Efficient Pattern Generation for Small-Delay Defects Using Selection of Critical Faults

Testing for small-delay defects (SDDs) has become necessary as technology further scales. Existing tools and methodologies for generating SDD patterns suffer from: limited long-paths sensitization capability, overwhelming pattern volume, time-consuming pattern generation process, and vague evaluations of pattern quality. Such situation places patterns in a dilemma where the generation and application effort are huge yet the results cannot reflect the physical phenomena clearly enough for correct binning and diagnosis. In this paper, we focus on establishing a pattern generation flow that produces patterns of high application value. Firstly, critical faults are identified in order to generate high-quality original pattern repository with n-detect ATPG.A novelpattern evaluation and selection method that further minimizes pattern count while maintaining the SDD detection ability is then presented. Top-off ATPG is then performed to ensure meeting the target fault coverage. Along with the flow, multiple evaluation metrics are also proposed to measure the pattern’s efficiency on SDD coverage, unique SDD detection, detectable SDD size, long path distribution, etc. Experimental results demonstrate that the proposed critical fault-based method improves long path sensitization efficiency by 2.5× without impairing its average delay and saves approximately 80 % CPU runtime compared with total fault-based method. Comparing with timing-aware ATPG, the generated pattern set detects equivalent or even more SDDs with significantly reduced pattern count.     

Phase Relations in the System Al2O3─Ce2Si2O7 in the Temperature Range 900° to 1925°C in Inert Atmosphere

Equilibrium relationships in the system Al₂O₃-Ce₂Si₂O₇ in inert atmosphere have been investigated in the temperature range 900° to 1925°C. A simple eutectic reaction was found at 1375°C and 51 mol% Ce₂Si₂O₇. A high-low polymorphic transformation in Ce₂Si₂O₇ was observed at 1274°C. New XRD patterns are suggested for both polymorphs of cerium pyrosilicate. The melting point of Ce₂Si₂O₇ was found to be 1788°C. A value for ΔH°_m,Ce2Si2O7 of 36.81 kJ/mol was calculated from the initial slope of the experimentally determined liquidus in equilibrium with the pyrosilicate phase.     

Isolation of a Rhizobium galegae strain-specific DNA probe

One-hundred-four cases of stones in the upper urinary tract treated by open surgery during 1979 to 1982 at the Tikur Anbessa Hospital have been retrospectively reviewed. Among the patients, 76.5% were between the age of 20 and 40 years and there was a predominance of men with a male to female ratio of 3.7:1. More than 50% of patients presented with a history of illness from one to five years and most of the presenting symptoms and signs were the same as reported by others. Fourteen of the 73 patients tested (19%) had positive urine culture. Conservative operations of pyelolithotomy and ureterolithtomy were made in 71.2% of the patients. Nephrolithotomy was made in 14.3%, partial nephrectomy in 3.8% and nephrectomy in 8.7%. Of the patients 92.3% had an uneventful postoperative course. Mortality was 1.9% and occurred in patients with stone anuria. Chemical analysis of stones from 25 patients showed calciumoxalate in 21, and calciumoxalate with additional phosphate in three patients. One patient had pure uric acid stone.