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排序方式: 共有312条查询结果,搜索用时 15 毫秒
1.
Nicole Jacqueline Jensen Helena Zander Wodschow Malin Nilsson Jrgen Rungby 《International journal of molecular sciences》2020,21(22)
Under normal physiological conditions the brain primarily utilizes glucose for ATP generation. However, in situations where glucose is sparse, e.g., during prolonged fasting, ketone bodies become an important energy source for the brain. The brain’s utilization of ketones seems to depend mainly on the concentration in the blood, thus many dietary approaches such as ketogenic diets, ingestion of ketogenic medium-chain fatty acids or exogenous ketones, facilitate significant changes in the brain’s metabolism. Therefore, these approaches may ameliorate the energy crisis in neurodegenerative diseases, which are characterized by a deterioration of the brain’s glucose metabolism, providing a therapeutic advantage in these diseases. Most clinical studies examining the neuroprotective role of ketone bodies have been conducted in patients with Alzheimer’s disease, where brain imaging studies support the notion of enhancing brain energy metabolism with ketones. Likewise, a few studies show modest functional improvements in patients with Parkinson’s disease and cognitive benefits in patients with—or at risk of—Alzheimer’s disease after ketogenic interventions. Here, we summarize current knowledge on how ketogenic interventions support brain metabolism and discuss the therapeutic role of ketones in neurodegenerative disease, emphasizing clinical data. 相似文献
2.
Shift in thinking to address the 21st century hunger gap 总被引:1,自引:1,他引:0
Malin Falkenmark 《Water Resources Management》2007,21(1):3-18
The present water policy debate is dominated by the 30 yr old mission to secure water supply and sanitation to all people.
The water needed to produce a nutritionally acceptable diet for one person is however 70 times as large as the amount needed
for domestic water supply. The food security dilemma is largest in arid climate regions, a situation constituting a formidable
challenge. It is suggested that an additional 5 600 km3/yr of consumptive water use will be needed to produce an adequate amount of food by 2050 – i.e almost a doubling of today’s
consumptive use of 6800 km3/yr. Past misinterpretations and conceptual deficiencies show the importance of a shift in thinking. Combining the scale of
the challenge and the time scale of the efforts to feed humanity and eradicate hunger leads to an impression of great urgency.
This urgency strengthens the call for international research both for supporting agricultural upgrading, and for much better
handling of issues of environmental sustainability. What stands out is the need of a new generation of water professionals,
able to handle complexity and able to incorporate water implications of land use and of ecosystem health in integrated water
resources management. It will for those reasons be essential and urgent to upgrade the educational system to producing this
new generation. 相似文献
3.
Bengt Sundén Tor Sköldheden 《International Communications in Heat and Mass Transfer》1985,12(5):559-566
An experimental investigation of heat transfer and pressure drop from a new type of corrugated channels is presented. The investigation has been carried out for Reynolds numbers in the range of for one corrugated and one smooth channel. It is found that the heat transfer from the corrugated channel is up to 3.5 times higher than for the smooth one. The pressure drop is however large (5 – 6 times the value of a smooth channel) and it is suggested that the corrugation height and length should be altered in order to balance the increases in heat transfer and pressure drop. 相似文献
4.
5.
To successfully manage today’s complex production systems it is essential to study operators’ perception of the system. The paper presents perceived production complexity assessed at seven manufacturing companies with the CompleXity Index (CXI) method. While other methods have measured product variants, layout, work content, tools and information items, CXI combines them into three areas. These three complexity areas (Station design, Work variance and Disturbance handling) help to create an understanding of the complex system by visualising how they contribute to complexity, and show the need to support the operators’ ability to handle the varying work. 相似文献
6.
7.
Recent studies have applied Grottfredson and Hirschi’s General Theory of Crime to investigate whether college students’ inclinations toward internet software piracy is related to low self-control and opportunity (i.e., computer ownership). Given the widespread use of the internet to illegally obtain copies of music and movies, it is important to understand the factors in this form of piracy as well. This study applied the self-control perspective to examine the attitudes of high school students toward the internet piracy of music and movies. Attitudes toward the internet piracy of music and movies were related to self-control, biological sex, internet experience, affiliation with deviant peers, and grade level in this study of high school students. This information is important because studies of internet piracy had not yet confirmed the presence and predictability of internet piracy in high school students. This study also suggests that piracy prevention efforts may be most appropriately focused on high school age individuals and directed toward increasing self-control. 相似文献
8.
The aim of this review is to provide an overview of proteomic studies in animal models of diabetes and to give some insight into the different methods available today in the rapidly developing field of proteomics. A summary of 31 papers published between 1997 and 2007 is presented. For instance, proteomics has been used to study the development of both type 1 and type 2 diabetes, diabetic complications in tissues like heart, kidney and retina and changes after treatment with anti-diabetic drugs like peroxisome proliferator-activated receptors agonists. Together, these studies give a good overview of a number of experimental approaches. Proteomics holds the promise of providing major contributions to the field of diabetes research. However, to achieve this, a number of issues need to be resolved. Appropriate data representation to facilitate data comparison, exchange, and verification is required, as well as improved statistical assessment of proteomic experiments. In addition, it is important to follow up the results with functional studies to be able to make biologically relevant conclusions. The potential of proteomics to dissect complex human disorders is now beginning to be realized. In the future, this will result in new important information concerning diabetes. 相似文献
9.
James Mason Erik Lundberg Pr Jonsson Hanna Nystrm Oskar Franklin Christina Lundin Peter Naredi Henrik Antti Malin Sund Daniel
hlund 《International journal of molecular sciences》2022,23(21)
Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death that typically presents at an advanced stage. No reliable markers for early detection presently exist. The prominent tumor stroma represents a source of circulating biomarkers for use together with cancer cell-derived biomarkers for earlier PDAC diagnosis. CA19-9 and CEA (cancer cell-derived biomarkers), together with endostatin and collagen IV (stroma-derived) were examined alone, or together, by multivariable modelling, using pre-diagnostic plasma samples (n = 259 samples) from the Northern Sweden Health and Disease Study biobank. Serial samples were available for a subgroup of future patients. Marker efficacy for future PDAC case prediction (n = 154 future cases) was examined by both cross-sectional (ROC analysis) and longitudinal analyses. CA19-9 performed well at, and within, six months to diagnosis and multivariable modelling was not superior to CA19-9 alone in cross-sectional analysis. Within six months to diagnosis, CA19-9 (AUC = 0.92) outperformed the multivariable model (AUC = 0.81) at a cross-sectional level. At diagnosis, CA19-9 (AUC = 0.995) and the model (AUC = 0.977) performed similarly. Longitudinal analysis revealed increases in CA19-9 up to two years to diagnosis which indicates a window of opportunity for early detection of PDAC. 相似文献
10.
Semiconductors - The transformation of a two-dimensional GaN layer into three-dimensional islands (2D–3D transition) under increasing temperature in a flow of ammonia is investigated... 相似文献