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Manana Kandashvili Georgi Gamkrelidze Lia Tsverava Tamar Lordkipanidze Eka Lepsveridze Vincenzo Lagani Maia Burjanadze Manana Dashniani Merab Kokaia Revaz Solomonia 《International journal of molecular sciences》2022,23(3)
Epilepsy is a severe neurological disease characterized by spontaneous recurrent seizures (SRS). A complex pathophysiological process referred to as epileptogenesis transforms a normal brain into an epileptic one. Prevention of epileptogenesis is a subject of intensive research. Currently, there are no clinically approved drugs that can act as preventive medication. Our previous studies have revealed highly promising antiepileptogenic properties of a compound–myo-inositol (MI) and the present research broadens previous results and demonstrates the long-term disease-modifying effect of this drug, as well as the amelioration of cognitive comorbidities. For the first time, we show that long-term treatment with MI: (i) decreases the frequency and duration of electrographic SRS in the hippocampus; (ii) has an ameliorating effect on spatial learning and memory deficit associated with epileptogenesis, and (iii) attenuates cell loss in the hippocampus. MI treatment also alters the expression of the glial fibrillary acidic protein, LRRC8A subunit of volume-regulated anion channels, and protein tyrosine phosphatase receptor type R, all expected to counteract the epileptogenesis. All these effects are still present even 4 weeks after MI treatment ceased. This suggests that MI may exert multiple actions on various epileptogenesis-associated changes in the brain and, therefore, could be considered as a candidate target for prevention of epileptogenesis. 相似文献
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Dodo Tavdidishvili ;Tsira Khutsidze ;Manana Pkhakadze ;Maia Vanidze ;Aleko Kalandia 《化学与化工:英文版》2014,(7):676-681
The proposed work aims to study phenol components (flavonoids) of bee bread and pollen obtained in Georgia using the HPLC (high-performance liquid chromatography) method, and to determine the content of biologically active compounds in them. The samples were taken in lmereti region (west Georgia). After extraction of samples, there were carried out spectral and HPLC analysis of compounds for the sake of qualitative and quantitative research of them. There are studied the flavonoid compounds of bee bread and pollen by using the HPLC methods, and naringin, rutin and quercetin are identified. Their amount counts about 20% of full content of flavonoids. The content of flavonols in bee bread and pollen has been established. It also has been determined that the amount of flavonoids during the storage period of products reduces to 6.17-5.03 g.kg-1. 相似文献
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Keti Tsomaia Leila Patarashvili Irakli Bebiashvili Elza Azmaiparashvili Manana Kakabadze Nikoloz Jalabadze Marom Sareli Sergey Gusev Dimitri Kordzaia 《Microscopy research and technique》2020,83(7):778-789
SEM of corrosion casts (CC) provides the opportunities to study the vessels and ducts in the phyllogenetic and ontogenetic (age‐related) settings, as well as the pathogenesis, compensation, and sanogenesis in different diseases and experimental models. Along with the refinement of SEM CC, the requirements toward casting media (CM) as nontoxicity, low viscosity, quick polymerization, resistance to corrosion solutions, availability, and so on, gradually has developed. We aimed to adapt the sets widely used in dental practice toward the modern requirements to the CC. The following ratio of the components of Protacryl‐M and Aycryl‐C sets were used for the preparation CM—0.25 g MAYCRYL Powder +0.08 g Benzoyl Peroxide +5.0 ml Protacryl‐M liquid component +0.2 Redont Colour (dye concentrate). The obtained solidifying mass was injected in the blood vessels and biliary ducts of the adult Wistar white rats. The SEM of CC of different organs’ vascular networks, as well as a biliary tract, reveals that offered CM excellently replicates the forms and branching features of studied tubular structures of all sizes and gives the adequate imprinting of their luminal surfaces. Besides, CM may provide the replication of perivascular spaces and give the casts having no analogous in the appropriate literature. The CM prepared by us perfectly reproduces all possibilities of famous rubbers widely used for the casting of different vascular–ductular structures. Besides, it presents the new implications, which should be implemented in the profound research of the connective‐tissue skeleton of different organs. 相似文献
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Helen Truby Rebecca Hiscutt Anne M Herriot Manana Stanley Anne deLooy Kenneth R Fox Susan Baic Paula J Robson Ian Macdonald Moira A Taylor Robert Ware Catherine Logan MBE Livingstone 《Nutrition journal》2008,7(1):1-13
Objective
To investigate the effect of commercial weight loss programmes on macronutrient composition and micronutrient adequacy over a 2 month period.Design
Adults were randomly allocated to follow the Slim Fast Plan, Weight Watchers Pure Points Programme, Dr Atkins' New Diet Revolution, or Rosemary Conley's "Eat Yourself Slim" Diet & Fitness Plan.Setting
A multi-centre randomised controlled trial.Subjects
293 adults, mean age 40.3 years and a mean BMI 31.7 (range 27–38) were allocated to follow one of the four diets or control group. Subjects completed a 7-day food and activity diary at baseline (prior to randomisation) and after 2 months. Diet records were analysed for nutrient composition using WinDiets (research version).Results
A significant shift in the macronutrient composition of the diet with concurrent alteration of the micronutrient profile was apparent with all diets. There was no evidence to suggest micronutrient deficiency in subjects on any of the dietary regimens. However, those sub-groups with higher needs for specific micronutrients, such as folate, iron or calcium may benefit from tailored dietary advice.Conclusion
The diets tested all resulted in considerable macronutrient change and resulted in an energy deficit indicating dietary compliance. Health professionals and those working in community and public health should be reassured of the nutritional adequacy of the diets tested.Trial Registration Number
NCT00327821 相似文献
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