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排序方式: 共有74条查询结果,搜索用时 15 毫秒
1.
A.M. Turpeinen M. Kumpu M. Rönnback L. Seppo H. Kautiainen T. Jauhiainen H. Vapaatalo R. Korpela 《Journal of Functional Foods》2009,1(3):260-265
The effects of a spread containing bioactive tripeptides isoleucine–proline–proline (IPP), valine–proline–proline (VPP) and plant sterols were studied in subjects with mild hypertension and elevated LDL cholesterol. Sixty-two subjects consumed 20 g/day spread containing 4.2 mg milk peptides and 2 g plant sterol esters or placebo for 10 weeks. Blood pressure was measured twice a week. Arterial stiffness was assessed by pulse wave analysis and by pulse wave velocity. Blood samples were analysed for serum lipids and high-sensitive CRP. A significant decrease was seen in systolic blood pressure (p = 0.026), but not in diastolic blood pressure (p = 0.53). Total cholesterol (p = 0.003) and LDL cholesterol (p = 0.002) decreased, whereas HDL cholesterol, triacylglycerols and CRP remained unchanged. No overall effects on arterial stiffness were seen. The results suggest that a spread containing bioactive milk peptides and plant sterols has a beneficial effect on two major cardiovascular risk factors, blood pressure and plasma lipids, in hypertensive, dyslipidemic subjects. Functional foods affecting two major risk factors can be valuable tools in managing cardiovascular risk. 相似文献
2.
重点介绍了美卓造纸机械公司研发的Val-Former靴刮刀叠网成形技术、OptiFormer夹网成形器和OptiFlo Ⅱ型流浆箱,以便为使用较高比例的混合废纸且在更高的车速下生产更低定量瓦楞原纸以及挂面纸板时,获得高效、低能耗和理想质量的产品. 相似文献
3.
M. Kalliokoski T. HildenF. Garcia J. HeinoR. Lauhakangas E. TuominenR. Turpeinen 《Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment》2012,664(1):223-230
An optical scanning system was commissioned and further developed in the Detector Laboratory of Helsinki Institute of Physics and University of Helsinki. It was designed to automatically scan, perform on-line analysis and to classify the overall quality of GEM-foils especially of the GEM-TPC detectors for Super-FRS at FAIR. The optical scanning system consists of precision positioning table, lighting, optics and operating system with analysis software. It has active scanning area of 95×95 cm2 and it can study this area with the minimum resolution of 128 lp/mm. Performance of the system and first results from the GEM-foil uniformity and quality analysis are presented. 相似文献
4.
Miia Turpeinen Jouko Uusitalo Terhi Lehtinen Marita Kailaj?rvi Olavi Pelkonen Jouni Vuorinen Pasi Tapanainen Camilla Stjernschantz Risto Lammintausta Mika Scheinin 《International journal of molecular sciences》2013,14(7):14064-14075
The objective of these investigations was to determine the possible effects of the novel selective estrogen receptor modulator, ospemifene, on cytochrome P450 (CYP)-mediated drug metabolism. Ospemifene underwent testing for possible effects on CYP enzyme activity in human liver microsomes and in isolated human hepatocytes. Based on the results obtained in vitro, three Phase 1 crossover pharmacokinetic studies were conducted in healthy postmenopausal women to assess the in vivo effects of ospemifene on CYP-mediated drug metabolism. Ospemifene and its main metabolites 4-hydroxyospemifene and 4′-hydroxyospemifene weakly inhibited a number of CYPs (CYP2B6, CYP2C9, CYP2C19, CYP2C8, and CYP2D6) in vitro. However, only CYP2C9 activity was inhibited by 4-hydroxyospemifene at clinically relevant concentrations. Induction of CYPs by ospemifene in cultured human hepatocytes was 2.4-fold or less. The in vivo studies showed that ospemifene did not have significant effects on the areas under the plasma concentration-time curves of the tested CYP substrates warfarin (CYP2C9), bupropion (CYP2B6) and omeprazole (CYP2C19), demonstrating that pretreatment with ospemifene did not alter their metabolism. Therefore, the risk that ospemifene will affect the pharmacokinetics of drugs that are substrates for CYP enzymes is low. 相似文献
5.
Javier Del SerAuthor Vitae Marja MatinmikkoAuthor VitaeSergio Gil-LópezAuthor Vitae Miia MustonenAuthor Vitae 《Applied Soft Computing》2012,12(2):921-930
This paper gravitates on the spectrum channel allocation problem where each compounding node of a cognitive radio network is assigned a frequency channel for transmission over a given outgoing link, based on optimizing an overall network performance metric dependant on the level of interference among nearby nodes. In this context, genetically inspired algorithms have been extensively used so far for solving this optimization problem in a computationally efficient manner. This work extends previous preliminary research carried out by the authors on the application of the heuristic Harmony Search (HS) algorithm to this scenario by presenting further results and derivations on both HS-based centralized and distributed spectrum allocation techniques. Among such advances, a novel adaptive island-like distributed allocation procedure is presented, which dramatically decreases the transmission rate required for exchanging control traffic among nodes at a quantifiable yet negligible performance penalty. Extensive simulation results executed over networks of increasing size verify, on one hand, that our proposed technique achieves near-optimum spectral channel assignments at a low computational complexity. On the other hand, the obtained results assess that HS vastly outperforms genetically inspired allocation algorithms for the set of simulated scenarios. Finally, the proposed adaptive distributed allocation approach is shown to attain a control traffic bandwidth saving of more than 90% with respect to the naive implementation of a HS-based island allocation procedure. 相似文献
6.
Pauliina Jäkälä Anu M. Turpeinen Kirsi Rajakari Riitta Korpela Heikki Vapaatalo 《International Dairy Journal》2010,20(5):366-370
Milk casein-derived biologically active tripeptides isoleucine–proline–proline and valine–proline–proline have shown antihypertensive effects both in animal and clinical studies. Contradictory findings from clinical intervention studies may be related to different manufacturing processes. The present study aimed to compare cardiovascular effects of two different tripeptide powders in spontaneously hypertensive rat (SHR). Rats received tripeptide powders produced either by Lactobacillus helveticus fermentation (A) or Lb. helveticus plus proline specific endoprotease (B) in drinking fluid for 8 weeks. Systolic blood pressure was recorded weekly. At the end, blood and tissue samples were collected and arterial responses studied. Blood pressure was 13.6 and 14.2 mmHg lower in the groups A and B, respectively, versus the water group (P < 0.01). Vascular responses of aorta and mesenteric artery did not differ between the groups. Both tripeptide products increased urinary cGMP (P < 0.001) and decreased albumin (P < 0.05). The fermentation process did not influence the cardiovascular effects of the tripeptide powders. 相似文献
7.
Role of microbes in controlling the speciation of arsenic and production of arsines in contaminated soils 总被引:7,自引:0,他引:7
Turpeinen R Pantsar-Kallio M Kairesalo T 《The Science of the total environment》2002,285(1-3):133-145
The influence of microbes on the speciation of arsenic and production of arsines in contaminated soils was investigated under laboratory conditions. Microbes were able to carry out reactions that resulted in changes in the speciation of arsenic in soil. The transformation of soil dominating species, arsenate [As(V)], under both aerobic and anaerobic conditions to arsenite [As(III)], monomethylarsonic acid [MMAA], dimethylarsinic acid [DMAA] and to volatile trimethylarsine [TMA] was, however, less than 0.5%, of which the production of TMA represented 0.02-0.3%. The volatilization process was also verified in the field, in the soil of a dumping area. The 'life-time' of arsines in air was, however, short and they were rapidly converted back to water soluble species, As(V) and trimethyl arsine oxide (TMAO). 相似文献
8.
Lara Valentín Beata Kluczek‐Turpeinen Pekka Oivanen Annele Hatakka Kari Steffen Marja Tuomela 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2009,84(6):851-858
BACKGROUND: For most dioxin‐contaminated sawmill soils, combustion is recommended. However, the process may be inefficient if the soil has a high organic matter content. The use of saprotrophic basidiomycetous fungi is an alternative for pretreatment of this kind of soil. A total of 147 fungi were evaluated for their ability to grow in sawmill soil. From this screening, the best soil colonizing fungi were selected to study their enzyme activities and degradation of soil organic matter. Pine (Pinus sylvestris) bark was used as a co‐substrate to propagate the fungi into the soil. The activities of manganese peroxidase (MnP), laccase, endo‐1,4‐β‐glucanase, endo‐1,4‐β‐xylanase, and endo‐1,4‐β‐mannanase were analysed from the inocula and fungal treated soil. RESULTS: The screening revealed that 56 out of 147 fungi were able to grow in non‐sterile soil, and most of them were litter‐decomposing fungi (LDF). In pine bark cultures, the highest enzyme activities were observed with Phanerochaete velutina, which produced 5 U g?1 of MnP. The activity of endo‐1,4‐β‐glucanase was generally higher than that of other hydrolytic enzymes. The highest carbon loss from soil with a high organic matter content was achieved by P. velutina (3.4%) and Stropharia rugosoannulata (2.4%). CONCLUSIONS: Many LDF, and in addition the white‐rot fungus P. velutina, are potential degraders of soil organic matter since they showed good growth and respiratory activity. Pine bark was a suitable lignocellulosic co‐substrate and a good promoter of MnP activity. Copyright © 2009 Society of Chemical Industry 相似文献
9.
This article uses decomposition method to analyse industrial electricity consumption in North-Western Russia, namely in Archangelsk oblast, the Republic of Karelia and Murmansk oblast. The case sectors, forestry and electricity, have in most cases developed similarly in the chosen regions during 1990–2001. The decomposition analysis shows that the reduction of economic activity has reduced electricity consumption in all three regions but that it is not always the main factor reducing consumption. The changes in energy efficiency increased consumption in the forestry sector in all regions while in the electricity sector it led to a reduction. The changes in the structures of the regional economies increased electricity consumption in electricity industry which gained importance due to developments in the manufacturing industry. In Murmansk, forestry sector has almost disappeared during the observation period. This was the main observed electricity consumption reduction caused by structural changes. Many of the developments can be better understood against the general knowledge of transition factors. 相似文献
10.
Aminou Mohamadou Gerard A. van Albada Ilpo Mutikainen Urho Turpeinen Jan Reedijk 《Inorganic chemistry communications》2010,13(10):1221-1224
A novel hexagonal-based honeycomb compound with overall formula {[KCr(C2O4)3][Cu(pypn)(H2O)](H2O)4} is reported in which pypn is with the tetradentate ligand (N,N′-bis(2-pyridylmethyl)-1,3-propanediamine). The [KCr(C2O4)3]2? moiety forms a hexagonal honeycomb structure, while the five-coordinated [Cu(pypn)(H2O)]2+ moiety is located in between the layers, partly filling the holes in the cavities. The synthesis, X-ray crystal structure and some spectroscopic properties are presented. The coordination of Cr(III) is octahedral, with a CrO6 chromophore, and the K+ ion is in a KO6 environment (K–O distances vary from 2.36 to 2.48 ?). The [KCr(C2O4)3]2? layers have the K+ ions in a Λ conformation, while the Cr(III) ions in the Δ conformation. The geometry around the Cu(II) is five-coordinated with four nitrogens from the chelating pypn ligand in a plane and the apical position being occupied by the oxygen atom of the coordinating water molecule. The packing of the cationic and the anionic layers appears to be of special interest. 相似文献