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排序方式: 共有1463条查询结果,搜索用时 15 毫秒
1.
Ivan Fortelný Monika Lapčíková František Lednický Zdeněk Starý Zdeněk Kruliš 《Polymer Engineering and Science》2008,48(3):564-571
This article is focused on the phase structure development in immiscible polymer blends during melt mixing. Nonuniformity of the phase structure, i.e., the coexistence of areas containing particles with markedly different size distribution, was detected in quenched and compression molded samples of a number of various blends prepared by long and intensive mixing in the chamber of a Plasticorder. The same effect was found also for polystyrene/polyamide blends prepared in a twin‐screw extruder. It was shown that neglecting nonuniformity of the phase structure can lead to considerable error in evaluation of the effect of system parameters on the blend morphology. The reasons for the effect were discussed and it was found that inhomogeneous flow field in mixers is a plausible explanation of the nonuniform phase structure. POLYM. ENG. SCI., 2008. © 2008 Society of Plastics Engineers 相似文献
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The Journal of Supercomputing - In this article, the authors suggested a rotation-invariant local binary pattern-based weighted generalized closest neighbor (RILBP-WGCN) method for HSI... 相似文献
4.
Monika Büscher 《Computer Supported Cooperative Work (CSCW)》2014,23(2):223-238
This article takes departure in Barbara Czarniawska’s discussion of ‘Nomadic Work as Life-Story Plot’. It contextualises her analysis of actors’ interpretations of nomadic work with a bi-focal review of the ambiguous realities of these phenomena. Firstly, an examination of key aspects of the socio-economic and political context of nomadic work in global neoliberal economies reveals precarious conditions that cloud romantic interpretations of nomadicity. Secondly, a review of studies of everyday practices of nomadic work shows how neoliberal, but also alternative futures are enacted through creative appropriation of collaborative technologies. One example is the work of digital ‘disaster deck’ volunteers and its potential for the mobilization of ‘rapid, highly localized assistance’ through closer collaboration between a distributed crowd, local communities, and official emergency responders (Starbird and Palen 2013). This and other examples suggest emergent new practices and politics of dwelling in mobility that are focused on sociality and collaboration, straddling virtual and physical commons. The twin critique developed in this response can augment narrative analysis to inform more integrated CSCW innovation that challenges the ‘brave new world of work’. 相似文献
5.
Monika Lachmapure Priti Paralikar Manikandan Palanisamy Monica Alves Mahendra Rai 《IET nanobiotechnology / IET》2017,11(7):809
Mycotic keratitis is mainly responsible for vision loss caused by various fungi. Sometimes, proper treatment of such infection is not possible due to unavailability of effective antifungal agents and development of resistance of such fungi to antimycotic drugs. Hence, it is necessary to search for potential antifungal agents, which can effectively eradicate fungal infection of eyes. Nanoparticles‐based antifungal drugs overcome this problem by increasing permeability and properties of drug molecules. In the present study, silver nanoparticles were synthesised by using Helminthosporium sp. and Chaetomium sp. following sequential reduction technique. The synthesised silver nanoparticles were detected primarily by UV‐visible spectrophotometer showing absorption spectra at 424 and 433 nm, respectively. Nanoparticles tracking analysis confirmed the mean particle size of silver nanoparticles as 45 and 55 nm. The synthesised AgNPs showed significant antifungal activity against fungi causing mycotic keratitis, when used alone and in combination with ketoconazole and amphotericin B in the range of 30–70 microgram per millilitre of minimum inhibitory concentration. Thus, the synthesised AgNPs can be used to enhance the activities of ketoconazole and amphotericin B.Inspec keywords: silver, nanoparticles, nanomedicine, antibacterial activity, diseases, permeability, ultraviolet spectra, visible spectra, particle sizeOther keywords: biogenic silver nanoparticles, fungi, mycotitic keratitis, vision loss, infection, antifungal agents, antimycotic drugs, antifungal drugs, permeability, Helminthosporium sp, Chaetomium sp, sequential reduction technique, UV‐visible spectrophotometer, mean particle size, ketoconazole, amphotericin B, wavelength 424 nm, wavelength 433 nm, size 45 nm, size 55 nm, Ag 相似文献
6.
Maria Giretova Lubomir Medvecky Radoslava Stulajterova Tibor Sopcak Jaroslav Briancin Monika Tatarkova 《Journal of materials science. Materials in medicine》2016,27(12):181
Polyhydroxybutyrate/chitosan/calcium phosphate composites are interesting biomaterials for utilization in regenerative medicine and they may by applied in reconstruction of deeper subchondral defects. Insufficient informations were found in recent papers about the influence of lysozyme degradation of chitosan in calcium phosphate/chitosan based composites on in vitro cytotoxicity and proliferation activity of osteoblasts. The effect of enzymatic chitosan degradation on osteoblasts proliferation was studied on composite films in which the porosity of origin 3D scaffolds was eliminated and the surface texture was modified. The significantly enhanced proliferation activity with faster population growth of osteoblasts were found on enzymatically degraded biopolymer composite films with α-tricalcium phosphate and nanohydroxyapatite. No cytotoxicity of composite films prepared from lysozyme degraded scaffolds containing a large fraction of low molecular weight chitosans (LMWC), was revealed after 10 days of cultivation. Contrary to above in the higher cytotoxicity origin untreated nanohydroxyapatite films and porous composite scaffolds. The results showed that the synergistic effect of surface distribution, morphology of nanohydroxyapatite particles, microtopography and the presence of LMWC due to chitosan degradation in composite films were responsible for compensation of the cytotoxicity of nanohydroxyapatite composite films or porous composite scaffolds. 相似文献
7.
Lei Xie Monika Leester-Schädel Gerhard Ziegmann Stephanus Büttgenbach 《Microsystem Technologies》2010,16(6):1009-1013
Micro injection molded polymeric parts coated with functional thin films/layers show off the promising applications in microsystems
area. But the unfavorable and unavoidable defect of weld line in micro injection molding part leads to detrimental mechanical
and surface properties. The possibility of the functional thin film for enhancing micro injection molded weld lines was investigated.
Two typical coating materials (aluminum and titanium) with various film thicknesses (400, 600, 800 nm) were deposited on one
side of the micro injection molded weld line tensile sample via physical vapor deposition (PVD) method. The coated micro weld
line samples were characterized by tensile tests. The results show that PVD films of aluminum and titanium can reinforce the
strength and stiffness of micro injection molded weld line, even at thin thickness levels. But when the film thickness is
increasing, the weaker adhesion between metallic films and polymers decreased the PVD films’ enhancing performance for micro
weld line mechanical properties due to the degradation of polymers related to longer time exposure under high temperature. 相似文献
8.
Nelsestuen GL Harvey SB Zhang Y Kasthuri RS Sinaiko AR Ely EW Bernard GR Homoncik M Jilma B 《Proteomics. Clinical applications》2008,2(2):158-166
Although numerous protein biomarkers have been correlated with advanced disease states, no new clinical assays have been developed. Goals often anticipate disease-specific protein changes that exceed values among healthy individuals, a property common to acute phase reactants. This review considers somewhat different approaches. It focuses on intact protein isoform ratios that present a biomarker without change in the total concentration of the protein. These will seldom be detected by peptide level analysis or by most antibody-based assays. For example, application of an inexpensive method to large sample groups resulted in observation of several polymorphisms, including the first structural polymorphism of apolipoprotein C1. Isoform distribution of this protein was altered and was eventually linked to increased obesity. Numerous other protein isoforms included C- and N-terminal proteolysis, changes of glycoisoform ratios and certain types of sulfhydryl oxidation. While many of these gave excellent statistical correlation with advanced disease, clinical utility was not apparent. More important may be that protein isoform ratios were very stable in each individual. Diagnosis by longitudinal analysis of the same individual might increase sensitivity of protein biomarkers by 20-fold or more. Protein changes that exceed the range of values found among healthy individuals may be uncommon. 相似文献
9.
Kobeissy FH Sadasivan S Oli MW Robinson G Larner SF Zhang Z Hayes RL Wang KK 《Proteomics. Clinical applications》2008,2(10-11):1467-1483
The rapidly growing field of neuroproteomics has expanded to track global proteomic changes underlying various neurological conditions such as traumatic brain injury (TBI), stroke, and Alzheimer's disease. TBI remains a major health problem with approximately 2?million incidents occurring annually in the United States, yet no affective treatment is available despite several clinical trials. The absence of brain injury diagnostic biomarkers was identified as a significant road-block to therapeutic development for brain injury. Recently, the field of neuroproteomics has undertaken major advances in the area of neurotrauma research, where several candidate markers have been identified and are being evaluated for their efficacy as biological biomarkers in the field of TBI. One scope of this review is to evaluate the current status of TBI biomarker discovery using neuroproteomics techniques, and at what stage we are at in their clinical validation. In addition, we will discuss the need for strengthening the role of systems biology and its application to the field of neuroproteomics due to its integral role in establishing a comprehensive understanding of specific brain disorder and brain function in general. Finally, to achieve true clinical input of these neuroproteomic findings, these putative biomarkers should be validated using preclinical and clinical samples and linked to clinical diagnostic assays including ELISA or other high-throughput assays. 相似文献
10.
Achim Müller Olga Heim M. Panneerselvam Monika Willert-Porada 《Materials Research Bulletin》2005,40(12):2153-2169
A modified microwave-assisted polyol method was applied to prepare nanoparticulate ceramic powders of different oxides, i.e. Gd2O3, AlO(OH) (boehmite) and TiO2. Due to the good dielectric properties of the utilised solvents, such as ethylene glycol, diethylene glycol and 1,4 butanediol, a significant decrease in reaction time was achieved under microwave heating. In the case of AlO(OH) and Gd2O3, <5 nm primary particle size were obtained. Boehmite was found to be intercalated with the solvent. The general applicability of the process is shown and the advantages in terms of properties and processibility are described. The powders thus prepared were investigated using X-ray diffractometry, electron microscopy and physisorption. 相似文献