Analysis of an EHF aplanatic zoned dielectric lens antenna

Zoned dielectric lenses, designed for wide-angle scanning characteristics, are serious contenders to reflector systems for multiple-beam communications and radar applications at EHF frequencies. An analysis is presented in which the zoned lens is approximated by an ideally thin spherical shell (phase transformer) in evaluating the phase aberrations in its aperture plane which are caused by off-axis scanning and deviations from the design frequency. Those results are used to produce a set of universal curves which predict the decrease in directive gain of the lens as a function of scan angle and frequency. Gain and radiation pattern measurements on a90 lambdazoned dielectric lens show agreement with these predictions and with ray-tracing and geometric optics calculations. This study establishes the validity of the spherical shell analysis as a means for rapid estimation of lens parameters for specific system requirements.     

Impurity local phonon nonradiative quenching of Yb3+fluorescence in ytterbium-doped silicate glasses

We have studied the concentration quenching of Yb³⁺ ion fluorescence in Yb-doped silicate glasses containing up to 3.4×10 ²¹ cm^-3 Yb³⁺ ions. The absorption and fluorescence spectra are similar to those obtained for the Yb³⁺ ion in many different matrices, with a radiative lifetime of approximately 1400 μs. The fluorescence decay curves were different among samples, with strong dependence on the Yb concentration. The decay curves could always be resolved into two exponential components, indicating that the ions reside in two different sites, each of a different characteristic nonradiative decay mechanism. The fast decay times ranged between 6 and 300 μs, and the slow ones ranged between 190 and 1250 μs in different samples. The sites where ions exhibit the fast decay most probably consist of pairs of Yb³⁺ ions. The nonradiative decay probabilities for each site mere directly proportional to the Yb³⁺ concentration in the same site. We propose that the fluorescence quenching occurs by multiphonon nonradiative transitions involving polar local phonon bands created by the presence of the Yb³⁺ ion     

Comparative clinical study of cefonicid, chloramphenicol, and penicillin in community-acquired pneumonia

Telomere length in human somatic cells gradually decreases with the number of cell divisions and is regarded as a marker of somatic cell turnover. Mucosal cells of the affected colon show rapid turnover in individuals with active ulcerative colitis (UC). Telomere length was determined by Southern blot analysis of terminal restriction fragments (TRFs) from the colonic mucosa of 17 patients with UC in remission, two of whom showed dysplasia, and 17 control subjects without colitis. For each individual, mean TRF length was compared between rectal mucosa and unaffected cecal mucosa. The mean TRF length of the rectal mucosa was significantly less than that of cecal mucosa in UC patients (7.87 +/- 0.36kb versus 8.77 +/- 0.21 kb; P = 0.0015, Wilcoxon signed rank test), whereas no significant difference was detected in the control subjects. The extent of telomere shortening was 10.6 +/- 3.35% in UC patients, compared with 0.8 +/- 0.64% in noncolitis controls (P = 0.0024, Mann-Whitney U-test). Four UC patients, two of whom had dysplasia, showed telomere shortening of more than 20% in the rectal mucosa. These observations suggest that telomere shortening in the colonic mucosa of individuals with UC may represent the history of mucosal inflammation during disease of long duration, and that it may contribute to aneuploidy in UC.     

Wide-angle microwave lens for line source applications

A new "time-delay" scanner consists of a constrained wide-angle two-dimensional microwave lens with a straight front face in which lens elements connect arbitrary points on the inner and outer contours. The lens can operate at very short pulse lengths and can scan more beamwidths than any previously known device of its type. A phase analysis shows that this design has very small coma aberrations and that the lens can generate fractional degree beams. Criteria developed for selecting optimum lens parameters are given. The radiation patterns of an experimental model in which the lens elements consist of coaxial cables show the expected wide-angle characteristics. In further tests incremental scanning was obtained through the use of phase shifters in the coaxial lens elements. The design of symmetrical three-dimensional lenses is briefly discussed. A table of lens contour parameters is given for an optimum lens design with scan anglealphaof30deg.     

Saccharomyces cerevisiae Gcs1 is an ADP-ribosylation factor GTPase-activating protein

Movement of material between intracellular compartments takes place through the production of transport vesicles derived from donor membranes. Vesicle budding that results from the interaction of cytoplasmic coat proteins (coatomer and clathrin) with intracellular organelles requires a type of GTP-binding protein termed ADP-ribosylation factor (ARF). The GTPase cycle of ARF proteins that allows the uncoating and fusion of a transport vesicle with a target membrane is mediated by ARF-dependent GTPase-activating proteins (GAPs). A previously identified yeast protein, Gcs1, exhibits structural similarity to a mammalian protein with ARF-GAP activity in vitro. We show herein that the Gcs1 protein also has ARF-GAP activity in vitro using two yeast Arf proteins as substrates. Furthermore, Gcs1 function is needed for the efficient secretion of invertase, as expected for a component of vesicle transport. The in vivo role of Gcs1 as an ARF GAP is substantiated by genetic interactions between mutations in the ARF1/ARF2 redundant pair of yeast ARF genes and a gcs1-null mutation; cells lacking both Gcs1 and Arf1 proteins are markedly impaired for growth compared with cells missing either protein. Moreover, cells with decreased levels of Arf1 or Arf2 protein, and thus with decreased levels of GTP-Arf, are markedly inhibited for growth by increased GCS1 gene dosage, presumably because increased levels of Gcs1 GAP activity further decrease GTP-Arf levels. Thus by both in vitro and in vivo criteria, Gcs1 is a yeast ARF GAP.     

Influence of an oligodendroglial component on the survival of patients with anaplastic astrocytomas: a report of Radiation Therapy Oncology Group 83-02

PURPOSE: Seven percent of patients with high grade gliomas enrolled in RTOG 83-02 had mixed astrocytoma/oligodenroglial elements on central pathology review. It has often been assumed that the most aggressive histologic component of a tumor determines biologic behavior; however in this trial, the survival of patients who had mixed glioblastomas/oligodenrogliomas was significantly longer than that of patients with pure glioblastomas (GBM). We therefore evaluated the effect of an oligodendroglial component on the survival of patients who had anaplastic astrocytomas (AAF) treated in the same trial. METHODS AND MATERIALS: One hundred nine patients who had AAF and 24 patients with mixed AAF/oligodendrogliomas (AAF/OL) were enrolled in a Phase I/II trial of randomized dose-escalation hyperfractioned radiotherapy plus BCNU. AAF/OL patients were older and more likely to have had more aggressive surgery than AAF patients. Other pretreatment characteristics were balanced between groups, as was assigned treatment. RESULTS: The median survival time for AAF was 3.0 years versus 7.3 years for AAF/OL (p = 0.019). In a multivariate analysis, adjusting for extent of surgical resection and age, an oligodendroglial component was an independent prognostic factor for survival. CONCLUSION: The results support the concept that AAFs with an oligodendroglial component have a better prognosis than pure AAF tumors, similar to the effect seen among patients with glioblastoma multiforme tumors. This better survival outcome should be taken into consideration in the design and stratification of future trials. Additionally, in contrast to patients with GBMs, patients who have AAF/OL have the potential for prolonged survival; therefore, late sequelae of treatment (both radiation and chemotherapy) must be weighed more heavily in the benefits to risks analysis.     

Performance limitations of a free-space optical communication satellite network owing to vibrations: heterodyne detection

Free-space optical communication between satellites in a distributed network can permit high data rates of communication between different places on Earth. To establish optical communication between any two satellites requires that the line of sight of their optics be aligned during the entire communication time. Because of the large distance between the satellites and the alignment accuracy required, the pointing from one satellite to another is complicated because of vibrations of the pointing system caused by two fundamental stochastic mechanisms: tracking noise created by the electro-optic tracker and vibrations derived from mechanical components. Vibration of the transmitter beam in the receiver plane causes a decrease in the received optical power. Vibrations of the receiver telescope relative to the received beam decrease the heterodyne mixing efficiency. These two factors increase the bit-error rate of a coherent detection network. We derive simple mathematical models of the network bit-error rate versus the system parameters and the transmitter and receiver vibration statistics. An example of a practical optical heterodyne free-space satellite optical communication network is presented. From this research it is clear that even low-amplitude vibration of the satellite-pointing systems dramatically decreases network performance.     

A galactosidase immunosorbent test for human immunoglobulin E

We report here the development of a galactosidase-immunosorbent test (GIST) for immunoglobulin E (IgE) antibodies in which the amount of galactosidase adsorbed to a cellulose disc is a single valued function of IgE concentration in human serum. Rabbit anti-IgE immunoglobulin insolubilized on cellulose discs is incubated sequentially with human serum, sheep anti-IgE serum, and a covalent conjugate of rabbit antisheep immunoglobulin with the enzyme beta-D-galactoside galactohydrolase (E.C.) 3.2.1.23). Colorimetric assay of enzyme conjugate adsorbed to discs permits quantitation of 1.0 to 25 ng of IgE per test. Concentrations of IgE in 48 sera as measured by the GIST gave a linear correlation coefficient of 0.97 with IgE concentrations as determined by radioimmunoassay. Preliminary studies indicate that the GIST makes possible nonisotopic measurement of ragweed-specific IgE antibiotics in human serum. The GIST for IgE is simple to perform and requires neither short-lived radioisotopes, expensive scintillation detection equipment, nor scarce, purified IgE.