The differential effect of polymyxin B1 on guinea pig lung mitochondrial and microsomal glycerophosphate acyltransferase

The activities of guinea pig lung mitochondrial and microsomal glycerophosphate acyltransferase differed in sensitivity to polymyxin B₁. At an antibiotic concentration of 1 mg/ml, the mitochondrial enzyme activity was stimulated twofold, but the microsomal enzyme activity was completely inhibited. Furthermore, the mitochondrial enzyme activity was stimulated by polymyxin B₁ without the addition of exogenous acyl-CoA. Additional experiments ruled out the possibility of polymyxin B₁ acting as a substrate for the mitochondrial acyltransferase. These results suggest either that the polymyxin B₁ sensitivity of mitochondrial and microsomal glycerophosphate acyltransferase is different or that their accessibility to substrates is different because the two isoenzymes are located differently in the different phospholipid microenvironment of the membranes.     

A waveform concatenation technique for text-to-speech synthesis

Designing text-to-speech systems capable of producing natural sounding speech segments in different Indian languages is a challenging and ongoing problem. Due to the large number of possible pronunciations in different Indian languages, a number of speech segments are needed to be stored in the speech database while a concatenative speech synthesis technique is used to achieve highly natural speech segments. However, the large speech database size makes it unusable for small hand held devices or human computer interactive systems with limited storage resources. In this paper, we proposed a fraction-based waveform concatenation technique to produce intelligible speech segments from a small footprint speech database. The results of all the experiments performed shows the effectiveness of the proposed technique in producing intelligible speech segments in different Indian languages even with very less storage and computation overhead compared to the existing syllable-based technique.     

Analyzing collective behavior from blogs using swarm intelligence

With the rapid growth of the availability and popularity of interpersonal and behavior-rich resources such as blogs and other social media avenues, emerging opportunities and challenges arise as people now can, and do, actively use computational intelligence to seek out and understand the opinions of others. The study of collective behavior of individuals has implications to business intelligence, predictive analytics, customer relationship management, and examining online collective action as manifested by various flash mobs, the Arab Spring (2011) and other such events. In this article, we introduce a nature-inspired theory to model collective behavior from the observed data on blogs using swarm intelligence, where the goal is to accurately model and predict the future behavior of a large population after observing their interactions during a training phase. Specifically, an ant colony optimization model is trained with behavioral trend from the blog data and is tested over real-world blogs. Promising results were obtained in trend prediction using ant colony based pheromone classier and CHI statistical measure. We provide empirical guidelines for selecting suitable parameters for the model, conclude with interesting observations, and envision future research directions.     

The interplay of conscious and automatic mechanisms in the context of routine use: An integrative and comparative study of contrasting mechanisms

Researchers have been closely studying how information technology services became a routine part of our lives. Studies have found that users who routinely use online services either consciously develop loyalty or automatically develop a habit. But many studies now mix the elements of conscious and automatic use despite the great differences in these phenomena. This study proposes a new theoretical framework of how the conscious and automatic mechanisms simultaneously, but differentially, regulate postadoption phenomena in the context of online information services. An empirical test confirms that these two mechanisms have highly discernible patterns that researchers and managers alike must heed.     

Tunable Emission in Heteroepitaxial Ln‐SURMOFs

By using a layer‐by‐layer (LbL) approach, lanthanide‐based, monolithic metal–organic framework (MOF) thin films are fabricated for optical applications. In particular, the LbL approach allows manufacturing of heteroepitaxial Tb(III)‐Eu(III)(BTC) coatings with precise thickness control. Adjusting the Tb(III)‐to‐Eu(III) ratio allows tuning of the emission color. The hetero‐multilayer architecture makes it possible to suppress the direct Tb(III)‐to‐Eu(III) energy transfer, an unwanted phenomenon present in the corresponding mixed‐metal bulk MOF structures. The resulting Ln‐MOF thin films, or Ln‐surface‐anchored MOFs (SURMOFs), are characterized by X‐ray diffraction, infra‐red reflection absorption spectroscopy, UV–vis, and photoluminescence measurements. The results demonstrate that the heteroepitaxial SURMOF architectures carry huge potential for fabricating optical coatings for a wide range of applications.     

Enhancement of modulation bandwidth of laser diodes by injection locking

In this letter, we suggest a new method for significantly enhancing the intrinsic bandwidth of a laser diode through the use of an injection locking technique. Our analysis shows that for moderate and high-injection levels, the bandwidth of a laser diode can be increased to several times its free-running bandwidth.     

Cut off frequency and transit time analysis of lightly doped drain (LDD) MOSFETs

Analytical model for the transconductance, cut off frequency, transit time and fringing capacitance of LDD MOSFETs is presented with a simple approach. The analysis is carried out considering the LDD device as a conventional MOSFET with a series resistance [Z.-H. Liu et al., Threshold voltage model for submicrometer MOSFETs. IEEE Trans Electron Devices 1993; ED-40: 86–94] and a simple closed form expressions for cut off frequency and transit time is obtained. The total gate capacitance, i.e. the geometric and fringing capacitance, is calculated for both LDD and non-LDD devices and lower fringing capacitance is reported in LDD devices. Lower cut-off frequencies and higher transit time are reported in LDD devices for the same channel length.     

An automated high-level topology generation procedure for continuous-time ΣΔ modulator

This paper presents an automated procedure for generation of high-level topologies for continuous-time ΣΔ modulator system. A functional topology of the system is generated from the given transfer function model of the modulator. Mathematical transformation technique is applied iteratively over the initial topology to generate a functional topology which is optimized for modulator sensitivity, hardware complexity and relative power consumption. This is then implemented using behavioral models of operational transconductance amplifiers and capacitors. The generated high-level topology is ensured to work with reasonable accuracy under non-ideal conditions. The entire procedure has been implemented in Matlab/Simulink environment. Numerical results have been provided to demonstrate the procedure.     

Cylindrical gate all around Schottky barrier MOSFET with insulated shallow extensions at source/drain for removal of ambipolarity: a novel approach

In this paper TCAD-based simulation of a novel insulated shallow extension (ISE) cylindrical gate all around (CGAA) Schottky barrier (SB) MOSFET has been reported,to eliminate the suicidal ambipolar behavior (bias-dependent OFF state leakage current) of conventional SB-CGAA MOSFET by blocking the metal-induced gap states as well as unwanted charge sharing between source/channel and drain/channel regions.This novel structure offers low barrier height at the source and offers high ON-state current.The ION/IoFF of ISE-CGAA-SB-MOS-FET increases by 1177 times and offers steeper subthreshold slope (～60 mV/decade).However a little reduction in peak cut off frequency is observed and to further improve the cut-off frequency dual metal gate architecture has been employed and a comparative assessment of single metal gate,dual metal gate,single metal gate with ISE,and dual metal gate with ISE has been presented.The improved performance of Schottky barrier CGAA MOSFET by the incorporation of ISE makes it an attractive candidate for CMOS digital circuit design.The numerical simulation is performed using the ATLAS-3D device simulator.     

Localization of isotropic and anisotropic wireless sensor networks in 2D and 3D fields

Telecommunication Systems - Internet of Things (IoT) has changed the way people live by transforming everything into smart systems. Wireless Sensor Network (WSN) forms an important part of IoT....