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1.
Deepika M. Malini Raajan N. R. Srinivasan A. 《Multimedia Tools and Applications》2022,81(9):12701-12724
Multimedia Tools and Applications - The three-dimensional models of brain tumors serve as diagnostic assistance for physicians, surgeons, and radiologists. The proposed system establishes an... 相似文献
2.
Sundaram Vickram Karunakaran Rohini Subramanian Srinivasan David Nancy Veenakumari Kumar Archana Krishnan Anbarasu Palanivelu Jeyanthi Sundaram Thanigaivel Govindarajan Gulothungan Nanmaran Rajendiran Padmalayam Sadanandan Srikumar 《International journal of molecular sciences》2021,22(4)
Zinc (Zn), the second-most necessary trace element, is abundant in the human body. The human body lacks the capacity to store Zn; hence, the dietary intake of Zn is essential for various functions and metabolism. The uptake of Zn during its transport through the body is important for proper development of the three major accessory sex glands: the testis, epididymis, and prostate. It plays key roles in the initial stages of germ cell development and spermatogenesis, sperm cell development and maturation, ejaculation, liquefaction, the binding of spermatozoa and prostasomes, capacitation, and fertilization. The prostate releases more Zn into the seminal plasma during ejaculation, and it plays a significant role in sperm release and motility. During the maternal, labor, perinatal, and neonatal periods, the part of Zn is vital. The average dietary intake of Zn is in the range of 8–12 mg/day in developing countries during the maternal period. Globally, the dietary intake of Zn varies for pregnant and lactating mothers, but the average Zn intake is in the range of 9.6–11.2 mg/day. The absence of Zn and the consequences of this have been discussed using critical evidence. The events and functions of Zn related to successful fertilization have been summarized in detail. Briefly, our current review emphasizes the role of Zn at each stage of human reproduction, from the spermatogenesis process to childbirth. The role of Zn and its supplementation in in vitro fertilization (IVF) opens opportunities for future studies on reproductive biology. 相似文献
3.
Three-dimensional models, or pharmacophores, describing Euclidean constraints on the location on small molecules of functional
groups (like hydrophobic groups, hydrogen acceptors and donors, etc.), are often used in drug design to describe the medicinal
activity of potential drugs (or ‘ligands’). This medicinal activity is produced by interaction of the functional groups on
the ligand with a binding site on a target protein. In identifying structure-activity relations of this kind there are three
principal issues: (1) It is often difficult to “align” the ligands in order to identify common structural properties that
may be responsible for activity; (2) Ligands in solution can adopt different shapes (or `conformations’) arising from torsional
rotations about bonds. The 3-D molecular substructure is typically sought on one or more low-energy conformers; and (3) Pharmacophore
models must, ideally, predict medicinal activity on some quantitative scale. It has been shown that the logical representation
adopted by Inductive Logic Programming (ILP) naturally resolves many of the difficulties associated with the alignment and
multi-conformation issues. However, the predictions of models constructed by ILP have hitherto only been nominal, predicting
medicinal activity to be present or absent. In this paper, we investigate the construction of two kinds of quantitative pharmacophoric
models with ILP: (a) Models that predict the probability that a ligand is “active”; and (b) Models that predict the actual
medicinal activity of a ligand. Quantitative predictions are obtained by the utilising the following statistical procedures
as background knowledge: logistic regression and naive Bayes, for probability prediction; linear and kernel regression, for
activity prediction. The multi-conformation issue and, more generally, the relational representation used by ILP results in
some special difficulties in the use of any statistical procedure. We present the principal issues and some solutions. Specifically,
using data on the inhibition of the protease Thermolysin, we demonstrate that it is possible for an ILP program to construct
good quantitative structure-activity models. We also comment on the relationship of this work to other recent developments
in statistical relational learning.
Editors: Tamás Horváth and Akihiro Yamamoto 相似文献
4.
Suboptimal parallel schemes for the acquisition of spreading sequences in chip-asynchronous spread-spectrum systems are considered. These acquisition schemes estimate the unknown delay of the received signal with respect to a locally generated spreading code. Two schemes are presented which are considerably easier to implement than the optimal estimator. An analytical expression is given for the error probability of the simpler of the two schemes, and it is shown that the average error probability of this scheme decreases exponentially with the signal-to-noise ratio. Numerical results show that the performance of both suboptimal estimators is comparable to that of the optimal estimator 相似文献
5.
The thermal decomposition products of pyridinium sulfate differ from those of pyridinium sulfate supported on zirconia which in turn differs from that of pyridine adsorbed on a sulfated zirconia. Unsupported pyridinium sulfate decomposes to produce pyridine and sulfuric acid, and these subsequently react to produce oxides of carbon and sulfur. Zirconia that is sulfated and then exposed to pyridine does not release detectable amount of pyridine during heating in an inert gas; rather the pyridine undergoes oxidation reduction reactions simultaneously to release CO2 and sulfur compounds. Pyridinium sulfate supported on zirconia decomposes upon heating to release pyridine and sulfuric acid, which reacts with the zirconia. The desorption of pyridine in one case and only CO2/SOx in the other case suggests that sulfated zirconia does not contain Brønsted acidity that can form pyridinium sulfate. 相似文献
6.
R. M. Pillai S. G. K. Pilhii A. D. Damodaran 《JOM Journal of the Minerals, Metals and Materials Society》2002,54(10):12-16
Indian artisans and craftsmen have long been masters at extracting and shaping metals and alloys, as proven by archaeological
finds from the 2nd—3rd millennia B.C. For example, two well-known artifacts, castings of the dancing girl of Mohenjo Daro
and the Mother Goddess of Adichanallur, Tamilnadu, depict a high degree of metallurgical knowledge. Those castings were formed
by the lost wax process, which later was modified and became known as investment casting. In various parts of India, this
age-old casting process is still being practiced, without any major modifications. This paper discusses details of the process
used by the Indian artisans of Swamimalai, Tamilnadu, and Mannar, Kerala, South India in shaping copper-base alloys into icons
and utensils, bells, and lamps. 相似文献
7.
M. Ravi U. T. S. Pillai B. C. Pai A. D. Damodaran E. S. Dwarakadasa 《Metallurgical and Materials Transactions A》2002,33(2):391-400
The effect of Fe content (0.2 to 0.6 pct) on the microstructure and mechanical properties of a cast Al-7Si-0.3Mg (LM 25/356)
alloy has been investigated. Further, 1 pct mischmetal (MM) additions (a mixture of rare-earth (RE) elements) were made to
these alloys, and their mechanical properties at room and at elevated temperatures (up to 200 °C) were evaluated. A structure-property
correlation on this alloy was attempted using optical microstructure analysis, fractographs, X-ray diffraction, energy-dispersive
analysis of X-rays (EDX), and quantitative metallography by image analysis. An increase in Fe content increased the volume
percentage of Fe-bearing intermetallic compounds (β and π phases), contributing to the loweryield strength (YS), ultimate tensile strength (UTS), percentage elongation, and higher
hardness. An addition of 1 pct MM to the alloys containing 0.2 and 0.6 pct Fe was found to refine the microstructure; modify
the eutectic silicon and La, Ce, and Nd present in the MM; form different intermetallic compounds with Al, Si, Fe, and Mg;
and improve the mechanical properties of the alloys both at room and elevated temperatures. 相似文献
8.
9.
10.
Axial bed depth profiles were experimentally measured in a rotary kiln containing ilmenite particles under steady state and transient conditions. The variables include feed rate of solids, inclination and rotational speed of the kiln. and dam height. The variation of the axial velocity with kiln axis was estimated. The semi-experimental model proposed by Perron and Bui (1990) was modified to include the effect of the variables of the present study. The mean residence time of solids was estimated from the fractional hold-up and expressed in terms of the process variables. The transients induced by a step change in any of the operating conditions were measured as variation of discharge rate of solids with time. 相似文献