Tensile Fracture Toughness Measurements in Ceramics

A novel procedure is outlined whereby fracture toughness values for ceramics can be measured under uniaxial tension (mode I) in specimens containing a fatigue crack. Circumferentially notched rods of rapolycrystalline aluminum oxide were precracked in cyclic compression to introduce a fatigue crack at room temperature, following the technique proposed by Suresh and co-workers.^7,10,11 Subsequently, the precracked rods were fractured in pure tension. Highly reproducible values of fracture toughness were obtained using this method.     

Generalized differentiability and integrability for fuzzy set-valued functions on time scales

This paper deals with the fuzzy set-valued functions of real variables on time scale whose values are normal, convex, upper semicontinuous and compactly supported fuzzy sets in \(\mathbb {R}^{n}\). We introduce and study the fundamental properties of new class of derivative called generalized delta derivative (\(\Delta _{g}\)-derivative) and generalized delta integral (\(\Delta _{g}\)-integral) for such fuzzy functions.     

Proteomic Biomarkers of the Apnea Hypopnea Index and Obstructive Sleep Apnea: Insights into the Pathophysiology of Presence,Severity, and Treatment Response

Obstructive sleep apnea (OSA), a disease associated with excessive sleepiness and increased cardiovascular risk, affects an estimated 1 billion people worldwide. The present study examined proteomic biomarkers indicative of presence, severity, and treatment response in OSA. Participants (n = 1391) of the Stanford Technology Analytics and Genomics in Sleep study had blood collected and completed an overnight polysomnography for scoring the apnea–hypopnea index (AHI). A highly multiplexed aptamer-based array (SomaScan) was used to quantify 5000 proteins in all plasma samples. Two separate intervention-based cohorts with sleep apnea (n = 41) provided samples pre- and post-continuous/positive airway pressure (CPAP/PAP). Multivariate analyses identified 84 proteins (47 positively, 37 negatively) associated with AHI after correction for multiple testing. Of the top 15 features from a machine learning classifier for AHI ≥ 15 vs. AHI < 15 (Area Under the Curve (AUC) = 0.74), 8 were significant markers of both AHI and OSA from multivariate analyses. Exploration of pre- and post-intervention analysis identified 5 of the 84 proteins to be significantly decreased following CPAP/PAP treatment, with pathways involving endothelial function, blood coagulation, and inflammatory response. The present study identified PAI-1, tPA, and sE-Selectin as key biomarkers and suggests that endothelial dysfunction and increased coagulopathy are important consequences of OSA, which may explain the association with cardiovascular disease and stroke.     

An experimentally validated thermo-mechanical model for the prediction of thermal contact conductance

A predictive model for estimating thermal contact conductance between two nominally flat metallic rough surfaces has been developed and experimentally validated. The predictive model consists of two complementary parts, the first of which is a surface deformation analysis to calculate the actual area of contact for each contact spot, while the second accounts for the effects of constriction resistance and gas gap conductance between the contacting surfaces. A surface characterization technique is developed which generates an equivalent 3-D surface profile from multiple 2-D profiles and determines the unique wavelengths of importance for the surface deformation and constriction resistance models. For given surface profiles and material properties of two contacting surfaces, and a specified contact pressure, the surface characterization technique filters out non-essential wavelengths on the surface, after which the surface deformation analysis calculates the deformation and contact area of each contacting asperity by considering three different modes of deformation, namely, elastic, elastic–plastic, and plastic. The constriction resistance model is then used to calculate the constriction resistance for each contacting asperity based on the area of contact and radius of curvature of the asperity. The constriction resistance values for all the contacting asperities are then used to calculate the total thermal contact conductance. An experimental facility has also been constructed to measure thermal contact conductance of interfaces to verify the results of the predictive model. Good agreement has been found between the model predictions and experimental measurements, validating the modeling approach.     

Wavelength Conversion Placement in WDM Mesh Optical Networks*

Wavelength conversion helps improve the performance of wavelength division multiplexed (WDM) optical networks that employ wavelength routing. In this paper, we address the problem of optimally placing a limited number of wavelength converters in mesh topologies. Two objective functions, namely, minimizing the average blocking probability and minimizing the maximum blocking probability over all routes, are considered. In the first part of the paper, we extend an earlier analytical model to compute the blocking probability on an arbitrary route in a mesh topology, given the traffic and locations of converters. We then propose heuristic algorithms to place wavelength converters, and evaluate the performance of the proposed heuristics using the analytical model. Results suggest that simple heuristics are sufficient to give near-optimal performance.     

The Impact of Mobility on Cellular Network Configuration

This paper proposes a model for configuring cellular networks to study the dynamics of mobility between a single cell and its adjacent cells. It differs from most models considered in the literature by explicitly incorporating the dependency between the handoff rate and the system state. Besides, the handoff rate is also a function of cell size and subscriber mobility. Extensive computational experiments were done to study the impact of various input parameters on specific performance measures. Several observations are made regarding the system performance and as to how they are affected by the complex interaction between subscriber mobility, cell size, number of channels and the mean call initiation rate. The results of these experiments show that the proposed model, where handoff rates are state-dependent, captures additional traffic due to mobility when compared to the traditional method of modeling handoffs using information about the average behavior. Finally, the economic impact of mobility on system configuration decisions is analyzed. Though an approximation, the above work provides interesting insights about the impact of mobility in configuring cellular networks.