Bioengineered magnetoferritin nanozymes for pathological identification of high-risk and ruptured atherosclerotic plaques in humans

Atherosclerotic plaque rupture results in thrombus formation and vessel occlusion, and is the leading cause of death worldwide. There is a pressing need to identify plaque vulnerability for the treatment of carotid and coronary artery diseases. Nanomaterials with enzyme-like properties have attracted significant interest by providing biological, diagnostic and prognostic information about the diseases. Here we showed that bioengineered magnetoferritin nanoparticles (M-HFn NPs) functionally mimic peroxidase enzyme and can intrinsically recognize plaque-infiltrated active macrophages, which drive atherosclerotic plaque progression and rupture and are significantly associated with the plaque vulnerability. The M-HFn nanozymes catalyze the oxidation of colorimetric substrates to give a color reaction that visualizes the recognized active macrophages for one-step pathological identification of plaque vulnerability. We examined 50 carotid endarterectomy specimens from patients with symptomatic carotid disease and demonstrated that the M-HFn nanozymes could distinguish active macrophage infiltration in ruptured and high-risk plaque tissues, and M-HFn staining displayed a significant correlation with plaque vulnerability (r = 0.89, P < 0.0001).

     

Study of equivalent efficiency calibration method for radioactive gas source measured on HPGe detectors

ABSTRACT

In view of the complexity of current detection efficiency calibration of radioactive gas sources, a method using solid planar sources to be equivalent to gas sources was studied. For the 50 mL gas source box, an optimal equivalent scheme was selected by Monte Carlo Simulations. Then, the full-energy-peak efficiency curve of gas sources at the measurement position of 25 cm, with source-to-detector distance of 25 cm, was fitted by measuring solid planar sources with known activity. To verify the accuracy of the efficiency curve, ⁴¹Ar, ¹³³Xe and ⁸⁷Kr gases were produced and determined by length-compensated method. Then, their full-energy-peak efficiencies at 25 cm position away from the detector were directly calibrated. The percentage efficiency deviations between interpolation from the efficiency curve and direct calibration are all less than 2.5%, which proves the accuracy of the equivalent method. This calibration method is a general one and can be also used for some other radioactive sample measurements, such as non-destructive analysis of gaseous fission product samples with a suitable source-to-detector distance.     

Plasmonic coupling-enhanced in situ photothermal nanoreactor with shape selective catalysis for C-C coupling reaction

Carbon-carbon (C-C) coupling reactions represent one of the most powerful tools for the synthesis of complex natural products, bioactive molecules developed as drugs and agrochemicals. In this work, a multifunctional nanoreactor for C-C coupling reaction was successfully fabricated via encapsulating the core-shell Cu@Ni nanocubes into ZIF-8 (Cu@Ni@ZIF-8). In this nanoreactor, Ni shell of the core-shell Cu@Ni nanocubes was the catalytical active center, and Cu core was in situ heating source for the catalyst by absorbing the visible light. Moreover, benefiting from the plasmonic resonance effect between Cu@Ni nanocubes encapsulated in ZIF-8, the absorption range of nanoreactor was widened and the utilization rate of visible light was enhanced. Most importantly, the microporous structure of ZIF-8 provided shape-selective of reactant. This composite was used for the highly shape-selective and stable photocatalysed C-C coupling reaction of boric acid under visible light irradiation. After five cycles, the nanoreactor still remained high catalytical activity. This Cu@Ni@ZIF-8 nanoreactor opens a way for photocatalytic C-C coupling reactions with shape-selectivity.

     

Anchoring DTPA grafted PEI onto carboxylated graphene oxide to effectively remove both heavy metal ions and dyes from wastewater with robust stability

Highly efficient adsorbents, which can effectively remove both metal ions and dyes from wastewater with robust stability, are strongly required for the remediation of current polluted aqueous system, but still a challenge to be realized. Herein, a new adsorbent has been designed to solve this problem by anchoring diethylene triamine pentaacetic acid (DTPA) grafted polyethyleneimine (PEI) onto carboxylated GO (GOC-g-PD). Given the amino and carboxyl active groups from PEI and GOC/DTPA, our GOC-g-PD displays good adsorption capacity against not only inorganic metal ions (Cu²⁺ and Pb²⁺) but also organic dye (methylene blue: MB). The maximum adsorption capacity of GOC-g-PD for Cu²⁺, Pb²⁺ and MB reached 309.60 mg·g^?1, 316.17 mg·g^?1 and 262.10 mg·g^?1, respectively. Furthermore, our GOC-g-PD also exhibits good cycling stability and chemical stability against wide pH values. These outstanding properties revealed our GOC-g-PD held great potential in purifying the sewage discharged from industries.

Graphical abstract

     

提高筛条辊轧质量的工艺措施

分析了筛条在辊轧过程中的变形因素 ,介绍了株洲洗煤机械厂在提高筛条辊轧质量上采取的新工艺及所取得的成果。     

利用ArcObjects实现DWG挂接MDB属性数据转入Geodatabase的方法

以某工程为例,介绍一种利用ArcObjects实现DWG挂接MDB属性数据直接转入Geodatabase的方法。     

清水泵间接驱动竖井液力提升技术模拟研究

工业过程的连续化是提高效率,降低消耗和改善作业环境的有效技术途径,也是其工艺技术水平发展的重要标志.清水泵间接驱动竖井液力提升技术借鉴相关领域的已有技术成就,并结合竖井提升的功能要求综合设计而成的一个全新的提升方案.有别于国外在矿山竖井液力管道连续提升的破磨造浆-浆泵(均质两相流)-固液分离的技术思路,对妨碍其大规模工业应用的提升能力(尤其是提升高度)、设备磨损、增压给矿及浓度控制、能耗等一系列技术难题均有所突破.模拟试验证明了这一创新方案的可行性.     

某平炉引风机振害基础的纠偏与加固

某平炉引风机基础座落在松软地基上，在长期的负荷运转中，产生了严重的沉降、倾斜、断裂，使风机运行处于非正常状态，为排除隐患，确保风机的连续运转，本文作者设计并实施了一系列加固、纠编、补强、减振措施，保证了一号平炉的连续安全生产。