MRT of experimental liver abscesses: a comparison of a new blood pool contrast medium with gadolinium-DTPA in animal experiments

PURPOSE: In an experimental pyogenic liver abscess model, the signal intensities were compared intraindividually and interindividually after the application of a new blood pool contrast agent, 24-gadolinium-DTPA (diethylenetriamine-pentaacetic acid) cascade polymer, and after the application of gadopentetate dimeglumine. METHODS: In 20 rabbits with experimentally induced liver abscesses, the relative signal intensities of the liver, abscess centre, abscess wall and portal vein were assessed before and between 30 seconds and 60 minutes after injection of a 25 mumol/kg dose of gadolinium polymer and of 100 mumol/kg of gadolinium-DTPA, respectively. Measurements were performed at 1.5 Tesla, using a head coil and a Flash-2-D sequence. RESULTS: The interindividual comparison (unpaired T-test, p < 0.05) yielded significant differences of the relative signal intensities of the abscess centre (at any time point after contrast-media application), abscess wall (between 15 and 60 minutes after contrast media application), and portal vein (between 30 seconds and 7.5 minutes after contrast media application). The interindividual comparison showed a significantly higher abscess centre-liver contrast (between 30 seconds and 12.5 minutes after contrast media application) and a significantly higher abscess wall-centre contrast (between two and 7.5 minutes after contrast media application) after the application of gadolinium polymer compared with gadopentetate dimeglumine. CONCLUSION: In this animal model, the higher abscess centre-liver contrast after the application of gadolinium polymer was the basis for a better and prolonged visibility of the abscesses, as compared with images acquired after injection of gadopentetate dimeglumine.     

Natrium-Aluminium-Silicate - Eigenschaften und Anwendungen

Sodium Aluminium Silicates - Properties and Application Sodium aluminium silicates in amorphous and crystalline form are used since many years in various technical processes. The crystalline sodium aluminium silicates, e. g. zeolites, belong to the group of structured silicates and are known for their reversible water uptake and alkaline earth exchange properties. Recently, sodium aluminium silicates have gained considerable importance since their cation exchanging ability can be utilized in washing agents for the removal of undesirable hardness of water. Thus, the polyphosphates used in washing agents can possibly be substituted. Zeolites can be supplied to the detergent industry in the form of powder or suspension. Production of the powder by spray drying does not involve special problems. Incorporation of the powder into the slurry of the detergent appears to be an anachronism from the viewpoint of energy saving. Optimization work on suspensions of zeolite yielded stable products with 45 to 48% zeolite content. The theory of critical particle concentration was applied in this work.     

Numerical simulation of non-linear chatter vibration in turning

In this paper, basic relationships and algorithms for numerical simulation of non-linear, self-excited vibrations in single degree-of-freedom cutting systems are presented. Non-linearities due to the tool leaving the cut, as well as interference between the cutting tool clearance face and cutting surface waviness, were taken into consideration. Examples of vibration simulation results are shown.     

The confused world of sulfate attack on concrete

External sulfate attack is not completely understood. Part I identifies the issues involved, pointing out disagreements, and distinguishes between the mere occurrence of chemical reactions of sulfates with hydrated cement paste and the damage or deterioration of concrete; only the latter are taken to represent sulfate attack. Furthermore, sulfate attack is defined as deleterious action involving sulfate ions; if the reaction is physical, then, it is physical sulfate attack that takes place. The discussion of the two forms of sulfate attack leads to a recommendation for distinct nomenclature. Sulfate attack on concrete structures in service is not widespread, and the amount of laboratory-based research seems to be disproportionately large. The mechanisms of attack by different sulfates—sodium, calcium, and magnesium—are discussed, including the issue of topochemical and through-solution reactions. The specific aspects of the action of magnesium sulfate are discussed, and the differences between laboratory conditions and field exposure are pointed out.Part II discusses the progress of sulfate attack and its manifestations. This is followed by a discussion of making sulfate-resisting concrete. One of the measures is to use Type V cement, and this topic is extensively discussed. Likewise, the influence of w/c on sulfate resistance is considered. The two parameters are not independent of one another. Moreover, the cation in the sulfate salt has a strong bearing on the efficiency of the Type V cement. Recent interpretations of the Bureau of Reclamation tests, both long term and accelerated, are evaluated, and it appears that they need reworking.Part III reviews the standards and guides for the classification of the severity of exposure of structures to sulfates and points out the lack of calibration of the various classes of exposure. A particular problem is the classification of soils because much depends on the extraction ratio of sulfate in the soil: there is a need for a standardized approach. Taking soil samples is discussed, with particular reference to interpreting highly variable contents of sulfates. The consequences of disturbed drainage of the soil adjacent to foundations and of excessive irrigation, coupled with the use of fertilizer, are described. Whether concrete has undergone sulfate attack can be established by determining the change in the compressive strength since the time of placing the concrete. The rejection of this method and the reliance on determining the tensile strength of concrete because of “layered damage” are erroneous. Scanning electron microscopy (SEM) should not be the primary, and certainly not the first, method of determining whether sulfate attack has occurred. Mathematical modeling will be of help in the future but, at present, cannot provide guidance on the sulfate resistance of concrete in structures.Part IV presents conclusions and an overview of the situation, with consideration of future improvements. Appendix A contains the classification of exposure to sulfate given by various codes and guides.     

Approximation Algorithms for <Emphasis Type="Italic">k</Emphasis>-hurdle Problems

The polynomial-time solvable k-hurdle problem is a natural generalization of the classical s-t minimum cut problem where we must select a minimum-cost subset S of the edges of a graph such that |p∩S|≥k for every s-t path p. In this paper, we describe a set of approximation algorithms for “k-hurdle” variants of the NP-hard multiway cut and multicut problems. For the k-hurdle multiway cut problem with r terminals, we give two results, the first being a pseudo-approximation algorithm that outputs a (k−1)-hurdle solution whose cost is at most that of an optimal solution for k hurdles. Secondly, we provide a 2(1-\frac1r)2(1-\frac{1}{r})-approximation algorithm based on rounding the solution of a linear program, for which we give a simple randomized half-integrality proof that works for both edge and vertex k-hurdle multiway cuts that generalizes the half-integrality results of Garg et al. for the vertex multiway cut problem. We also describe an approximation-preserving reduction from vertex cover as evidence that it may be difficult to achieve a better approximation ratio than 2(1-\frac1r)2(1-\frac{1}{r}). For the k-hurdle multicut problem in an n-vertex graph, we provide an algorithm that, for any constant ε>0, outputs a ⌈(1−ε)k⌉-hurdle solution of cost at most O(log n) times that of an optimal k-hurdle solution, and we obtain a 2-approximation algorithm for trees.     

Ubiquitin Ligases in Longevity and Aging Skeletal Muscle

The development and prevalence of diseases associated with aging presents a global health burden on society. One hallmark of aging is the loss of proteostasis which is caused in part by alterations to the ubiquitin–proteasome system (UPS) and lysosome–autophagy system leading to impaired function and maintenance of mass in tissues such as skeletal muscle. In the instance of skeletal muscle, the impairment of function occurs early in the aging process and is dependent on proteostatic mechanisms. The UPS plays a pivotal role in degradation of misfolded and aggregated proteins. For the purpose of this review, we will discuss the role of the UPS system in the context of age-related loss of muscle mass and function. We highlight the significant role that E3 ubiquitin ligases play in the turnover of key components (e.g., mitochondria and neuromuscular junction) essential to skeletal muscle function and the influence of aging. In addition, we will briefly discuss the contribution of the UPS system to lifespan. By understanding the UPS system as part of the proteostasis network in age-related diseases and disorders such as sarcopenia, new discoveries can be made and new interventions can be developed which will preserve muscle function and maintain quality of life with advancing age.