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排序方式: 共有193条查询结果,搜索用时 0 毫秒
1.
H King MC McCulloch JA Barrie E Kyriakides CV Beechey BM Cattanach IR Griffiths 《Canadian Metallurgical Quarterly》1997,26(8):557-566
Animals with spontaneous mutations affecting myelin formation have provided useful information about the genetic and cellular mechanisms regulating normal and abnormal myelination. In this paper we describe a novel murine mutation termed hindshaker (hsh), which is inherited in an autosomal recessive manner. Affected mice are characterised by a variable tremor of the hind end which commences at about 2 weeks of age and largely disappears in animals older than 6 weeks. There is hypomyelination affecting predominantly the spinal cord, although the optic nerves and brain are involved to a much lesser degree. The defect of thinly myelinated and naked axons is maximal at 20 days of age and largely resolves with time so that in the adult most axons are myelinated. The myelin structure appears normal and immunostains for the major proteins. Although the distribution of oligodendrocytes in the spinal cord is similar to normal during the period of hypomyelination, there are fewer mature cells. The hsh mutation appears to delay the maturation of oligodendrocytes, particularly in the spinal cord. Additionally, there is a considerable variation in phenotypic expression and in penetrance when the mutation is expressed on different genetic backgrounds, suggesting the hsh locus is subject to the influence of modifying gene(s). Identification of the hsh gene should identify a factor important in the development of oligodendrocytes, particularly those in the spinal cord. 相似文献
2.
Poly(epichlorohydrin-g-styrene) copolymers, P(ECH-g-S)s, have been prepared in solution by two different methods of coupling polyepichlorohydrin, PECH, with polystyrene, PS, containing a functional end group. In the first method, polystyryl carboxylic acid, PSCOOH, prepared from living polystyrene, was converted to the corresponding potassium salt which was coupled with PECH in dimethyl formamide solution usually at 60°C. In the second method, polystyryl potassium, PS?K+, in tetrahydrofuran solution was end-capped with propylene sulphide to form PSCH2CH(CH3)S?K+ which was coupled directly with PECH in tetrahydrofuran at 40°C. Grafting by the first reaction was relatively slow but occurred without significant adverse side reactions. The grafting by the second reaction was relatively fast, but side reactions occurred resulting in a cleavage of the graft copolymer. The graft copolymers were purified by fractional precipitation and extraction procedures and were characterized by infra-red and ultra-violet spectroscopy, microanalysis, gel permeation chromatography, differential scanning calorimetry, solution viscometry, dynamic mechanical testing, and electron microscopy. Solution properties of the graft copolymers in benzene-carbon tetrachloride and toluene-cyclohexane mixtures were studied. There was evidence of micelle formation in dilute solutions of the mixed solvents and microphase separation of components in the solid state. Nucleophilic substitution of chlorine atoms in PECH by phenyl acetate (C6H5 CH2COO-) and thiophenoxide (C6H5S-) groups was performed. 相似文献
3.
Dennis D. Pietronigro Myron L. Seligman W. Barrie G. Jones Harry B. Demopoulos 《Lipids》1976,11(11):808-813
Deoxyribonucleic acid (DNA) is associated with the cell membrane of prokaryotes and the inner nuclear membrane of eukaryotes.
The unsaturated fatty acids of phospholipids, which constitute the bilaminar structure of membranes, undergo autoxidation
in the presence of O2. Calf thymus DNA was incubated with methyl archidonate-enriched phosphatidyl choline liposomes in order to study the effect
of DNA upon the oxidation of phospholipids while present in their natural in vivo bilayer configuration. DNA retarded the
rate of lipid oxidation and the TBA test, but it did not alter the induction period. These results suggest that DNA is scavenging
free radicals produced within the phospholipid bilayer. 相似文献
4.
Kunsoo Han Robert J. Kauffman Barrie R. Nault 《Information Technology and Management》2008,9(3):181-200
Implementation and maintenance of interorganizational systems (IOS) require investments by all the participating firms. Compared
with intraorganizational systems, however, there are additional uncertainties and risks. This is because the benefits of IOS
investment depend not only on a firm’s own decisions, but also on those of its business partners. Without appropriate levels
of investment by all the firms participating in an IOS, they cannot reap the full benefits. Drawing upon the literature in
institutional economics, we examine IOS ownership as a means to induce value-maximizing noncontractible investments. We model
the impact of two factors derived from the theory of incomplete contracts and transaction cost economics: relative importance
of investments and specificity of investments. We apply the model to a vendor-managed inventory system (VMI) in a supply chain
setting. We show that when the specificity of investments is high, this is a more critical determinant of optimal ownership
structure than the relative importance of investments. As technologies used in IOS become increasingly redeployable and reusable,
and less specific, the relative importance of investments becomes a dominant factor. We also show that the bargaining mechanism—or
the agreed upon approach to splitting the incremental payoffs—that is used affects the relationship between these factors
in determining the optimal ownership structure of an IOS.
相似文献
Barrie R. NaultEmail: |
5.
Christian Wolkersdorfer Rob Bowell Ingar F. Walder Steinar Nilssen Marja Liisa R?is?nen P?ivi Heikkinen Kari Pulkkinen Kirsti Korkka-Niemi Veli-Pekka Salonen Georgia Destouni Andrea Hasche Andrzej J. Witkowski A. Blachère S. Morel D. Lefort Sanda Mid?i? Irem Silajd?i? R. H. Coulton K. P. Williams Ben Rees Kevin B. Hallberg D. Barrie Johnson 《Mine Water and the Environment》2012,31(3):237-238
6.
Barrie M. Ratcliffe 《Planning Perspectives》2013,28(2):189-193
This paper addresses itself to a problem that faces all cities but which was — and was seen to be — an ever more grave one for the burgeoning cities of nineteenth century Europe: environmental pollution. This problem — and in particular sewage which is the focus of the article — has as yet been little studied by historians. The paper shows, first, that in Paris in the period 1750–1850 the city was confronted by rapidly increasing quantities of sewage and that for complex cultural, class and scientific reasons Parisian elites came to perceive sewage removal as a problem that required solution and to adopt a series of strategies to do so. It shows, secondly, that the city's administration brought about changes which were of greater import than those effected under Haussmann in the 1850s and 1860s. The limits to what it could do were imposed not by short‐sightedness or parsimony, but by long‐term structural constraints of different orders, attitudinal, technological, power relationships in the capitalist city. 相似文献
7.
Dr. Alexander J. M. Disney Prof. Barrie Kellam Dr. Lodewijk V. Dekker 《ChemMedChem》2016,11(9):972-979
The natural product staurosporine is a high‐affinity inhibitor of nearly all mammalian protein kinases. The labelling of staurosporine has proven effective as a means of generating protein kinase research tools. Most tools have been generated by acylation of the 4′‐methylamine of the sugar moiety of staurosporine. Herein we describe the alkylation of this group as a first step to generate a fluorescently labelled staurosporine. Following alkylation, a polyethylene glycol linker was installed, allowing subsequent attachment of fluorescein. We report that this fluorescein–staurosporine conjugate binds to cAMP‐dependent protein kinase in the nanomolar range. Furthermore, its binding can be antagonised with unmodified staurosporine as well as ATP, indicating it targets the ATP binding site in a similar fashion to native staurosporine. This reagent has potential application as a screening tool for protein kinases of interest. 相似文献
8.
Rossana Grilli Marie Laure Abel Mark A. Baker Barrie Dunn John F. Watts 《International Journal of Adhesion and Adhesives》2011,31(7):687-694
A thermodynamic study of the adsorption of an epoxy acrylate resin used for UV-cured coatings on two different anticorrosion pretreatments on aluminium alloys relevant to aerospace industry has been undertaken. Aluminium alloy Al2219 specimens, treated with an inorganic chromate based conversion coating (Alodine 1200S) and an organic titanium based conversion coating (Nabutan STI/310), were immersed in solutions of different concentrations of the resin and adsorption isotherms were determined by assessing the uptake of the adsorbate, as a function of solution concentration, by time-of-flight secondary ion mass spectrometry (ToF-SIMS). The results show different behaviour for the two substrates, which can be attributed to the organic component of the titanium based coating. In the case of the inorganic conversion coating a clear plateau is achieved at relatively low concentrations and at a lower level of adsorption than for the hybrid coating. The data for both the coatings conform well to the Langmuir model, the organic coating, as well as showing a higher level of adsorption of the resin, also presents oscillatory behaviour at low concentration, which is shown to be complementary to the behaviour of the reactive diluent included with the epoxy acrylate to aid processing. A discussion of this competitive adsorption of the epoxy resin and the diluent on the different substrates is presented, based on considerations of the chemistry of the systems under investigation. 相似文献
9.
In many industries, agent-intermediated markets are inefficient because information about latent demand and supply never gets to market. We demonstrate how information technology (IT) in the form of an agent-intermediated electronic market (EM) alleviates this problem by enhancing the agent-as-market-maker using the international freight transportation industry as an example. We find that an EM increases agent participation and investment thereby increasing demand and supply. Because of tradeoffs between incentives for investment, the EM chooses a profit allocation between agents resulting in limited agent participation. In addition, when price depends on demand and supply balances, price and volume in the market can increase simultaneously. 相似文献
10.
Monster A. Willem Pittore J. Barrie W. 《IEEE transactions on bio-medical engineering》1980,(2):110-112
Inability to predict the intramusclar orientation, depth, and distribution of a motor unit's muscle fibers within a human skeletal muscle complicates unit size estimation. A data collection system is described that is suitable for systematic study of this problem. 相似文献