Therapist-aided exposure for women with lifelong vaginismus: A replicated single-case design.

Vaginismus is commonly described as a persistent difficulty in allowing vaginal entry of a penis or other object. Lifelong vaginismus occurs when a woman has never been able to have intercourse. A replicated single-case A-B-phase design was used to investigate the effectiveness of therapist-aided exposure for lifelong vaginismus. A baseline period (Phase A) was contrasted with exposure + follow-up (Phase B), using random switching between phases. The main outcome measure (intercourse ability) was assessed daily for 24 weeks. Ten women participated. The exposure consisted of a maximum of three 2-hr sessions during 1 week at a university hospital. The participant performed vaginal penetration exercises on herself, in the presence of a female therapist. Two follow-up sessions were scheduled over a 5-week period. Nine of the 10 participants reported having intercourse after treatment, and in 5 of the 9, intercourse was possible within the 1st week of treatment. The results remained at 1-year follow-up. Furthermore, exposure was successful in decreasing fear and negative penetration beliefs posttreatment and at 3-month and 1-year follow-ups. Therapist-aided exposure appears to be an effective treatment for lifelong vaginismus. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Radiomics and Machine Learning in Oral Healthcare

The increasing storage of information, data, and forms of knowledge has led to the development of new technologies that can help to accomplish complex tasks in different areas, such as in dentistry. In this context, the role of computational methods, such as radiomics and Artificial Intelligence (AI) applications, has been progressing remarkably for dentomaxillofacial radiology (DMFR). These tools bring new perspectives for diagnosis, classification, and prediction of oral diseases, treatment planning, and for the evaluation and prediction of outcomes, minimizing the possibilities of human errors. A comprehensive review of the state‐of‐the‐art of using radiomics and machine learning (ML) for imaging in oral healthcare is presented in this paper. Although the number of published studies is still relatively low, the preliminary results are very promising and in a near future, an augmented dentomaxillofacial radiology (ADMFR) will combine the use of radiomics‐based and AI‐based analyses with the radiologist's evaluation. In addition to the opportunities and possibilities, some challenges and limitations have also been discussed for further investigations.     

Interpreting reinterpretation: the 13th conference of the European Association for Urban History,Helsinki, 24–28 August 2016

A sunny Helsinki was the backdrop for the 13th biannual conference of the European Association for Urban History (EAUH). The EAUH was established in 1989 with the aim to create a common platform to historians, geographers, sociologists, planners, and other scholars working with a multidisciplinary approach on urban history in different time periods. The first EAUH conference took place in Amsterdam in 1992 and the next one will take place in Rome during 2018 (for further information about EAUH, please visit the website: http://www.eauh.eu/). The ambitious theme of the 13th conference was Reinterpreting Cities. For planning historians, this theme held ample promise on programmatic, methodological, and theoretical levels. With 592 participants, 44 main sessions, and 30 specialist sessions, we decided to look at the conference through a specific lens. Based on a selection of relevant panels, therefore, we formulated two questions: first, how can a reinterpretation of cities lead to new theories on the city and connect to existing theories in other disciplines? And second, how can a reinterpretation of urban history connect to the ‘real world’, for example, planning practices? This conference report explores the ways in which this conference actually reinterpreted the city, in particular, how it connected to the spatial dimension and planning history.     

Do science-technology interactions pay off when developing technology?

We investigate the relationship between the science intensity of technology domains and country's performance within these domains. The number of references in patents to scientific articles is considered as an approximation of the science intensity of a technology domain whereas a country's technological performance is measured in terms of its technological productivity (i.e. number of patents per capita). We use USPTO patent-data for eight European countries in ten technological domains. A variance analysis (ANOVA) is applied. Country as an independent variable does not explain a significant portion of the observed variance in science intensity (p=0.25). Technology domain, however, explains a significant portion of the observed variance (p<0.001). Moreover, in science intensive fields we find a positive relation between the science linkage intensity of these fields and the technological productivity of the respective countries involved. These findings seem to suggest the relevancy of designing innovation policies, aimed at fostering interaction between knowledge generating actors and technology producers, in a field specific manner. This revised version was published online in August 2006 with corrections to the Cover Date.     

Chemical characterisation of marine aerosol at Amsterdam Island during the austral summer of 2006–2007

Atmospheric aerosols were collected in separate fine (<2.5 μm) and coarse (>2.5 μm) size fractions in the period December 2006–March 2007 at Amsterdam Island in the southern Indian Ocean. A major objective of the study was to assess biogenic impact on the marine aerosol. The samples were analysed for organic carbon, water-soluble organic carbon, major inorganic ionic species, and organic species, including methanesulphonate (MSA), dicarboxylic acids, and organosulphates. The concentrations of sea salt, non-sea-salt sulphate, and water-soluble and water-insoluble organic matter (WSOM and WIOM) were estimated. Sea salt dominated the composition of the aerosol and accounted for 83% and 91% of the sum of the mass of the four aerosol types in the fine and coarse size fractions, respectively. WSOM, which can serve as a proxy for biogenic secondary organic aerosol (SOA), accounted for only 2.8% of the sum of the mass of the four aerosol types in the fine size fraction. MSA was the dominating organic compound with a median concentration of 47 ng m^?3. The organosulphates were characterised as sulphate esters of hydroxyl acids and a dihydroxylaldehyde, which may originate from the oxidation of algal/bacterial unsaturated fatty acid residues. No evidence was found for isoprene SOA.     

Assessing the foreign control of production of technology: The case of a small open economy

Summary International R&D activities have grown significantly over the last two decades. Both the number of actors involved, as well as the importance of the technological activity carried out abroad, has considerably increased. We aim to quantify the international generation of knowledge for the case of Belgium, using indicators based on EPO and USPTO patent data (1978-2001). We distinguish among Belgian applicants, affiliates of foreign firms located in Belgium as well as Belgian based firms with affiliates abroad. This approach allows to improve existing indicators of internationalisation of technology based on patent data. The results are consistent with what can be expected for a small open economy as Belgium. A large part of patents with Belgian inventors are assigned to Belgian affiliates of foreign firms. Hence our more complete indicator of foreign ownership gives a substantially higher foreign control of Belgian inventors. Relatively more knowledge generated by Belgian inventors flows out of the country towards foreign owners of technology, than that knowledge generated abroad is owned by Belgian patent applicants. But the share of foreign inventors to Belgian assigned patents is considerably increasing over time, especially in the subcategory of Belgian firms with foreign affiliates.     

Cognitive-behavioral therapy for women with lifelong vaginismus: A randomized waiting-list controlled trial of efficacy.

Women with lifelong vaginismus (N = 117) were randomly assigned to cognitive-behavioral group therapy, cognitive-behavioral bibliotherapy, or a waiting list. Manualized treatment comprised sexual education, relaxation exercises, gradual exposure, cognitive therapy, and sensate focus therapy. Group therapy consisted of ten 2-hr sessions with 6 to 9 participants per group. Assistance with minimal-contact bibliotherapy consisted of 6 biweekly, 15-min telephone contacts. Twenty-one percent of the participants left the study before posttreatment assessment. Intent-to-treat analysis revealed that successful intercourse at posttreatment was reported by 14% of the treated participants compared with none of the participants in the control condition. At the 12-month follow-up 21% of the group therapy participants and 15% of the bibliotherapy participants, respectively, reported successful intercourse. Cognitive-behavioral treatment of lifelong vaginismus was thus found to be efficacious, but the small effect size of the treatment warrants future efforts to improve the treatment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Can technology lead to a competitive advantage? A case study of Flanders using european patent data

The study tries to analyze regional technological capabilities, linking technological positions to economic strength of the region. To measure this link, we correlate the EPO patent data with trade data to assess the degree to which technological advantages are translated into comparative advantages for the Flemish region in Belgium. The analysis for Flanders provides some interesting insights. Following the skewed distribution of firms, the technological areas in which Flanders is able to build, a strong position are very specific: printing technology, weaving technology, photography and recently also telecommunications. Weak positions are outspoken in car technology. Linking these strengths and weaknesses in technological areas to economic activity revealed an important mismatch between both. Most of the Flemish patents are in sectors without any comparative advantage, while most of the sectors where Flanders does hold a comparative advantage, like chemicals and pharmaceuticals, do not show strong technological advantages in terms of patents. Given the mismatch that was detected between technological positions and economic advantages, it is of crucial importance to better understand the (missing) links between the various actors in the regional innovation system. The analysis points out two important issues. The large and growing number of foreign applications to Belgian/Flemish inventors and the large number of subsidiaries of foreign firms among Belgian/Flemish applications illustrate the pervasiveness of the foreign dimension in the Belgian/Flemish technological landscape. Also very specific to the Belgian/Flemish situation, is the limited importance of universities or research centers in terms of patenting activities.     

Towards a multipolar science world: trends and impact

This paper brings together recent statistical evidence on international (co-)publications and (foreign) PhD-students and scholars to document shifts in geographic sources of scientific production and the impact this has on flows of scientific talent and partnering for scientific collaboration. The evidence demonstrates that despite the continued dominance of the US and the increasing importance of the EU, the TRIAD is in relative decline. Other geographic sources of science outside the TRIAD are rising, both in quantity, but also, although still to a lesser extent, in quality. Especially China drives this non-TRIAD growth. This catching-up of non-TRIAD countries drives a slow but real process of global convergence. It nevertheless leaves a less equal non-TRIAD science community, as the growth of China, is not matched by other non-TRIAD countries. Despite the rise of China’s own scientific production, and the increasing return flows of overseas students and scholars, the outward flows of Asian talents have not diminished over time. The data suggest a high correlation between the patterns of international mobility of scientists and the patterns of international collaborations. The large and stable flow of Chinese human capital into the US forms the basis on which stable international US-Chinese scientific networks are built. With the EU lacking this Chinese human capital circulation, it is more difficult to build up similar strong and stable networks.     

Hydroxydicarboxylic acids: markers for secondary organic aerosol from the photooxidation of alpha-pinene

Detailed organic analysis of fine (PM2.5) rural aerosol collected during summer at K-puszta, Hungary from a mixed deciduous/coniferous forest site shows the presence of polar oxygenated compounds that are also formed in laboratory irradiated alpha-pinene/NOx/air mixtures. In the present work, two major photooxidation products of alpha-pinene were characterized as the hydroxydicarboxylic acids, 3-hydroxyglutaric acid, and 2-hydroxy-4-isopropyladipic acid, based on chemical, chromatographic, and mass spectral data. Different types of volatile derivatives, including trimethylsilyl ester/ether, methyl ester trimethylsilyl ether, and ethyl ester trimethylsilyl ether derivatives were measured by gas chromatography/mass spectrometry (GC/MS), and their electron ionization (El) spectra were interpreted in detail. The proposed structures of the hydroxydicarboxylic acids were confirmed or supported with reference compounds. 2-Hydroxy-4-isopropyladipic acid formally corresponds to a further reaction product of pinic acid involving addition of a molecule of water and opening of the dimethylcyclobutane ring; this proposal is supported by a laboratory irradiation experiment with alpha-pinene/NOJ0 air. In addition, we report the presence of a structurally related minor alpha-pinene photooxidation product, which was tentatively identified as the C7 homolog of 3-hydroxyglutaric acid, 3-hydroxy-4,4-dimethylglutaric acid. The detection of 2-hydroxy-4-isopropyladipic acid in ambient aerosol provides an explanation for the relatively low atmospheric concentrations of pinic acid found during daytime in forest environments.