Microfluidics for particle synthesis from photocrosslinkable materials

This paper is a review of microfluidics for particle synthesis from photocrosslinkable materials. Microfluidics for particle synthesis is rapidly gaining attention as a viable method for the synthesis of particles with applications in drug delivery, security, abrasives, rheology, catalysis and other areas. Particle synthesis can follow several schemes, but the focus of this review is particle synthesis from photocrosslinkable materials. In these systems, solid particles are formed by the light-initiated cross-linking of precursor materials. This review begins with a discussion of photocrosslinkable materials, typically synthetic hydrogels for particle synthesis applications. Next, polydimethyl siloxane and glass devices are presented as the primary microfluidic devices for synthesis from photocrosslinkable materials. Then, the review discusses three types of polymeric particles: spherical, spheroidal and Janus. Subsequently, composite particles and metal or metal oxide particles are discussed. The review closes with a discussion of particle throughput and the outlook for the field of particle synthesis from photocrosslinkable materials.     

Formation of Quasicrystals and Related Structures in Systems of Aluminum with Transition Metals. Part 1. Binary Systems Formed by Aluminum with 3d Metals

Quasiperiodic phases (quasicrystals) with symmetries forbidden by classic crystallography have been observed in systems of aluminum with transition metals. In binary systems, these phases are metastable; they were obtained for the first time by rapid solidification of melts. We consider the formation of the quasicrystals and we refine the phase diagrams for binary systems A – 3d-M (from V to Ni) in which quasicrystals have been observed.     

Evidence for Oxidative Pathways in the Pathogenesis of PD: Are Antioxidants Candidate Drugs to Ameliorate Disease Progression?

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that arises due to a complex and variable interplay between elements including age, genetic, and environmental risk factors that manifest as the loss of dopaminergic neurons. Contemporary treatments for PD do not prevent or reverse the extent of neurodegeneration that is characteristic of this disorder and accordingly, there is a strong need to develop new approaches which address the underlying disease process and provide benefit to patients with this debilitating disorder. Mitochondrial dysfunction, oxidative damage, and inflammation have been implicated as pathophysiological mechanisms underlying the selective loss of dopaminergic neurons seen in PD. However, results of studies aiming to inhibit these pathways have shown variable success, and outcomes from large-scale clinical trials are not available or report varying success for the interventions studied. Overall, the available data suggest that further development and testing of novel therapies are required to identify new potential therapies for combating PD. Herein, this review reports on the most recent development of antioxidant and anti-inflammatory approaches that have shown positive benefit in cell and animal models of disease with a focus on supplementation with natural product therapies and selected synthetic drugs.     

Eco-Sustainable Silk Fibroin/Pomegranate Peel Extract Film as an Innovative Green Material for Skin Repair

Skin disorders are widespread around the world, affecting people of all ages, and oxidative stress represents one of the main causes of alteration in the normal physiological parameters of skin cells. In this work, we combined a natural protein, fibroin, with antioxidant compounds extracted in water from pomegranate waste. We demonstrate the effective and facile fabrication of bioactive and eco-sustainable films of potential interest for skin repair. The blended films are visually transparent (around 90%); flexible; stable in physiological conditions and in the presence of trypsin for 12 days; able to release the bioactive compounds in a controlled manner; based on Fickian diffusion; and biocompatible towards the main skin cells, keratinocytes and fibroblasts. Furthermore, reactive oxygen species (ROS) production tests demonstrated the high capacity of our films to reduce the oxidative stress induced in cells, which is responsible for various skin diseases.     

选择降压转换器的无源组件

电源设计往往是系统最后一个考虑因素。这时,大部分用户可选择一个有效模块——输入一个DC电压生成另一个电压。这个模块可以有不同规格,以步降方式生成低电压,或以步升方式生成高电压。同时,还有大量专用方案,如步升/步降、反激式和单端初级电感转换器（sepic）,这种DC-DC转换器可生成大于、小于或等于输入电压的输出电压。对于基于AC电源工作的系统,     

Old World Archaeometallurgy

Over the last twenty years, there has been a discernable increase in the number of scholars who have focused their research on metal production, working and use in antiquity, a field of study which has come to be known as archaeometallurgy. Materials scientists and conservators have worked primarily in the laboratory while archaeologists have conducted fieldwork geared to the study of metal technology in cultural context with laboratory analysis as one portion of the interpretive program.     

信号链的集成与去集成

研究了混合信号链中的每一个模块集成的可能性,重点讨论了ADC和DAC,并分析了模块功能的集成与去集成的利弊.     

Carbon‐Based Anodes for Lithium Sulfur Full Cells with High Cycle Stability

The lithium sulfur battery system has been studied since the late 1970s and has seen renewed interest in recent years. However, even after three decades of intensive research, prolonged cycling can only be achieved when a large excess of electrolyte and lithium is used. Here, for the first time, a balanced and stable lithium sulfur full cell is demonstrated with silicon–carbon as well as all‐carbon anodes. More than 1000 cycles, a specific capacity up to 1470 mAh g^?1 _sulfur (720 mAh g^?1 _cathode), and a high coulombic efficiency of over 99% even with a low amount of electrolyte are achieved. The alternative anodes do not suffer from electrolyte depletion, which is found to be the main cause of cell failure when using metallic lithium anodes.     

Comparative psychometric analysis of vector and isochrone cardiac activation maps

Isochronal cardiac activation maps can be constructed from local activation times associated with spatial locations, and are frequently used to study cardiac arrhythmias. Cardiac velocity vector mapping has been proposed as an alternative method to study cardiac activation in both clinical and research environments. Velocity vectors inherently contain more information than scalar measures of latency, but it is unknown how vector maps and isochronal maps compare when they are used to identify patterns and features associated with arrhythmias. In order to quantitatively compare these two visualization methods, eight cardiologists were asked to complete forced-choice tasks in which they selected ablation sites based on synthetic vector or isochronal maps. Maps varied in arrhythmia complexity, number of vectors or activation times included, and errors in magnitude or angle for maps of velocity vectors. Quantitative comparison was achieved by using psychometric functions to characterize the learning curve and the total number of measurements needed in order to choose a correct ablation site. For simple arrhythmias, performance with vector maps was superior to isochronal maps. Subjects required fewer measurements, and learned more rapidly by studying vector maps. For more complex arrhythmias, there was no significant difference in performance between vector and isochronal maps. However, arrhythmia features were clearer with vector maps, even though this clarity did not necessarily change the ablation site choice. When errors were added to vector maps, performance was satisfactory for angle errors < 55 degrees, and speed errors did not affect performance.