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1.
Temporal order and functional analysis of mutations within the Fli-1 and p53 genes during the erythroleukemias induced by F-MuLV 总被引:1,自引:0,他引:1
JC Howard S Yousefi G Cheong A Bernstein Y Ben-David 《Canadian Metallurgical Quarterly》1993,8(10):2721-2729
The erythroleukemias induced by Friend murine leukemia virus (F-MuLV) result from the accumulation of a number of genetic changes, including activation of the Fli-1 proto-oncogene and inactivation of the p53 tumor suppressor gene. We have determined the temporal order of mutation of the genes involved in this multistage malignancy, by serial in vivo transplantation of F-MuLV induced primary erythroleukemias into syngenic Balb/c mice. These primary tumors are capable of growing when transplanted into syngenic mice, but die after several days of in vitro culture. From the transplanted tumors grown in syngenic mice, erythropoietin-dependent cell lines were established in culture that are clonally related to cells in the primary tumors. We show that retroviral insertional activation of the Fli-1 ets family member is the first detectable genetic event in F-MuLV induced primary erythroleukemias. Mutations in the p53 gene were observed in the Epo-dependent cell lines but not in the transplanted erythroleukemias used to establish these cell lines in culture. These data suggest that activation of Fli-1 plays an important role in the early stages of F-MuLV-induced leukemia, perhaps by altering the self-renewal probabilities of erythroid progenitor cells and that p53 mutations immortalize these cells, enabling them to grow in vitro in the presence of Epo. 相似文献
2.
Yousefi M. Chaudhuri S.K. Safavi-Naeini S. 《Antennas and Propagation, IEEE Transactions on》1994,42(1):38-46
Dielectric resonators (DR's) are widely used in telecommunication systems. A method is proposed here to find the resonant frequency and field distribution in a substrate-mounted DR structure. The field of a dielectric rod has been decomposed into a combination of guided modes with unknown coefficients and an unknown continuous spectrum of radiation field. The unknowns are then obtained by applying two generalized impedance boundary conditions (GIBC's) representing the substrate and air layers at the top and bottom of the DR. This leads to the calculation of the total (guided+radiation) field as well as the resonant frequency of the structure 相似文献
3.
Many regulators use benchmarking as part of the incentive-based regulation of natural monopolies so as to reduce the possibilities for gaming. However, the use of benchmarking can lead firms to pursue virtual rather than true performance improvements by gaming the regulator’s benchmarking in a number of ways that are contrary to the intentions of the scheme. 相似文献
4.
Engineering with Computers - In this study, the Ritz–Galerkin method based on Legendre multiwavelet functions is introduced to solve multi-term time-space convection–diffusion equations... 相似文献
5.
Rasoul Rahmani Nima M. A. Langeroudi Rozbeh Yousefi Milad Mahdian Mohammadmehdi Seyedmahmoudian 《Neural computing & applications》2014,25(3-4):879-888
In this paper, a five-level cascaded H-bridge multilevel inverters topology is applied on induction motor control known as direct torque control (DTC) strategy. More inverter states can be generated by a five-level inverter which improves voltage selection capability. This paper also introduces two different control methods to select the appropriate output voltage vector for reducing the torque and flux error to zero. The first is based on the conventional DTC scheme using a pair of hysteresis comparators and look up table to select the output voltage vector for controlling the torque and flux. The second is based on a new fuzzy logic controller using Sugeno as the inference method to select the output voltage vector by replacing the hysteresis comparators and lookup table in the conventional DTC, to which the results show more reduction in torque ripple and feasibility of smooth stator current. By using Matlab/Simulink, it is verified that using five-level inverter in DTC drive can reduce the torque ripple in comparison with conventional DTC, and further torque ripple reduction is obtained by applying fuzzy logic controller. The simulation results have also verified that using a fuzzy controller instead of a hysteresis controller has resulted in reduction in the flux ripples significantly as well as reduces the total harmonic distortion of the stator current to below 4 %. 相似文献
6.
Fatemeh Ghods Hamed Yousefi Ali Mohammad Afshin Hemmatyar Ali Movaghar 《Computer Networks》2013,57(18):3812-3825
Data aggregation is a key, yet time-consuming functionality in wireless sensor networks (WSNs). Multi-channel design is a promising technique to alleviate interference as a primary reason for long latency of TDMA aggregation scheduling. Indeed, it provides more potential of parallel transmissions over different frequency channels, thus minimizing time latency. In this paper, we focus on designing a multi-channel minimum latency aggregation scheduling protocol, named MC-MLAS, using a new joint approach for tree construction, channel assignment, and transmission scheduling. To our best knowledge, this is the first work in the literature which combines orthogonal channels and partially overlapping channels to consider the total latency involved in data aggregation. Extensive simulations verify the superiority of MC-MLAS in WSNs. 相似文献
7.
Fischer A.P.A. Yousefi M. Lenstra D. Carter M.W. Vemuri G. 《IEEE journal of selected topics in quantum electronics》2004,10(5):944-954
We report experimental results on the nonlinear dynamical response of a semiconductor laser subjected to time-delayed (>5 ns), frequency selective, optical feedback from a Fabry-Pe/spl acute/rot interferometer type of filter. Three regimes of interest, based on the relative value of the filter bandwidth with respect to the relevant laser parameters (relaxation oscillation frequency and external cavity mode spacing), are identified, viz. a wide filter case, an intermediate filter width case, and a narrow filter case. The dynamical response of the laser is shown to be quite different in each of these regimes. The principal results are 1) the laser's linewidth enhancement factor, coupled with the nonlinear response of the filter, can be exploited to induce nonlinear dynamics in the instantaneous optical frequency of the laser light on a time scale related to the time-delay of the feedback, 2) a mode mismatch effect which arises from a detuning between the filter center frequency and the nearest external cavity mode and manifests itself in a reduction of the maximum light available for feedback, and 3) a reduction in, or even disappearance of, relaxation oscillations in the laser dynamics when a filter of appropriate width is chosen. More generally, it is observed that certain dynamics that occur due to unfiltered optical feedback may be suppressed when the feedback light is spectrally filtered. 相似文献
8.
Seyyed Ali Shojaee Mohammad Maleki Shahraki Mohammad Ali Faghihi Sani Ali Nemati Abbas Yousefi 《Journal of Materials Science: Materials in Electronics》2010,21(6):571-577
This paper describes a solution-based technique for fabrication of varistor grade composite nanopowders. The method consists
of coating major varistor dopants on the surface of the ZnO nanoparticles. As a result, a homogenous mixture of dopants and
ZnO nanoparticles will be achieved. TEM results indicated that a composite layer of dopants with the average particle size
of 9 nm on the surface of ZnO nanoparticles has been successfully prepared. Sintering of the coated powders was performed
in temperatures as low as 850 °C and final specimens with average particle size of 900 nm and density of 98.5% were achieved.
In comparison to conventional mixing, varistors prepared from coated nanopowders exhibited superior electrical properties
and microstructure homogeneity. The improvement of electrical properties can be attributed to small grain size, homogenous
distribution of dopants and elimination of large Bi-Pockets. In addition, the processing route of schottky barrier formation
is quite different from what is generally considered as the method of barrier formation in ZnO grain boundaries. 相似文献
9.
Camila I. Irion Monique Williams Jose Condor Capcha Trevor Eisenberg Guerline Lambert Lauro M. Takeuchi Grace Seo Keyvan Yousefi Rosemeire Kanashiro-Takeuchi Keith A. Webster Karen C. Young Joshua M. Hare Lina A. Shehadeh 《International journal of molecular sciences》2022,23(12)
Alport syndrome (AS) is a hereditary renal disorder with no etiological therapy. In the preclinical Col4a3-/- model of AS, disease progression and severity vary depending on mouse strain. The sodium-glucose cotransporter 2 (SGLT2) is emerging as an attractive therapeutic target in cardiac/renal pathologies, but its application to AS remains untested. This study investigates cardiorespiratory function and SGLT2 renal expression in Col4a3-/- mice from three different genetic backgrounds, 129x1/SvJ, C57Bl/6 and Balb/C. male Col4a3-/- 129x1/SvJ mice displayed alterations consistent with heart failure with preserved ejection fraction (HFpEF). Female, but not male, C57Bl/6 and Balb/C Col4a3-/- mice exhibited mild changes in systolic and diastolic function of the heart by echocardiography. Male C57Bl/6 Col4a3-/- mice presented systolic dysfunction by invasive hemodynamic analysis. All strains except Balb/C males demonstrated alterations in respiratory function. SGLT2 expression was significantly increased in AS compared to WT mice from all strains. However, cardiorespiratory abnormalities and SGLT2 over-expression were significantly less in AS Balb/C mice compared to the other two strains. Systolic blood pressure was significantly elevated only in mutant 129x1/SvJ mice. The results provide further evidence for strain-dependent cardiorespiratory and hypertensive phenotype variations in mouse AS models, corroborated by renal SGLT2 expression, and support ongoing initiatives to develop SGLT2 inhibitors for the treatment of AS. 相似文献
10.